AU2014236728B2 - Method of treating metabolic disorders using PLA2G12A polypeptides and PLA2G12A mutant polypeptides - Google Patents
Method of treating metabolic disorders using PLA2G12A polypeptides and PLA2G12A mutant polypeptides Download PDFInfo
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- AU2014236728B2 AU2014236728B2 AU2014236728A AU2014236728A AU2014236728B2 AU 2014236728 B2 AU2014236728 B2 AU 2014236728B2 AU 2014236728 A AU2014236728 A AU 2014236728A AU 2014236728 A AU2014236728 A AU 2014236728A AU 2014236728 B2 AU2014236728 B2 AU 2014236728B2
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- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A—HUMAN NECESSITIES
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- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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Landscapes
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| PCT/US2014/026736 WO2014151962A1 (en) | 2013-03-15 | 2014-03-13 | Method of treating metabolic disorders using pla2g12a polypeptides and pla2g12a mutant polypeptides |
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| AU2014236728A1 AU2014236728A1 (en) | 2015-09-24 |
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| AU2014236728B2 (en) | 2013-03-15 | 2018-09-13 | Amgen Inc. | Method of treating metabolic disorders using PLA2G12A polypeptides and PLA2G12A mutant polypeptides |
| US10436802B2 (en) | 2014-09-12 | 2019-10-08 | Biogen Ma Inc. | Methods for treating spinal muscular atrophy |
| EP3263600A1 (en) | 2016-07-01 | 2018-01-03 | Université Claude Bernard Lyon 1 | Inhibition of pla2r1 for the prevention and/or the treatment of type 2-diabetes |
| JP2022532153A (ja) * | 2019-05-08 | 2022-07-13 | ツインピッグ バイオラブ インコーポレイテッド | ホスホリパーゼａ２を有効成分として含む肥満予防または治療用組成物 |
| WO2021001377A1 (en) * | 2019-07-02 | 2021-01-07 | Fundacion Para La Investigacion Medica Aplicada | cPLA2e INDUCING AGENTS AND USES THEREOF |
| AR121446A1 (es) * | 2020-02-28 | 2022-06-08 | Ionis Pharmaceuticals Inc | Compuestos y métodos para modular smn2 |
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| WO2012151159A1 (en) * | 2011-05-02 | 2012-11-08 | Ngm Biopharmaceuticals, Inc. | Methods of modulating pla2g12a levels and treating disorders associated therewith |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| DE3374837D1 (en) | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| EP0143949B1 (en) | 1983-11-01 | 1988-10-12 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Pharmaceutical composition containing urokinase |
| US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| US5470582A (en) | 1992-02-07 | 1995-11-28 | Syntex (U.S.A.) Inc. | Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles |
| EP1141334B1 (en) * | 1998-12-24 | 2008-10-08 | Sylus Pharmaceuticals Ltd | Human glycosylphosphatidylinositol specific phospholipase d variants and uses thereof |
| US20140099295A1 (en) * | 2011-05-02 | 2014-04-10 | Ngm Biopharmaceuticals, Inc. | Methods of Treating Glucose Metabolism Disorders |
| AU2014236728B2 (en) | 2013-03-15 | 2018-09-13 | Amgen Inc. | Method of treating metabolic disorders using PLA2G12A polypeptides and PLA2G12A mutant polypeptides |
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| WO2012151159A1 (en) * | 2011-05-02 | 2012-11-08 | Ngm Biopharmaceuticals, Inc. | Methods of modulating pla2g12a levels and treating disorders associated therewith |
Non-Patent Citations (1)
| Title |
|---|
| MORGANE ROUAULT ET AL, "Novel Mammalian Group XII Secreted Phospholipase A 2 Lacking Enzymatic Activity + , +", BIOCHEMISTRY, (2003-10), vol. 42, no. 39, doi:10.1021/bi0349930, ISSN 0006-2960, pages 11494 - 11503 * |
Also Published As
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| CA2906540A1 (en) | 2014-09-25 |
| JP2016515123A (ja) | 2016-05-26 |
| US9474792B2 (en) | 2016-10-25 |
| US20160008439A1 (en) | 2016-01-14 |
| WO2014151962A1 (en) | 2014-09-25 |
| EP2968480B1 (en) | 2020-10-14 |
| JP6434485B2 (ja) | 2018-12-05 |
| EP2968480A1 (en) | 2016-01-20 |
| CA2906540C (en) | 2021-01-12 |
| AU2014236728A1 (en) | 2015-09-24 |
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