AU2011202594A1 - Apparatus and method for optimal tissue separation - Google Patents
Apparatus and method for optimal tissue separation Download PDFInfo
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- AU2011202594A1 AU2011202594A1 AU2011202594A AU2011202594A AU2011202594A1 AU 2011202594 A1 AU2011202594 A1 AU 2011202594A1 AU 2011202594 A AU2011202594 A AU 2011202594A AU 2011202594 A AU2011202594 A AU 2011202594A AU 2011202594 A1 AU2011202594 A1 AU 2011202594A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1442—Probes having pivoting end effectors, e.g. forceps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00601—Cutting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/0063—Sealing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00767—Voltage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00875—Resistance or impedance
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Abstract
APPARATUS AND METHOD FOR OPTIMAL TISSUE Abstract A system and method for optimizing tissue separation using modulated or duty 5 cycle controlled waveforms (40) on desiccated tissue, where the desiccated tissue has a high electrical impedance. In bipolar electrosurgical procedures, tissue separation is separated with the application of an electrical signal. When tissue does not completely separate and becomes desiccated, generator (30) may generate a duty cycle controlled waveform (40) with specified duty cycle (42) and frequency or modulated waveform (60). 10 Modulated waveform (60) is generated by adding or multiplying one or more waveforms (40) together. Modulated or duty cycle waveforms (40) create power pulses with higher voltages and a low RMS value. Power pulses drive power and create heat in the high impedance tissue. The creation of heat helps to mobilize water content adjacent to the desiccated tissue. The heating and mobilization of water induces motion into the tissue is and aids in the complete separation of tissue while keeping the RMS power low. ELECTROSURGICAL 10 42a2 b 24a- \ 24b \29 34- 37- 38- 31 CONTROLLER POWER RF OUTPUT 35> SUPPLY STAGE MICROPROCESSOR 39 36> 9 MEMORYCRCUITRY
Description
S&F Ref: P000358 AUSTRALIA PATENTS ACT 1990 COMPLETE SPECIFICATION FOR A STANDARD PATENT Name and Address Tyco Healthcare Group, LP, of c/o Covidien, Energy of Applicant: based Devices Attn: IP Legal, Mailstop A-36, 5920 Longbow Drive, Boulder, Colorado, 80301, United States of America Actual Inventor(s): Gary M. Couture Address for Service: Spruson & Ferguson St Martins Tower Level 35 31 Market Street Sydney NSW 2000 (CCN 3710000177) Invention Title: Apparatus and method for optimal tissue separation The following statement is a full description of this invention, including the best method of performing it known to me/us: 5845c(5226340_1) 1 APPARATUS AND METHOD FOR OPTIMAL TISSUE SEPARATION Background Technical Field 5 The present disclosure relates to an electrosurgical system and method and, more particularly, to duty cycle controlled waveforms and modulated waveforms for use in optimizing tissue separation. Background of Related Art Energy-based tissue treatment is well known in the art. Various types of energy 10 (e.g., electrical, ohmic, resistive, ultrasonic, microwave, cryogenic, laser, etc.) are applied to tissue to achieve a desired result. Electrosurgery involves application of high radio frequency electrical current to a surgical site to cut, ablate, coagulate or seal tissue. In monopolar electrosurgery, a source or active electrode delivers radio frequency energy from the electrosurgical generator to the tissue and a return electrode carries the current 15 back to the generator. In bipolar electrosurgery, one of the electrodes of the hand-held instrument functions as the active electrode and the other as the return electrode. The return electrode is placed in close proximity to the active electrode such that an electrical circuit is formed between the two electrodes (e.g., electrosurgical forceps). In this manner, the applied electrical current is limited to the body tissue positioned between the 20 electrodes. During the cutting process, the generator supplies an electrical signal at a fixed sinusoidal frequency to an electrosurgical instrument to cut the tissue. Occasionally, the tissue will not completely separate and become completely desiccated because the tissue dries or loses moisture as the electrical signal is applied to the tissue. The desiccated 25 tissue has a very high electrical impedance. An object of the invention is to provide modulated or duty cycle controlled waveforms with higher voltages to completely separate the tissue while keeping the root mean square (RMS) power low. Object of the Invention It is the object of the present invention to substantially overcome or ameliorate one 30 or more of the disadvantages of the prior art, or at least provide a useful alternative.
2 Summary of the Invention A system and method for optimizing tissue separation using modulated or duty cycle controlled waveforms on desiccated tissue, where the desiccated tissue has a high electrical impedance. In bipolar electrosurgical procedures, tissue separation is separated 5 with the application of an electrical signal. When tissue does not completely separate and becomes desiccated, a generator may generate a duty cycle controlled waveform with a specified duty cycle and frequency or a modulated waveform. The modulated waveform is generated by adding or multiplying one or more waveforms together. The modulated or duty cycle controlled waveforms create power pulses with higher voltages and a low to RMS value. The power pulses drive power and create heat in the high impedance tissue. The creation of heat helps to mobilize water content adjacent to the desiccated tissue. The heating and mobilization of water induces motion into the tissue and aids in the complete separation of tissue while keeping the RMS power low. According to an embodiment of the present disclosure, a method for optimizing is tissue separation including the steps of grasping a section of tissue with an electrosurgical instrument and sending a pulse waveform to the instrument to seal the tissue. The method further includes the steps of sending a sinusoidal waveform to the instrument to cut the tissue and determining if the tissue is completely separated. In response to determining the tissue is not completely separated, the method further includes the step of generating a 20 duty cycle controlled waveform or a modulated waveform. The duty cycle controlled and the modulated waveform have a larger voltage than the sinusoidal waveform used to cut the tissue and a low root mean square (RMS) power value. The method then sends the duty cycle controlled or the modulated waveform to the instrument to completely separate the tissue. 25 According to another embodiment of the present disclosure, a method for performing a surgical procedure includes the step of grasping a section of tissue with an electrosurgical instrument and sending a pulse waveform to the instrument to seal the tissue. The method also includes the steps of sending a sinusoidal waveform to the instrument to cut the tissue and determining if the tissue is completely separated. In 30 response to determining the tissue is not completely separated, the method further includes the step of generating with a generator a duty cycle controlled waveform from pulsing a fundamental frequency at a specified duty cycle. The duty cycle controlled waveform has a larger voltage than the sinusoidal waveform used to cut the tissue and a low root mean square (RMS) power value. The method then sends the duty cycle 35 controlled waveform to the instrument to completely separate the tissue.
3 According to another embodiment of the present disclosure, a system for performing a surgical procedure includes an electrosurgical instrument configured to grasp a section of tissue and a generator. The generator is configured to selectively supply an electrical signal to the electrosurgical instrument in three phases. In a first 5 phase, the generator sends a pulsed waveform to the electrosurgical instrument to seal the tissue. In a second phase, the generator sends a sinusoidal waveform to the instrument to cut the tissue. In a third phase, the generator sends a duty controlled waveform or a modulated waveform to cut unseparated tissue with a larger voltage than the sinusoidal waveform used to cut the tissue and a low root mean square (RMS) power value. 10 Further, the generator can automatically initiate the third phase upon determining the tissue separation in the second phase was unsuccessful. A sensor determines an electrical impedance of the cut tissue. Alternatively, a user may be alerted to the unsuccessful tissue separation in the second phase. The user is then prompted to initiate the generator to supply energy using the third phase. is Brief Description of the Drawings Various embodiments of the present disclosure are described herein with reference to the drawings wherein: Fig. 1 is a schematic block diagram of a bipolar electrosurgical system in accordance with an embodiment of the present disclosure; 20 Fig. 2 is an enlarged, schematic end view showing one embodiment of an electrode assembly of the present disclosure; Fig. 3 is a schematic block diagram of a generator in accordance with an embodiment of the present disclosure; Fig. 4 illustrates a duty cycle controlled waveform according to an embodiment 25 of the present disclosure; Fig. 5(a) illustrates a beat frequency waveform according to an embodiment of the present disclosure; Fig. 5(b) illustrates a fundamental frequency waveform according to an embodiment of the present disclosure; 30 Fig. 6 illustrates a modulated output according to an embodiment of the present disclosure; and Fig. 7 is a flow diagram of a process for optimizing tissue separation using duty cycle controlled and modulated waveforms according to an embodiment of the present disclosure.
4 Detailed Description Particular embodiments of the present disclosure are described hereinbelow with reference to the accompanying drawings. In the following description, well-known functions or constructions are not described in detail to avoid obscuring the present 5 disclosure in unnecessary detail. The generator according to the present disclosure can perform bipolar electrosurgical procedures, including vessel sealing procedures. The generator may include a plurality of outputs for interfacing with various electrosurgical instruments (e.g., bipolar electrosurgical forceps, footswitch, etc.). Further, the generator includes to electronic circuitry configured for generating radio frequency power specifically suited for various electrosurgical modes (e.g., cutting, blending, division, etc.) and procedures (e.g., bipolar, vessel sealing). Fig. 1 is a schematic illustration of a bipolar electrosurgical system according to the present disclosure. The system includes bipolar electrosurgical forceps 10 having one 15 or more electrodes for treating tissue of a patient P. The electrosurgical forceps 10 include, opposing jaw members 11 and 16 having an active electrode 14 and a return electrode 13, respectively, disposed therein. The active electrode 14 and the return electrode 13 are connected to the generator 30 through cable 18, which includes the supply and return lines 4, 8 coupled to the active terminal 31 and return terminal 32, 20 respectively (see Fig. 3). The electrosurgical forceps 10 are coupled to the generator 30 at a connector 21 having connections to the active terminal 31 and return terminal 32 (e.g., pins) via a plug disposed at the end of the cable 18, wherein the plug includes contacts from the supply and return lines 4, 8. The generator 30 includes suitable input controls (e.g., buttons, activators, 25 switches, touch screen, etc.) for controlling the generator 30. In addition, the generator 30 may include one or more display screens for providing the user with variety of output information (e.g., intensity settings, treatment complete indicators, etc.). The controls allow the user to adjust power of the RF energy, waveform parameters including a fundamental frequency, a beat frequency, duty cycle, and/or other parameters to achieve 30 the desired waveform suitable for a particular task (e.g., coagulating, tissue sealing, intensity setting, etc.). Fig. 2 is an enlarged, schematic end view showing one embodiment of an electrode assembly 20 of the present disclosure. During the so called "sealing phase", the jaw members 11 and 16 are closed about tissue and the cutting element 26 may be 35 configured to form a requisite gap between opposing sealing surfaces 22a, 24a, and 22b, 5 24b. During activation of the sealing phase, the cutting element 26 is not necessarily energized such that the majority of the current is concentrated between diametrically opposing sealing surfaces between 22a and 24a and 22b and 24b to effectively seal the tissue. Additionally, stop members (not shown) may be disposed on the sealing surfaces, s adjacent to the sealing surfaces, or on the insulators 28, 29 to regulate the gap distance between opposing sealing surfaces 22a, 24a and22a, 24b. The electrode assembly 20 in this embodiment only includes one cutting element 26. The cutting element 26 is disposed opposite insulator 29 which provides a dual function during activation of the electrode assembly 20: 1) provides a uniform gap 10 between sealing surfaces 22a and 24a and 22b and 24b during the sealing phase (eliminating a need for the above-mentioned stop members); and 2) prevents the electrode 20 from shorting during the sealing and cutting phases. During activation, the cutting element 26 is energized to a first potential "+" and the opposing sealing surfaces 22a, 24a, and 22b, 24b are energized to a second electrical potential "-" which creates an area of 15 high power density between the two previously formed tissue seals and cuts the tissue. Additionally, Fig. 2 is one example of electrode assembly 20, other embodiments of electrode assemblies are disclosed in US Patent No. 7,276,068, issued on October 2, 2007, entitled "Vessel Sealing Instrument with Electrical Cutting Mechanism", the disclosure of which is herein incorporated by reference in its entirety. 20 Fig. 3 shows a schematic block diagram of the generator 30 having a controller 34, a DC power supply 37, and an RF output stage 38. The power supply 37 is connected to a conventional AC source (e.g., electrical wall outlet) and is adapted to provide high voltage DC power to an RF output stage 38 that converts high voltage DC power into RF energy. RF output stage 38 delivers the RF energy to an active terminal 31. The energy 25 is returned thereto via the return terminal 32. The generator 30 may include a plurality of connectors (not shown) to accommodate various types of electrosurgical instruments (e.g., instrument, electrosurgical forceps 10, etc.). Further, the generator 30 may be configured to operate in a variety of modes such as ablation, bipolar cutting, coagulation, sealing, etc. The 30 generator 30 may also include a switching mechanism (e.g., relays) to switch the supply of RF energy between the connectors. The controller 34 includes a microprocessor 35 operably connected to a memory 36, which may be volatile type memory (e.g., RAM) and/or non-volatile type memory (e.g., flash media, disk media, etc.). The microprocessor 35 is operably connected to the 35 power supply 37 and/or RF output stage 38 allowing the microprocessor 35 to control the 6 output of the generator 30 according to either open and/or closed control loop schemes. Those skilled in the art will appreciate that the microprocessor 35 may be substituted by any logic processor (e.g., control circuit) adapted to perform the calculations discussed herein. 5 A closed loop control scheme or feedback control loop is provided that includes sensor circuitry 39 having one or more sensors (not shown) for measuring a variety of tissue and energy properties (e.g., tissue impedance, tissue temperature, output current and/or voltage, etc.). The sensor circuitry 39 provides feedback to the controller 34. Such sensors are within the purview of those skilled in the art. The controller 34 then io signals the HVPS 37 and/or RF output phase 38 which then adjusts the DC and/or RF power supply, respectively. The controller 34 also receives input signals from the input controls of the generator 30 or the instrument 10. The controller 34 utilizes the input signals to adjust power outputted by the generator 30 and/or performs other control functions thereon. is The forceps 10 is configured to operate in three modes or phases: (1) electrosurgical tissue sealing, (2) bipolar electrosurgical cutting, and (3) duty cycle controlled or modulated waveform bipolar electrosurgical cutting. The third mode or phase is applied when the tissue does not completely separate causing the tissue to have a very high electrical impedance. 20 Fig. 4 illustrates a duty cycle controlled waveform 40 for use in the third phase. The waveform 40 is shown with a fundamental frequency 45 and a duty cycle 42, where the duty cycle is the percentage of "on" time in a repetition rate 44. The time difference between pulses is the percentage of "off" time 46 in the repetition rate 44. The fundamental frequency 45 can range from 424 kHz to 520 kHz. More 25 specifically, the fundamental frequency ranges from 448 KHz to 496 kHz. The duty cycle 42 can range from 5% to 50% of the "on" time in the repetition rate 44, and more specifically from 5% to 20% of the "on" time in the repetition rate 44. The duty cycle controlled waveform 40 allows for a higher voltage to be applied to the tissue while keeping the RMS power low. A high RMS power may damage the 30 polymers used in the electrodes or cause other undeterminable effects. The duty cycle controlled waveform 40 creates power pulses, where the power and voltage are in an exponential relationship, as shown below: P=V 2/R The power pulses drive power and create heat in the high impedance tissue. The 35 creation of heat mobilizes water content next to the high impedance desiccated tissue.
7 The heating and mobilization of water induces motion in the tissue and aids in complete separation of tissue. Fig, 5(a) illustrates a beat frequency waveform 50. The beat frequency 47 can range from .5 kHz to 20 kHz. Fig. 5(b) illustrates a fundamental frequency waveform 55. 5 Modulated waveform 60 in Fig. 6 illustrates the multiplication of the beat frequency waveform 50 and the fundamental frequency waveform 55. The resulting modulated waveform 60 creates a modulated effect that allows for a more smooth transition of energy delivery. Further, the resulting waveform 50 defines a technique of more complex energy delivery that results in a more destructive arc that improves tissue 10 vaporization. Moreover, the modulated waveform 60 allows for a higher voltage to be applied to the tissue while keeping the RMS power low. The modulated waveform 60 creates power pulses, where the power and voltage are in a exponential relationship. The power pulses drive power and create heat in the high impedance tissue. The creation of heat mobilizes water content next to the high impedance desiccated tissue. The heating is and mobilization of water induces motion in the tissue and aids in complete separation of tissue. In alternative embodiments, the beat frequency waveform 50 and the fundamental frequency waveform 55 can be added together to form a modulated waveform. Additionally, the fundamental frequency waveform 55 can be added or 20 multiplied with itself, a sine wave, a square wave, a triangular wave, a duty cycle controlled waveform, or other waveform. Further, the beat frequency waveform 50 can be added or multiplied with itself, a sine wave, a square wave, a triangular wave, a duty cycle controlled waveform, or other waveform. Additionally, this modality of combining frequencies can be combined with other tissue degradation techniques to optimize the 25 surgical procedure. Fig. 7 is a flow diagram of a process 700 for optimizing tissue separation by controlling waveform and duty cycle parameters. The process 700 starts with step 705, which invokes clamping or grasping tissue with the instrument 710. The generator then sends a pulse waveform to the instrument 10 to seal the tissue at step 715. To cut the 30 tissue at step 720, the generator sends a small precise sinusoidal waveform to the instrument. Next, a sensor (not shown) on the instrument 10 and/or sensor circuitry 39 is used to determine if the tissue is completely separated at step 725 by measuring the electrical impedance of the cut tissue. If the sensor circuitry measures a high electrical impedance across the tissue, then the tissue is not completely separated. If the tissue is 35 not completely separated, then the generator generates an electrical signal at step 730 with 8 a duty cycle controlled waveform 40 or a modulated waveform 60. The electrical signal sent in step 730 can automatically be sent by the generator 30 if the tissue is not completely separated in step 720. Alternatively, a user may be prompted that the tissue was not completely separated in step 720. Then, the user may be prompted to initiate the 5 generator 30 to generate the electrical signal in step 730. Then, the generator sends the electrical signal to the instrument 10 to finish cutting the tissue at step 740. The process 700 then ends at step 745 after sending the electrical signal or after determining the tissue is completely separated. While several embodiments of the disclosure have been shown in the drawings 1o and/or discussed herein, it is not intended that the disclosure be limited thereto, as it is intended that the disclosure be as broad in scope as the art will allow and that the specification be read likewise. Therefore, the above description should not be construed as limiting, but merely as exemplifications of particular embodiments. Those skilled in the art will envision other modifications within the scope and spirit of the claims is appended hereto.
Claims (15)
- 2. The method according to claim 1, wherein the duty cycle controlled waveform pulses a fundamental frequency at a specified duty cycle and the duty cycle is is between about 5% and 50% of each cycle.
- 3. The method according to claim 2, wherein the fundamental frequency is between about 424 kHz and 520 kHz.
- 4. The method according to claim 3, wherein the fundamental frequency is between about 448kHz and 496kHz. 20 5. The method according to claim 1, wherein the modulated waveform is generated by adding or multiplying one or more different waveforms together and the one or more different waveforms can be a parameter specified waveform, a sinusoidal waveform, a triangular waveform, a square waveform, or the duty cycle controlled waveform. 25 6. The method according to claim 1, wherein the modulated waveform is generated from adding or multiplying two or more sine waves together.
- 7. The method according to claim 1, wherein the modulated waveform is generated from adding or multiplying a sine wave and a square wave together.
- 8. The method according to claim 1, wherein the modulated waveform is 30 generated from adding or multiplying a sine wave and a triangle wave together. 10
- 9. The method according to claim 1, wherein the modulated waveform is generated by multiplying a sine wave at specified beat frequency by a sine wave at a specified fundamental frequency and the beat frequency is a between about .5 kHz and 20kHz. s 10. The method according to claim 9, wherein the fundamental frequency is between about 448kHz and 496kHz.
- 11. The method according to claim 1, wherein the instrument is a bipolar forceps.
- 12. A method for performing an electrosurgical procedure, the method 10 comprising: grasping a section of tissue with an electrosurgical instrument; sending a pulse waveform to the instrument to seal the tissue; sending a sinusoidal waveform to the instrument to cut the tissue; determining if the tissue is completely separated; 1s in response to determining the tissue is not completely separated, generating with a generator a duty cycle controlled waveform from pulsing a fundamental frequency at a specified duty cycle, wherein the duty cycle controlled waveform has a larger voltage than the sinusoidal waveform used to cut the tissue and a low root mean square (RMS) power value; and 20 sending the duty cycle controlled waveform to the instrument to completely separate the tissue.
- 13. A system for performing an electrosurgical procedure, comprising: an electrosurgical instrument configured to grasp a section of tissue; and a generator configured to selectively supply an electrical signal to the 25 electrosurgical instrument in three phases, a first phase that sends a pulsed waveform to the electrosurgical instrument to seal the tissue, a second phase that sends a sinusoidal waveform to the instrument to cut the tissue, and a third phase that sends a duty controlled waveform or a modulated waveform to cut unseparated tissue with a larger voltage than the sinusoidal waveform used to cut the tissue and a low root mean square (RMS) power 30 value.
- 14. The system of claim 13, wherein the third phase is initiated automatically when determined if unsuccessful tissue separation during the second phase. 11
- 15. The system of claim 13, further comprising a user is alerted to unsuccessful tissue separation during the second phase.
- 16. The system of claim 15, wherein the user is prompted to initiate the generator to supply energy using the third phase. 5 17. The system of claim 13, further comprising: a sensor on the instrument to measure an electrical impedance of the of cut tissue.
- 18. The system according to claim 13, wherein the duty cycle controlled waveform pulses a fundamental frequency at a specified duty cycle and the fundamental 1o frequency is between about 424 kHz and 520 kHz and the duty cycle is between about 5% and 20% of each cycle.
- 19. The system according to claim 13, wherein the modulated waveform is generated by adding or multiplying one or more different waveforms together and the one or more different waveforms can be a parameter specified waveform, a sinusoidal is waveform, a triangular waveform, a square waveform, or the duty cycle controlled waveform.
- 20. The system according to claim 13, wherein the modulated waveform is generated by multiplying a sine wave at specified beat frequency by a sine wave at a specified fundamental frequency and the beat frequency is a between about .5 kHz and 20 20 kHz and the fundamental frequency is between about 448kHz and 496kHz. Dated 30 May, 2011 Tyco Healthcare Group, LP Patent Attorneys for the Applicant/Nominated Person SPRUSON & FERGUSON 25
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US12/793,136 US8668690B2 (en) | 2010-06-03 | 2010-06-03 | Apparatus and method for optimal tissue separation |
US12/793,136 | 2010-06-03 |
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EP (1) | EP2392280B1 (en) |
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-
2010
- 2010-06-03 US US12/793,136 patent/US8668690B2/en active Active
-
2011
- 2011-05-31 CA CA2741891A patent/CA2741891A1/en not_active Abandoned
- 2011-06-01 AU AU2011202594A patent/AU2011202594B2/en not_active Ceased
- 2011-06-02 JP JP2011124678A patent/JP5670837B2/en not_active Expired - Fee Related
- 2011-06-03 EP EP11168660A patent/EP2392280B1/en active Active
Also Published As
Publication number | Publication date |
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US8668690B2 (en) | 2014-03-11 |
AU2011202594B2 (en) | 2012-08-30 |
EP2392280B1 (en) | 2013-03-13 |
EP2392280A1 (en) | 2011-12-07 |
CA2741891A1 (en) | 2011-12-03 |
JP2011251128A (en) | 2011-12-15 |
US20110301607A1 (en) | 2011-12-08 |
JP5670837B2 (en) | 2015-02-18 |
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