AU2012326485B2 - 2-methylene-vitamin D analogs and their uses - Google Patents
2-methylene-vitamin D analogs and their uses Download PDFInfo
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- AU2012326485B2 AU2012326485B2 AU2012326485A AU2012326485A AU2012326485B2 AU 2012326485 B2 AU2012326485 B2 AU 2012326485B2 AU 2012326485 A AU2012326485 A AU 2012326485A AU 2012326485 A AU2012326485 A AU 2012326485A AU 2012326485 B2 AU2012326485 B2 AU 2012326485B2
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- Prior art keywords
- hydrogen
- group
- hydroxy
- methylene
- taken together
- Prior art date
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Classifications
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- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
Landscapes
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- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161550172P | 2011-10-21 | 2011-10-21 | |
| US61/550,172 | 2011-10-21 | ||
| PCT/US2012/059667 WO2013059060A1 (en) | 2011-10-21 | 2012-10-11 | 2-methylene-vitamin d analogs and their uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2012326485A1 AU2012326485A1 (en) | 2014-04-24 |
| AU2012326485B2 true AU2012326485B2 (en) | 2016-12-08 |
Family
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|---|---|---|---|
| AU2012326485A Ceased AU2012326485B2 (en) | 2011-10-21 | 2012-10-11 | 2-methylene-vitamin D analogs and their uses |
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|---|---|
| US (1) | US8410080B1 (https=) |
| EP (1) | EP2768804B1 (https=) |
| JP (1) | JP6114292B2 (https=) |
| AU (1) | AU2012326485B2 (https=) |
| CA (1) | CA2851283C (https=) |
| WO (1) | WO2013059060A1 (https=) |
Families Citing this family (1)
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| CA2991260A1 (en) * | 2015-08-05 | 2017-02-09 | Wisconsin Alumni Research Foundation | Synthesis and biological activity of 2-methylene analogs of calcitriol and related compounds |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666634A (en) | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| US5086191A (en) | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| EP0619306B1 (en) | 1993-04-05 | 1996-09-11 | Wisconsin Alumni Research Foundation | 19-Nor-vitamin D3 compounds with substituent at 2-position |
| US5843928A (en) | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US6392071B1 (en) | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US5945410A (en) | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| JPH11171859A (ja) * | 1997-09-19 | 1999-06-29 | Chugai Pharmaceut Co Ltd | ビタミンｄ誘導体およびその製造方法 |
| US6080879A (en) * | 1998-05-19 | 2000-06-27 | Tetrionics, Inc. | Hexafluoro-vitamin synthesis and crystallization method, solvent and product |
| US6114317A (en) * | 1998-05-21 | 2000-09-05 | Wisconsin Alumni Research Foundation | Method of locking 1α-OH of vitamin D compounds in axial orientation |
| CA2390859A1 (en) * | 1999-12-02 | 2001-06-14 | The Penn State Research Foundation | Treatment of inflammatory bowel disease with vitamin d compounds |
| US6382071B1 (en) | 2000-08-07 | 2002-05-07 | Gilbert A. Bertani | Bola capturing apparatus |
| NZ524657A (en) * | 2000-09-08 | 2004-12-24 | Wisconsin Alumni Res Found | 1 alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications |
| NZ533424A (en) * | 2001-12-13 | 2006-08-31 | Wisconsin Alumni Res Found | Vitamin D derivative, methods of purifying and uses in treating psoriasis, cancer, autoimmune diseases, inflammatory diseases, skin conidtions and renal ostepdystrophy |
| US6627622B2 (en) | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| US6566352B1 (en) | 2002-02-18 | 2003-05-20 | Wisconsin Alumni Research Foudation | 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses |
| US7259143B2 (en) * | 2002-09-05 | 2007-08-21 | Wisconsin Alumni Research Foundation | Method of extending the dose range of vitamin D compounds |
| US20080249068A1 (en) * | 2002-09-05 | 2008-10-09 | Deluca Hector F | Method of Extending the Dose Range of Vitamin D Compounds |
| MX2007006261A (es) * | 2004-11-22 | 2007-07-10 | Wisconsin Alumni Res Found | Analogos de 17,20(z)-deshidro vitamina d y sus usos. |
| RU2440980C2 (ru) * | 2006-06-02 | 2012-01-27 | Ниппон Синяку Ко., Лтд. | 9,10-секопрегнановое производное и фармацевтические средства |
| AU2007300214A1 (en) * | 2006-09-28 | 2008-04-03 | Wisconsin Alumni Research Foundation | 2-methylene-(20R,25S)-19,27-dinor-(22E)-vitamin D analogs |
| US8377913B2 (en) * | 2007-11-20 | 2013-02-19 | Abbvie Inc. | Vitamin D receptor activators and methods of making |
-
2012
- 2012-10-11 CA CA2851283A patent/CA2851283C/en not_active Expired - Fee Related
- 2012-10-11 JP JP2014537120A patent/JP6114292B2/ja not_active Expired - Fee Related
- 2012-10-11 EP EP12781531.4A patent/EP2768804B1/en not_active Not-in-force
- 2012-10-11 WO PCT/US2012/059667 patent/WO2013059060A1/en not_active Ceased
- 2012-10-11 AU AU2012326485A patent/AU2012326485B2/en not_active Ceased
- 2012-10-11 US US13/649,240 patent/US8410080B1/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| PubChem Open Chemistry Database - Compound Summary for CID 53325740 [viewed on internet on 26 July 2016] , Published 16 July 2016 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US8410080B1 (en) | 2013-04-02 |
| AU2012326485A1 (en) | 2014-04-24 |
| EP2768804A1 (en) | 2014-08-27 |
| JP2014532622A (ja) | 2014-12-08 |
| CA2851283A1 (en) | 2013-04-25 |
| CA2851283C (en) | 2020-07-14 |
| EP2768804B1 (en) | 2018-02-28 |
| US20130102574A1 (en) | 2013-04-25 |
| JP6114292B2 (ja) | 2017-04-12 |
| WO2013059060A1 (en) | 2013-04-25 |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |