AU2014324580B2 - Cardiolipin-targeted peptides inhibit beta-amyloid oligomer toxicity - Google Patents

Cardiolipin-targeted peptides inhibit beta-amyloid oligomer toxicity Download PDF

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Publication number
AU2014324580B2
AU2014324580B2 AU2014324580A AU2014324580A AU2014324580B2 AU 2014324580 B2 AU2014324580 B2 AU 2014324580B2 AU 2014324580 A AU2014324580 A AU 2014324580A AU 2014324580 A AU2014324580 A AU 2014324580A AU 2014324580 B2 AU2014324580 B2 AU 2014324580B2
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AU
Australia
Prior art keywords
arg
lys
phe
dmt
aromatic
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Ceased
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AU2014324580A
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English (en)
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AU2014324580A1 (en
Inventor
Alexander V. Birk
Margarita REN
Paul Szabo
Hazel H. Szeto
Brian Yinge ZHAO
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Cornell University
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Cornell University
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Publication of AU2014324580A1 publication Critical patent/AU2014324580A1/en
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Publication of AU2014324580B2 publication Critical patent/AU2014324580B2/en
Priority to AU2020203424A priority Critical patent/AU2020203424A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07Tetrapeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/005Enzyme inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2014324580A 2013-09-30 2014-09-29 Cardiolipin-targeted peptides inhibit beta-amyloid oligomer toxicity Ceased AU2014324580B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2020203424A AU2020203424A1 (en) 2013-09-30 2020-05-25 Cardiolipin-targeted peptides inhibit beta-amyloid oligomer toxicity

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361884722P 2013-09-30 2013-09-30
US61/884,722 2013-09-30
PCT/US2014/058049 WO2015048647A1 (en) 2013-09-30 2014-09-29 Cardiolipin-targeted peptides inhibit beta-amyloid oligomer toxicity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020203424A Division AU2020203424A1 (en) 2013-09-30 2020-05-25 Cardiolipin-targeted peptides inhibit beta-amyloid oligomer toxicity

Publications (2)

Publication Number Publication Date
AU2014324580A1 AU2014324580A1 (en) 2016-04-21
AU2014324580B2 true AU2014324580B2 (en) 2020-02-27

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
AU2014324580A Ceased AU2014324580B2 (en) 2013-09-30 2014-09-29 Cardiolipin-targeted peptides inhibit beta-amyloid oligomer toxicity
AU2020203424A Abandoned AU2020203424A1 (en) 2013-09-30 2020-05-25 Cardiolipin-targeted peptides inhibit beta-amyloid oligomer toxicity

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2020203424A Abandoned AU2020203424A1 (en) 2013-09-30 2020-05-25 Cardiolipin-targeted peptides inhibit beta-amyloid oligomer toxicity

Country Status (7)

Country Link
US (1) US20160375088A1 (https=)
EP (1) EP3052115A4 (https=)
JP (2) JP6434523B2 (https=)
CN (1) CN106163537A (https=)
AU (2) AU2014324580B2 (https=)
CA (1) CA2925757A1 (https=)
WO (1) WO2015048647A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3052115A4 (en) * 2013-09-30 2017-09-27 Cornell University Cardiolipin-targeted peptides inhibit beta-amyloid oligomer toxicity
WO2015095077A1 (en) * 2013-12-16 2015-06-25 Cornell University Methods and compositions for treating and preventing cognitive dysfunction
CA3020393A1 (en) * 2016-04-11 2017-10-19 Carnot, Llc Chiral peptides
CN107320711A (zh) * 2017-03-24 2017-11-07 南京大学 化合物ss‑31在制备治疗弗里德赖希共济失调及相关疾病药物中的应用
AU2020368789B2 (en) * 2019-10-16 2024-01-18 Naturesense Co., Ltd. Peptide for improving memory and preventing or alleviating cognitive impairment, composition containing same and preparation method therefor
CN117881411A (zh) 2021-06-01 2024-04-12 艾迪雅生物有限责任公司 用于眼部药物的延长释放药物递送系统和使用方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004070054A2 (en) * 2003-02-04 2004-08-19 Cornell Research Foundation, Inc. Methods for preventing mitochondrial permeability transition
WO2005072295A2 (en) * 2004-01-23 2005-08-11 Cornell Research Foundation, Inc. Methods for reducing oxidative damage
WO2007035640A2 (en) * 2005-09-16 2007-03-29 Cornell Research Foundation, Inc. Methods for reducing cd36 expression

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1307219A4 (en) * 1999-08-13 2005-04-06 Univ Columbia METHODS OF INHIBITING BETA FIBRILLE BINDING BETA TO RAGE RECEPTOR, AND CONSEQUENCES THEREOF
CN101440124B (zh) * 2003-02-04 2012-07-18 科内尔研究基金会 用于防止线粒体通透性改变的方法
AU2012271691A1 (en) * 2011-06-14 2014-01-16 Stealth Peptides International, Inc. Aromatic-cationic peptides and uses of same
EP3052115A4 (en) * 2013-09-30 2017-09-27 Cornell University Cardiolipin-targeted peptides inhibit beta-amyloid oligomer toxicity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004070054A2 (en) * 2003-02-04 2004-08-19 Cornell Research Foundation, Inc. Methods for preventing mitochondrial permeability transition
WO2005072295A2 (en) * 2004-01-23 2005-08-11 Cornell Research Foundation, Inc. Methods for reducing oxidative damage
WO2007035640A2 (en) * 2005-09-16 2007-03-29 Cornell Research Foundation, Inc. Methods for reducing cd36 expression

Also Published As

Publication number Publication date
JP6434523B2 (ja) 2018-12-05
AU2020203424A1 (en) 2020-06-11
JP2019052158A (ja) 2019-04-04
CN106163537A (zh) 2016-11-23
JP2016533392A (ja) 2016-10-27
EP3052115A4 (en) 2017-09-27
EP3052115A1 (en) 2016-08-10
AU2014324580A1 (en) 2016-04-21
WO2015048647A1 (en) 2015-04-02
CA2925757A1 (en) 2015-04-02
US20160375088A1 (en) 2016-12-29

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired