AU2014265483B2 - Anti-influenza compositions and methods - Google Patents

Anti-influenza compositions and methods Download PDF

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Publication number
AU2014265483B2
AU2014265483B2 AU2014265483A AU2014265483A AU2014265483B2 AU 2014265483 B2 AU2014265483 B2 AU 2014265483B2 AU 2014265483 A AU2014265483 A AU 2014265483A AU 2014265483 A AU2014265483 A AU 2014265483A AU 2014265483 B2 AU2014265483 B2 AU 2014265483B2
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AU
Australia
Prior art keywords
compound
lower alkyl
orn
independently
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2014265483A
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English (en)
Other versions
AU2014265483A1 (en
Inventor
Yarlagadda S. Babu
Shanta Bantia
Pravin L. Kotian
William P. Sheridan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocryst Pharmaceuticals Inc
Original Assignee
Biocryst Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocryst Pharmaceuticals Inc filed Critical Biocryst Pharmaceuticals Inc
Publication of AU2014265483A1 publication Critical patent/AU2014265483A1/en
Application granted granted Critical
Publication of AU2014265483B2 publication Critical patent/AU2014265483B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2014265483A 2013-05-14 2014-05-14 Anti-influenza compositions and methods Active AU2014265483B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361823133P 2013-05-14 2013-05-14
US201361823135P 2013-05-14 2013-05-14
US61/823,133 2013-05-14
US61/823,135 2013-05-14
PCT/US2014/038000 WO2014186465A1 (en) 2013-05-14 2014-05-14 Anti-influenza compositions and methods

Publications (2)

Publication Number Publication Date
AU2014265483A1 AU2014265483A1 (en) 2015-12-17
AU2014265483B2 true AU2014265483B2 (en) 2018-08-02

Family

ID=51898845

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014265483A Active AU2014265483B2 (en) 2013-05-14 2014-05-14 Anti-influenza compositions and methods

Country Status (6)

Country Link
US (2) US9499554B2 (enExample)
EP (1) EP2996685B1 (enExample)
JP (1) JP6417568B2 (enExample)
AU (1) AU2014265483B2 (enExample)
CA (1) CA2911424C (enExample)
WO (1) WO2014186465A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112250601B (zh) * 2020-09-08 2022-09-27 天津应天成科技有限公司 安全无毒去除帕拉米韦三水合物中间体m9中镍离子杂质的方法
CN118119624A (zh) 2021-08-20 2024-05-31 盐野义制药株式会社 具有病毒增殖抑制作用的核苷衍生物及其前药

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013148746A1 (en) * 2012-03-30 2013-10-03 Rohm And Haas Company Product and method for making uniform, spherical, acrylic polymeric beads

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6420549B1 (en) 1995-06-06 2002-07-16 Isis Pharmaceuticals, Inc. Oligonucleotide analogs having modified dimers
AU2200199A (en) * 1997-12-17 1999-07-19 Biocryst Pharmaceuticals, Inc. Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors
CN101610772B (zh) * 2007-02-16 2013-01-16 富山化学工业株式会社 包含吡嗪衍生物的药物组合物和使用吡嗪衍生物的联合用药的方法
EP2192923A2 (en) * 2007-08-27 2010-06-09 Massachusetts Institute of Technology Bi-functional polymer-attached inhibitors of influenza virus
EA201101564A1 (ru) * 2009-05-15 2012-07-30 Редкс Фарма Лимитед Редокс производные лекарственных средств
US20130023585A1 (en) 2010-04-02 2013-01-24 Tsrl, Inc. Neuraminidase Inhibitors
RS56870B1 (sr) 2010-10-15 2018-04-30 Biocryst Pharm Inc Pirolopirimidinski derivati za primenu u lečenju virusnih infekcija

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013148746A1 (en) * 2012-03-30 2013-10-03 Rohm And Haas Company Product and method for making uniform, spherical, acrylic polymeric beads

Also Published As

Publication number Publication date
EP2996685A4 (en) 2016-12-07
HK1222560A1 (en) 2017-07-07
WO2014186465A1 (en) 2014-11-20
JP6417568B2 (ja) 2018-11-07
US20170137429A1 (en) 2017-05-18
AU2014265483A1 (en) 2015-12-17
US9499554B2 (en) 2016-11-22
EP2996685A1 (en) 2016-03-23
US20160096842A1 (en) 2016-04-07
CA2911424C (en) 2021-11-30
JP2016518451A (ja) 2016-06-23
CA2911424A1 (en) 2014-11-20
EP2996685B1 (en) 2019-03-27

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FGA Letters patent sealed or granted (standard patent)