AU2013298653B2 - Quinone compounds and their uses for the treatment of cancer - Google Patents
Quinone compounds and their uses for the treatment of cancer Download PDFInfo
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- AU2013298653B2 AU2013298653B2 AU2013298653A AU2013298653A AU2013298653B2 AU 2013298653 B2 AU2013298653 B2 AU 2013298653B2 AU 2013298653 A AU2013298653 A AU 2013298653A AU 2013298653 A AU2013298653 A AU 2013298653A AU 2013298653 B2 AU2013298653 B2 AU 2013298653B2
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- 235000011007 phosphoric acid Nutrition 0.000 description 1
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- 229920002981 polyvinylidene fluoride Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- CPTBDICYNRMXFX-UHFFFAOYSA-N procarbazine Chemical compound CNNCC1=CC=C(C(=O)NC(C)C)C=C1 CPTBDICYNRMXFX-UHFFFAOYSA-N 0.000 description 1
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- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
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- 229960001052 streptozocin Drugs 0.000 description 1
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- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 208000014794 superficial urinary bladder carcinoma Diseases 0.000 description 1
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- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 1
- QIWDGSYHBCMXSI-UHFFFAOYSA-J tetrasodium;(2-methyl-4-phosphonatooxynaphthalen-1-yl) phosphate;hexahydrate Chemical compound O.O.O.O.O.O.[Na+].[Na+].[Na+].[Na+].C1=CC=CC2=C(OP([O-])([O-])=O)C(C)=CC(OP([O-])([O-])=O)=C21 QIWDGSYHBCMXSI-UHFFFAOYSA-J 0.000 description 1
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- 239000002562 thickening agent Substances 0.000 description 1
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- 230000001988 toxicity Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
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- GBABOYUKABKIAF-IELIFDKJSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-IELIFDKJSA-N 0.000 description 1
- 229960002066 vinorelbine Drugs 0.000 description 1
- CILBMBUYJCWATM-PYGJLNRPSA-N vinorelbine ditartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC CILBMBUYJCWATM-PYGJLNRPSA-N 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
- C07D203/14—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom with carbocyclic rings directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/396—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having three-membered rings, e.g. aziridine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1213486.2 | 2012-07-30 | ||
| GBGB1213486.2A GB201213486D0 (en) | 2012-07-30 | 2012-07-30 | Quinone compounds and their uses for the treatment of cancer |
| PCT/EP2013/065968 WO2014020012A1 (en) | 2012-07-30 | 2013-07-30 | Quinone compounds and their uses for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2013298653A1 AU2013298653A1 (en) | 2015-02-19 |
| AU2013298653B2 true AU2013298653B2 (en) | 2017-10-19 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013298653A Ceased AU2013298653B2 (en) | 2012-07-30 | 2013-07-30 | Quinone compounds and their uses for the treatment of cancer |
Country Status (16)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115887684B (zh) * | 2022-12-02 | 2025-02-14 | 南京邮电大学 | 基于dna折纸和阿霉素前药构筑的递药纳米体系及方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6156744A (en) * | 1998-03-19 | 2000-12-05 | Cancer Research Campaign Tech (London) | DT-diaphorase directed anti-tumor agents |
| WO2006009893A2 (en) * | 2004-06-21 | 2006-01-26 | Hutchison Medipharma Enterprises Limited | Cancer chemotherapy |
| EP2134322B1 (en) * | 2007-03-13 | 2019-02-20 | Spectrum Pharmaceuticals, Inc. | Intravesical apaziquone administration following transurethral resection for treating bladder cancer |
-
2012
- 2012-07-30 GB GBGB1213486.2A patent/GB201213486D0/en not_active Ceased
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2013
- 2013-07-30 MX MX2015000969A patent/MX361650B/es active IP Right Grant
- 2013-07-30 CA CA2880021A patent/CA2880021C/en not_active Expired - Fee Related
- 2013-07-30 US US14/418,394 patent/US9266829B2/en not_active Expired - Fee Related
- 2013-07-30 RU RU2015105036A patent/RU2688675C2/ru not_active IP Right Cessation
- 2013-07-30 WO PCT/EP2013/065968 patent/WO2014020012A1/en active Application Filing
- 2013-07-30 AU AU2013298653A patent/AU2013298653B2/en not_active Ceased
- 2013-07-30 GB GB1422799.5A patent/GB2519004B/en not_active Expired - Fee Related
- 2013-07-30 JP JP2015524762A patent/JP6317742B2/ja not_active Expired - Fee Related
- 2013-07-30 EP EP13742640.9A patent/EP2882743B1/en not_active Not-in-force
- 2013-07-30 DK DK13742640.9T patent/DK2882743T3/en active
- 2013-07-30 NO NO13742640A patent/NO2882743T3/no unknown
- 2013-07-30 CN CN201380040388.1A patent/CN104583200B/zh not_active Expired - Fee Related
- 2013-07-30 IN IN1223DEN2015 patent/IN2015DN01223A/en unknown
- 2013-07-30 ES ES13742640.9T patent/ES2662917T3/es active Active
- 2013-07-30 BR BR112015001837-8A patent/BR112015001837B1/pt not_active IP Right Cessation
- 2013-07-30 KR KR1020157002128A patent/KR102142164B1/ko not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| HIDEO NAKAO, et al., "Antileukemic Agent. II. New 2,5-Bis(1-aziridinyl)-p-benzoquinone Derivatives", Chem. Pharm. Bull., (19721231), pages 1968 - 1979 * |
| Masafumi Yoshimoto, et al., "Quantitative Structure-Activity Relationships in 2,5-Bis ( 1 -aziridinyl) -p -benzoquinone Derivatives against Leukemia L-1210", Journal of Medicinal Chemistry, (19791231), pages 491 - 496 * |
| Parveen Khan,et al., Journal of Chromatography B, (19990611), doi:doi:10.1016/S0378-4347(99)00177-2, pages 287 - 295 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015524815A (ja) | 2015-08-27 |
| ES2662917T3 (es) | 2018-04-10 |
| WO2014020012A1 (en) | 2014-02-06 |
| IN2015DN01223A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-06-26 |
| GB201213486D0 (en) | 2012-09-12 |
| NO2882743T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2018-05-12 |
| HK1209111A1 (zh) | 2016-03-24 |
| CN104583200A (zh) | 2015-04-29 |
| CN104583200B (zh) | 2017-07-25 |
| CA2880021C (en) | 2020-01-14 |
| CA2880021A1 (en) | 2014-02-06 |
| MX2015000969A (es) | 2015-09-23 |
| RU2015105036A (ru) | 2016-09-20 |
| AU2013298653A1 (en) | 2015-02-19 |
| JP6317742B2 (ja) | 2018-04-25 |
| MX361650B (es) | 2018-12-13 |
| GB2519004B (en) | 2016-03-30 |
| EP2882743B1 (en) | 2017-12-13 |
| KR20150036215A (ko) | 2015-04-07 |
| BR112015001837A2 (pt) | 2017-07-04 |
| KR102142164B1 (ko) | 2020-08-06 |
| DK2882743T3 (en) | 2018-03-12 |
| GB2519004A (en) | 2015-04-08 |
| RU2688675C2 (ru) | 2019-05-22 |
| EP2882743A1 (en) | 2015-06-17 |
| BR112015001837B1 (pt) | 2021-11-16 |
| US20150210639A1 (en) | 2015-07-30 |
| US9266829B2 (en) | 2016-02-23 |
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