AU2013224041B2 - Thiadiazolidinediones as GSK-3 inhibitors - Google Patents

Thiadiazolidinediones as GSK-3 inhibitors Download PDF

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Publication number
AU2013224041B2
AU2013224041B2 AU2013224041A AU2013224041A AU2013224041B2 AU 2013224041 B2 AU2013224041 B2 AU 2013224041B2 AU 2013224041 A AU2013224041 A AU 2013224041A AU 2013224041 A AU2013224041 A AU 2013224041A AU 2013224041 B2 AU2013224041 B2 AU 2013224041B2
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Australia
Prior art keywords
compound
formula
inhibitors
disease
pharmaceutically acceptable
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AU2013224041A
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AU2013224041A1 (en
Inventor
Javier DE CRISTOBAL BLANCO
Juan Manuel Dominguez Correa
Ana Fuertes Huerta
Susana Herrero Santos
Javier Lopez Ogalla
Olga Martinez Montero
Miguel Medina Padilla
Francisco Palomo Nicolau
Maria Angeles Perez De La Cruz Moreno
Beatriz Rodriguez Salguero
Jorge Sanchez-Quesada
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ASD Therapeutics Partners LLC
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ASD Therapeutics Partners LLC
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Priority to AU2017248556A priority Critical patent/AU2017248556B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2013224041A 2012-02-24 2013-02-22 Thiadiazolidinediones as GSK-3 inhibitors Active AU2013224041B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2017248556A AU2017248556B2 (en) 2012-02-24 2017-10-20 Thiadiazolidinediones as gsk-3 inhibitors

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12382066.4 2012-02-24
EP12382066 2012-02-24
PCT/EP2013/053554 WO2013124413A1 (en) 2012-02-24 2013-02-22 Thiadiazolidinediones as gsk-3 inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017248556A Division AU2017248556B2 (en) 2012-02-24 2017-10-20 Thiadiazolidinediones as gsk-3 inhibitors

Publications (2)

Publication Number Publication Date
AU2013224041A1 AU2013224041A1 (en) 2014-09-25
AU2013224041B2 true AU2013224041B2 (en) 2017-08-24

Family

ID=47747639

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2013224041A Active AU2013224041B2 (en) 2012-02-24 2013-02-22 Thiadiazolidinediones as GSK-3 inhibitors
AU2017248556A Active AU2017248556B2 (en) 2012-02-24 2017-10-20 Thiadiazolidinediones as gsk-3 inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2017248556A Active AU2017248556B2 (en) 2012-02-24 2017-10-20 Thiadiazolidinediones as gsk-3 inhibitors

Country Status (18)

Country Link
US (2) US9371299B2 (https=)
EP (1) EP2838888B1 (https=)
JP (2) JP6073377B2 (https=)
AU (2) AU2013224041B2 (https=)
CA (1) CA2865351C (https=)
CY (1) CY1119231T1 (https=)
DK (1) DK2838888T3 (https=)
ES (1) ES2632428T3 (https=)
HR (1) HRP20170964T1 (https=)
HU (1) HUE035089T2 (https=)
IN (1) IN2014DN07885A (https=)
LT (1) LT2838888T (https=)
NZ (1) NZ630615A (https=)
PL (1) PL2838888T3 (https=)
PT (1) PT2838888T (https=)
SI (1) SI2838888T1 (https=)
WO (1) WO2013124413A1 (https=)
ZA (1) ZA201406225B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6073377B2 (ja) 2012-02-24 2017-02-01 エーエスディー セラピューティクス パートナーズ エルエルシーＡｓｄ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｐａｒｔｎｅｒｓ Ｌｌｃ Ｇｓｋ−３阻害剤としての新規チアジアゾリジンジオン
PL2970890T3 (pl) 2013-03-14 2020-11-16 The Brigham And Women's Hospital, Inc. Kompozycje i sposoby ekspansji i hodowli nabłonkowych komórek macierzystych
MX388409B (es) * 2014-06-12 2025-03-19 Cedars Sinai Medical Center Composiciones y metodos para tratar canceres.
EP3189134A1 (en) 2014-09-03 2017-07-12 The Brigham and Women's Hospital, Inc. Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss
US11021687B2 (en) 2016-01-08 2021-06-01 The Brigham And Women's Hospital, Inc. Production of differentiated enteroendocrine cells and insulin producing cells
US11260130B2 (en) 2016-03-02 2022-03-01 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV
US10213511B2 (en) 2016-03-02 2019-02-26 Frequency Therapeutics, Inc. Thermoreversible compositions for administration of therapeutic agents
US10201540B2 (en) 2016-03-02 2019-02-12 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I
EP3562827A1 (en) 2016-12-30 2019-11-06 Frequency Therapeutics, Inc. 1h-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells
US11617745B2 (en) 2018-08-17 2023-04-04 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by downregulating FOXO
JP2021533788A (ja) 2018-08-17 2021-12-09 フリークエンシー セラピューティクス インコーポレイテッド Ｊａｇ−１を上方制御することにより有毛細胞を生成するための組成物及び方法
CN113168150B (zh) * 2018-10-16 2024-05-10 意大利技术联盟有限责任公司 具有被处理幅材的评估系统的卷绕机和方法
EP3920885A1 (en) 2019-02-08 2021-12-15 Frequency Therapeutics, Inc. Valproic acid compounds and wnt agonists for treating ear disorders
CA3207901A1 (en) * 2021-02-11 2022-08-18 Jason Roberts Compositions and methods for treating arrhythmogenic cardiomyopathy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080033012A1 (en) * 2000-05-11 2008-02-07 Cosenjo Superior De Investigaciones Cientificas, A Spain Corporation Enzyme inhibitors
KR100837785B1 (ko) * 2007-01-17 2008-06-13 한국화학연구원 1,2,4-티아다이아졸리딘-3,5-다이온 화합물을 포함하는염증관련 질환의 치료 및 예방을 위한 약제학적 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2166328B1 (es) * 2000-05-11 2003-09-16 Consejo Superior Investigacion Inhibidores heterociclicos del enzima gsk 3 utiles en el tratamiento de procesos neurodegenerativos e hiperproliferativos
EP1586318A1 (en) 2004-04-05 2005-10-19 Neuropharma S.A.U. Thiadiazolidinones as GSK-3 inhibitors
JP6073377B2 (ja) 2012-02-24 2017-02-01 エーエスディー セラピューティクス パートナーズ エルエルシーＡｓｄ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｐａｒｔｎｅｒｓ Ｌｌｃ Ｇｓｋ−３阻害剤としての新規チアジアゾリジンジオン

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080033012A1 (en) * 2000-05-11 2008-02-07 Cosenjo Superior De Investigaciones Cientificas, A Spain Corporation Enzyme inhibitors
KR100837785B1 (ko) * 2007-01-17 2008-06-13 한국화학연구원 1,2,4-티아다이아졸리딘-3,5-다이온 화합물을 포함하는염증관련 질환의 치료 및 예방을 위한 약제학적 조성물

Non-Patent Citations (1)

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Title
CAS Registry Number 1350207-15-6; STN Entry Date 7 December 2011; 4-methyl-2-(phenylmethyl)-1,2,4-Thiadiazolidine-3,5-dione *

Also Published As

Publication number Publication date
DK2838888T3 (en) 2017-07-17
CA2865351C (en) 2019-08-20
JP2017081974A (ja) 2017-05-18
SI2838888T1 (sl) 2017-09-29
AU2013224041A1 (en) 2014-09-25
WO2013124413A1 (en) 2013-08-29
JP6518270B2 (ja) 2019-05-22
CY1119231T1 (el) 2018-02-14
JP6073377B2 (ja) 2017-02-01
AU2017248556B2 (en) 2018-08-09
US20150038538A1 (en) 2015-02-05
ES2632428T3 (es) 2017-09-13
JP2015508092A (ja) 2015-03-16
EP2838888A1 (en) 2015-02-25
HUE035089T2 (hu) 2018-05-02
IN2014DN07885A (https=) 2015-04-24
AU2017248556A1 (en) 2017-11-09
US9371299B2 (en) 2016-06-21
HK1207366A1 (en) 2016-01-29
ZA201406225B (en) 2016-05-25
LT2838888T (lt) 2017-08-10
NZ630615A (en) 2015-09-25
PL2838888T3 (pl) 2017-12-29
EP2838888B1 (en) 2017-04-12
HRP20170964T1 (hr) 2017-10-06
PT2838888T (pt) 2017-07-18
US20160257660A1 (en) 2016-09-08
US9469618B2 (en) 2016-10-18
CA2865351A1 (en) 2013-08-29

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