AU2012236852A1 - Methods of targeted treatment of Frontotemporal lobar degeneration - Google Patents

Methods of targeted treatment of Frontotemporal lobar degeneration Download PDF

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Publication number
AU2012236852A1
AU2012236852A1 AU2012236852A AU2012236852A AU2012236852A1 AU 2012236852 A1 AU2012236852 A1 AU 2012236852A1 AU 2012236852 A AU2012236852 A AU 2012236852A AU 2012236852 A AU2012236852 A AU 2012236852A AU 2012236852 A1 AU2012236852 A1 AU 2012236852A1
Authority
AU
Australia
Prior art keywords
alkyl
oxazepin
group
hydroxybenzamide
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2012236852A
Other languages
English (en)
Inventor
Jean-Francois BLAIN
Gerhard Koenig
Holger Patzke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forum Pharmaceuticals Inc
Original Assignee
Forum Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forum Pharmaceuticals Inc filed Critical Forum Pharmaceuticals Inc
Publication of AU2012236852A1 publication Critical patent/AU2012236852A1/en
Assigned to FORUM PHARMACEUTICALS, INC. reassignment FORUM PHARMACEUTICALS, INC. Amend patent request/document other than specification (104) Assignors: ENVIVO PHARMACEUTICALS, INC.
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D267/20—[b, f]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2012236852A 2011-03-26 2012-03-26 Methods of targeted treatment of Frontotemporal lobar degeneration Abandoned AU2012236852A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161467989P 2011-03-26 2011-03-26
US61/467,989 2011-03-26
PCT/US2012/030527 WO2012135097A1 (en) 2011-03-26 2012-03-26 Methods of targeted treatment of frontotemporal lobar degeneration

Publications (1)

Publication Number Publication Date
AU2012236852A1 true AU2012236852A1 (en) 2013-09-26

Family

ID=45931040

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012236852A Abandoned AU2012236852A1 (en) 2011-03-26 2012-03-26 Methods of targeted treatment of Frontotemporal lobar degeneration

Country Status (13)

Country Link
US (1) US20140179678A1 (https=)
EP (1) EP2691099A1 (https=)
JP (2) JP5995956B2 (https=)
CN (2) CN103561747B (https=)
AR (1) AR085572A1 (https=)
AU (1) AU2012236852A1 (https=)
CA (1) CA2831291A1 (https=)
IL (1) IL228405A0 (https=)
MX (1) MX2013011096A (https=)
RU (1) RU2013147810A (https=)
TW (1) TW201247205A (https=)
UY (1) UY33973A (https=)
WO (1) WO2012135097A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10149836B2 (en) 2014-03-21 2018-12-11 The Board Of Regents Of The University Of Texas System Isoxazole treatments for frontotemporal dementia
US10189841B2 (en) 2015-11-20 2019-01-29 Forma Therapeutics, Inc. Purinones as ubiquitin-specific protease 1 inhibitors
AR119149A1 (es) * 2019-06-12 2021-11-24 Arkuda Therapeutics Derivados de isoquinolina como moduladores de la progranulina
US20230201269A1 (en) * 2020-04-24 2023-06-29 Spinalcyte, Llc Treatment of frontotemporal dementia using fibroblasts and products thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6723564B2 (en) 1998-05-07 2004-04-20 Sequenom, Inc. IR MALDI mass spectrometry of nucleic acids using liquid matrices
CN101573333B (zh) * 2006-10-28 2013-06-12 梅特希尔基因公司 组蛋白脱乙酰酶抑制剂
US20090291444A1 (en) * 2008-03-31 2009-11-26 Jason Eriksen Methods and materials for detecting and treating dementia
US20110288070A1 (en) * 2008-05-05 2011-11-24 ROGERS Kathryn Methods for treating cognitive disorders using inhibitors of histone deacetylase
WO2009137499A1 (en) * 2008-05-05 2009-11-12 Envivo Pharmaceuticals, Inc. Inhibitors of histone deacetylase

Also Published As

Publication number Publication date
TW201247205A (en) 2012-12-01
JP2014511848A (ja) 2014-05-19
CN103561747A (zh) 2014-02-05
IL228405A0 (en) 2013-12-31
JP5995956B2 (ja) 2016-09-21
EP2691099A1 (en) 2014-02-05
CN105748484A (zh) 2016-07-13
CA2831291A1 (en) 2012-10-04
RU2013147810A (ru) 2015-05-10
US20140179678A1 (en) 2014-06-26
CN103561747B (zh) 2016-04-06
MX2013011096A (es) 2014-06-06
WO2012135097A1 (en) 2012-10-04
AR085572A1 (es) 2013-10-09
JP2017019826A (ja) 2017-01-26
UY33973A (es) 2012-10-31
NZ615177A (en) 2016-02-26

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Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application