AU2012213775B2 - 7-Azaindole derivatives - Google Patents

7-Azaindole derivatives Download PDF

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Publication number
AU2012213775B2
AU2012213775B2 AU2012213775A AU2012213775A AU2012213775B2 AU 2012213775 B2 AU2012213775 B2 AU 2012213775B2 AU 2012213775 A AU2012213775 A AU 2012213775A AU 2012213775 A AU2012213775 A AU 2012213775A AU 2012213775 B2 AU2012213775 B2 AU 2012213775B2
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denotes
compound
atoms
tautomer
stereoisomer
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AU2012213775A
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AU2012213775A8 (en
AU2012213775A1 (en
Inventor
Dieter Dorsch
Gnuni Amatunu KARAPETYAN
Eugen Merkul
Thomas J. J. Mueller
Christian Sirrenberg
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Merck Patent GmbH
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Merck Patent GmbH
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Publication of AU2012213775A8 publication Critical patent/AU2012213775A8/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2012213775A 2011-02-01 2012-01-09 7-Azaindole derivatives Ceased AU2012213775B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102011009961.1 2011-02-01
DE102011009961A DE102011009961A1 (de) 2011-02-01 2011-02-01 7-Azaindolderivate
PCT/EP2012/000067 WO2012104007A2 (de) 2011-02-01 2012-01-09 7-azaindolderivate

Publications (3)

Publication Number Publication Date
AU2012213775A1 AU2012213775A1 (en) 2013-09-19
AU2012213775A8 AU2012213775A8 (en) 2013-10-24
AU2012213775B2 true AU2012213775B2 (en) 2016-11-10

Family

ID=45554609

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012213775A Ceased AU2012213775B2 (en) 2011-02-01 2012-01-09 7-Azaindole derivatives

Country Status (18)

Country Link
US (3) US8981101B2 (https=)
EP (3) EP2746281B1 (https=)
JP (1) JP5891249B2 (https=)
KR (1) KR20140014158A (https=)
CN (3) CN105732617B (https=)
AR (1) AR085110A1 (https=)
AU (1) AU2012213775B2 (https=)
BR (1) BR112013019028A2 (https=)
CA (2) CA3082435A1 (https=)
DE (1) DE102011009961A1 (https=)
EA (1) EA201300873A1 (https=)
ES (3) ES2861048T3 (https=)
HK (1) HK1226394A1 (https=)
IL (1) IL227689A0 (https=)
MX (1) MX2013008212A (https=)
SG (1) SG192133A1 (https=)
WO (1) WO2012104007A2 (https=)
ZA (1) ZA201306542B (https=)

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DE102010053347A1 (de) * 2010-12-03 2012-06-06 Merck Patent Gmbh 3-Hetaryl-substituierte Pyrrolo[2,3-b] pyridin-derivative als PDK1-Inhibitoren
DE102011009961A1 (de) * 2011-02-01 2012-08-02 Merck Patent Gmbh 7-Azaindolderivate
CA2863717C (en) * 2012-02-21 2021-09-28 Lars Burgdorf Furopyridine derivatives
DE102012019369A1 (de) * 2012-10-02 2014-04-03 Merck Patent Gmbh 7-Azaindolderivat
FR3001219A1 (fr) * 2013-01-22 2014-07-25 Centre Nat Rech Scient Inhibiteurs de kinases
GB201303109D0 (en) 2013-02-21 2013-04-10 Domainex Ltd Novel pyrimidine compounds
DK2970265T3 (en) * 2013-03-15 2018-10-01 Plexxikon Inc HETEROCYCLIC COMPOUNDS AND APPLICATIONS THEREOF
US20140303121A1 (en) 2013-03-15 2014-10-09 Plexxikon Inc. Heterocyclic compounds and uses thereof
TW201613916A (en) 2014-06-03 2016-04-16 Gilead Sciences Inc TANK-binding kinase inhibitor compounds
NZ729618A (en) 2014-09-26 2018-07-27 Gilead Sciences Inc Aminotriazine derivatives useful as tank-binding kinase inhibitor compounds
CN107530302A (zh) * 2015-03-04 2018-01-02 丹娜法伯癌症研究院 Melk的水杨酸酯抑制剂和使用方法
WO2016164641A1 (en) * 2015-04-08 2016-10-13 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
MX2017015357A (es) * 2015-06-29 2018-03-16 Merck Patent Gmbh Compuestos inhibidores de serina/treonina-proteina cinasa (tbk)/inhibidor de cinasa de factor nuclear kappa-b subunidad epsilon (ikk-epsilon) y usos de los mismos.
CU20180059A7 (es) 2015-12-17 2018-10-04 Gilead Sciences Inc Compuestos inhibidores de la quinasa de unión a tank
EP3390387B1 (en) 2015-12-18 2021-11-17 Bayer Pharma Aktiengesellschaft Heteroarylbenzimidazole compounds
CN105906608B (zh) * 2016-05-03 2018-10-19 中山大学 8-氨基喹啉-松果体素杂联体及其药物组合物
WO2017207534A1 (en) 2016-06-03 2017-12-07 Bayer Pharma Aktiengesellschaft Substituted heteroarylbenzimidazole compounds
GB201702947D0 (en) 2017-02-23 2017-04-12 Domainex Ltd Novel compounds
JP7131837B2 (ja) * 2017-06-19 2022-09-06 アビスコ セラピューティクス カンパニー リミテッド Ｃｓｆ－１ｒ阻害活性を有するアザアリール誘導体、その製造方法および応用
US10717735B2 (en) 2017-10-13 2020-07-21 Plexxikon Inc. Solid forms of a compound for modulating kinases
CN112839648B (zh) * 2018-06-07 2025-04-04 达萨玛治疗公司 Sarm1抑制剂
CN112839647B (zh) * 2018-06-07 2025-09-23 达萨玛治疗公司 Sarm1抑制剂
KR20200046680A (ko) * 2018-10-25 2020-05-07 한국과학기술원 Pdk1 저해제를 포함하는 역노화 유도용 조성물
WO2025016273A1 (zh) * 2023-07-14 2025-01-23 拜西欧斯（北京）生物技术有限公司 异喹啉衍生物、包含其的药物组合物以及它们的用途

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US20070203142A1 (en) * 2006-01-17 2007-08-30 Luc Farmer Azaindoles useful as inhibitors of janus kinases
WO2012000595A1 (en) * 2010-06-28 2012-01-05 Merck Patent Gmbh 2,4- diaryl - substituted [1,8] naphthyridines as kinase inhibitors for use against cancer

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WO2005095400A1 (en) * 2004-03-30 2005-10-13 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of jak and other protein kinases
WO2006063167A1 (en) * 2004-12-08 2006-06-15 Smithkline Beecham Corporation 1h-pyrrolo[2,3-b]pyridines
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Also Published As

Publication number Publication date
HK1226394A1 (zh) 2017-09-29
JP5891249B2 (ja) 2016-03-22
US20160130269A1 (en) 2016-05-12
ES2861048T3 (es) 2021-10-05
US8981101B2 (en) 2015-03-17
CA2826051A1 (en) 2012-08-09
IL227689A0 (en) 2013-11-25
CN105712991A (zh) 2016-06-29
CN103502247A (zh) 2014-01-08
DE102011009961A1 (de) 2012-08-02
BR112013019028A2 (pt) 2016-10-04
JP2014509313A (ja) 2014-04-17
US9725446B2 (en) 2017-08-08
WO2012104007A3 (de) 2013-10-17
ES2634643T3 (es) 2017-09-28
EP2746281A3 (de) 2014-10-08
CN105732617A (zh) 2016-07-06
EP2746281B1 (de) 2017-04-26
AU2012213775A8 (en) 2013-10-24
CN105712991B (zh) 2017-12-01
US20150152104A1 (en) 2015-06-04
AU2012213775A1 (en) 2013-09-19
EP2670748A2 (de) 2013-12-11
CN105732617B (zh) 2017-12-01
EP3133074A2 (de) 2017-02-22
EA201300873A1 (ru) 2014-02-28
SG192133A1 (en) 2013-08-30
CA3082435A1 (en) 2012-08-09
WO2012104007A2 (de) 2012-08-09
EP2670748B1 (de) 2016-09-28
US9266887B2 (en) 2016-02-23
AR085110A1 (es) 2013-09-11
CN103502247B (zh) 2016-02-24
ES2608317T3 (es) 2017-04-07
US20130310391A1 (en) 2013-11-21
EP2746281A2 (de) 2014-06-25
MX2013008212A (es) 2013-08-26
CA2826051C (en) 2020-08-18
EP3133074A3 (de) 2017-05-17
EP3133074B1 (de) 2020-12-09
KR20140014158A (ko) 2014-02-05
ZA201306542B (en) 2014-05-28

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