AU2013326463B2 - Use of masitinib for treatment of cancer in patient subpopulations identified using predictor factors - Google Patents
Use of masitinib for treatment of cancer in patient subpopulations identified using predictor factors Download PDFInfo
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- AU2013326463B2 AU2013326463B2 AU2013326463A AU2013326463A AU2013326463B2 AU 2013326463 B2 AU2013326463 B2 AU 2013326463B2 AU 2013326463 A AU2013326463 A AU 2013326463A AU 2013326463 A AU2013326463 A AU 2013326463A AU 2013326463 B2 AU2013326463 B2 AU 2013326463B2
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| US20160244845A1 (en) * | 2013-10-04 | 2016-08-25 | Ab Science | Method for determining the prognosis of pancreatic cancer |
| MX2016014574A (es) * | 2014-05-08 | 2017-02-23 | Oncoethix Gmbh | El uso de compuestos de tienotriazolodiazepina para el tratamiento de cancer de mama triple-negativo. |
| TW201615222A (zh) * | 2014-10-24 | 2016-05-01 | 朗齊生物醫學股份有限公司 | 免疫疾病用藥臨床新應用 |
| EP3280448B1 (en) | 2015-04-10 | 2020-12-30 | Capsugel Belgium NV | Abiraterone acetate lipid formulations |
| RS62108B1 (sr) | 2016-03-02 | 2021-08-31 | Eisai R&D Man Co Ltd | Antitelo-lek konjugati na bazi eribulina i postupci primene |
| NZ745778A (en) * | 2016-03-25 | 2022-07-01 | Ab Science | Use of masitinib for treatment of an amyotrophic lateral sclerosis patient subpopulation |
| CN107267454B (zh) * | 2016-04-07 | 2025-05-23 | 内蒙古原生元生物科技有限公司 | 一种脐血nk细胞的体外扩增方法及其试剂盒与应用 |
| AU2018209164B2 (en) | 2017-01-17 | 2021-11-04 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| CN110381938A (zh) * | 2017-02-01 | 2019-10-25 | 大连万春布林医药有限公司 | 减少中性粒细胞缺乏症的方法 |
| CN118903436A (zh) | 2018-01-31 | 2024-11-08 | 德西费拉制药有限责任公司 | 治疗肥大细胞增多症的组合疗法 |
| US20210398672A1 (en) * | 2018-10-29 | 2021-12-23 | Northwestern University | Big Data-Driven Personalized Management of Chronic Pain |
| WO2020115108A1 (en) * | 2018-12-06 | 2020-06-11 | Sørlandet Sykehus Hf | Egfr inhibitors and their use in the treatment of neuroathic pain |
| WO2020115261A1 (en) * | 2018-12-07 | 2020-06-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating melanoma |
| NZ784949A (en) | 2019-08-12 | 2025-09-26 | Deciphera Pharmaceuticals Llc | Ripretinib for treating gastrointestinal stromal tumors |
| SMT202400484T1 (it) | 2019-12-30 | 2025-01-14 | Deciphera Pharmaceuticals Llc | Composizioni di 1-(4-bromo-5-(1-etil-7-(metilammino)-2-osso-1,2-diidro-1,6-naftiridin-3-il)-2-fluorofenil)-3-fenilurea |
| CN114214396A (zh) * | 2020-06-30 | 2022-03-22 | 宁波市康宁医院(宁波市精神疾病预防控制中心、宁波市微循环与莨菪类药研究所) | Gabrd甲基化作为抗海洛因复吸靶点的应用 |
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| WO2011092338A1 (en) * | 2010-02-01 | 2011-08-04 | Ab Science | Combined treatment of pancreatic cancer with gemcitabine and masitinib |
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| US20100143935A1 (en) | 2006-12-01 | 2010-06-10 | Apocell, Inc. | c-KIT Phosphorylation in Cancer |
| JP2010515708A (ja) | 2007-01-12 | 2010-05-13 | アブ サイエンス | 代謝拮抗薬およびチロシンキナーゼ阻害剤を用いた固形癌の併用治療 |
| SI2118099T1 (sl) | 2007-02-13 | 2011-11-30 | Ab Science | Postopek za sintezo 2-aminotiazolnih spojin kot kinaznih inhibitorjev |
| WO2011056963A1 (en) | 2009-11-04 | 2011-05-12 | The University Of North Carolina At Chapel Hill | Methods and compositions for predicting survival in subjects with cancer |
| WO2012170640A1 (en) * | 2011-06-07 | 2012-12-13 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for trail-drug combination therapy |
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Patent Citations (1)
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|---|---|---|---|---|
| WO2011092338A1 (en) * | 2010-02-01 | 2011-08-04 | Ab Science | Combined treatment of pancreatic cancer with gemcitabine and masitinib |
Non-Patent Citations (2)
| Title |
|---|
| HUMBERT MARTINE ET AL, "Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model", PLOS ONE, (20100101), vol. 5, no. 3, pages e9430 - 1 * |
| Mitry (Cancer Chemother Pharmacol 2010 Vol 66 pages 395-403) * |
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| JP6234466B2 (ja) | 2017-11-22 |
| TW201414475A (zh) | 2014-04-16 |
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| EP2903616A1 (en) | 2015-08-12 |
| WO2014053650A1 (en) | 2014-04-10 |
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| CN104968347A (zh) | 2015-10-07 |
| EP2903616B8 (en) | 2018-02-07 |
| SG11201502626PA (en) | 2015-05-28 |
| JP2015532296A (ja) | 2015-11-09 |
| US20150272945A1 (en) | 2015-10-01 |
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| EA037368B1 (ru) | 2021-03-19 |
| EP2903616B1 (en) | 2017-12-13 |
| AR092899A1 (es) | 2015-05-06 |
| US10238649B2 (en) | 2019-03-26 |
| ES2656640T3 (es) | 2018-02-27 |
| CA2886979A1 (en) | 2014-04-10 |
| BR112015007144A2 (pt) | 2017-12-12 |
| TWI609686B (zh) | 2018-01-01 |
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| IL238107B (en) | 2018-03-29 |
| AU2013326463A1 (en) | 2015-04-16 |
| ZA201503054B (en) | 2016-11-30 |
| DK2903616T3 (da) | 2018-01-29 |
| NZ706420A (en) | 2018-08-31 |
| SI2903616T1 (en) | 2018-02-28 |
| KR102149483B1 (ko) | 2020-08-28 |
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