AU2013259548A1 - Conformationally specific viral immunogens - Google Patents

Conformationally specific viral immunogens Download PDF

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Publication number
AU2013259548A1
AU2013259548A1 AU2013259548A AU2013259548A AU2013259548A1 AU 2013259548 A1 AU2013259548 A1 AU 2013259548A1 AU 2013259548 A AU2013259548 A AU 2013259548A AU 2013259548 A AU2013259548 A AU 2013259548A AU 2013259548 A1 AU2013259548 A1 AU 2013259548A1
Authority
AU
Australia
Prior art keywords
protein
protein complex
viral
animal
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2013259548A
Other languages
English (en)
Inventor
Christopher Patrick Marshall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of AU2013259548A1 publication Critical patent/AU2013259548A1/en
Priority to AU2018200502A priority Critical patent/AU2018200502B2/en
Priority to AU2019216695A priority patent/AU2019216695A1/en
Priority to AU2021204169A priority patent/AU2021204169B2/en
Priority to AU2024201200A priority patent/AU2024201200A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56988—HIV or HTLV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
AU2013259548A 2012-05-09 2013-05-09 Conformationally specific viral immunogens Abandoned AU2013259548A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2018200502A AU2018200502B2 (en) 2012-05-09 2018-01-22 Conformationally specific viral immunogens
AU2019216695A AU2019216695A1 (en) 2012-05-09 2019-08-16 Conformationally specific viral immunogens
AU2021204169A AU2021204169B2 (en) 2012-05-09 2021-06-21 Conformationally specific viral immunogens
AU2024201200A AU2024201200A1 (en) 2012-05-09 2024-02-22 Conformationally specific viral immunogens

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261644830P 2012-05-09 2012-05-09
US61/644,830 2012-05-09
PCT/US2013/040228 WO2013169961A1 (en) 2012-05-09 2013-05-09 Conformationally specific viral immunogens

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018200502A Division AU2018200502B2 (en) 2012-05-09 2018-01-22 Conformationally specific viral immunogens

Publications (1)

Publication Number Publication Date
AU2013259548A1 true AU2013259548A1 (en) 2014-11-27

Family

ID=49548782

Family Applications (5)

Application Number Title Priority Date Filing Date
AU2013259548A Abandoned AU2013259548A1 (en) 2012-05-09 2013-05-09 Conformationally specific viral immunogens
AU2018200502A Ceased AU2018200502B2 (en) 2012-05-09 2018-01-22 Conformationally specific viral immunogens
AU2019216695A Abandoned AU2019216695A1 (en) 2012-05-09 2019-08-16 Conformationally specific viral immunogens
AU2021204169A Active AU2021204169B2 (en) 2012-05-09 2021-06-21 Conformationally specific viral immunogens
AU2024201200A Abandoned AU2024201200A1 (en) 2012-05-09 2024-02-22 Conformationally specific viral immunogens

Family Applications After (4)

Application Number Title Priority Date Filing Date
AU2018200502A Ceased AU2018200502B2 (en) 2012-05-09 2018-01-22 Conformationally specific viral immunogens
AU2019216695A Abandoned AU2019216695A1 (en) 2012-05-09 2019-08-16 Conformationally specific viral immunogens
AU2021204169A Active AU2021204169B2 (en) 2012-05-09 2021-06-21 Conformationally specific viral immunogens
AU2024201200A Abandoned AU2024201200A1 (en) 2012-05-09 2024-02-22 Conformationally specific viral immunogens

Country Status (7)

Country Link
US (6) US20130302366A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (2) EP2846828B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (4) JP2015518819A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (5) AU2013259548A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2873048C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN2014DN09445A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO2013169961A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3677279A1 (en) * 2013-07-25 2020-07-08 Calder Biosciences Inc. Conformationally stabilized rsv pre-fusion f proteins
CA2920016A1 (en) 2013-08-03 2015-02-12 Avatar Medical, Llc Influenza hemagglutinin proteins and methods of use thereof
CN119529036A (zh) 2017-08-07 2025-02-28 考尔德生物科技有限公司 构象稳定的rsv预融合f蛋白
WO2019178521A1 (en) 2018-03-16 2019-09-19 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Compositions and methods for vaccination against respiratory syncitial virus infection
KR20230022412A (ko) * 2020-05-12 2023-02-15 더 리전트 오브 더 유니버시티 오브 캘리포니아 Sars-cov2 중화 단일 도메인 항체 구성체

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7311920B1 (en) * 1999-10-08 2007-12-25 University Of Maryland Biotechnology Institute Virus coat protein/receptor chimeras and methods of use
AU7877900A (en) 1999-10-13 2001-04-23 Chiron Corporation Method of obtaining cellular immune responses from proteins
AU1207301A (en) 1999-10-15 2001-04-30 Avatar Medical, Llc Stabilized proteins
US6465425B1 (en) 2000-02-10 2002-10-15 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins
US7179468B1 (en) * 2000-06-08 2007-02-20 Cornell Research Foundation, Inc. Antigen for developing neutralizing antibodies to human immunodeficiency virus
EP1463521A4 (en) 2001-12-17 2009-06-24 Us Gov Health & Human Serv INHIBITOR OF GP41
WO2004069863A2 (en) 2003-02-04 2004-08-19 New York University Constrained hiv v3 loop peptides as immunogens and receptor antagonists
JP5009614B2 (ja) * 2003-07-03 2012-08-22 アバター バイオテクノロジーズ，インク． 免疫原性を低減した分子の取得方法
JP5069558B2 (ja) * 2004-06-01 2012-11-07 メルク・シャープ・エンド・ドーム・コーポレイション ＨＩＶｇｐ４１融合中間物質の安定したペプチド模倣薬
WO2007149491A2 (en) * 2006-06-19 2007-12-27 Progenics Pharmaceuticals, Inc. Soluble stabilized trimeric hiv env proteins and uses thereof
EP2562184B1 (en) * 2007-07-27 2015-10-07 immatics biotechnologies GmbH Novel immunogenic epitopes for immunotherapy
AU2008287340A1 (en) 2007-08-15 2009-02-19 Amunix, Inc. Compositions and methods for modifying properties of biologically active polypeptides
WO2009048631A1 (en) * 2007-10-11 2009-04-16 University Of Tennessee Research Foundation PREPARATION OF PURIFIED COVALENTYLY CROSS-LINKED A β OLIGOMERS AND USES THEREOF
SMT202000101T1 (it) * 2008-10-10 2020-03-13 Childrens Medical Center Vaccino con trimero di env di hiv-1 stabilizzato biochimicamente
WO2011066221A1 (en) 2009-11-24 2011-06-03 International Aids Vaccine Initiative Immunogen prioritization for vaccine design
EP2572196A4 (en) 2010-05-18 2014-04-23 Christopher P Marshall ANTIGEN IDENTIFICATION TEST THAT ACTIVATES B-CELL RECEPTORS COMPRISING NEUTRALIZING ANTIBODIES
US20130149336A1 (en) * 2011-10-27 2013-06-13 Brian L. Hjelle Methods for Screening Viral Like Particles and Identifying Neutralizing Epitopes and Related Vaccines, Constructs, and Libraries
WO2013107290A1 (en) 2012-01-20 2013-07-25 The Government of the Hong Kong Special Administrative Region of the People's Republic of China A novel paramyxovirus and uses thereof

Also Published As

Publication number Publication date
US20210322512A1 (en) 2021-10-21
EP2846828B1 (en) 2018-11-21
US20130317205A1 (en) 2013-11-28
EP2846828A4 (en) 2015-07-01
IN2014DN09445A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2015-07-17
US20180117116A1 (en) 2018-05-03
US10155023B2 (en) 2018-12-18
WO2013169961A1 (en) 2013-11-14
CA2873048C (en) 2020-10-27
AU2019216695A1 (en) 2019-09-05
JP2022163180A (ja) 2022-10-25
CA2873048A1 (en) 2013-11-14
US11752191B2 (en) 2023-09-12
AU2024201200A1 (en) 2024-03-14
US20240238369A1 (en) 2024-07-18
AU2018200502A1 (en) 2018-02-15
JP7472209B2 (ja) 2024-04-22
US20190105368A1 (en) 2019-04-11
JP6692853B2 (ja) 2020-05-13
AU2021204169A1 (en) 2021-07-15
EP2846828A1 (en) 2015-03-18
JP2020125323A (ja) 2020-08-20
AU2021204169B2 (en) 2023-11-23
US20130302366A1 (en) 2013-11-14
JP2018150330A (ja) 2018-09-27
EP3483174A1 (en) 2019-05-15
AU2018200502B2 (en) 2019-10-03
JP2015518819A (ja) 2015-07-06

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