AU2011278308B2 - Nanoparticle-guided radiotherapy - Google Patents

Nanoparticle-guided radiotherapy Download PDF

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Publication number
AU2011278308B2
AU2011278308B2 AU2011278308A AU2011278308A AU2011278308B2 AU 2011278308 B2 AU2011278308 B2 AU 2011278308B2 AU 2011278308 A AU2011278308 A AU 2011278308A AU 2011278308 A AU2011278308 A AU 2011278308A AU 2011278308 B2 AU2011278308 B2 AU 2011278308B2
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AU
Australia
Prior art keywords
imaging
nano
sized particles
composition according
target tissue
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Ceased
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AU2011278308A
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AU2011278308A1 (en
Inventor
Morten Albrechtsen
Thomas Lars Andresen
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Danmarks Tekniske Universitet
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Danmarks Tekniske Universitet
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Ceased legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/48—Diagnostic techniques
    • A61B6/481—Diagnostic techniques involving the use of contrast agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A61B5/0035—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • A61B6/032—Transmission computed tomography [CT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • A61B6/037—Emission tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0423—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0423—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A61K49/0428—Surface-modified nanoparticles, e.g. immuno-nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/103—Treatment planning systems
    • A61N5/1039—Treatment planning systems using functional images, e.g. PET or MRI
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1064—Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring
    • A61N5/1065—Beam adjustment
    • A61N5/1067—Beam adjustment in real time, i.e. during treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/40—Arrangements for generating radiation specially adapted for radiation diagnosis
    • A61B6/4064—Arrangements for generating radiation specially adapted for radiation diagnosis specially adapted for producing a particular type of beam
    • A61B6/4092—Arrangements for generating radiation specially adapted for radiation diagnosis specially adapted for producing a particular type of beam for producing synchrotron radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A61N2005/1061—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using an x-ray imaging system having a separate imaging source

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Optics & Photonics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Pulmonology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Radiation-Therapy Devices (AREA)
AU2011278308A 2010-07-16 2011-07-15 Nanoparticle-guided radiotherapy Ceased AU2011278308B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US36491710P 2010-07-16 2010-07-16
EP10169862.9 2010-07-16
EP10169862 2010-07-16
US61/364,917 2010-07-16
PCT/EP2011/062122 WO2012007567A1 (en) 2010-07-16 2011-07-15 Nanoparticle-guided radiotherapy

Publications (2)

Publication Number Publication Date
AU2011278308A1 AU2011278308A1 (en) 2013-01-31
AU2011278308B2 true AU2011278308B2 (en) 2014-09-04

Family

ID=43063934

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011278308A Ceased AU2011278308B2 (en) 2010-07-16 2011-07-15 Nanoparticle-guided radiotherapy

Country Status (9)

Country Link
US (1) US20130204121A1 (https=)
EP (1) EP2593186A1 (https=)
JP (1) JP2013532629A (https=)
CN (1) CN103079642A (https=)
AU (1) AU2011278308B2 (https=)
BR (1) BR112013000907A2 (https=)
CA (1) CA2804849A1 (https=)
MX (1) MX2013000501A (https=)
WO (1) WO2012007567A1 (https=)

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US9370490B2 (en) 2012-02-28 2016-06-21 Loma Linda University Methods for the production, modification and use of metallic nanoparticles
WO2013164725A1 (en) 2012-05-02 2013-11-07 Koninklijke Philips N.V. Spectral ct visualization of imageable drug eluting beads
US10035009B2 (en) 2013-04-15 2018-07-31 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for treating pancreatic cancer
RU2703303C2 (ru) * 2013-05-24 2019-10-16 Данмаркс Текниске Университет Состав геля для лучевой терапии под визуальным контролем
FR3018451A1 (fr) * 2014-03-13 2015-09-18 Chromalys Nanoparticules pour leur utilisation dans la detection de tumeurs mobiles
CN103894557B (zh) * 2014-03-19 2016-01-20 丽水市中心医院 磁共振成像下可视的功能化金纳米粒子的制备方法及应用
US10004695B2 (en) 2014-04-16 2018-06-26 Trustees Of Boston University GM3 functionalized nanoparticles
WO2016004222A1 (en) * 2014-07-01 2016-01-07 Georgia Regents University Bio-compatible radiopaque dental fillers for imaging
JP6501191B2 (ja) * 2014-12-02 2019-04-17 シグマテクノロジー有限会社 マイクロ・ナノバブルによる洗浄方法及び洗浄装置
WO2016115140A1 (en) * 2015-01-13 2016-07-21 Boston Scientific Scimed, Inc. Cancer cell membrane depolarization
WO2016137013A1 (ja) * 2015-02-26 2016-09-01 国立大学法人北海道大学 放射線治療用の病変識別マーカーおよび放射線治療用の病変識別マーカーキット
CA3015663A1 (en) * 2016-03-07 2017-09-14 Memorial Sloan Kettering Cancer Center Bone marrow-, reticuloendothelial system-, and/or lymph node-targeted radiolabeled liposomes and methods of their diagnostic and therapeutic use
KR102162400B1 (ko) * 2016-05-13 2020-10-06 시그마 테크놀로지 유겐가이샤 생체 투여 가능한 수용액 및 그 제조 방법
EP3500311B1 (en) 2016-08-16 2020-05-27 ETH Zurich Transmembrane ph-gradient polymersomes and their use in the scavenging of ammonia and its methylated analogs
US20190201557A1 (en) * 2016-08-25 2019-07-04 National University Corporation Hokkaido University Lesion identification marker utilizing bone cement for use in radiation therapy, and lesion identification marker kit for use in radiation therapy
WO2019028453A1 (en) * 2017-08-04 2019-02-07 The Cleveland Clinic Foundation RADIATION THERAPY WITH TEMPORAL ATTENUATION
DK3668927T3 (da) 2017-09-12 2024-03-25 Eth Zuerich Transmembran ph-gradient polymersom til kvantificering af ammoniak i kropsvæsker
IL265914B (en) * 2019-04-08 2020-11-30 Convergent R N R Ltd System and method for optimization of radiotherapy treatments
FR3099052B1 (fr) * 2019-07-23 2022-03-25 Univ Franche Comte Structures particulaires à base de nanoparticules d’or, leurs procédés de préparation et leurs utilisations dans le traitement des tumeurs solides
US10929981B1 (en) * 2019-08-21 2021-02-23 Ping An Technology (Shenzhen) Co., Ltd. Gross tumor volume segmentation method and computer device
US12082956B2 (en) * 2019-09-09 2024-09-10 Universidad De La Frontera Integral systems of orthovoltage sources that induce ionizing radiation
CN111467174B (zh) * 2019-12-20 2023-02-17 联影(常州)医疗科技有限公司 一种头部固定装置、血管减影造影系统及透射方法
IT202000001048A1 (it) 2020-01-21 2021-07-21 Univ Degli Studi Padova Nanoparticelle multifunzionali a base di nanoleghe metalliche per usi diagnostici e terapeutici.
IT202100001049A1 (it) 2021-01-21 2022-07-21 Univ Degli Studi Padova Nanoparticelle multifunzionali a base di nanoleghe metalliche per usi diagnostici e terapeutici.

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Also Published As

Publication number Publication date
AU2011278308A1 (en) 2013-01-31
BR112013000907A2 (pt) 2017-10-31
CN103079642A (zh) 2013-05-01
JP2013532629A (ja) 2013-08-19
EP2593186A1 (en) 2013-05-22
US20130204121A1 (en) 2013-08-08
WO2012007567A1 (en) 2012-01-19
CA2804849A1 (en) 2012-01-19
MX2013000501A (es) 2013-06-05

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