AU2012277514A1 - Crystalline form of indazolyl amide derivatives for the treatment glucocorticoid receptor mediated disorders - Google Patents
Crystalline form of indazolyl amide derivatives for the treatment glucocorticoid receptor mediated disorders Download PDFInfo
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- AU2012277514A1 AU2012277514A1 AU2012277514A AU2012277514A AU2012277514A1 AU 2012277514 A1 AU2012277514 A1 AU 2012277514A1 AU 2012277514 A AU2012277514 A AU 2012277514A AU 2012277514 A AU2012277514 A AU 2012277514A AU 2012277514 A1 AU2012277514 A1 AU 2012277514A1
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- PWQIGBOSLQHOBT-ZETCQYMHSA-N tert-butyl n-[(2s)-1-[methoxy(methyl)amino]-1-oxopropan-2-yl]carbamate Chemical compound CON(C)C(=O)[C@H](C)NC(=O)OC(C)(C)C PWQIGBOSLQHOBT-ZETCQYMHSA-N 0.000 description 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 229960000257 tiotropium bromide Drugs 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 229940074410 trehalose Drugs 0.000 description 1
- DBGVGMSCBYYSLD-UHFFFAOYSA-N tributylstannane Chemical compound CCCC[SnH](CCCC)CCCC DBGVGMSCBYYSLD-UHFFFAOYSA-N 0.000 description 1
- 125000004205 trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- XQKBFQXWZCFNFF-UHFFFAOYSA-K triiodosamarium Chemical compound I[Sm](I)I XQKBFQXWZCFNFF-UHFFFAOYSA-K 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 229940070384 ventolin Drugs 0.000 description 1
- DAFYYTQWSAWIGS-DEOSSOPVSA-N vilanterol Chemical compound C1=C(O)C(CO)=CC([C@@H](O)CNCCCCCCOCCOCC=2C(=CC=CC=2Cl)Cl)=C1 DAFYYTQWSAWIGS-DEOSSOPVSA-N 0.000 description 1
- 229960004026 vilanterol Drugs 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 238000004457 water analysis Methods 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161502656P | 2011-06-29 | 2011-06-29 | |
| US61/502,656 | 2011-06-29 | ||
| PCT/GB2012/051503 WO2013001294A1 (en) | 2011-06-29 | 2012-06-27 | Crystalline form of indazolyl amide derivatives for the treatment glucocorticoid receptor mediated disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2012277514A1 true AU2012277514A1 (en) | 2014-01-09 |
Family
ID=46420454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2012277514A Abandoned AU2012277514A1 (en) | 2011-06-29 | 2012-06-27 | Crystalline form of indazolyl amide derivatives for the treatment glucocorticoid receptor mediated disorders |
Country Status (16)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017161518A1 (en) | 2016-03-23 | 2017-09-28 | Astrazeneca Ab | New physical form |
| CN108314670B (zh) * | 2018-02-06 | 2020-04-07 | 江苏八巨药业有限公司 | 一种(s)-2-氯-1-(6-氟-1-苯并二氢吡喃-2-基)-乙醇的制备方法 |
| JPWO2022114105A1 (enrdf_load_stackoverflow) * | 2020-11-27 | 2022-06-02 | ||
| CN116283781B (zh) * | 2022-12-16 | 2025-05-13 | 药康众拓(江苏)医药科技有限公司北京分公司 | 一种氘代n-苯基吲唑酰胺类化合物、药物组合物和用途 |
| KR102571432B1 (ko) * | 2023-02-08 | 2023-08-29 | 주식회사 에스씨엘테라퓨틱스 | 인다졸릴에스테르 및 아미드 유도체를 포함하는 암 치료용 조성물 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9302777D0 (sv) | 1993-08-27 | 1993-08-27 | Astra Ab | Process for conditioning substances |
| SE9101090D0 (sv) | 1991-04-11 | 1991-04-11 | Astra Ab | Process for conditioning of water-soluble substances |
| GB0315509D0 (en) | 2003-07-02 | 2003-08-06 | Meridica Ltd | Dispensing device |
| JO2754B1 (en) | 2006-12-21 | 2014-03-15 | استرازينكا ايه بي | Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders |
| WO2008079073A1 (en) | 2006-12-22 | 2008-07-03 | Astrazeneca Ab | Indazolyl sulphonamide derivatives for the treatment of glucocorticoid receptor mediated disorders |
| RU2013104637A (ru) | 2010-07-21 | 2014-08-27 | Астразенека Аб | Ингалятор |
| JP5850932B2 (ja) | 2010-07-21 | 2016-02-03 | アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ | 吸入器 |
-
2012
- 2012-06-27 SG SG2013089966A patent/SG195309A1/en unknown
- 2012-06-27 CA CA2839398A patent/CA2839398A1/en not_active Abandoned
- 2012-06-27 BR BR112013031759A patent/BR112013031759A2/pt not_active IP Right Cessation
- 2012-06-27 KR KR1020137033086A patent/KR20140036230A/ko not_active Withdrawn
- 2012-06-27 AU AU2012277514A patent/AU2012277514A1/en not_active Abandoned
- 2012-06-27 CN CN201280039142.8A patent/CN103814015A/zh active Pending
- 2012-06-27 WO PCT/GB2012/051503 patent/WO2013001294A1/en active Application Filing
- 2012-06-27 MX MX2013014566A patent/MX2013014566A/es not_active Application Discontinuation
- 2012-06-27 EP EP12731150.4A patent/EP2726464A1/en not_active Withdrawn
- 2012-06-27 RU RU2013153466/04A patent/RU2013153466A/ru not_active Application Discontinuation
- 2012-06-27 IN IN23MUN2014 patent/IN2014MN00023A/en unknown
- 2012-06-27 JP JP2014517935A patent/JP2014527955A/ja active Pending
- 2012-06-28 TW TW101123228A patent/TW201305115A/zh unknown
- 2012-06-28 UY UY0001034170A patent/UY34170A/es not_active Application Discontinuation
- 2012-06-29 AR ARP120102359A patent/AR086818A1/es unknown
-
2013
- 2013-12-13 ZA ZA2013/09480A patent/ZA201309480B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014527955A (ja) | 2014-10-23 |
| ZA201309480B (en) | 2015-10-28 |
| UY34170A (es) | 2013-01-31 |
| AR086818A1 (es) | 2014-01-22 |
| WO2013001294A1 (en) | 2013-01-03 |
| BR112013031759A2 (pt) | 2016-12-13 |
| KR20140036230A (ko) | 2014-03-25 |
| RU2013153466A (ru) | 2015-08-10 |
| TW201305115A (zh) | 2013-02-01 |
| EP2726464A1 (en) | 2014-05-07 |
| MX2013014566A (es) | 2014-09-25 |
| CN103814015A (zh) | 2014-05-21 |
| IN2014MN00023A (enrdf_load_stackoverflow) | 2015-06-12 |
| SG195309A1 (en) | 2013-12-30 |
| CA2839398A1 (en) | 2013-01-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |