AU2014207429B2 - Selective glycosidase regimen for immune programming and treatment of cancer - Google Patents
Selective glycosidase regimen for immune programming and treatment of cancer Download PDFInfo
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- AU2014207429B2 AU2014207429B2 AU2014207429A AU2014207429A AU2014207429B2 AU 2014207429 B2 AU2014207429 B2 AU 2014207429B2 AU 2014207429 A AU2014207429 A AU 2014207429A AU 2014207429 A AU2014207429 A AU 2014207429A AU 2014207429 B2 AU2014207429 B2 AU 2014207429B2
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- 201000005112 urinary bladder cancer Diseases 0.000 description 1
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- ZOCKGBMQLCSHFP-KQRAQHLDSA-N valrubicin Chemical compound O([C@H]1C[C@](CC2=C(O)C=3C(=O)C4=CC=CC(OC)=C4C(=O)C=3C(O)=C21)(O)C(=O)COC(=O)CCCC)[C@H]1C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O1 ZOCKGBMQLCSHFP-KQRAQHLDSA-N 0.000 description 1
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Classifications
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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-
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01023—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01049—Alpha-N-acetylgalactosaminidase (3.2.1.49)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/0105—Alpha-N-acetylglucosaminidase (3.2.1.50)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01051—Alpha-L-fucosidase (3.2.1.51)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (1)
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| AU2019200688A AU2019200688B2 (en) | 2013-01-18 | 2019-02-01 | Selective glycosidase regimen for immune programming and treatment of cancer |
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| US201361754056P | 2013-01-18 | 2013-01-18 | |
| US61/754,056 | 2013-01-18 | ||
| PCT/US2014/011995 WO2014113641A1 (en) | 2013-01-18 | 2014-01-17 | Selective glycosidase regimen for immune programming and treatment of cancer |
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| AU2014207429A1 AU2014207429A1 (en) | 2015-07-02 |
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| AU2019200688A Ceased AU2019200688B2 (en) | 2013-01-18 | 2019-02-01 | Selective glycosidase regimen for immune programming and treatment of cancer |
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Country Status (9)
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| US (2) | US20150352193A1 (https=) |
| EP (2) | EP2945644A4 (https=) |
| JP (1) | JP2016505043A (https=) |
| KR (1) | KR20150107738A (https=) |
| CN (1) | CN104936611A (https=) |
| AU (2) | AU2014207429B2 (https=) |
| CA (1) | CA2896899A1 (https=) |
| MX (1) | MX2015009260A (https=) |
| WO (1) | WO2014113641A1 (https=) |
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| AU2013323472B2 (en) | 2012-09-28 | 2018-07-05 | Ellis KLINE | Glycosidase regimen for treatment of infectious disease |
| WO2016162867A1 (en) * | 2015-04-08 | 2016-10-13 | Efranat Ltd. | Combination therapy of macrophage activating factor and pd-1 signaling inhibitors |
| CN105256036B (zh) * | 2015-10-26 | 2019-02-12 | 中国人民解放军第二军医大学 | 一种检测血清中lncARSR的试剂盒及其在检测肾癌舒尼替尼耐药中的应用 |
| US11554145B2 (en) | 2019-01-31 | 2023-01-17 | The Chinese University Of Hong Kong | Therapeutic and prophylactic treatment for colorectal cancer |
| CN111500715B (zh) * | 2019-01-31 | 2022-03-11 | 北京大学 | 用于预测结直肠癌术后复发与转移的检测组合物、检测装置、检测试剂盒及应用 |
| BR112021026852A2 (pt) * | 2019-07-03 | 2022-02-22 | Palleon Pharmaceuticals Inc | Sialidases recombinantes e métodos de uso das mesmas |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20010036455A1 (en) * | 2000-04-07 | 2001-11-01 | Kline Ellis L. | Methods and compositions for treating neoplasms |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4071408A (en) | 1976-11-01 | 1978-01-31 | Research Corporation | Neuraminidase |
| DE3302160A1 (de) | 1983-01-22 | 1984-07-26 | Ing. Erich Pfeiffer GmbH & Co KG, 7760 Radolfzell | Betaetigbare dosiereinrichtung |
| DE3315334A1 (de) | 1983-04-28 | 1984-10-31 | Pfeiffer Erich Gmbh & Co Kg | Zerstaeuber- oder dosierpumpe |
| DE3715301A1 (de) | 1987-05-08 | 1988-11-24 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung fuer medien |
| DE3722470A1 (de) | 1987-07-08 | 1989-01-19 | Pfeiffer Erich Gmbh & Co Kg | Handbetaetigbare austragvorrichtung fuer medien |
| US5326749A (en) | 1989-11-20 | 1994-07-05 | Nobuto Yamamoto | Macrophage activating factor from vitamin D binding protein |
| IT1252228B (it) | 1991-12-17 | 1995-06-05 | T Associated Bio Technologies | Procedimento per la produzione di neuraminidasi |
| US6562588B2 (en) | 1993-05-17 | 2003-05-13 | Genentech, Inc. | Sialidase and recombinant cell lines |
| US5985859A (en) | 1994-04-14 | 1999-11-16 | The University Of Alabama | Methods of inhibiting bacterial sialidase |
| US6410269B1 (en) * | 1995-06-07 | 2002-06-25 | Nobuto Yamamoto | Preparation of potent macrophage activating factors derived from cloned vitamin D binding protein and its domain and their therapeutic usage for cancer, HIV-infection and osteopetrosis |
| DE19525734A1 (de) | 1995-07-14 | 1997-01-16 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung für fließfähige Medien, insbesondere für den Austrag in nur einem Hub |
| DE10146815B4 (de) | 2001-09-18 | 2005-05-04 | Ing. Erich Pfeiffer Gmbh | Spender für Medien |
| WO2003026803A1 (de) | 2001-09-21 | 2003-04-03 | Ing. Erich Pfeiffer Gmbh | Dosiervorrichtung mit einer pumpvorrichtung |
| DE10164452A1 (de) | 2001-12-21 | 2003-07-03 | Pfeiffer Erich Gmbh & Co Kg | Spender für Medien |
| CA2992643C (en) | 2002-03-13 | 2019-06-18 | Genomic Health, Inc. | Gene expression profiling in biopsied tumor tissues |
| US20040231909A1 (en) | 2003-01-15 | 2004-11-25 | Tai-Yang Luh | Motorized vehicle having forward and backward differential structure |
| ES2609234T3 (es) | 2003-06-24 | 2017-04-19 | Genomic Health, Inc. | Predicción de la probabilidad de recidiva de cáncer |
| US7526387B2 (en) | 2003-07-10 | 2009-04-28 | Genomic Health, Inc. | Expression profile algorithm and test for cancer prognosis |
| US7892752B2 (en) * | 2005-04-26 | 2011-02-22 | Dwek Raymond A | Glycosylation markers for cancer diagnosing and monitoring |
| AU2007317333A1 (en) * | 2006-11-02 | 2008-05-15 | Seattle Genetics, Inc. | Methods of treating neoplastic, autoimmune and inflammatory diseases |
| BRPI0807768A2 (pt) | 2007-02-20 | 2014-06-24 | Dsm Ip Assests Bv | Nova sialidase. |
| JP5523313B2 (ja) * | 2007-07-03 | 2014-06-18 | チルドレンズ ホスピタル アンド リサーチ センター アット オークランド | ポリシアル酸誘導体、製造方法、ならびにがん抗原産生の増強およびターゲティングにおける使用 |
| JP5583117B2 (ja) | 2008-05-14 | 2014-09-03 | ユニバーシティー ヘルス ネットワーク | 非小細胞肺癌およびアジュバント化学療法に関する予後診断的および予測的な遺伝子シグネチャー |
| US20110238322A1 (en) | 2008-11-03 | 2011-09-29 | Precision Therapeutics, Inc. | Methods of simulating chemotherapy for a patient |
| US20100331210A1 (en) | 2009-05-29 | 2010-12-30 | Precision Therapeutics, Inc. | Methods and systems for evaluating the sensitivity or resistance of tumor specimens to chemotherapeutic agents |
| TW201113372A (en) * | 2009-08-22 | 2011-04-16 | Charles Knezevich | Tumoricidal, bactericidal, or viricidal macrophage activation |
| WO2013038997A1 (ja) * | 2011-09-14 | 2013-03-21 | 医療法人再生未来 | 医薬組成物およびその製造方法 |
-
2014
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- 2014-01-17 CA CA2896899A patent/CA2896899A1/en not_active Abandoned
- 2014-01-17 KR KR1020157018524A patent/KR20150107738A/ko not_active Ceased
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- 2014-01-17 US US14/760,809 patent/US20150352193A1/en not_active Abandoned
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- 2014-01-17 MX MX2015009260A patent/MX2015009260A/es unknown
- 2014-01-17 EP EP14740546.8A patent/EP2945644A4/en not_active Withdrawn
- 2014-01-17 JP JP2015553844A patent/JP2016505043A/ja active Pending
- 2014-01-17 EP EP19162169.7A patent/EP3563864A1/en not_active Withdrawn
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2019
- 2019-02-01 AU AU2019200688A patent/AU2019200688B2/en not_active Ceased
- 2019-03-14 US US16/353,168 patent/US20190201503A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010036455A1 (en) * | 2000-04-07 | 2001-11-01 | Kline Ellis L. | Methods and compositions for treating neoplasms |
Non-Patent Citations (2)
| Title |
|---|
| ALLEY ET AL., "Effectiveness of neuraminidase in experimental immunotherapy of two murine pulmonary carcinomas.", CANCER RES., (1977-01-01), vol. 37, no. 1, pages 95 - 101. * |
| ARCARO ET AL., "Beta-galactosidase and alpha-mannosidase inhibit formation of multicellular nodules in breast cancer cell cultures.", ANTICANCER RES., (2004-01-01), vol. 24, no. 1, pages 139 - 44. * |
Also Published As
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|---|---|
| EP3563864A1 (en) | 2019-11-06 |
| EP2945644A4 (en) | 2016-10-26 |
| JP2016505043A (ja) | 2016-02-18 |
| WO2014113641A1 (en) | 2014-07-24 |
| AU2019200688A1 (en) | 2019-02-21 |
| US20190201503A1 (en) | 2019-07-04 |
| CA2896899A1 (en) | 2014-07-24 |
| AU2019200688B2 (en) | 2020-08-06 |
| MX2015009260A (es) | 2015-10-15 |
| US20150352193A1 (en) | 2015-12-10 |
| CN104936611A (zh) | 2015-09-23 |
| KR20150107738A (ko) | 2015-09-23 |
| EP2945644A1 (en) | 2015-11-25 |
| AU2014207429A1 (en) | 2015-07-02 |
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