AU2012300252B2 - Methods and compositions to detect the level of lysosomal exocytosis activity and methods of use - Google Patents
Methods and compositions to detect the level of lysosomal exocytosis activity and methods of use Download PDFInfo
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- AU2012300252B2 AU2012300252B2 AU2012300252A AU2012300252A AU2012300252B2 AU 2012300252 B2 AU2012300252 B2 AU 2012300252B2 AU 2012300252 A AU2012300252 A AU 2012300252A AU 2012300252 A AU2012300252 A AU 2012300252A AU 2012300252 B2 AU2012300252 B2 AU 2012300252B2
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
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- A61K38/00—Medicinal preparations containing peptides
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- A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
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- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161529675P | 2011-08-31 | 2011-08-31 | |
| US61/529,675 | 2011-08-31 | ||
| US201161544855P | 2011-10-07 | 2011-10-07 | |
| US61/544,855 | 2011-10-07 | ||
| PCT/US2012/052629 WO2013033074A2 (en) | 2011-08-31 | 2012-08-28 | Methods and compositions to detect the level of lysosomal exocytosis activity and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2012300252A1 AU2012300252A1 (en) | 2014-03-20 |
| AU2012300252B2 true AU2012300252B2 (en) | 2017-10-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2012300252A Active AU2012300252B2 (en) | 2011-08-31 | 2012-08-28 | Methods and compositions to detect the level of lysosomal exocytosis activity and methods of use |
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Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011001341A (es) | 2008-08-19 | 2011-03-29 | Xenoport Inc | Prodrogas de metil hidrogeno fumarato, sus composiciones farmaceuticas, y metodos de uso. |
| DK2751279T3 (da) * | 2011-08-31 | 2017-11-20 | St Jude Children's Res Hospital | Fremgangsmåder og sammensætninger til påvisning af niveauet af lysosomal exocytose-aktivitet og fremgangsmåder til anvendelse |
| EP2887934A1 (en) | 2012-08-22 | 2015-07-01 | XenoPort, Inc. | Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects |
| US9597292B2 (en) | 2012-08-22 | 2017-03-21 | Xenoport, Inc. | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
| US10179118B2 (en) | 2013-03-24 | 2019-01-15 | Arbor Pharmaceuticals, Llc | Pharmaceutical compositions of dimethyl fumarate |
| WO2014197860A1 (en) | 2013-06-07 | 2014-12-11 | Xenoport, Inc. | Method of making monomethyl fumarate |
| US9421182B2 (en) | 2013-06-21 | 2016-08-23 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
| JP2016534133A (ja) | 2013-09-06 | 2016-11-04 | ゼノポート,インコーポレイティド | (n,n−ジエチルカルバモイル)メチル メチル(2e)ブト−2−エン−1,4−ジオエートの結晶形態、その合成方法及び使用 |
| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
| WO2016179481A1 (en) * | 2015-05-07 | 2016-11-10 | Cardelli James Allen | Cancer treatment via repositioned tricyclic anti-depressant-like drugs as anti-cancer agents and new combinations of such drugs |
| AU2016343812A1 (en) * | 2015-10-30 | 2018-05-10 | Ultragenyx Pharmaceutical Inc. | Methods and compositions for the treatment of amyloidosis |
| AU2017233072B2 (en) * | 2016-03-18 | 2020-12-24 | Nantcell, Inc. | Multimodal vector for dendritic cell infection |
| DK3366063T3 (da) * | 2017-01-04 | 2020-04-27 | Ericsson Telefon Ab L M | Fremgangsmåde, basisstation og brugerindretning til at sende/modtage systeminformation |
| CN114555800A (zh) | 2019-07-05 | 2022-05-27 | 国立大学法人德岛大学 | 经修饰的神经氨酸酶 |
| JP2025504704A (ja) * | 2022-01-31 | 2025-02-14 | センス リサーチ ファウンデーション | 老化細胞表面マーカー |
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| US4873192A (en) | 1987-02-17 | 1989-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Process for site specific mutagenesis without phenotypic selection |
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| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| WO1997015588A1 (en) | 1995-10-26 | 1997-05-01 | St. Jude Children's Research Hospital | Protective protein/cathepsin a and precursor: crystallization, x-ray diffraction, three-dimensional structure determination and rational drug design |
| WO1998031817A2 (en) * | 1997-01-14 | 1998-07-23 | Hopital Sainte-Justine | Human lysosomal sialidase and therapeutic uses thereof |
| ES2752800T3 (es) * | 2000-05-01 | 2020-04-06 | Cerecin Inc | Uso de triglicéridos de cadena media para el tratamiento y la prevención de la enfermedad del Parkinson resultante de un metabolismo neuronal reducido |
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2016
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2019
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2022
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| ANNUNZIATA, I. et al., Nature Communications, 2013, vol. 4, Article 2734, doi:10.1038/ncomms3734 * |
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| US9399791B2 (en) | 2016-07-26 |
| CA2847057A1 (en) | 2013-03-07 |
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| US20140193392A1 (en) | 2014-07-10 |
| US20180057854A1 (en) | 2018-03-01 |
| US20200087704A1 (en) | 2020-03-19 |
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| US9840727B2 (en) | 2017-12-12 |
| US10533208B2 (en) | 2020-01-14 |
| CY1119689T1 (el) | 2018-04-04 |
| EP2751279A2 (en) | 2014-07-09 |
| US20220406435A1 (en) | 2022-12-22 |
| US20140377245A9 (en) | 2014-12-25 |
| CA2847057C (en) | 2019-06-11 |
| EP2751279B1 (en) | 2017-10-04 |
| US20160304933A1 (en) | 2016-10-20 |
| LT2751279T (lt) | 2017-12-11 |
| HRP20171909T1 (hr) | 2018-01-26 |
| HUE037829T2 (hu) | 2018-09-28 |
| WO2013033074A2 (en) | 2013-03-07 |
| US12640251B2 (en) | 2026-05-26 |
| AU2012300252A1 (en) | 2014-03-20 |
| SI2751279T1 (en) | 2018-01-31 |
| DK2751279T3 (da) | 2017-11-20 |
| JP6228121B2 (ja) | 2017-11-08 |
| PL2751279T3 (pl) | 2018-03-30 |
| JP2014526904A (ja) | 2014-10-09 |
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