AU2013291964B2 - Novel therapeutic treatments with anti-HER2 antibodies having a low fucosylation - Google Patents
Novel therapeutic treatments with anti-HER2 antibodies having a low fucosylation Download PDFInfo
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- AU2013291964B2 AU2013291964B2 AU2013291964A AU2013291964A AU2013291964B2 AU 2013291964 B2 AU2013291964 B2 AU 2013291964B2 AU 2013291964 A AU2013291964 A AU 2013291964A AU 2013291964 A AU2013291964 A AU 2013291964A AU 2013291964 B2 AU2013291964 B2 AU 2013291964B2
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Biophysics (AREA)
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- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Radiology & Medical Imaging (AREA)
- Mycology (AREA)
- Pathology (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
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| US201261673216P | 2012-07-18 | 2012-07-18 | |
| US201261673201P | 2012-07-18 | 2012-07-18 | |
| US201261673229P | 2012-07-18 | 2012-07-18 | |
| US61/673,201 | 2012-07-18 | ||
| US61/673,229 | 2012-07-18 | ||
| US61/673,216 | 2012-07-18 | ||
| EP12197768 | 2012-12-18 | ||
| EP12197768.0 | 2012-12-18 | ||
| PCT/EP2013/065189 WO2014013019A1 (en) | 2012-07-18 | 2013-07-18 | Novel therapeutic treatments with anti-her2 antibodies having a low fucosylation |
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| AU2013291964A1 AU2013291964A1 (en) | 2015-02-05 |
| AU2013291964B2 true AU2013291964B2 (en) | 2017-12-14 |
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| AU2013291964A Expired - Fee Related AU2013291964B2 (en) | 2012-07-18 | 2013-07-18 | Novel therapeutic treatments with anti-HER2 antibodies having a low fucosylation |
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| US (1) | US20150166664A1 (enExample) |
| EP (1) | EP2874658A1 (enExample) |
| JP (1) | JP2015528802A (enExample) |
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| CN (1) | CN104394887A (enExample) |
| AU (1) | AU2013291964B2 (enExample) |
| BR (1) | BR112014032169A2 (enExample) |
| CA (1) | CA2875486A1 (enExample) |
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| NZ (1) | NZ701974A (enExample) |
| SG (1) | SG11201407841YA (enExample) |
| WO (1) | WO2014013019A1 (enExample) |
| ZA (1) | ZA201408938B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| LU92659B1 (en) * | 2015-02-23 | 2016-08-24 | Glycotope Gmbh | Glycooptimized antibody drug conjugates |
| JP2020512382A (ja) * | 2017-03-29 | 2020-04-23 | グリコトープ ゲーエムベーハー | Ｐｄ−ｌ１抗体およびｔａ−ｍｕｃ１抗体 |
| US12103978B2 (en) * | 2018-06-15 | 2024-10-01 | Shanghai Miracogen Inc. | Methods and materials for treating cancer |
| CA3112043A1 (en) | 2018-09-10 | 2020-03-19 | Mirati Therapeutics, Inc. | Combination therapies |
| CN113999313A (zh) * | 2020-07-28 | 2022-02-01 | 百奥泰生物制药股份有限公司 | 抗her2抗体及其应用 |
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| WO2004065540A2 (en) * | 2003-01-22 | 2004-08-05 | Glycart Biotechnology Ag | Fusion constructs and use of same to produce antibodies with increased fc receptor binding affinity and effector function |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| PL220113B1 (pl) | 1999-01-15 | 2015-08-31 | Genentech Inc | Wariant macierzystego polipeptydu zawierającego region Fc, polipeptyd zawierający wariant regionu Fc o zmienionym powinowactwie wiązania receptora Fc gamma (FcγR), polipeptyd zawierający wariant regionu Fc o zmienionym powinowactwie wiązania noworodkowego receptora Fc (FcRn), kompozycja, wyizolowany kwas nukleinowy, wektor, komórka gospodarza, sposób otrzymywania wariantu polipeptydu, zastosowanie wariantu polipeptydu i sposób otrzymywania wariantu regionu Fc |
| EP2278003B2 (en) | 1999-04-09 | 2020-08-05 | Kyowa Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
| MXPA03000105A (es) | 2000-06-28 | 2004-09-13 | Glycofi Inc | Metodo para producir glicoproteinas modificadas. |
| JP2005532253A (ja) | 2001-10-25 | 2005-10-27 | ジェネンテック・インコーポレーテッド | 糖タンパク質組成物 |
| JPWO2003084569A1 (ja) | 2002-04-09 | 2005-08-11 | 協和醗酵工業株式会社 | 抗体組成物含有医薬 |
| FR2858235B1 (fr) | 2003-07-31 | 2006-02-17 | Lab Francais Du Fractionnement | Utilisation d'anticorps optimises en adcc pour traiter les patients faibles repondeurs |
| JPWO2005053742A1 (ja) * | 2003-12-04 | 2007-06-28 | 協和醗酵工業株式会社 | 抗体組成物を含有する医薬 |
| WO2005086875A2 (en) * | 2004-03-11 | 2005-09-22 | City Of Hope | A humanized anti-cea t84.66 antibody and uses thereof |
| DOP2006000029A (es) * | 2005-02-07 | 2006-08-15 | Genentech Inc | Antibody variants and uses thereof. (variantes de un anticuerpo y usos de las mismas) |
| CN103436574B (zh) | 2006-09-10 | 2016-08-10 | 葛莱高托普有限公司 | 骨髓白血病来源的细胞在抗体表达中的用途 |
| CN102666874B (zh) * | 2009-10-07 | 2016-06-01 | 宏观基因有限公司 | 由于岩藻糖基化程度的改变而表现出改善的效应子功能的含Fc区的多肽及其使用方法 |
| US20120258496A1 (en) * | 2010-09-27 | 2012-10-11 | Boehringer Ingelheim International Gmbh | Production of low fucose antibodies in h4-ii-e rat cells |
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2013
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- 2013-07-18 JP JP2015522098A patent/JP2015528802A/ja active Pending
- 2013-07-18 NZ NZ701974A patent/NZ701974A/en not_active IP Right Cessation
- 2013-07-18 AU AU2013291964A patent/AU2013291964B2/en not_active Expired - Fee Related
- 2013-07-18 CN CN201380034959.0A patent/CN104394887A/zh active Pending
- 2013-07-18 KR KR20157004250A patent/KR20150036710A/ko not_active Withdrawn
- 2013-07-18 MX MX2015000730A patent/MX2015000730A/es unknown
- 2013-07-18 WO PCT/EP2013/065189 patent/WO2014013019A1/en not_active Ceased
- 2013-07-18 MA MA37961A patent/MA37961A1/fr unknown
- 2013-07-18 EA EA201590237A patent/EA201590237A1/ru unknown
- 2013-07-18 US US14/412,797 patent/US20150166664A1/en not_active Abandoned
- 2013-07-18 EP EP13739973.9A patent/EP2874658A1/en not_active Withdrawn
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2014
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2015
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004065540A2 (en) * | 2003-01-22 | 2004-08-05 | Glycart Biotechnology Ag | Fusion constructs and use of same to produce antibodies with increased fc receptor binding affinity and effector function |
Non-Patent Citations (3)
| Title |
|---|
| BEANO ALESSANDRA ET AL, "Correlation between NK function and response to trastuzumab in metastatic breast cancer patients", JOURNAL OF TRANSLATIONAL MEDICINE, BIOMED CENTRAL, LONDON, GB, (20080516), vol. 6, no. 1, ISSN 1479-5876, page 25 * |
| SUZUKI EIJI, "A nonfucosylated anti-HER2 antibody augments antibody-dependent cellular cytotoxicity in breast cancer patients.", CLINICAL CANCER RESEARCH, (20070315), vol. 13, no. 6, PAGE 1875 - 1882. * |
| T. T. JUNTTILA ET AL, CANCER RESEARCH, (20100601), vol. 70, no. 11, doi:10.1158/0008-5472.CAN-09-3704, ISSN 0008-5472, pages 4481 - 4489 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2875486A1 (en) | 2014-01-23 |
| MX2015000730A (es) | 2015-08-06 |
| IL236714A0 (en) | 2015-02-26 |
| EA201590237A1 (ru) | 2015-05-29 |
| MA37961A1 (fr) | 2016-06-30 |
| CN104394887A (zh) | 2015-03-04 |
| NZ701974A (en) | 2018-03-23 |
| ZA201408938B (en) | 2016-09-28 |
| EP2874658A1 (en) | 2015-05-27 |
| AU2013291964A1 (en) | 2015-02-05 |
| WO2014013019A1 (en) | 2014-01-23 |
| BR112014032169A2 (pt) | 2017-08-01 |
| JP2015528802A (ja) | 2015-10-01 |
| SG11201407841YA (en) | 2015-02-27 |
| US20150166664A1 (en) | 2015-06-18 |
| KR20150036710A (ko) | 2015-04-07 |
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