AU2010211289B2 - Vector(s) containing an inducible gene encoding a CDK4/CDK6 inhibitor useful for treating neurodegenerative disorders or diseases associated with an unscheduled activation of the cell cycle - Google Patents
Vector(s) containing an inducible gene encoding a CDK4/CDK6 inhibitor useful for treating neurodegenerative disorders or diseases associated with an unscheduled activation of the cell cycle Download PDFInfo
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- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
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- C12N2310/00—Structure or type of the nucleic acid
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Applications Claiming Priority (3)
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| EP09001521.5 | 2009-02-04 | ||
| EP09001521A EP2218784A1 (en) | 2009-02-04 | 2009-02-04 | Vector(s) containing an inducible gene encoding a CDK4/CD6 inhibitor useful for treating neurodegenerative disorders |
| PCT/EP2010/000702 WO2010089122A2 (en) | 2009-02-04 | 2010-02-04 | Vector(s) containing an inducible gene encoding a cdk4/cdk6 inhibitor useful for treating neurodegenerative disorders or diseases associated with an unscheduled activation of the cell cycle |
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| AU2010211289A1 AU2010211289A1 (en) | 2011-09-01 |
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| US8653324B2 (en) * | 2010-06-11 | 2014-02-18 | Fox Chase Cancer Center | TetO-p16 transgenic mice |
| WO2012050975A2 (en) * | 2010-09-29 | 2012-04-19 | The University Of North Carolina At Chapel Hill | Novel circular mammalian rna molecules and uses thereof |
| KR101255338B1 (ko) * | 2010-12-15 | 2013-04-16 | 포항공과대학교 산학협력단 | 표적 세포에 대한 폴리뉴클레오티드 전달체 |
| CN103501812A (zh) | 2011-04-29 | 2014-01-08 | 西莱克塔生物科技公司 | 用于过敏症治疗的致耐受性合成纳米载体 |
| CN118370823A (zh) | 2013-05-03 | 2024-07-23 | 西莱克塔生物科技公司 | 用于降低的或增强的药效学作用的致耐受性合成纳米载体和治疗性大分子 |
| WO2016037162A1 (en) * | 2014-09-07 | 2016-03-10 | Selecta Biosciences, Inc. | Methods and compositions for attenuating anti-viral transfer vector immune responses |
| WO2017075335A1 (en) | 2015-10-28 | 2017-05-04 | Voyager Therapeutics, Inc. | Regulatable expression using adeno-associated virus (aav) |
| HUE072005T2 (hu) | 2017-03-11 | 2025-10-28 | Cartesian Therapeutics Inc | Gyulladásgátlókkal és immunszupresszánst tartalmazó szintetikus nanohordozókkal történõ kombinált kezeléssel összefüggõ eljárások és készítmények |
| CN108319816B (zh) * | 2018-02-27 | 2021-04-23 | 广州大学 | 一种基于基因通路识别小分子核糖核酸的方法 |
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| US20070117769A1 (en) * | 2003-09-29 | 2007-05-24 | Maines Mahin D | Methods of modulating cell cycle and cell signaling pathways using biliverdin reductase |
| WO2011025566A1 (en) * | 2009-08-26 | 2011-03-03 | Shi-Lung Lin | Development of universal cancer drugs and vaccines |
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| DE19936034C1 (de) * | 1999-07-30 | 2001-01-25 | Univ Leipzig | Rekombiniertes, neuronalspezifisch aktiviertes, transkribierbares lineares DNA-Konstrukt |
| DE602005023181D1 (de) * | 2004-07-21 | 2010-10-07 | Dana Farber Cancer Inst Inc | Lentivirusvektoren und deren verwendung |
| EP1838841A2 (en) * | 2004-12-23 | 2007-10-03 | The Ludwig Institute for Cancer Research | Engineered dopamine neurons and uses thereof |
| US20080300202A1 (en) * | 2006-05-18 | 2008-12-04 | The State of Oregon acting by and through the State Board of Higher Education on behalf of the | Subtractive transgenics |
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2016
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070117769A1 (en) * | 2003-09-29 | 2007-05-24 | Maines Mahin D | Methods of modulating cell cycle and cell signaling pathways using biliverdin reductase |
| WO2011025566A1 (en) * | 2009-08-26 | 2011-03-03 | Shi-Lung Lin | Development of universal cancer drugs and vaccines |
Non-Patent Citations (9)
Also Published As
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| CA2751531A1 (en) | 2010-08-12 |
| WO2010089122A3 (en) | 2010-12-09 |
| WO2010089122A2 (en) | 2010-08-12 |
| EP2620447B1 (en) | 2015-09-09 |
| EP2620447A1 (en) | 2013-07-31 |
| EP2218784A1 (en) | 2010-08-18 |
| US20120004277A1 (en) | 2012-01-05 |
| JP5869884B2 (ja) | 2016-02-24 |
| AU2010211289A1 (en) | 2011-09-01 |
| CN102356156A (zh) | 2012-02-15 |
| KR101378353B1 (ko) | 2014-04-10 |
| JP2012516691A (ja) | 2012-07-26 |
| KR20110121704A (ko) | 2011-11-08 |
| US20160144054A1 (en) | 2016-05-26 |
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