AU2014233317B2 - Transgenic animals with customizable traits - Google Patents
Transgenic animals with customizable traits Download PDFInfo
- Publication number
- AU2014233317B2 AU2014233317B2 AU2014233317A AU2014233317A AU2014233317B2 AU 2014233317 B2 AU2014233317 B2 AU 2014233317B2 AU 2014233317 A AU2014233317 A AU 2014233317A AU 2014233317 A AU2014233317 A AU 2014233317A AU 2014233317 B2 AU2014233317 B2 AU 2014233317B2
- Authority
- AU
- Australia
- Prior art keywords
- promoter
- keratin
- protein
- nucleic acid
- animal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 241001465754 Metazoa Species 0.000 title claims abstract description 185
- 230000009261 transgenic effect Effects 0.000 title claims description 92
- 102100026887 Beta-defensin 103 Human genes 0.000 claims abstract description 10
- 101710187196 Beta-defensin 103 Proteins 0.000 claims abstract description 10
- 108090000623 proteins and genes Proteins 0.000 claims description 150
- 102000004169 proteins and genes Human genes 0.000 claims description 124
- 150000007523 nucleic acids Chemical class 0.000 claims description 121
- 230000014509 gene expression Effects 0.000 claims description 109
- 102000039446 nucleic acids Human genes 0.000 claims description 107
- 108020004707 nucleic acids Proteins 0.000 claims description 107
- 241000283690 Bos taurus Species 0.000 claims description 55
- 230000001939 inductive effect Effects 0.000 claims description 47
- 238000005215 recombination Methods 0.000 claims description 38
- 230000006798 recombination Effects 0.000 claims description 37
- 210000004027 cell Anatomy 0.000 claims description 35
- YVLPJIGOMTXXLP-UHFFFAOYSA-N 15-cis-phytoene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CC=CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C YVLPJIGOMTXXLP-UHFFFAOYSA-N 0.000 claims description 28
- 108010072151 Agouti Signaling Protein Proteins 0.000 claims description 23
- 108091026890 Coding region Proteins 0.000 claims description 23
- 102000004378 Melanocortin Receptors Human genes 0.000 claims description 22
- 108090000950 Melanocortin Receptors Proteins 0.000 claims description 22
- 230000035897 transcription Effects 0.000 claims description 22
- 238000013518 transcription Methods 0.000 claims description 22
- 102000006822 Agouti Signaling Protein Human genes 0.000 claims description 21
- 108700028369 Alleles Proteins 0.000 claims description 21
- 239000004098 Tetracycline Substances 0.000 claims description 19
- 210000002752 melanocyte Anatomy 0.000 claims description 19
- 229960002180 tetracycline Drugs 0.000 claims description 19
- 229930101283 tetracycline Natural products 0.000 claims description 19
- 235000019364 tetracycline Nutrition 0.000 claims description 19
- 150000003522 tetracyclines Chemical class 0.000 claims description 19
- 230000002401 inhibitory effect Effects 0.000 claims description 18
- 241000282414 Homo sapiens Species 0.000 claims description 17
- 102000003425 Tyrosinase Human genes 0.000 claims description 16
- 108060008724 Tyrosinase Proteins 0.000 claims description 16
- YVLPJIGOMTXXLP-UUKUAVTLSA-N 15,15'-cis-Phytoene Natural products C(=C\C=C/C=C(\CC/C=C(\CC/C=C(\CC/C=C(\C)/C)/C)/C)/C)(\CC/C=C(\CC/C=C(\CC/C=C(\C)/C)/C)/C)/C YVLPJIGOMTXXLP-UUKUAVTLSA-N 0.000 claims description 14
- YVLPJIGOMTXXLP-BAHRDPFUSA-N 15Z-phytoene Natural products CC(=CCCC(=CCCC(=CCCC(=CC=C/C=C(C)/CCC=C(/C)CCC=C(/C)CCC=C(C)C)C)C)C)C YVLPJIGOMTXXLP-BAHRDPFUSA-N 0.000 claims description 14
- 235000011765 phytoene Nutrition 0.000 claims description 14
- 230000004913 activation Effects 0.000 claims description 13
- 230000001105 regulatory effect Effects 0.000 claims description 13
- 241000287828 Gallus gallus Species 0.000 claims description 12
- 241000699666 Mus <mouse, genus> Species 0.000 claims description 10
- 150000003431 steroids Chemical class 0.000 claims description 9
- 210000001519 tissue Anatomy 0.000 claims description 9
- 241000701022 Cytomegalovirus Species 0.000 claims description 8
- UPEZCKBFRMILAV-JNEQICEOSA-N Ecdysone Natural products O=C1[C@H]2[C@@](C)([C@@H]3C([C@@]4(O)[C@@](C)([C@H]([C@H]([C@@H](O)CCC(O)(C)C)C)CC4)CC3)=C1)C[C@H](O)[C@H](O)C2 UPEZCKBFRMILAV-JNEQICEOSA-N 0.000 claims description 7
- 241000282326 Felis catus Species 0.000 claims description 7
- 101000872516 Homo sapiens E3 ubiquitin-protein ligase HERC2 Proteins 0.000 claims description 7
- UPEZCKBFRMILAV-UHFFFAOYSA-N alpha-Ecdysone Natural products C1C(O)C(O)CC2(C)C(CCC3(C(C(C(O)CCC(C)(C)O)C)CCC33O)C)C3=CC(=O)C21 UPEZCKBFRMILAV-UHFFFAOYSA-N 0.000 claims description 7
- UPEZCKBFRMILAV-JMZLNJERSA-N ecdysone Chemical compound C1[C@@H](O)[C@@H](O)C[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@@H]([C@H](O)CCC(C)(C)O)C)CC[C@]33O)C)C3=CC(=O)[C@@H]21 UPEZCKBFRMILAV-JMZLNJERSA-N 0.000 claims description 7
- 102100034745 E3 ubiquitin-protein ligase HERC2 Human genes 0.000 claims description 6
- 102000004190 Enzymes Human genes 0.000 claims description 6
- 108090000790 Enzymes Proteins 0.000 claims description 6
- 102100034574 P protein Human genes 0.000 claims description 6
- 101710181008 P protein Proteins 0.000 claims description 6
- 108010083111 Ubiquitin-Protein Ligases Proteins 0.000 claims description 6
- 102000006275 Ubiquitin-Protein Ligases Human genes 0.000 claims description 6
- 230000001588 bifunctional effect Effects 0.000 claims description 6
- 230000002500 effect on skin Effects 0.000 claims description 6
- 241001580935 Aglossa pinguinalis Species 0.000 claims description 5
- 102100021519 Hemoglobin subunit beta Human genes 0.000 claims description 5
- 108091005904 Hemoglobin subunit beta Proteins 0.000 claims description 5
- 241001494479 Pecora Species 0.000 claims description 5
- 108010050749 geranylgeranyltransferase type-I Proteins 0.000 claims description 5
- 108010085238 Actins Proteins 0.000 claims description 4
- 241000283073 Equus caballus Species 0.000 claims description 4
- 101100413186 Mus musculus Ripply2 gene Proteins 0.000 claims description 4
- 102000004459 Nitroreductase Human genes 0.000 claims description 4
- 102000010292 Peptide Elongation Factor 1 Human genes 0.000 claims description 4
- 108010077524 Peptide Elongation Factor 1 Proteins 0.000 claims description 4
- 101710138480 Ras-related protein Rab7 Proteins 0.000 claims description 4
- 229930182558 Sterol Natural products 0.000 claims description 4
- 108060004506 lycopene beta-cyclase Proteins 0.000 claims description 4
- 108060004507 lycopene cyclase Proteins 0.000 claims description 4
- 108020001162 nitroreductase Proteins 0.000 claims description 4
- 150000003432 sterols Chemical class 0.000 claims description 4
- 235000003702 sterols Nutrition 0.000 claims description 4
- 102100022900 Actin, cytoplasmic 1 Human genes 0.000 claims description 3
- YJQPYGGHQPGBLI-UHFFFAOYSA-N Novobiocin Natural products O1C(C)(C)C(OC)C(OC(N)=O)C(O)C1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-UHFFFAOYSA-N 0.000 claims description 3
- 108020005497 Nuclear hormone receptor Proteins 0.000 claims description 3
- 102000007399 Nuclear hormone receptor Human genes 0.000 claims description 3
- 108010034634 Repressor Proteins Proteins 0.000 claims description 3
- 102000009661 Repressor Proteins Human genes 0.000 claims description 3
- WTIJXIZOODAMJT-WBACWINTSA-N [(3r,4s,5r,6s)-5-hydroxy-6-[4-hydroxy-3-[[5-[[4-hydroxy-7-[(2s,3r,4s,5r)-3-hydroxy-5-methoxy-6,6-dimethyl-4-(5-methyl-1h-pyrrole-2-carbonyl)oxyoxan-2-yl]oxy-8-methyl-2-oxochromen-3-yl]carbamoyl]-4-methyl-1h-pyrrole-3-carbonyl]amino]-8-methyl-2-oxochromen- Chemical compound O([C@@H]1[C@H](C(O[C@H](OC=2C(=C3OC(=O)C(NC(=O)C=4C(=C(C(=O)NC=5C(OC6=C(C)C(O[C@@H]7[C@@H]([C@H](OC(=O)C=8NC(C)=CC=8)[C@@H](OC)C(C)(C)O7)O)=CC=C6C=5O)=O)NC=4)C)=C(O)C3=CC=2)C)[C@@H]1O)(C)C)OC)C(=O)C1=CC=C(C)N1 WTIJXIZOODAMJT-WBACWINTSA-N 0.000 claims description 3
- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 claims description 3
- 210000002510 keratinocyte Anatomy 0.000 claims description 3
- 229960002950 novobiocin Drugs 0.000 claims description 3
- YJQPYGGHQPGBLI-KGSXXDOSSA-N novobiocin Chemical compound O1C(C)(C)[C@H](OC)[C@@H](OC(N)=O)[C@@H](O)[C@@H]1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-KGSXXDOSSA-N 0.000 claims description 3
- 108020004017 nuclear receptors Proteins 0.000 claims description 3
- 230000000754 repressing effect Effects 0.000 claims description 3
- 230000035939 shock Effects 0.000 claims description 3
- 241000283707 Capra Species 0.000 claims description 2
- 241000282994 Cervidae Species 0.000 claims description 2
- 241000699800 Cricetinae Species 0.000 claims description 2
- 241001508691 Martes zibellina Species 0.000 claims description 2
- 235000011779 Menyanthes trifoliata Nutrition 0.000 claims description 2
- 241000772415 Neovison vison Species 0.000 claims description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 2
- 241000283216 Phocidae Species 0.000 claims description 2
- 241000288906 Primates Species 0.000 claims description 2
- 101150002757 RSL1 gene Proteins 0.000 claims description 2
- 241000700159 Rattus Species 0.000 claims description 2
- 108090000848 Ubiquitin Proteins 0.000 claims description 2
- 102000044159 Ubiquitin Human genes 0.000 claims description 2
- 241000282485 Vulpes vulpes Species 0.000 claims description 2
- 239000003446 ligand Substances 0.000 claims description 2
- QYYXITIZXRMPSZ-UHFFFAOYSA-N n'-tert-butyl-n'-(3,5-dimethylbenzoyl)-2-ethyl-3-methoxybenzohydrazide Chemical compound CCC1=C(OC)C=CC=C1C(=O)NN(C(C)(C)C)C(=O)C1=CC(C)=CC(C)=C1 QYYXITIZXRMPSZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000005556 hormone Substances 0.000 claims 2
- 229940088597 hormone Drugs 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- PFFIDZXUXFLSSR-UHFFFAOYSA-N 1-methyl-N-[2-(4-methylpentan-2-yl)-3-thienyl]-3-(trifluoromethyl)pyrazole-4-carboxamide Chemical compound S1C=CC(NC(=O)C=2C(=NN(C)C=2)C(F)(F)F)=C1C(C)CC(C)C PFFIDZXUXFLSSR-UHFFFAOYSA-N 0.000 claims 1
- 241000272525 Anas platyrhynchos Species 0.000 claims 1
- 241000272814 Anser sp. Species 0.000 claims 1
- 241000282470 Canis latrans Species 0.000 claims 1
- 241000499489 Castor canadensis Species 0.000 claims 1
- 241000700199 Cavia porcellus Species 0.000 claims 1
- 241000700112 Chinchilla Species 0.000 claims 1
- 241001233242 Lontra Species 0.000 claims 1
- 241001508687 Mustela erminea Species 0.000 claims 1
- 241001504654 Mustela nivalis Species 0.000 claims 1
- 241000699700 Ondatra zibethicus Species 0.000 claims 1
- 241000009328 Perro Species 0.000 claims 1
- 241000282898 Sus scrofa Species 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 39
- 239000000049 pigment Substances 0.000 abstract description 39
- 108010051219 Cre recombinase Proteins 0.000 abstract description 21
- 230000008488 polyadenylation Effects 0.000 abstract description 14
- 102000018332 Keratin-14 Human genes 0.000 abstract description 10
- 108010066321 Keratin-14 Proteins 0.000 abstract description 10
- 239000000463 material Substances 0.000 abstract description 10
- 108010054624 red fluorescent protein Proteins 0.000 abstract description 5
- 239000000232 Lipid Bilayer Substances 0.000 abstract description 2
- 235000018102 proteins Nutrition 0.000 description 122
- 210000003491 skin Anatomy 0.000 description 43
- 208000012641 Pigmentation disease Diseases 0.000 description 32
- 108010091086 Recombinases Proteins 0.000 description 32
- 102000018120 Recombinases Human genes 0.000 description 32
- 150000001413 amino acids Chemical group 0.000 description 27
- 230000019612 pigmentation Effects 0.000 description 27
- 230000015572 biosynthetic process Effects 0.000 description 22
- 238000003786 synthesis reaction Methods 0.000 description 22
- 230000032258 transport Effects 0.000 description 22
- 108020004414 DNA Proteins 0.000 description 20
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 20
- 125000003729 nucleotide group Chemical group 0.000 description 20
- 230000002068 genetic effect Effects 0.000 description 19
- 241000699670 Mus sp. Species 0.000 description 18
- 239000000637 Melanocyte-Stimulating Hormone Substances 0.000 description 17
- 108010007013 Melanocyte-Stimulating Hormones Proteins 0.000 description 17
- 241000282472 Canis lupus familiaris Species 0.000 description 16
- 102000011782 Keratins Human genes 0.000 description 15
- 108010076876 Keratins Proteins 0.000 description 15
- 239000002773 nucleotide Substances 0.000 description 15
- 241000253994 Acyrthosiphon pisum Species 0.000 description 14
- 108091028043 Nucleic acid sequence Proteins 0.000 description 13
- 108091023040 Transcription factor Proteins 0.000 description 13
- 102000040945 Transcription factor Human genes 0.000 description 13
- 229960003722 doxycycline Drugs 0.000 description 13
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 description 12
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 description 12
- 108700019146 Transgenes Proteins 0.000 description 12
- 239000003157 biological pigment Substances 0.000 description 12
- 210000000078 claw Anatomy 0.000 description 12
- 230000009368 gene silencing by RNA Effects 0.000 description 12
- 108091033319 polynucleotide Chemical group 0.000 description 12
- 102000040430 polynucleotide Human genes 0.000 description 12
- 239000002157 polynucleotide Chemical group 0.000 description 12
- 241000894007 species Species 0.000 description 12
- 210000004209 hair Anatomy 0.000 description 11
- 108020004999 messenger RNA Proteins 0.000 description 11
- 239000003795 chemical substances by application Substances 0.000 description 10
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 9
- 108020004459 Small interfering RNA Proteins 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 239000013598 vector Substances 0.000 description 9
- 230000008859 change Effects 0.000 description 8
- 210000002780 melanosome Anatomy 0.000 description 8
- 230000035772 mutation Effects 0.000 description 8
- 238000000059 patterning Methods 0.000 description 8
- 101710163270 Nuclease Proteins 0.000 description 7
- 101150030875 RAB7A gene Proteins 0.000 description 7
- 235000021466 carotenoid Nutrition 0.000 description 7
- 150000001747 carotenoids Chemical class 0.000 description 7
- 239000003086 colorant Substances 0.000 description 7
- 238000011161 development Methods 0.000 description 7
- 230000018109 developmental process Effects 0.000 description 7
- 230000014616 translation Effects 0.000 description 7
- 108010070520 Keratin-2 Proteins 0.000 description 6
- 102000005714 Keratin-2 Human genes 0.000 description 6
- 230000003213 activating effect Effects 0.000 description 6
- 235000013330 chicken meat Nutrition 0.000 description 6
- -1 cumate Chemical compound 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 230000001404 mediated effect Effects 0.000 description 6
- 230000005012 migration Effects 0.000 description 6
- 238000013508 migration Methods 0.000 description 6
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 125000002652 ribonucleotide group Chemical group 0.000 description 6
- 238000013519 translation Methods 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 5
- 102100026158 Melanophilin Human genes 0.000 description 5
- 101710158003 Melanophilin Proteins 0.000 description 5
- 108700008625 Reporter Genes Proteins 0.000 description 5
- 108091028664 Ribonucleotide Proteins 0.000 description 5
- 108091006047 fluorescent proteins Proteins 0.000 description 5
- 102000034287 fluorescent proteins Human genes 0.000 description 5
- 230000001965 increasing effect Effects 0.000 description 5
- 230000008099 melanin synthesis Effects 0.000 description 5
- 210000000282 nail Anatomy 0.000 description 5
- 229920001184 polypeptide Polymers 0.000 description 5
- 239000002243 precursor Substances 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 230000002441 reversible effect Effects 0.000 description 5
- 239000002336 ribonucleotide Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 210000002023 somite Anatomy 0.000 description 5
- 210000000130 stem cell Anatomy 0.000 description 5
- 238000011830 transgenic mouse model Methods 0.000 description 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 4
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 4
- 102000053602 DNA Human genes 0.000 description 4
- 241000283086 Equidae Species 0.000 description 4
- 108010000521 Human Growth Hormone Proteins 0.000 description 4
- 102000002265 Human Growth Hormone Human genes 0.000 description 4
- 239000000854 Human Growth Hormone Substances 0.000 description 4
- 108020004684 Internal Ribosome Entry Sites Proteins 0.000 description 4
- 102000006830 Luminescent Proteins Human genes 0.000 description 4
- 108010047357 Luminescent Proteins Proteins 0.000 description 4
- 102100034216 Melanocyte-stimulating hormone receptor Human genes 0.000 description 4
- 241000699660 Mus musculus Species 0.000 description 4
- 108091034117 Oligonucleotide Proteins 0.000 description 4
- 108010021428 Type 1 Melanocortin Receptor Proteins 0.000 description 4
- 241000700605 Viruses Species 0.000 description 4
- 230000004075 alteration Effects 0.000 description 4
- 235000015278 beef Nutrition 0.000 description 4
- 230000027455 binding Effects 0.000 description 4
- 108010006025 bovine growth hormone Proteins 0.000 description 4
- 230000001276 controlling effect Effects 0.000 description 4
- 238000004132 cross linking Methods 0.000 description 4
- 239000005547 deoxyribonucleotide Substances 0.000 description 4
- 125000002637 deoxyribonucleotide group Chemical group 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 230000011664 signaling Effects 0.000 description 4
- 230000005030 transcription termination Effects 0.000 description 4
- 238000011144 upstream manufacturing Methods 0.000 description 4
- OINNEUNVOZHBOX-QIRCYJPOSA-K 2-trans,6-trans,10-trans-geranylgeranyl diphosphate(3-) Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP([O-])(=O)OP([O-])([O-])=O OINNEUNVOZHBOX-QIRCYJPOSA-K 0.000 description 3
- 208000010711 Cattle disease Diseases 0.000 description 3
- 108020004705 Codon Proteins 0.000 description 3
- 241000484025 Cuniculus Species 0.000 description 3
- 102100029725 Ectonucleoside triphosphate diphosphohydrolase 3 Human genes 0.000 description 3
- 108700028146 Genetic Enhancer Elements Proteins 0.000 description 3
- OINNEUNVOZHBOX-XBQSVVNOSA-N Geranylgeranyl diphosphate Natural products [P@](=O)(OP(=O)(O)O)(OC/C=C(\CC/C=C(\CC/C=C(\CC/C=C(\C)/C)/C)/C)/C)O OINNEUNVOZHBOX-XBQSVVNOSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 101001012432 Homo sapiens Ectonucleoside triphosphate diphosphohydrolase 3 Proteins 0.000 description 3
- 101001007024 Homo sapiens Keratin, type I cuticular Ha7 Proteins 0.000 description 3
- 101001007025 Homo sapiens Keratin, type I cuticular Ha8 Proteins 0.000 description 3
- 102000008070 Interferon-gamma Human genes 0.000 description 3
- 108010074328 Interferon-gamma Proteins 0.000 description 3
- 102100023131 Keratin, type I cuticular Ha1 Human genes 0.000 description 3
- 101710150717 Keratin, type I cuticular Ha1 Proteins 0.000 description 3
- 102100023127 Keratin, type I cuticular Ha2 Human genes 0.000 description 3
- 101710150712 Keratin, type I cuticular Ha2 Proteins 0.000 description 3
- 102100028355 Keratin, type I cuticular Ha4 Human genes 0.000 description 3
- 101710150715 Keratin, type I cuticular Ha4 Proteins 0.000 description 3
- 102100028354 Keratin, type I cuticular Ha5 Human genes 0.000 description 3
- 101710150713 Keratin, type I cuticular Ha5 Proteins 0.000 description 3
- 102100028341 Keratin, type I cuticular Ha6 Human genes 0.000 description 3
- 101710150527 Keratin, type I cuticular Ha6 Proteins 0.000 description 3
- 102100028335 Keratin, type I cuticular Ha7 Human genes 0.000 description 3
- 102100028334 Keratin, type I cuticular Ha8 Human genes 0.000 description 3
- 102100032705 Keratin, type I cytoskeletal 23 Human genes 0.000 description 3
- 101710183652 Keratin, type I cytoskeletal 23 Proteins 0.000 description 3
- 102100032704 Keratin, type I cytoskeletal 24 Human genes 0.000 description 3
- 101710183646 Keratin, type I cytoskeletal 24 Proteins 0.000 description 3
- 102100032703 Keratin, type I cytoskeletal 25 Human genes 0.000 description 3
- 101710183654 Keratin, type I cytoskeletal 25 Proteins 0.000 description 3
- 102100037154 Keratin, type I cytoskeletal 26 Human genes 0.000 description 3
- 101710183655 Keratin, type I cytoskeletal 26 Proteins 0.000 description 3
- 102100037153 Keratin, type I cytoskeletal 27 Human genes 0.000 description 3
- 101710183657 Keratin, type I cytoskeletal 27 Proteins 0.000 description 3
- 102100037159 Keratin, type I cytoskeletal 28 Human genes 0.000 description 3
- 101710183672 Keratin, type I cytoskeletal 28 Proteins 0.000 description 3
- 102100037158 Keratin, type I cytoskeletal 39 Human genes 0.000 description 3
- 101710183429 Keratin, type I cytoskeletal 39 Proteins 0.000 description 3
- 102100037157 Keratin, type I cytoskeletal 40 Human genes 0.000 description 3
- 101710183583 Keratin, type I cytoskeletal 40 Proteins 0.000 description 3
- 102100023129 Keratin, type I cytoskeletal 9 Human genes 0.000 description 3
- 102100028340 Keratin, type II cuticular Hb1 Human genes 0.000 description 3
- 101710115634 Keratin, type II cuticular Hb1 Proteins 0.000 description 3
- 102100028339 Keratin, type II cuticular Hb2 Human genes 0.000 description 3
- 101710115630 Keratin, type II cuticular Hb2 Proteins 0.000 description 3
- 102100037379 Keratin, type II cuticular Hb3 Human genes 0.000 description 3
- 101710115632 Keratin, type II cuticular Hb3 Proteins 0.000 description 3
- 102100037370 Keratin, type II cuticular Hb4 Human genes 0.000 description 3
- 101710115521 Keratin, type II cuticular Hb4 Proteins 0.000 description 3
- 102100037381 Keratin, type II cuticular Hb5 Human genes 0.000 description 3
- 101710115522 Keratin, type II cuticular Hb5 Proteins 0.000 description 3
- 101710115528 Keratin, type II cuticular Hb6 Proteins 0.000 description 3
- 102100022905 Keratin, type II cytoskeletal 1 Human genes 0.000 description 3
- 102100022925 Keratin, type II cytoskeletal 1b Human genes 0.000 description 3
- 101710083825 Keratin, type II cytoskeletal 1b Proteins 0.000 description 3
- 102100022926 Keratin, type II cytoskeletal 2 oral Human genes 0.000 description 3
- 101710119848 Keratin, type II cytoskeletal 2 oral Proteins 0.000 description 3
- 102100025759 Keratin, type II cytoskeletal 3 Human genes 0.000 description 3
- 102100025758 Keratin, type II cytoskeletal 4 Human genes 0.000 description 3
- 102100025756 Keratin, type II cytoskeletal 5 Human genes 0.000 description 3
- 102100023974 Keratin, type II cytoskeletal 7 Human genes 0.000 description 3
- 102100025370 Keratin, type II cytoskeletal 71 Human genes 0.000 description 3
- 101710083672 Keratin, type II cytoskeletal 71 Proteins 0.000 description 3
- 102100025380 Keratin, type II cytoskeletal 72 Human genes 0.000 description 3
- 101710083675 Keratin, type II cytoskeletal 72 Proteins 0.000 description 3
- 102100025381 Keratin, type II cytoskeletal 73 Human genes 0.000 description 3
- 101710083589 Keratin, type II cytoskeletal 73 Proteins 0.000 description 3
- 102100025366 Keratin, type II cytoskeletal 74 Human genes 0.000 description 3
- 101710083592 Keratin, type II cytoskeletal 74 Proteins 0.000 description 3
- 102100025367 Keratin, type II cytoskeletal 75 Human genes 0.000 description 3
- 101710083590 Keratin, type II cytoskeletal 75 Proteins 0.000 description 3
- 102100023969 Keratin, type II cytoskeletal 78 Human genes 0.000 description 3
- 101710083630 Keratin, type II cytoskeletal 78 Proteins 0.000 description 3
- 102100023975 Keratin, type II cytoskeletal 79 Human genes 0.000 description 3
- 101710083624 Keratin, type II cytoskeletal 79 Proteins 0.000 description 3
- 102100023972 Keratin, type II cytoskeletal 8 Human genes 0.000 description 3
- 102100023977 Keratin, type II cytoskeletal 80 Human genes 0.000 description 3
- 101710083648 Keratin, type II cytoskeletal 80 Proteins 0.000 description 3
- 108010070514 Keratin-1 Proteins 0.000 description 3
- 102000012786 Keratin-10 Human genes 0.000 description 3
- 108010065038 Keratin-10 Proteins 0.000 description 3
- 102000012747 Keratin-12 Human genes 0.000 description 3
- 108010065086 Keratin-12 Proteins 0.000 description 3
- 102000012809 Keratin-13 Human genes 0.000 description 3
- 108010065070 Keratin-13 Proteins 0.000 description 3
- 102000018260 Keratin-15 Human genes 0.000 description 3
- 108010066330 Keratin-15 Proteins 0.000 description 3
- 102000018280 Keratin-16 Human genes 0.000 description 3
- 108010066364 Keratin-16 Proteins 0.000 description 3
- 102000018331 Keratin-17 Human genes 0.000 description 3
- 108010066325 Keratin-17 Proteins 0.000 description 3
- 102000018329 Keratin-18 Human genes 0.000 description 3
- 108010066327 Keratin-18 Proteins 0.000 description 3
- 102000018317 Keratin-19 Human genes 0.000 description 3
- 108010066302 Keratin-19 Proteins 0.000 description 3
- 102000057615 Keratin-20 Human genes 0.000 description 3
- 108010066370 Keratin-20 Proteins 0.000 description 3
- 108010070918 Keratin-3 Proteins 0.000 description 3
- 108010070921 Keratin-4 Proteins 0.000 description 3
- 108010070553 Keratin-5 Proteins 0.000 description 3
- 108010070557 Keratin-6 Proteins 0.000 description 3
- 102000005706 Keratin-6 Human genes 0.000 description 3
- 108010070507 Keratin-7 Proteins 0.000 description 3
- 108010070511 Keratin-8 Proteins 0.000 description 3
- 108010070585 Keratin-9 Proteins 0.000 description 3
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 3
- 101800000520 Melanotropin gamma Proteins 0.000 description 3
- 102100027467 Pro-opiomelanocortin Human genes 0.000 description 3
- 108010073062 Transcription Activator-Like Effectors Proteins 0.000 description 3
- 108700009124 Transcription Initiation Site Proteins 0.000 description 3
- 239000000090 biomarker Substances 0.000 description 3
- 150000001746 carotenes Chemical class 0.000 description 3
- 235000005473 carotenes Nutrition 0.000 description 3
- 230000002759 chromosomal effect Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 210000001671 embryonic stem cell Anatomy 0.000 description 3
- 108010048367 enhanced green fluorescent protein Proteins 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 239000005090 green fluorescent protein Substances 0.000 description 3
- 230000008642 heat stress Effects 0.000 description 3
- 238000002744 homologous recombination Methods 0.000 description 3
- 230000006801 homologous recombination Effects 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 229960003130 interferon gamma Drugs 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- 230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 description 3
- 230000010076 replication Effects 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 241000272517 Anseriformes Species 0.000 description 2
- 241001124076 Aphididae Species 0.000 description 2
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- 241001408630 Chloroclystis Species 0.000 description 2
- 206010010957 Copper deficiency Diseases 0.000 description 2
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 2
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 2
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 2
- 108091092195 Intron Proteins 0.000 description 2
- 102100037382 Keratin, type II cuticular Hb6 Human genes 0.000 description 2
- 241000270322 Lepidosauria Species 0.000 description 2
- 101800000992 Melanocyte-stimulating hormone beta Proteins 0.000 description 2
- 102400000747 Melanocyte-stimulating hormone beta Human genes 0.000 description 2
- 101710129905 Melanotropin beta Proteins 0.000 description 2
- 102400000744 Melanotropin gamma Human genes 0.000 description 2
- 101100503585 Mus musculus Furin gene Proteins 0.000 description 2
- 108010057466 NF-kappa B Proteins 0.000 description 2
- 102000003945 NF-kappa B Human genes 0.000 description 2
- 229930193140 Neomycin Natural products 0.000 description 2
- 108091093037 Peptide nucleic acid Proteins 0.000 description 2
- 108010053210 Phycocyanin Proteins 0.000 description 2
- 108010029485 Protein Isoforms Proteins 0.000 description 2
- 102000001708 Protein Isoforms Human genes 0.000 description 2
- 102100030019 Ras-related protein Rab-7a Human genes 0.000 description 2
- 101710113718 Ras-related protein Rab7A Proteins 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 2
- ANVAOWXLWRTKGA-XHGAXZNDSA-N all-trans-alpha-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1C(C)=CCCC1(C)C ANVAOWXLWRTKGA-XHGAXZNDSA-N 0.000 description 2
- 108010004469 allophycocyanin Proteins 0.000 description 2
- 102000012265 beta-defensin Human genes 0.000 description 2
- 108050002883 beta-defensin Proteins 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- FDSDTBUPSURDBL-LOFNIBRQSA-N canthaxanthin Chemical compound CC=1C(=O)CCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)CCC1(C)C FDSDTBUPSURDBL-LOFNIBRQSA-N 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 229930002875 chlorophyll Natural products 0.000 description 2
- 235000019804 chlorophyll Nutrition 0.000 description 2
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 2
- 210000000349 chromosome Anatomy 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 235000013365 dairy product Nutrition 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 239000012636 effector Substances 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 229940011871 estrogen Drugs 0.000 description 2
- 239000000262 estrogen Substances 0.000 description 2
- 238000012239 gene modification Methods 0.000 description 2
- 230000005017 genetic modification Effects 0.000 description 2
- 235000013617 genetically modified food Nutrition 0.000 description 2
- 239000003862 glucocorticoid Substances 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 230000003648 hair appearance Effects 0.000 description 2
- 230000037308 hair color Effects 0.000 description 2
- 244000309465 heifer Species 0.000 description 2
- 239000010985 leather Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000002679 microRNA Substances 0.000 description 2
- 229960004927 neomycin Drugs 0.000 description 2
- 239000002777 nucleoside Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 150000004713 phosphodiesters Chemical class 0.000 description 2
- 239000013612 plasmid Substances 0.000 description 2
- 102000054765 polymorphisms of proteins Human genes 0.000 description 2
- 229920002477 rna polymer Polymers 0.000 description 2
- 210000001626 skin fibroblast Anatomy 0.000 description 2
- 230000009870 specific binding Effects 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002194 synthesizing effect Effects 0.000 description 2
- 229940037128 systemic glucocorticoids Drugs 0.000 description 2
- 238000011200 topical administration Methods 0.000 description 2
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 2
- 230000005945 translocation Effects 0.000 description 2
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 2
- WHNFPRLDDSXQCL-UHFFFAOYSA-N α-melanotropin Chemical compound C=1N=CNC=1CC(C(=O)NC(CC=1C=CC=CC=1)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)NC(CCCCN)C(=O)N1C(CCC1)C(=O)NC(C(C)C)C(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CCSC)NC(=O)C(CO)NC(=O)C(NC(=O)C(CO)NC(C)=O)CC1=CC=C(O)C=C1 WHNFPRLDDSXQCL-UHFFFAOYSA-N 0.000 description 2
- WHNFPRLDDSXQCL-UAZQEYIDSA-N α-msh Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(N)=O)NC(=O)[C@H](CO)NC(C)=O)C1=CC=C(O)C=C1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 0.000 description 2
- SFVVQRJOGUKCEG-OPQSFPLASA-N β-MSH Chemical compound C1C[C@@H](O)[C@H]2C(COC(=O)[C@@](O)([C@@H](C)O)C(C)C)=CCN21 SFVVQRJOGUKCEG-OPQSFPLASA-N 0.000 description 2
- GZWUQPQBOGLSIM-VOOUCTBASA-N γ msh Chemical compound C([C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(O)=O)C(C)C)C1=CC=C(O)C=C1 GZWUQPQBOGLSIM-VOOUCTBASA-N 0.000 description 2
- DEEUSUJLZQQESV-BQUSTMGCSA-N (-)-stercobilin Chemical compound N1C(=O)[C@H](C)[C@@H](CC)[C@@H]1CC1=C(C)C(CCC(O)=O)=C(\C=C/2C(=C(C)C(C[C@H]3[C@@H]([C@@H](CC)C(=O)N3)C)=N\2)CCC(O)=O)N1 DEEUSUJLZQQESV-BQUSTMGCSA-N 0.000 description 1
- JKQXZKUSFCKOGQ-JLGXGRJMSA-N (3R,3'R)-beta,beta-carotene-3,3'-diol Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-JLGXGRJMSA-N 0.000 description 1
- SGKRLCUYIXIAHR-NLJUDYQYSA-N (4r,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-NLJUDYQYSA-N 0.000 description 1
- NCYCYZXNIZJOKI-IOUUIBBYSA-N 11-cis-retinal Chemical compound O=C/C=C(\C)/C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-IOUUIBBYSA-N 0.000 description 1
- 108020005345 3' Untranslated Regions Proteins 0.000 description 1
- NNMALANKTSRILL-LXENMSTPSA-N 3-[(2z,5e)-2-[[3-(2-carboxyethyl)-5-[(z)-[(3e,4r)-3-ethylidene-4-methyl-5-oxopyrrolidin-2-ylidene]methyl]-4-methyl-1h-pyrrol-2-yl]methylidene]-5-[(4-ethyl-3-methyl-5-oxopyrrol-2-yl)methylidene]-4-methylpyrrol-3-yl]propanoic acid Chemical compound O=C1C(CC)=C(C)C(\C=C\2C(=C(CCC(O)=O)C(=C/C3=C(C(C)=C(\C=C/4\C(\[C@@H](C)C(=O)N\4)=C\C)N3)CCC(O)=O)/N/2)C)=N1 NNMALANKTSRILL-LXENMSTPSA-N 0.000 description 1
- GLWKVDXAQHCAIO-REYDXQAISA-N 3-[(2z,5z)-2-[[3-(2-carboxyethyl)-5-[[(2r)-4-ethenyl-3-methyl-5-oxo-1,2-dihydropyrrol-2-yl]methyl]-4-methyl-1h-pyrrol-2-yl]methylidene]-5-[[(3z,4r)-3-ethylidene-4-methyl-5-oxopyrrol-2-yl]methylidene]-4-methylpyrrol-3-yl]propanoic acid Chemical compound C\C=C1\[C@@H](C)C(=O)N=C1\C=C(/N\1)C(C)=C(CCC(O)=O)C/1=C/C1=C(CCC(O)=O)C(C)=C(C[C@@H]2C(=C(C=C)C(=O)N2)C)N1 GLWKVDXAQHCAIO-REYDXQAISA-N 0.000 description 1
- 102100026041 Acrosin Human genes 0.000 description 1
- 108090000107 Acrosin Proteins 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 102000007469 Actins Human genes 0.000 description 1
- 208000031295 Animal disease Diseases 0.000 description 1
- 241000269350 Anura Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- GWZYPXHJIZCRAJ-UHFFFAOYSA-N Biliverdin Natural products CC1=C(C=C)C(=C/C2=NC(=Cc3[nH]c(C=C/4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)C(=C2C)CCC(=O)O)NC1=O GWZYPXHJIZCRAJ-UHFFFAOYSA-N 0.000 description 1
- RCNSAJSGRJSBKK-NSQVQWHSSA-N Biliverdin IX Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(\C=C/2C(=C(C)C(=C/C=3C(=C(C=C)C(=O)N=3)C)/N\2)CCC(O)=O)N1 RCNSAJSGRJSBKK-NSQVQWHSSA-N 0.000 description 1
- 241000157302 Bison bison athabascae Species 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- 241000030939 Bubalus bubalis Species 0.000 description 1
- 241000282421 Canidae Species 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- 241000269333 Caudata Species 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 241000700114 Chinchillidae Species 0.000 description 1
- 241001112695 Clostridiales Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 108091035707 Consensus sequence Proteins 0.000 description 1
- 101710095468 Cyclase Proteins 0.000 description 1
- 102000018832 Cytochromes Human genes 0.000 description 1
- 108010052832 Cytochromes Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 230000004543 DNA replication Effects 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- 102000000541 Defensins Human genes 0.000 description 1
- 108010002069 Defensins Proteins 0.000 description 1
- 241000702421 Dependoparvovirus Species 0.000 description 1
- AHMIDUVKSGCHAU-UHFFFAOYSA-N Dopaquinone Natural products OC(=O)C(N)CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-UHFFFAOYSA-N 0.000 description 1
- 208000032274 Encephalopathy Diseases 0.000 description 1
- 108091029865 Exogenous DNA Proteins 0.000 description 1
- 108010046276 FLP recombinase Proteins 0.000 description 1
- 108010057573 Flavoproteins Proteins 0.000 description 1
- 102000003983 Flavoproteins Human genes 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 102100039556 Galectin-4 Human genes 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241001272567 Hominoidea Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000608765 Homo sapiens Galectin-4 Proteins 0.000 description 1
- 101000954762 Homo sapiens Proto-oncogene Wnt-3 Proteins 0.000 description 1
- 101000727979 Homo sapiens Remodeling and spacing factor 1 Proteins 0.000 description 1
- 101000867466 Homo sapiens Segment polarity protein dishevelled homolog DVL-2 Proteins 0.000 description 1
- 102000004286 Hydroxymethylglutaryl CoA Reductases Human genes 0.000 description 1
- 108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 description 1
- AHMIDUVKSGCHAU-LURJTMIESA-N L-dopaquinone Chemical compound [O-]C(=O)[C@@H]([NH3+])CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-LURJTMIESA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 241000713666 Lentivirus Species 0.000 description 1
- 241000428198 Lutrinae Species 0.000 description 1
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 101800001751 Melanocyte-stimulating hormone alpha Proteins 0.000 description 1
- 102400000740 Melanocyte-stimulating hormone alpha Human genes 0.000 description 1
- 101710200814 Melanotropin alpha Proteins 0.000 description 1
- 240000008821 Menyanthes trifoliata Species 0.000 description 1
- 108700011259 MicroRNAs Proteins 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 241000282339 Mustela Species 0.000 description 1
- 241000428199 Mustelinae Species 0.000 description 1
- 102100030856 Myoglobin Human genes 0.000 description 1
- 108010062374 Myoglobin Proteins 0.000 description 1
- 241000699705 Ondatra Species 0.000 description 1
- 241000282579 Pan Species 0.000 description 1
- 241000282376 Panthera tigris Species 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- OOUTWVMJGMVRQF-DOYZGLONSA-N Phoenicoxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)C(=O)C(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)C(=O)CCC2(C)C OOUTWVMJGMVRQF-DOYZGLONSA-N 0.000 description 1
- IGJXAXFFKKRFKU-UHFFFAOYSA-N Phycoerythrobilin Natural products CC=C/1C(NC(C1C)=O)=Cc2[nH]c(C=C3/N=C(CC4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C IGJXAXFFKKRFKU-UHFFFAOYSA-N 0.000 description 1
- 101710173432 Phytoene synthase Proteins 0.000 description 1
- 108010064851 Plant Proteins Proteins 0.000 description 1
- 241000282405 Pongo abelii Species 0.000 description 1
- 102100022880 Rab proteins geranylgeranyltransferase component A 2 Human genes 0.000 description 1
- 101710108889 Rab proteins geranylgeranyltransferase component A 2 Proteins 0.000 description 1
- 102100029771 Remodeling and spacing factor 1 Human genes 0.000 description 1
- 108091027981 Response element Proteins 0.000 description 1
- 102100040756 Rhodopsin Human genes 0.000 description 1
- 108090000820 Rhodopsin Proteins 0.000 description 1
- 102100032753 Segment polarity protein dishevelled homolog DVL-2 Human genes 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 108091081024 Start codon Proteins 0.000 description 1
- TYOWQSLRVAUSMI-UHFFFAOYSA-N Sterecobilin-IXalpha Natural products N1C(=O)C(C)C(CC)C1CC(C(=C1CCC(O)=O)C)=NC1=CC1=C(CCC(O)=O)C(C)=C(CC2C(C(CC)C(=O)N2)C)N1 TYOWQSLRVAUSMI-UHFFFAOYSA-N 0.000 description 1
- 206010042434 Sudden death Diseases 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 241000283968 Syncerus caffer Species 0.000 description 1
- UNKYOXKQMHLGPW-UHFFFAOYSA-N Urobilin IXalpha Natural products CCC1=C(C)C(=O)NC1CC2=NC(=Cc3[nH]c(CC4NC(=O)C(=C4C)CC)c(C)c3CCC(=O)O)C(=C2C)CCC(=O)O UNKYOXKQMHLGPW-UHFFFAOYSA-N 0.000 description 1
- 108020000999 Viral RNA Proteins 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 102000052549 Wnt-3 Human genes 0.000 description 1
- JKQXZKUSFCKOGQ-LQFQNGICSA-N Z-zeaxanthin Natural products C([C@H](O)CC=1C)C(C)(C)C=1C=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-LQFQNGICSA-N 0.000 description 1
- QOPRSMDTRDMBNK-RNUUUQFGSA-N Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCC(O)C1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C QOPRSMDTRDMBNK-RNUUUQFGSA-N 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- JKQXZKUSFCKOGQ-LOFNIBRQSA-N all-trans-Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C JKQXZKUSFCKOGQ-LOFNIBRQSA-N 0.000 description 1
- 239000011795 alpha-carotene Substances 0.000 description 1
- 235000003903 alpha-carotene Nutrition 0.000 description 1
- ANVAOWXLWRTKGA-HLLMEWEMSA-N alpha-carotene Natural products C(=C\C=C\C=C(/C=C/C=C(\C=C\C=1C(C)(C)CCCC=1C)/C)\C)(\C=C\C=C(/C=C/[C@H]1C(C)=CCCC1(C)C)\C)/C ANVAOWXLWRTKGA-HLLMEWEMSA-N 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 235000016614 betalains Nutrition 0.000 description 1
- QBUVFDKTZJNUPP-UHFFFAOYSA-N biliverdin-IXalpha Natural products N1C(=O)C(C)=C(C=C)C1=CC1=C(C)C(CCC(O)=O)=C(C=C2C(=C(C)C(C=C3C(=C(C=C)C(=O)N3)C)=N2)CCC(O)=O)N1 QBUVFDKTZJNUPP-UHFFFAOYSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000003181 biological factor Substances 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 235000012682 canthaxanthin Nutrition 0.000 description 1
- 239000001659 canthaxanthin Substances 0.000 description 1
- 229940008033 canthaxanthin Drugs 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000012707 chemical precursor Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000011260 co-administration Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000036757 core body temperature Effects 0.000 description 1
- 108010082025 cyan fluorescent protein Proteins 0.000 description 1
- 230000003413 degradative effect Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000001177 diphosphate Substances 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical class [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 229940069417 doxy Drugs 0.000 description 1
- HALQELOKLVRWRI-VDBOFHIQSA-N doxycycline hyclate Chemical group O.[Cl-].[Cl-].CCO.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H]([NH+](C)C)[C@@H]1[C@H]2O.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H]([NH+](C)C)[C@@H]1[C@H]2O HALQELOKLVRWRI-VDBOFHIQSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000008144 egg development Effects 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 230000004720 fertilization Effects 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- HRQKOYFGHJYEFS-RZWPOVEWSA-N gamma-carotene Natural products C(=C\C=C\C(=C/C=C/C=C(\C=C\C=C(/C=C/C=1C(C)(C)CCCC=1C)\C)/C)\C)(\C=C\C=C(/CC/C=C(\C)/C)\C)/C HRQKOYFGHJYEFS-RZWPOVEWSA-N 0.000 description 1
- 238000010363 gene targeting Methods 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 108060003552 hemocyanin Proteins 0.000 description 1
- 244000144980 herd Species 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000009399 inbreeding Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000012678 infectious agent Substances 0.000 description 1
- 230000008798 inflammatory stress Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000010039 intracellular degradation Effects 0.000 description 1
- 230000010189 intracellular transport Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000000670 ligand binding assay Methods 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 235000012680 lutein Nutrition 0.000 description 1
- 239000001656 lutein Substances 0.000 description 1
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 description 1
- 229960005375 lutein Drugs 0.000 description 1
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 description 1
- 235000012661 lycopene Nutrition 0.000 description 1
- 239000001751 lycopene Substances 0.000 description 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
- 229960004999 lycopene Drugs 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 230000003061 melanogenesis Effects 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000006609 metabolic stress Effects 0.000 description 1
- 108091070501 miRNA Proteins 0.000 description 1
- 238000000520 microinjection Methods 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 208000024191 minimally invasive lung adenocarcinoma Diseases 0.000 description 1
- 210000000933 neural crest Anatomy 0.000 description 1
- 150000003833 nucleoside derivatives Chemical class 0.000 description 1
- 238000009400 out breeding Methods 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 108091006059 phosphorescent proteins Proteins 0.000 description 1
- 108060006184 phycobiliprotein Proteins 0.000 description 1
- 108010012759 phycoerythrobilin Proteins 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 235000021118 plant-derived protein Nutrition 0.000 description 1
- 150000004291 polyenes Chemical class 0.000 description 1
- 230000023603 positive regulation of transcription initiation, DNA-dependent Effects 0.000 description 1
- 230000001124 posttranscriptional effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 108010008359 protein kinase C lambda Proteins 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 239000001054 red pigment Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 210000003705 ribosome Anatomy 0.000 description 1
- 210000004918 root sheath Anatomy 0.000 description 1
- 102200128616 rs121908751 Human genes 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000004055 small Interfering RNA Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229960001603 tamoxifen Drugs 0.000 description 1
- 101150061166 tetR gene Proteins 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- AIBOHNYYKWYQMM-MXBSLTGDSA-N torulene Chemical compound CC(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C AIBOHNYYKWYQMM-MXBSLTGDSA-N 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 230000014723 transformation of host cell by virus Effects 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- 125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000010798 ubiquitination Methods 0.000 description 1
- 230000034512 ubiquitination Effects 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- KDCCOOGTVSRCHX-UHFFFAOYSA-N urobilin Chemical compound CCC1=C(C)C(=O)NC1CC1=C(C)C(CCC(O)=O)=C(C=C2C(=C(C)C(CC3C(=C(CC)C(=O)N3)C)=N2)CCC(O)=O)N1 KDCCOOGTVSRCHX-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1
- 235000008210 xanthophylls Nutrition 0.000 description 1
- 150000003735 xanthophylls Chemical class 0.000 description 1
- 108091005957 yellow fluorescent proteins Proteins 0.000 description 1
- 235000010930 zeaxanthin Nutrition 0.000 description 1
- 239000001775 zeaxanthin Substances 0.000 description 1
- 229940043269 zeaxanthin Drugs 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Molecular Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2017213487A AU2017213487B2 (en) | 2013-03-15 | 2017-08-09 | Transgenic animals with customizable traits |
| AU2019204084A AU2019204084A1 (en) | 2013-03-15 | 2019-06-11 | Transgenic animals with customizable traits |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/837,405 US20130212723A1 (en) | 2012-02-15 | 2013-03-15 | Transgenic animals with customizable traits |
| US13/837,405 | 2013-03-15 | ||
| PCT/US2014/029918 WO2014145196A2 (en) | 2013-03-15 | 2014-03-15 | Transgenic animals with customizable traits |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017213487A Division AU2017213487B2 (en) | 2013-03-15 | 2017-08-09 | Transgenic animals with customizable traits |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2014233317A1 AU2014233317A1 (en) | 2015-10-29 |
| AU2014233317B2 true AU2014233317B2 (en) | 2017-08-31 |
Family
ID=51538427
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014233317A Ceased AU2014233317B2 (en) | 2013-03-15 | 2014-03-15 | Transgenic animals with customizable traits |
| AU2017213487A Ceased AU2017213487B2 (en) | 2013-03-15 | 2017-08-09 | Transgenic animals with customizable traits |
| AU2019204084A Abandoned AU2019204084A1 (en) | 2013-03-15 | 2019-06-11 | Transgenic animals with customizable traits |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017213487A Ceased AU2017213487B2 (en) | 2013-03-15 | 2017-08-09 | Transgenic animals with customizable traits |
| AU2019204084A Abandoned AU2019204084A1 (en) | 2013-03-15 | 2019-06-11 | Transgenic animals with customizable traits |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP2967017A4 (ja) |
| JP (1) | JP2016512697A (ja) |
| CN (1) | CN105357960B (ja) |
| AU (3) | AU2014233317B2 (ja) |
| BR (1) | BR112015023414A2 (ja) |
| CA (1) | CA2906936A1 (ja) |
| HK (1) | HK1214732A1 (ja) |
| MX (1) | MX2015013253A (ja) |
| WO (1) | WO2014145196A2 (ja) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105814214A (zh) | 2013-10-25 | 2016-07-27 | 家畜改良有限公司 | 遗传标记和其用途 |
| CN107022549B (zh) * | 2017-04-19 | 2021-06-01 | 华中农业大学 | 黄颡鱼β防御素基因及其β防御素抗菌肽及其应用 |
| CN107177630A (zh) * | 2017-05-09 | 2017-09-19 | 华南农业大学 | 一种无外源标记基因的抗pcv2转基因猪制备方法 |
| CN111206042B (zh) * | 2020-02-25 | 2021-08-31 | 中国科学院昆明植物研究所 | 一种表达酮式类胡萝卜素的融合基因、重组载体及其应用 |
| CN113564186B (zh) * | 2021-07-16 | 2023-07-25 | 山西大学 | 苹果黄蚜Tre基因及其核酸干扰剂制备方法与应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002086098A2 (en) * | 2001-03-05 | 2002-10-31 | University Of Virginia Patent Foundation | A lac operator-repressor system |
| WO2013123365A1 (en) * | 2012-02-15 | 2013-08-22 | Mice With Horns, Llc | Transgenic animals with customizable traits |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1127121B1 (en) * | 1998-10-27 | 2005-12-14 | Anticancer, Inc. | Construction d'une retrovirus exprimant le locus mel de streptomyces, et son expression dans des cellules mammiferes |
| WO2010025736A2 (en) * | 2008-09-05 | 2010-03-11 | Aarhus Universitet | Nuclear receptor sensor system in transgenic animal |
-
2014
- 2014-03-15 CA CA2906936A patent/CA2906936A1/en not_active Abandoned
- 2014-03-15 CN CN201480024934.7A patent/CN105357960B/zh not_active Expired - Fee Related
- 2014-03-15 EP EP14763711.0A patent/EP2967017A4/en not_active Withdrawn
- 2014-03-15 JP JP2016503281A patent/JP2016512697A/ja active Pending
- 2014-03-15 BR BR112015023414A patent/BR112015023414A2/pt not_active Application Discontinuation
- 2014-03-15 AU AU2014233317A patent/AU2014233317B2/en not_active Ceased
- 2014-03-15 MX MX2015013253A patent/MX2015013253A/es unknown
- 2014-03-15 WO PCT/US2014/029918 patent/WO2014145196A2/en active Application Filing
-
2016
- 2016-03-08 HK HK16102648.4A patent/HK1214732A1/zh unknown
-
2017
- 2017-08-09 AU AU2017213487A patent/AU2017213487B2/en not_active Ceased
-
2019
- 2019-06-11 AU AU2019204084A patent/AU2019204084A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002086098A2 (en) * | 2001-03-05 | 2002-10-31 | University Of Virginia Patent Foundation | A lac operator-repressor system |
| WO2013123365A1 (en) * | 2012-02-15 | 2013-08-22 | Mice With Horns, Llc | Transgenic animals with customizable traits |
Non-Patent Citations (3)
| Title |
|---|
| CRONIN, C. A. et al., Genes & Development, 2001, vol. 15, pages 1506-1517 * |
| DONG, C. et al., RNA, 2012, vol. 18, pages 1679-1686 * |
| MILLS, A. A., Genes & Development, 2001, vol. 15 pages 1461-1467 * |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2015013253A (es) | 2016-04-07 |
| EP2967017A2 (en) | 2016-01-20 |
| JP2016512697A (ja) | 2016-05-09 |
| CA2906936A1 (en) | 2014-09-18 |
| AU2017213487B2 (en) | 2019-07-04 |
| AU2017213487A1 (en) | 2017-08-31 |
| BR112015023414A2 (pt) | 2017-11-28 |
| AU2019204084A1 (en) | 2019-07-04 |
| AU2014233317A1 (en) | 2015-10-29 |
| CN105357960A (zh) | 2016-02-24 |
| EP2967017A4 (en) | 2016-11-09 |
| HK1214732A1 (zh) | 2016-08-05 |
| CN105357960B (zh) | 2018-02-16 |
| WO2014145196A2 (en) | 2014-09-18 |
| WO2014145196A3 (en) | 2015-02-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2013221342B2 (en) | Transgenic animals with customizable traits | |
| US20150013025A1 (en) | Transgenic animals with customizable traits | |
| AU2017213487B2 (en) | Transgenic animals with customizable traits | |
| US20150320019A1 (en) | Transgenic animals with cutomizable traits | |
| AU2008286791A1 (en) | Transgenic chickens with an inactivated endogenous gene locus | |
| AU737678B2 (en) | Transgenic animal with recombinant vascular endothelial growth factor B (VEGF-B) DNA and uses thereof | |
| US20160044901A1 (en) | Transgenic Animals With Customizable Traits | |
| US20210345592A1 (en) | Genetically modified sterile avians and method for the reconstitution thereof | |
| US20090105170A1 (en) | Multiple Heat Shock Elements | |
| US20230200363A1 (en) | Transgenic fluorescent ornamental amphibians | |
| US20050022259A1 (en) | Transgenic animal model for cancer and stem cells |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |