AU2010223527A1 - Addition salts of tromethamine with azabiphenylaminobenzoic acid derivatives as DHODH inhibitors - Google Patents

Addition salts of tromethamine with azabiphenylaminobenzoic acid derivatives as DHODH inhibitors Download PDF

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Publication number
AU2010223527A1
AU2010223527A1 AU2010223527A AU2010223527A AU2010223527A1 AU 2010223527 A1 AU2010223527 A1 AU 2010223527A1 AU 2010223527 A AU2010223527 A AU 2010223527A AU 2010223527 A AU2010223527 A AU 2010223527A AU 2010223527 A1 AU2010223527 A1 AU 2010223527A1
Authority
AU
Australia
Prior art keywords
salt
formula
inhibitors
group
cyclopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2010223527A
Other languages
English (en)
Inventor
Francesc Carrera Carrera
Laurent Debethune
Nuria Garcia Gonzalez
Montserrat Julia Jane
Xavier Serra Masia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almirall SA
Original Assignee
Almirall SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40671396&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2010223527(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Almirall SA filed Critical Almirall SA
Publication of AU2010223527A1 publication Critical patent/AU2010223527A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2010223527A 2009-03-13 2010-03-11 Addition salts of tromethamine with azabiphenylaminobenzoic acid derivatives as DHODH inhibitors Abandoned AU2010223527A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09382032A EP2230232A1 (fr) 2009-03-13 2009-03-13 Sels adjuvants de trométhamine dotés de dérivés d'acide azabiphénylaminobenzoïque en tant qu'inhibiteurs de la DHOD
EP09382032.2 2009-03-13
PCT/EP2010/001549 WO2010102825A1 (fr) 2009-03-13 2010-03-11 Sels d'addition de trométhamine avec des dérivés d'acide azabiphénylaminobenzoïque comme inhibiteurs de dhodh

Publications (1)

Publication Number Publication Date
AU2010223527A1 true AU2010223527A1 (en) 2011-08-25

Family

ID=40671396

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010223527A Abandoned AU2010223527A1 (en) 2009-03-13 2010-03-11 Addition salts of tromethamine with azabiphenylaminobenzoic acid derivatives as DHODH inhibitors

Country Status (21)

Country Link
US (1) US20120003183A1 (fr)
EP (2) EP2230232A1 (fr)
JP (1) JP2012520251A (fr)
KR (1) KR20110126695A (fr)
CN (1) CN102341372A (fr)
AR (1) AR075737A1 (fr)
AU (1) AU2010223527A1 (fr)
CA (1) CA2754785A1 (fr)
CL (1) CL2011002213A1 (fr)
CO (1) CO6501157A2 (fr)
EA (1) EA201101298A1 (fr)
EC (1) ECSP11011384A (fr)
IL (1) IL214517A0 (fr)
MX (1) MX2011009147A (fr)
NZ (1) NZ594491A (fr)
PE (1) PE20120328A1 (fr)
SG (2) SG173824A1 (fr)
TW (1) TW201033177A (fr)
UY (1) UY32465A (fr)
WO (1) WO2010102825A1 (fr)
ZA (1) ZA201105743B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2319596B1 (es) 2006-12-22 2010-02-08 Laboratorios Almirall S.A. Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico.
UY31272A1 (es) 2007-08-10 2009-01-30 Almirall Lab Nuevos derivados de ácido azabifenilaminobenzoico
EP2135610A1 (fr) 2008-06-20 2009-12-23 Laboratorios Almirall, S.A. Combinaison comportant des inhibiteurs DHODH et de la méthotrexate
EP2239256A1 (fr) 2009-03-13 2010-10-13 Almirall, S.A. Sel de sodium de l'acide 5-cyclopropyl-2-{[2-(2,6-difluorophényl)pyrimidin-5-yl]amino}benzoïque en tant qu'inhibiteurs de la DHOD
EP2314577A1 (fr) 2009-10-16 2011-04-27 Almirall, S.A. Procédé de fabrication de l'acide 2-[(3,5-difluoro-3'-méthoxy-1,1'-biphényl-4-yl)amino]nicotinique
CN110903219A (zh) * 2018-09-18 2020-03-24 广东东阳光药业有限公司 酰胺衍生物的盐及其制备方法
US20220055995A1 (en) * 2018-12-21 2022-02-24 Les Laboratoires Servier Sas Crystalline and salt forms of an organic compound and pharmaceutical compositions thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9804343D0 (en) 1998-02-27 1998-04-22 Univ Cardiff Chemical compounds
DE60226855D1 (de) 2001-04-05 2008-07-10 Aventis Pharma Inc Verwendung von (z)-2-cyano-3-hydroxy-but-2-ensäure-(4'-trifluoromethylphenyl)-amid zur behandlung der multiplen sklerose
PE20030120A1 (es) * 2001-06-19 2003-02-12 Merck & Co Inc Sal amina de un antagonista de receptor de integrin
WO2003006424A1 (fr) 2001-07-10 2003-01-23 4Sc Ag Nouveaux composes utilises comme agents anti-inflammatoires, immunomodulateurs et anti-proliferatoires
WO2004056746A1 (fr) 2002-12-23 2004-07-08 4Sc Ag Composes d'acide dicarboxylique de cycloalcene servant d'agents anti-inflammatoires, d'immunomodulation et anti-proliferation
EP1581478A1 (fr) 2002-12-23 2005-10-05 4Sc Ag Inhibiteurs de l'enzyme dhodh et leur procede d'identification
JP2008500393A (ja) 2004-05-21 2008-01-10 ザ ユーエービー リサーチ ファンデーション ピリミジン合成インヒビターに関する組成物および方法
WO2006022442A1 (fr) 2004-08-24 2006-03-02 Santen Pharmaceutical Co., Ltd. Nouveaux derives d’amides heterocycliques ayant une activite d’inhibition de la dihydroorotate deshydrogenase
AU2005295511A1 (en) 2004-10-19 2006-04-27 Aventis Pharmaceuticals Inc. Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating inflammatory bowel disease
UY31272A1 (es) 2007-08-10 2009-01-30 Almirall Lab Nuevos derivados de ácido azabifenilaminobenzoico

Also Published As

Publication number Publication date
JP2012520251A (ja) 2012-09-06
US20120003183A1 (en) 2012-01-05
ECSP11011384A (es) 2011-11-30
EA201101298A1 (ru) 2012-04-30
EP2406222A1 (fr) 2012-01-18
EP2230232A1 (fr) 2010-09-22
CL2011002213A1 (es) 2012-03-09
CN102341372A (zh) 2012-02-01
IL214517A0 (en) 2011-09-27
PE20120328A1 (es) 2012-03-29
WO2010102825A1 (fr) 2010-09-16
TW201033177A (en) 2010-09-16
SG10201400568PA (en) 2014-07-30
CO6501157A2 (es) 2012-08-15
AR075737A1 (es) 2011-04-20
UY32465A (es) 2010-05-31
KR20110126695A (ko) 2011-11-23
NZ594491A (en) 2013-11-29
MX2011009147A (es) 2011-09-15
CA2754785A1 (fr) 2010-09-16
SG173824A1 (en) 2011-09-29
ZA201105743B (en) 2012-04-25

Similar Documents

Publication Publication Date Title
EP2406225B1 (fr) Sels adjuvants d'amines contenant des groupes hydroxyle et/ou carbonyle avec des dérivés d'acides aminonicotiques en tant qu'inhibiteurs de la dhodh
US8501943B2 (en) Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor
CA2674512C (fr) Derives d'acides amino nicotinique et isonicotinique comme inhibiteurs de la dhodh
US20120003183A1 (en) Addition salts of tromethamine with azabiphenylaminobenzoic acid derivatives as dhodh inhibitors

Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period