AU2014248321A1 - Novel alpha4beta7 peptide dimer antagonists - Google Patents
Novel alpha4beta7 peptide dimer antagonists Download PDFInfo
- Publication number
- AU2014248321A1 AU2014248321A1 AU2014248321A AU2014248321A AU2014248321A1 AU 2014248321 A1 AU2014248321 A1 AU 2014248321A1 AU 2014248321 A AU2014248321 A AU 2014248321A AU 2014248321 A AU2014248321 A AU 2014248321A AU 2014248321 A1 AU2014248321 A1 AU 2014248321A1
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- Prior art keywords
- xaa
- group
- acid
- peptide dimer
- lys
- Prior art date
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- Abandoned
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Classifications
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- C07K7/04—Linear peptides containing only normal peptide links
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- A—HUMAN NECESSITIES
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70546—Integrin superfamily
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Engineering & Computer Science (AREA)
- Immunology (AREA)
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- Pulmonology (AREA)
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- Diabetes (AREA)
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- Zoology (AREA)
- Toxicology (AREA)
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- Pain & Pain Management (AREA)
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- Hematology (AREA)
- Otolaryngology (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| AU2018220168A AU2018220168A1 (en) | 2013-04-02 | 2018-08-27 | Novel alpha4beta7 peptide dimer antagonists |
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| US201361807714P | 2013-04-02 | 2013-04-02 | |
| US61/807,714 | 2013-04-02 | ||
| US14/229,784 | 2014-03-28 | ||
| US14/229,784 US20140294901A1 (en) | 2013-04-02 | 2014-03-28 | Novel a4b7 peptide dimer antagonists |
| PCT/US2014/032391 WO2014165448A1 (en) | 2013-04-02 | 2014-03-31 | NOVEL α4β7 PEPTIDE DIMER ANTAGONISTS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| AU2014248321A1 true AU2014248321A1 (en) | 2015-10-29 |
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| AU2018220168A Abandoned AU2018220168A1 (en) | 2013-04-02 | 2018-08-27 | Novel alpha4beta7 peptide dimer antagonists |
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Country Status (10)
| Country | Link |
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| US (2) | US20140294901A1 (https=) |
| EP (1) | EP2981544B1 (https=) |
| JP (1) | JP6499157B2 (https=) |
| KR (1) | KR20160011625A (https=) |
| CN (1) | CN105339383A (https=) |
| AU (2) | AU2014248321A1 (https=) |
| CA (1) | CA2908593A1 (https=) |
| HK (1) | HK1221233A1 (https=) |
| SG (2) | SG11201508178UA (https=) |
| WO (1) | WO2014165448A1 (https=) |
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| US9273093B2 (en) | 2012-10-11 | 2016-03-01 | Protagonist Therapeutics, Inc. | α4β7 peptide dimer antagonists |
| DK2968443T3 (da) | 2013-03-15 | 2021-12-06 | Protagonist Therapeutics Inc | Hepcidinanaloger og anvendelser deraf |
| PT3143037T (pt) | 2014-05-16 | 2021-09-24 | Protagonist Therapeutics Inc | Antagonistas peptídicos tioéter de integrina alfa4beta7 |
| US9624268B2 (en) | 2014-07-17 | 2017-04-18 | Protagonist Therapeutics, Inc. | Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases |
| KR20170108936A (ko) | 2014-10-01 | 2017-09-27 | 프로타고니스트 테라퓨틱스, 인코포레이티드 | 신규한 α4β7 펩타이드 단량체 및 이량체 길항제 |
| EP3201217A4 (en) | 2014-10-01 | 2018-07-18 | Protagonist Therapeutics Inc. | Novel cyclic monomer and dimer peptides having integrin antagonist activity |
| US10787490B2 (en) | 2015-07-15 | 2020-09-29 | Protaganist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| JP7174627B2 (ja) * | 2015-10-23 | 2022-11-17 | ウニフェルシタイト・トゥヴェンテ | インテグリン結合ペプチド及びその使用 |
| US20190002503A1 (en) | 2015-12-30 | 2019-01-03 | Protagonist Therapeutics, Inc. | Analogues of hepcidin mimetics with improved in vivo half lives |
| WO2017165676A1 (en) * | 2016-03-23 | 2017-09-28 | Protagonist Therapeutics, Inc. | METHODS FOR SYNTHESIZING α4β7 PEPTIDE ANTAGONISTS |
| EP3681900A4 (en) | 2017-09-11 | 2021-09-08 | Protagonist Therapeutics, Inc. | OPIOID AGONIST PEPTIDES AND THEIR USES |
| EP3749345A4 (en) | 2018-02-08 | 2022-04-06 | Protagonist Therapeutics, Inc. | CONJUGATED HEPCIDIN MIMETICS |
| TW202019948A (zh) | 2018-07-12 | 2020-06-01 | 美商領導醫療有限公司 | 介白素-23受體之肽抑制劑及其治療發炎疾病之用途 |
| CN114341161A (zh) | 2019-07-10 | 2022-04-12 | 领导医疗有限公司 | 白细胞介素-23受体的肽抑制剂及其用于治疗炎症性疾病的用途 |
| HRP20250769T1 (hr) | 2020-01-15 | 2025-08-29 | Janssen Biotech, Inc. | Peptidni inhibitori receptora za interleukin-23 i njihova uporaba u liječenju upalnih bolesti |
| AU2021209086A1 (en) | 2020-01-15 | 2022-08-04 | Janssen Biotech, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| AU2021383828A1 (en) | 2020-11-20 | 2023-07-06 | Janssen Pharmaceutica Nv | Compositions of peptide inhibitors of interleukin-23 receptor |
| WO2023288019A2 (en) | 2021-07-14 | 2023-01-19 | Janssen Biotech, Inc. | Lipidated peptide inhibitors of interleukin-23 receptor |
| CN114874107B (zh) * | 2022-07-12 | 2022-11-29 | 中山大学附属第七医院(深圳) | 一种氨基脂质及其制备方法和应用 |
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| US6037324A (en) * | 1996-01-04 | 2000-03-14 | Leukosite, Inc. | Inhibitors of MAdCAM-1-mediated interactions and methods of use therefor |
| GB9613112D0 (en) * | 1996-06-21 | 1996-08-28 | Zeneca Ltd | Chemical compounds |
| US6818617B1 (en) * | 1997-08-15 | 2004-11-16 | Temple University- Of The Commonwealth System Of Higher Education | EC-3, an inhibitor of α4β1 and α4β7 integrins |
| EP1033983A1 (en) * | 1997-11-24 | 2000-09-13 | Merck & Co., Inc. | Cyclic amino acid derivatives as cell adhesion inhibitors |
| WO2002055106A2 (en) * | 2001-01-09 | 2002-07-18 | Merck Patent Gmbh | Combination therapy using receptor tyrosine kinase inhibitors and angiogenesis inhibitors |
| GB0610395D0 (en) * | 2006-05-25 | 2006-07-05 | Ge Healthcare Ltd | Novel imaging agents |
| EP2109480B1 (en) * | 2006-12-07 | 2017-06-28 | The Government of the United States of America as Represented by the Secretary of the Department of Health and Human Services | Use of antagonists of the interaction between hiv gp120 and alpha4beta7 integrin |
| WO2009039185A1 (en) * | 2007-09-17 | 2009-03-26 | The Trustees Of Columbia University In The City Of New York | Uses of immunologically modified scaffold for tissue prevascularization and cell transplantation |
| JP2011231085A (ja) * | 2010-04-30 | 2011-11-17 | Osaka Prefecture Univ | 環状ペプチド |
| EP2444101A1 (en) * | 2010-10-21 | 2012-04-25 | Universitätsklinikum Freiburg | Selective targeting of the CD40L/Mac-1 interaction by small peptide inhibitors and its use for the treatment of inflammation and atherogenesis |
| US9273093B2 (en) * | 2012-10-11 | 2016-03-01 | Protagonist Therapeutics, Inc. | α4β7 peptide dimer antagonists |
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2014
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- 2014-03-31 SG SG11201508178UA patent/SG11201508178UA/en unknown
- 2014-03-31 SG SG10201708103RA patent/SG10201708103RA/en unknown
- 2014-03-31 EP EP14779463.0A patent/EP2981544B1/en active Active
- 2014-03-31 WO PCT/US2014/032391 patent/WO2014165448A1/en not_active Ceased
- 2014-03-31 CA CA2908593A patent/CA2908593A1/en not_active Abandoned
- 2014-03-31 HK HK16109329.5A patent/HK1221233A1/zh unknown
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- 2014-03-31 AU AU2014248321A patent/AU2014248321A1/en not_active Abandoned
- 2014-03-31 CN CN201480028920.2A patent/CN105339383A/zh active Pending
- 2014-03-31 KR KR1020157031177A patent/KR20160011625A/ko not_active Withdrawn
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2017
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2018
- 2018-08-27 AU AU2018220168A patent/AU2018220168A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20140294901A1 (en) | 2014-10-02 |
| US20190002500A1 (en) | 2019-01-03 |
| WO2014165448A1 (en) | 2014-10-09 |
| JP6499157B2 (ja) | 2019-04-10 |
| EP2981544B1 (en) | 2019-09-04 |
| SG11201508178UA (en) | 2015-11-27 |
| CA2908593A1 (en) | 2014-10-09 |
| SG10201708103RA (en) | 2017-11-29 |
| AU2018220168A1 (en) | 2018-09-13 |
| HK1221233A1 (zh) | 2017-05-26 |
| JP2016518351A (ja) | 2016-06-23 |
| EP2981544A1 (en) | 2016-02-10 |
| CN105339383A (zh) | 2016-02-17 |
| KR20160011625A (ko) | 2016-02-01 |
| EP2981544A4 (en) | 2016-12-07 |
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