AU2014268880B2 - Automated sterilization process integrated with a blow fill seal machine - Google Patents
Automated sterilization process integrated with a blow fill seal machine Download PDFInfo
- Publication number
- AU2014268880B2 AU2014268880B2 AU2014268880A AU2014268880A AU2014268880B2 AU 2014268880 B2 AU2014268880 B2 AU 2014268880B2 AU 2014268880 A AU2014268880 A AU 2014268880A AU 2014268880 A AU2014268880 A AU 2014268880A AU 2014268880 B2 AU2014268880 B2 AU 2014268880B2
- Authority
- AU
- Australia
- Prior art keywords
- product
- pathway
- holding tank
- product pathway
- sterilizing agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000034 method Methods 0.000 title claims abstract description 116
- 230000008569 process Effects 0.000 title claims abstract description 112
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 106
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 90
- 230000037361 pathway Effects 0.000 claims abstract description 247
- 239000003206 sterilizing agent Substances 0.000 claims abstract description 89
- 238000009472 formulation Methods 0.000 claims description 30
- 239000000203 mixture Substances 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 7
- 238000004140 cleaning Methods 0.000 claims description 7
- 238000012544 monitoring process Methods 0.000 claims description 4
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 claims description 3
- 239000000047 product Substances 0.000 description 242
- 238000011109 contamination Methods 0.000 description 12
- 230000036512 infertility Effects 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 5
- 230000001276 controlling effect Effects 0.000 description 4
- 238000002955 isolation Methods 0.000 description 4
- 244000052616 bacterial pathogen Species 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000012865 aseptic processing Methods 0.000 description 2
- 238000000071 blow moulding Methods 0.000 description 2
- 238000012790 confirmation Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 238000009455 aseptic packaging Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012263 liquid product Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000009928 pasteurization Methods 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 238000009512 pharmaceutical packaging Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000009666 routine test Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/24—Apparatus using programmed or automatic operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
- A61L2/06—Hot gas
- A61L2/07—Steam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/02—Machines characterised by the incorporation of means for making the containers or receptacles
- B65B3/022—Making containers by moulding of a thermoplastic material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B2210/00—Specific aspects of the packaging machine
- B65B2210/06—Sterilising or cleaning machinery or conduits
- B65B2210/08—Cleaning nozzles, funnels or guides through which articles are introduced into containers or wrappers
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/902,385 | 2013-05-24 | ||
| US13/902,385 US9034249B2 (en) | 2013-05-24 | 2013-05-24 | Automated sterilization process integrated with a blow fill seal machine |
| PCT/US2014/038183 WO2014189761A1 (en) | 2013-05-24 | 2014-05-15 | Automated sterilization process integrated with a blow fill seal machine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2014268880A1 AU2014268880A1 (en) | 2015-11-12 |
| AU2014268880A8 AU2014268880A8 (en) | 2015-12-03 |
| AU2014268880B2 true AU2014268880B2 (en) | 2017-09-28 |
Family
ID=51933989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014268880A Ceased AU2014268880B2 (en) | 2013-05-24 | 2014-05-15 | Automated sterilization process integrated with a blow fill seal machine |
Country Status (10)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11027862B2 (en) | 2014-06-23 | 2021-06-08 | Woodstock Sterile Solutions, Inc. | Cold blow-fill-seal packaging system and process |
| CN107198657A (zh) * | 2016-03-17 | 2017-09-26 | 江苏大红鹰恒顺药业有限公司 | 集无菌配制和吹灌封三合一塑料安瓿无菌制剂工艺及系统 |
| CA3021989A1 (en) | 2016-04-25 | 2017-11-02 | Marc Andrew Koska | Medical delivery system |
| CA3056223A1 (en) | 2017-03-27 | 2018-10-04 | Regeneron Pharmaceuticals, Inc. | Sterilization methods for medical products and sterilized medical products |
| AR113037A1 (es) * | 2017-08-22 | 2020-01-22 | Scherer Technologies Llc R P | Sistemas y métodos para llenar envases |
| EP3710086A4 (en) | 2017-11-17 | 2021-11-17 | Koska Family Limited | SYSTEMS AND PROCESSES FOR FLUID DISPENSERS |
| JP2019098118A (ja) * | 2017-12-08 | 2019-06-24 | 大日本印刷株式会社 | 除菌フィルタの殺菌方法及び殺菌装置 |
| JP2019136543A (ja) * | 2019-04-26 | 2019-08-22 | 大日本印刷株式会社 | 除菌フィルタの殺菌方法及び殺菌装置 |
| USD1052082S1 (en) | 2020-06-01 | 2024-11-19 | Koska Family Limited | Sealed fluid container |
| CN114317262A (zh) * | 2020-09-30 | 2022-04-12 | 北京瑷格干细胞科技有限公司 | 一种培养箱用恒温摇床及培养箱用恒温摇床控制方法 |
| JP7176555B2 (ja) * | 2020-11-09 | 2022-11-22 | 大日本印刷株式会社 | 除菌フィルタを備えるエア供給配管の殺菌方法 |
| USD992110S1 (en) | 2021-08-10 | 2023-07-11 | Koska Family Limited | Sealed fluid container |
| US11471551B1 (en) | 2021-09-09 | 2022-10-18 | Micron Pure, Llc | Apparatus for inactivation of airborne pathogens |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3464085A (en) | 1966-09-26 | 1969-09-02 | Dow Chemical Co | Packaging apparatus |
| DE3033821C2 (de) | 1980-09-09 | 1982-09-09 | Gerhard 7166 Sulzbach-Laufen Hansen | Verfahren und Vorrichtung zum Herstellen eines Behälters aus einem heißsiegelbaren Kunststoffschlauch und durch das Verfahren und mittels der Vorrichtung hergestellter Behälter |
| JPS59194745A (ja) * | 1983-04-19 | 1984-11-05 | ハウス食品工業株式会社 | 液状物を連続的に処理可能な殺菌充填装置 |
| US4979347A (en) | 1988-05-19 | 1990-12-25 | Snow Brand Milk Products Co., Ltd. | Fill- and pack in a non-germ atmosphere machine |
| US4989649A (en) * | 1989-09-14 | 1991-02-05 | Automatic Liquid Packaging, Inc. | Fill machine sterilization process |
| US5636763A (en) | 1993-11-04 | 1997-06-10 | Furness; Geoffrey M. | Gas pressurized liquid delivery system |
| DE4439231C1 (de) | 1994-11-03 | 1996-04-25 | Bernd Hansen | Blasformverfahren zum Herstellen eines verschlossenen Behältnisses und nach diesem Verfahren hergestelltes Behältnis |
| US7038219B2 (en) | 1996-05-22 | 2006-05-02 | Purepulse Technologies, Inc. | Sterilization of packages and their contents using light |
| US6142169A (en) * | 1997-03-28 | 2000-11-07 | Tetra Laval Holdings & Finance, Sa | Sterile tank venting system for a filling machine |
| EP1012047B1 (en) | 1997-04-21 | 2004-01-07 | Graham Packaging Company, L.P. | System for blow-molding, filling and capping containers |
| US5979514A (en) * | 1998-01-28 | 1999-11-09 | Tetra Laval Holdings & Finance, Sa | Hygienic fill system for a packaging machine |
| DE69822444T2 (de) | 1998-06-30 | 2005-01-20 | Tetra Laval Holdings & Finance S.A. | Einheit zum Sterilisieren von Verpackungsmaterial |
| DE19917441C2 (de) * | 1999-04-17 | 2001-10-11 | Bosch Gmbh Robert | Vorrichtung zum Dosieren und Abfüllen einer Flüssigkeit in Verpackungsbehälter |
| JP2004081036A (ja) * | 2002-08-23 | 2004-03-18 | Echigo Seika Co Ltd | 固形具材入り容器包装食品の処理方法 |
| US20050019239A1 (en) | 2003-07-24 | 2005-01-27 | Bowen John G. | Apparatus and methods for variably sterilizing aqueous liquids |
| US20060032189A1 (en) | 2004-08-13 | 2006-02-16 | Giacobbe Frederick W | Process and method of sterilizing aseptic containers |
| US9056145B2 (en) | 2005-08-22 | 2015-06-16 | John Guy Bowen | Self-contained, self-cleaning aqueous liquid sterilizer |
| EP2065164A1 (fr) | 2007-11-27 | 2009-06-03 | Aisapack Holding SA | Procédé de fabrication d'un emballage pour remplissage à chaud ainsi qu'un tel emballage |
| WO2010024165A1 (ja) | 2008-08-28 | 2010-03-04 | 東洋製罐株式会社 | プリフォームの圧縮成形金型及びプリフォーム、これを用いた飲・食料品無菌充填システム及びブロー成形容器の製造方法 |
| EP2361099B1 (en) | 2009-02-23 | 2012-09-12 | Noxilizer, Inc. | Method for gas sterilization |
| CN102247287B (zh) * | 2010-05-20 | 2013-05-15 | 石家庄四药有限公司 | 一种聚丙烯塑瓶大输液制瓶及灭菌方法 |
| DE102011013125A1 (de) | 2011-03-04 | 2012-09-06 | Krones Aktiengesellschaft | Blasmaschine mit Reinraum und sterilisierbar verbundenen Bauteilen |
| JP5838720B2 (ja) | 2011-10-25 | 2016-01-06 | 大日本印刷株式会社 | 殺菌処理ライン及びその浄化方法 |
-
2013
- 2013-05-24 US US13/902,385 patent/US9034249B2/en active Active
-
2014
- 2014-05-15 AU AU2014268880A patent/AU2014268880B2/en not_active Ceased
- 2014-05-15 JP JP2016514975A patent/JP6588010B2/ja not_active Expired - Fee Related
- 2014-05-15 CA CA2913146A patent/CA2913146C/en active Active
- 2014-05-15 WO PCT/US2014/038183 patent/WO2014189761A1/en active Application Filing
- 2014-05-15 ES ES14801486T patent/ES2718599T3/es active Active
- 2014-05-15 CN CN201480028942.9A patent/CN105228653B/zh not_active Expired - Fee Related
- 2014-05-15 EP EP14801486.3A patent/EP3003404B1/en not_active Not-in-force
- 2014-05-15 BR BR112015029042A patent/BR112015029042B8/pt not_active IP Right Cessation
- 2014-05-23 AR ARP140102039A patent/AR096398A1/es active IP Right Grant
-
2015
- 2015-03-13 US US14/656,858 patent/US9533065B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112015029042B8 (pt) | 2020-06-30 |
| US20150182653A1 (en) | 2015-07-02 |
| EP3003404B1 (en) | 2019-01-02 |
| WO2014189761A1 (en) | 2014-11-27 |
| JP2016523598A (ja) | 2016-08-12 |
| JP6588010B2 (ja) | 2019-10-09 |
| AU2014268880A1 (en) | 2015-11-12 |
| AR096398A1 (es) | 2015-12-30 |
| US20140348700A1 (en) | 2014-11-27 |
| ES2718599T3 (es) | 2019-07-03 |
| CN105228653A (zh) | 2016-01-06 |
| EP3003404A1 (en) | 2016-04-13 |
| US9034249B2 (en) | 2015-05-19 |
| CN105228653B (zh) | 2018-06-01 |
| AU2014268880A8 (en) | 2015-12-03 |
| CA2913146C (en) | 2021-03-09 |
| BR112015029042A2 (pt) | 2017-07-25 |
| US9533065B2 (en) | 2017-01-03 |
| CA2913146A1 (en) | 2014-11-27 |
| BR112015029042B1 (pt) | 2020-06-09 |
| EP3003404A4 (en) | 2017-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TH | Corrigenda |
Free format text: IN VOL 29 , NO 44 , PAGE(S) 6703 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME R.P. SCHERER TECHNOLOGIES, LLC, APPLICATION NO. 2014268880, UNDER INID (72) ADD CO-INVENTOR AMIR, MUHAMMAD |
|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |