AU2012324012A1 - Quaternized buprenorphine analogs - Google Patents

Quaternized buprenorphine analogs Download PDF

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Publication number
AU2012324012A1
AU2012324012A1 AU2012324012A AU2012324012A AU2012324012A1 AU 2012324012 A1 AU2012324012 A1 AU 2012324012A1 AU 2012324012 A AU2012324012 A AU 2012324012A AU 2012324012 A AU2012324012 A AU 2012324012A AU 2012324012 A1 AU2012324012 A1 AU 2012324012A1
Authority
AU
Australia
Prior art keywords
alkyl
membered
compound
methyl
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2012324012A
Other languages
English (en)
Inventor
Donald J. Kyle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Pharma LP
Original Assignee
Purdue Pharma LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Pharma LP filed Critical Purdue Pharma LP
Publication of AU2012324012A1 publication Critical patent/AU2012324012A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2012324012A 2011-12-08 2012-12-07 Quaternized buprenorphine analogs Abandoned AU2012324012A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161568451P 2011-12-08 2011-12-08
US61/568,451 2011-12-08
PCT/IB2012/002695 WO2013084060A1 (fr) 2011-12-08 2012-12-07 Analogues de buprénorphine quaternisés

Publications (1)

Publication Number Publication Date
AU2012324012A1 true AU2012324012A1 (en) 2013-06-27

Family

ID=47557399

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012324012A Abandoned AU2012324012A1 (en) 2011-12-08 2012-12-07 Quaternized buprenorphine analogs

Country Status (5)

Country Link
US (1) US9096606B2 (fr)
EP (1) EP2788358B1 (fr)
JP (1) JP5946921B2 (fr)
AU (1) AU2012324012A1 (fr)
WO (1) WO2013084060A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG188300A1 (en) 2010-09-21 2013-04-30 Purdue Pharma Lp Buprenorphine analogs
CA2890655A1 (fr) 2012-11-09 2014-05-15 Purdue Pharma L.P. Analogues de benzomorphane et leur utilisation
US9175000B2 (en) 2012-12-07 2015-11-03 Purdue Pharma L.P. Buprenorphine analogs
EP2951160B1 (fr) 2013-01-31 2019-04-24 Purdue Pharma LP Analogues de benzomorphane et leur utilisation
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
US9994571B2 (en) 2013-12-26 2018-06-12 Purdue Pharma L.P. 10-substituted morphinan hydantoins
CA2934913A1 (fr) 2013-12-26 2015-07-02 Purdue Pharma L.P. Morphinanes a cycle contracte et leur utilisation
WO2015097548A1 (fr) 2013-12-26 2015-07-02 Purdue Pharma L.P. Analogues 7-bêta-alkyle d'orvinols
EP3087079B1 (fr) 2013-12-26 2019-04-03 Purdue Pharma LP Morphinanes oxabicyclo[2.2.2]octane modulateurs des récepteurs aux opiacés
WO2015099863A1 (fr) 2013-12-27 2015-07-02 Purdue Pharma L.P. Analogues de la morphinane 6-substitués et 7-substitués, et leurs utilisations
CA2950567A1 (fr) 2014-05-27 2015-12-03 Purdue Pharma L.P. Morphinanes spirocycliques et utilisation associee
CA2951697A1 (fr) 2014-06-13 2015-12-17 Purdue Pharma L.P. Derives d'azamophinan et leur utilisation
MA41125A (fr) 2014-12-05 2017-10-10 Purdue Pharma Lp Dérivés de 6.7-cyclomorphinane et leur utilisation
WO2018125716A1 (fr) 2017-01-02 2018-07-05 Purdue Pharma L.P. Dérivés de morphinane et leur utilisation

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US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
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IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
CA2224517A1 (fr) 1995-06-12 1996-12-27 G.D. Searle & Co. Compositions comprenant un inhibiteur de cyclooxygenase-2 et un inhibiteur de 5-lipoxygenase
ATE276242T1 (de) 1997-05-30 2004-10-15 Banyu Pharma Co Ltd 2-oxoimidazol-derivate
BR9909666A (pt) 1998-03-26 2001-09-11 Japan Tobacco Inc Derivados de amida e antagonistas de nociceptina
CA2439859A1 (fr) * 2001-03-02 2002-09-12 Donna-Donigi Gale N-but-3-enyl norbuprenorphine et utilisations
GB0622694D0 (en) * 2006-11-14 2006-12-27 Serentis Ltd Use of opioid compounds in wound healing
US20110105381A2 (en) 2007-02-16 2011-05-05 Pharmacofore, Inc. Prodrugs of Peripheral Phenolic Opioid Antagonists
KR101519682B1 (ko) * 2007-08-09 2015-05-19 렌슬러 폴리테크닉 인스티튜트 4급 오피오이드 카르복스아미드
US20110112129A2 (en) * 2007-11-26 2011-05-12 Pharmacofore, Inc. Peripheral Phenolic Opioid Antagonist
KR101274107B1 (ko) 2007-11-30 2013-06-13 퍼듀 퍼머 엘피 벤조모르판 화합물
WO2009138734A2 (fr) * 2008-05-14 2009-11-19 Serentis Limited Utilisation de composés opiacés pour les douleurs périphériques, la cicatrisation des plaies et la formation de cicatrices
WO2010014229A1 (fr) 2008-07-30 2010-02-04 Purdue Pharma L.P. Analogues de buprénorphine
SG188300A1 (en) 2010-09-21 2013-04-30 Purdue Pharma Lp Buprenorphine analogs
CA2890655A1 (fr) 2012-11-09 2014-05-15 Purdue Pharma L.P. Analogues de benzomorphane et leur utilisation
US9175000B2 (en) 2012-12-07 2015-11-03 Purdue Pharma L.P. Buprenorphine analogs
EP2951160B1 (fr) 2013-01-31 2019-04-24 Purdue Pharma LP Analogues de benzomorphane et leur utilisation
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs

Also Published As

Publication number Publication date
US9096606B2 (en) 2015-08-04
JP5946921B2 (ja) 2016-07-06
EP2788358A1 (fr) 2014-10-15
WO2013084060A1 (fr) 2013-06-13
EP2788358B1 (fr) 2018-08-29
JP2015502952A (ja) 2015-01-29
US20140364448A1 (en) 2014-12-11

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Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted