AU2014285701C1 - RNAi agent for inhibition of Chikungunya virus - Google Patents

RNAi agent for inhibition of Chikungunya virus Download PDF

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Publication number
AU2014285701C1
AU2014285701C1 AU2014285701A AU2014285701A AU2014285701C1 AU 2014285701 C1 AU2014285701 C1 AU 2014285701C1 AU 2014285701 A AU2014285701 A AU 2014285701A AU 2014285701 A AU2014285701 A AU 2014285701A AU 2014285701 C1 AU2014285701 C1 AU 2014285701C1
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AU
Australia
Prior art keywords
chikungunya virus
sirna
nivsi
rnai agent
chikungunya
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AU2014285701A
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English (en)
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AU2014285701A1 (en
AU2014285701B2 (en
Inventor
A. Vidya Arankalle
D. Mangesh Gokhale
Satyendra Kumar
S. Mandar Paingankar
Deepti Parashar
S. Sapna Shinde
B. A. Sudeep
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Indian Council of Medical Research
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Indian Council of Medical Research
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2014285701A 2013-07-02 2014-07-02 RNAi agent for inhibition of Chikungunya virus Active AU2014285701C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1960/DEL/2013 2013-07-02
PCT/IN2014/000441 WO2015001570A1 (en) 2013-07-02 2014-07-02 Rnai agent for inhibition of chikungunya virus
IN1960DE2013 IN2013DE01960A (OSRAM) 2013-07-02 2014-07-02

Publications (3)

Publication Number Publication Date
AU2014285701A1 AU2014285701A1 (en) 2016-01-21
AU2014285701B2 AU2014285701B2 (en) 2021-04-01
AU2014285701C1 true AU2014285701C1 (en) 2021-07-15

Family

ID=51383914

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014285701A Active AU2014285701C1 (en) 2013-07-02 2014-07-02 RNAi agent for inhibition of Chikungunya virus

Country Status (6)

Country Link
US (1) US9574195B2 (OSRAM)
EP (1) EP3017046B1 (OSRAM)
CN (1) CN105392886B (OSRAM)
AU (1) AU2014285701C1 (OSRAM)
IN (1) IN2013DE01960A (OSRAM)
WO (1) WO2015001570A1 (OSRAM)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200024793A (ko) * 2017-07-06 2020-03-09 애로우헤드 파마슈티컬스 인코포레이티드 알파-ENaC의 발현을 억제하기 위한 RNAi 작용제 및 사용 방법

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
D Parashar ET AL, "[P1.62] RNA interference inhibits Chikungunya virus replication in mammalian cells", (2010-11-07), URL: http://elsevier.conference-services.net/resources/247/2020/pdf/ANTI2010_0023.pdf, (2014-12-11) *

Also Published As

Publication number Publication date
EP3017046B1 (en) 2019-09-11
CN105392886B (zh) 2019-10-22
AU2014285701A1 (en) 2016-01-21
US20160145621A1 (en) 2016-05-26
CN105392886A (zh) 2016-03-09
AU2014285701B2 (en) 2021-04-01
EP3017046A1 (en) 2016-05-11
US9574195B2 (en) 2017-02-21
IN2013DE01960A (OSRAM) 2015-06-26
WO2015001570A1 (en) 2015-01-08

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT FILED 06 APR 2021

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