AU2010317390A1 - Pharmaceutical combination of prostaglandin compound and NSAID for the treatment of glaucoma and ocular hypertension - Google Patents
Pharmaceutical combination of prostaglandin compound and NSAID for the treatment of glaucoma and ocular hypertension Download PDFInfo
- Publication number
- AU2010317390A1 AU2010317390A1 AU2010317390A AU2010317390A AU2010317390A1 AU 2010317390 A1 AU2010317390 A1 AU 2010317390A1 AU 2010317390 A AU2010317390 A AU 2010317390A AU 2010317390 A AU2010317390 A AU 2010317390A AU 2010317390 A1 AU2010317390 A1 AU 2010317390A1
- Authority
- AU
- Australia
- Prior art keywords
- effective amount
- composition
- pharmaceutically acceptable
- ocular hypertension
- glaucoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 title claims abstract description 28
- 206010018307 Glaucoma and ocular hypertension Diseases 0.000 title claims abstract description 25
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 title claims abstract description 24
- -1 prostaglandin compound Chemical class 0.000 title claims abstract description 22
- 239000000203 mixture Substances 0.000 claims abstract description 67
- 229960003655 bromfenac Drugs 0.000 claims abstract description 27
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- 229960002368 travoprost Drugs 0.000 claims abstract description 27
- 238000000034 method Methods 0.000 claims description 30
- 150000003839 salts Chemical class 0.000 claims description 27
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- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
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- 239000003963 antioxidant agent Substances 0.000 description 2
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- 239000006172 buffering agent Substances 0.000 description 2
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
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- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
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- GGXICVAJURFBLW-CEYXHVGTSA-N latanoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 GGXICVAJURFBLW-CEYXHVGTSA-N 0.000 description 2
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- 239000002997 ophthalmic solution Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
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- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- 239000004255 Butylated hydroxyanisole Substances 0.000 description 1
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
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- 241000124008 Mammalia Species 0.000 description 1
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- 150000001735 carboxylic acids Chemical class 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2761/CHE/2009 | 2009-11-11 | ||
| IN2761CH2009 | 2009-11-11 | ||
| PCT/IN2010/000717 WO2011058579A1 (en) | 2009-11-11 | 2010-11-01 | Pharmaceutical combination of prostaglandin compound and nsaid for the treatment of glaucoma and ocular hypertension |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2010317390A1 true AU2010317390A1 (en) | 2012-06-07 |
Family
ID=43587393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2010317390A Abandoned AU2010317390A1 (en) | 2009-11-11 | 2010-11-01 | Pharmaceutical combination of prostaglandin compound and NSAID for the treatment of glaucoma and ocular hypertension |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20120232140A1 (enExample) |
| EP (1) | EP2498768A1 (enExample) |
| JP (1) | JP2013510845A (enExample) |
| CN (1) | CN102711748A (enExample) |
| AU (1) | AU2010317390A1 (enExample) |
| BR (1) | BR112012010936A2 (enExample) |
| CA (1) | CA2780611A1 (enExample) |
| MX (1) | MX2012005447A (enExample) |
| RU (1) | RU2012124216A (enExample) |
| WO (1) | WO2011058579A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2765988B9 (en) * | 2011-10-12 | 2025-01-08 | Bausch & Lomb Incorporated | Ocular composition containing bromfenac with increased bioavailability |
| JP6185725B2 (ja) * | 2012-02-24 | 2017-08-23 | わかもと製薬株式会社 | 水性医薬組成物 |
| WO2021001806A1 (en) * | 2019-07-04 | 2021-01-07 | Ocular Discovery Ltd. | Stable dipyridamole formulations with reduced impurities |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5631287A (en) * | 1994-12-22 | 1997-05-20 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
| US6011062A (en) * | 1994-12-22 | 2000-01-04 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
| US6646001B2 (en) * | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
| PE20020146A1 (es) * | 2000-07-13 | 2002-03-31 | Upjohn Co | Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2) |
| CN100341498C (zh) * | 2003-01-21 | 2007-10-10 | 千寿制药株式会社 | 含有2－氨基－3－(4－溴苯甲酰基)苯乙酸的水成液制剂 |
| US20050119262A1 (en) * | 2003-08-21 | 2005-06-02 | Pharmacia Corporation | Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent |
-
2010
- 2010-11-01 JP JP2012538470A patent/JP2013510845A/ja not_active Withdrawn
- 2010-11-01 RU RU2012124216/15A patent/RU2012124216A/ru unknown
- 2010-11-01 WO PCT/IN2010/000717 patent/WO2011058579A1/en not_active Ceased
- 2010-11-01 EP EP10803392.9A patent/EP2498768A1/en not_active Withdrawn
- 2010-11-01 BR BR112012010936A patent/BR112012010936A2/pt not_active IP Right Cessation
- 2010-11-01 CN CN2010800511948A patent/CN102711748A/zh active Pending
- 2010-11-01 MX MX2012005447A patent/MX2012005447A/es unknown
- 2010-11-01 US US13/508,947 patent/US20120232140A1/en not_active Abandoned
- 2010-11-01 AU AU2010317390A patent/AU2010317390A1/en not_active Abandoned
- 2010-11-01 CA CA2780611A patent/CA2780611A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN102711748A (zh) | 2012-10-03 |
| JP2013510845A (ja) | 2013-03-28 |
| WO2011058579A1 (en) | 2011-05-19 |
| EP2498768A1 (en) | 2012-09-19 |
| CA2780611A1 (en) | 2011-05-19 |
| US20120232140A1 (en) | 2012-09-13 |
| RU2012124216A (ru) | 2013-12-20 |
| BR112012010936A2 (pt) | 2017-10-17 |
| MX2012005447A (es) | 2012-07-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |