AU2011326566B2 - Crystalline solids of a MetAP-2 inhibitor and methods of making and using same - Google Patents

Crystalline solids of a MetAP-2 inhibitor and methods of making and using same Download PDF

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Publication number
AU2011326566B2
AU2011326566B2 AU2011326566A AU2011326566A AU2011326566B2 AU 2011326566 B2 AU2011326566 B2 AU 2011326566B2 AU 2011326566 A AU2011326566 A AU 2011326566A AU 2011326566 A AU2011326566 A AU 2011326566A AU 2011326566 B2 AU2011326566 B2 AU 2011326566B2
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AU
Australia
Prior art keywords
crystalline
dimethylaminoethoxy
crystalline form
ray diffraction
diffraction pattern
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2011326566A
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English (en)
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AU2011326566A1 (en
Inventor
Thomas Crawford
Hayley A. Reece
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Larimar Therapeutics Inc
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Zafgen Inc
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Publication of AU2011326566A1 publication Critical patent/AU2011326566A1/en
Application granted granted Critical
Publication of AU2011326566B2 publication Critical patent/AU2011326566B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/32—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2011326566A 2010-11-09 2011-11-09 Crystalline solids of a MetAP-2 inhibitor and methods of making and using same Ceased AU2011326566B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41165510P 2010-11-09 2010-11-09
US61/411,655 2010-11-09
PCT/US2011/059966 WO2012064838A1 (en) 2010-11-09 2011-11-09 Crystalline solids of a metap-2 inhibitor and methods of making and using same

Publications (2)

Publication Number Publication Date
AU2011326566A1 AU2011326566A1 (en) 2013-05-30
AU2011326566B2 true AU2011326566B2 (en) 2016-12-01

Family

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Family Applications (1)

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AU2011326566A Ceased AU2011326566B2 (en) 2010-11-09 2011-11-09 Crystalline solids of a MetAP-2 inhibitor and methods of making and using same

Country Status (18)

Country Link
US (4) US8349891B2 (OSRAM)
EP (1) EP2638023B1 (OSRAM)
JP (1) JP6239977B2 (OSRAM)
KR (1) KR101892768B1 (OSRAM)
CN (2) CN106905267A (OSRAM)
AU (1) AU2011326566B2 (OSRAM)
BR (1) BR112013011550A2 (OSRAM)
CA (1) CA2817199C (OSRAM)
EA (1) EA029941B1 (OSRAM)
ES (1) ES2610216T3 (OSRAM)
IL (1) IL226238B (OSRAM)
MX (1) MX2013005208A (OSRAM)
MY (1) MY177039A (OSRAM)
NZ (1) NZ610569A (OSRAM)
PH (1) PH12013500934A1 (OSRAM)
SG (1) SG190688A1 (OSRAM)
UA (1) UA111479C2 (OSRAM)
WO (1) WO2012064838A1 (OSRAM)

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US20120004162A1 (en) 2008-12-04 2012-01-05 Vath James E Methods of Treating an Overweight or Obese Subject
CA2777108A1 (en) 2009-10-09 2011-04-14 Zafgen Corporation Sulphone compounds and methods of making and using same
BR112012016793A2 (pt) 2010-01-08 2018-07-31 Zafgen Corp compostos tipo fumagilol e métodos de fazer e usar os mesmos
US8815309B2 (en) 2010-01-08 2014-08-26 Zafgen, Inc. Methods of treating a subject with benign prostate hyperplasia
WO2011127304A2 (en) 2010-04-07 2011-10-13 Zafgen Corporation Methods of treating an overweight subject
US9895449B2 (en) 2010-05-25 2018-02-20 Syndevrx, Inc. Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof
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JP5913310B2 (ja) 2010-07-22 2016-04-27 ザフゲン，インコーポレイテッド 三環式化合物ならびにその作製および使用方法
PH12013500934A1 (en) 2010-11-09 2022-10-24 Zafgen Inc Crystalline solids of a metap-2 inhibitor and methods of making and using same
WO2012075020A1 (en) 2010-11-29 2012-06-07 Zafgen Corporation Treatment of obesity using non-daily administration of 6 - 0 - (4 - dimethylaminoethoxy) cinnamoyl fumagillol
BR112013018771A2 (pt) 2011-01-26 2019-09-17 Zafgen Inc compostos de tetrazol e métodos para fazer e usar os mesmos
MX343688B (es) 2011-05-06 2016-11-16 Zafgen Inc Compuestos tricíclicos de sulfonamida y pirazolo y métodos para su fabricación y uso.
US9187494B2 (en) 2011-05-06 2015-11-17 Zafgen, Inc. Aryl-substituted tricyclic sulfonamides as methionyl aminopeptidase 2 modulators
CA2835261C (en) 2011-05-06 2019-06-04 Zafgen, Inc. Partially saturated tricyclic compounds and methods of making and using same
US9359369B2 (en) 2012-01-18 2016-06-07 Zafgen, Inc. Tricyclic sulfonamide compounds and methods of making and using same
CN104169268A (zh) 2012-01-18 2014-11-26 扎夫根股份有限公司 三环砜化合物及其制备和使用方法
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WO2013169857A1 (en) 2012-05-08 2013-11-14 Zafgen, Inc. Treating hypothalamic obesity with metap2 inhibitors
JP6177888B2 (ja) 2012-05-09 2017-08-09 ザフゲン，インコーポレイテッド フマギロール型化合物ならびにその製造および使用方法
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JP2015536981A (ja) 2012-11-05 2015-12-24 ザフゲン，インコーポレイテッド 三環式化合物ならびにその製造および使用方法
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HUE040434T2 (hu) * 2013-02-21 2019-03-28 Pfizer Szelektív CDK4/6 inhibitor szilárd alakjai
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US9173956B2 (en) 2013-04-10 2015-11-03 Syndevrx, Inc. METAP2 inhibitors and methods of treating obesity
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CN106432255A (zh) 2015-08-11 2017-02-22 扎夫根公司 烟曲霉素醇螺环化合物和制备和使用其的方法
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CA3008960C (en) 2016-01-11 2024-07-02 Syndevrx, Inc. TREATMENT OF TUMORS INDUCED BY METABOLIC DYSFUNCTION
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Also Published As

Publication number Publication date
ES2610216T3 (es) 2017-04-26
US20120316233A1 (en) 2012-12-13
EA201390675A1 (ru) 2013-08-30
JP6239977B2 (ja) 2017-11-29
KR101892768B1 (ko) 2018-08-28
US20130197078A1 (en) 2013-08-01
SG190688A1 (en) 2013-07-31
EP2638023B1 (en) 2016-09-07
MX2013005208A (es) 2013-08-01
CN106905267A (zh) 2017-06-30
EP2638023A1 (en) 2013-09-18
US9371312B2 (en) 2016-06-21
US8349891B2 (en) 2013-01-08
NZ610569A (en) 2015-06-26
MY177039A (en) 2020-09-03
KR20140009994A (ko) 2014-01-23
BR112013011550A2 (pt) 2017-10-24
IL226238A0 (en) 2013-07-31
PH12013500934A1 (en) 2022-10-24
US20150018413A1 (en) 2015-01-15
US8735447B2 (en) 2014-05-27
CA2817199A1 (en) 2012-05-18
WO2012064838A1 (en) 2012-05-18
CN103347870A (zh) 2013-10-09
AU2011326566A1 (en) 2013-05-30
US9827221B2 (en) 2017-11-28
JP2013543867A (ja) 2013-12-09
UA111479C2 (uk) 2016-05-10
US20170087119A1 (en) 2017-03-30
CA2817199C (en) 2019-01-15
IL226238B (en) 2019-02-28
EA029941B1 (ru) 2018-06-29

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