AU2009320350B2 - Methods and compositions for inhibiting Clostridium difficile spore germination and outgrowth - Google Patents
Methods and compositions for inhibiting Clostridium difficile spore germination and outgrowth Download PDFInfo
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- AU2009320350B2 AU2009320350B2 AU2009320350A AU2009320350A AU2009320350B2 AU 2009320350 B2 AU2009320350 B2 AU 2009320350B2 AU 2009320350 A AU2009320350 A AU 2009320350A AU 2009320350 A AU2009320350 A AU 2009320350A AU 2009320350 B2 AU2009320350 B2 AU 2009320350B2
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- JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11074708P | 2008-11-03 | 2008-11-03 | |
| US61/110,747 | 2008-11-03 | ||
| US12283508P | 2008-12-16 | 2008-12-16 | |
| US61/122,835 | 2008-12-16 | ||
| US15013609P | 2009-02-05 | 2009-02-05 | |
| US61/150,136 | 2009-02-05 | ||
| PCT/US2009/005929 WO2010062369A2 (en) | 2008-11-03 | 2009-11-02 | Methods and compositions for inhibiting clostridium difficile spore germination and outgrowth |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2009320350A1 AU2009320350A1 (en) | 2010-06-03 |
| AU2009320350B2 true AU2009320350B2 (en) | 2015-09-24 |
Family
ID=42226300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2009320350A Ceased AU2009320350B2 (en) | 2008-11-03 | 2009-11-02 | Methods and compositions for inhibiting Clostridium difficile spore germination and outgrowth |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9340569B2 (enExample) |
| EP (1) | EP2367839A4 (enExample) |
| JP (1) | JP5620392B2 (enExample) |
| AU (1) | AU2009320350B2 (enExample) |
| CA (1) | CA2779413A1 (enExample) |
| WO (1) | WO2010062369A2 (enExample) |
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| US9079935B2 (en) | 2012-08-13 | 2015-07-14 | The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas | Reducing risk of contracting Clostridium-difficile associated disease |
| US8906668B2 (en) | 2012-11-23 | 2014-12-09 | Seres Health, Inc. | Synergistic bacterial compositions and methods of production and use thereof |
| CN104955466A (zh) | 2012-11-23 | 2015-09-30 | 赛里斯治疗公司 | 协同细菌组合物和其制造方法和用途 |
| KR102222273B1 (ko) | 2013-02-04 | 2021-03-08 | 세레스 테라퓨틱스, 인코포레이티드 | 조성물 및 방법 |
| WO2014121304A1 (en) | 2013-02-04 | 2014-08-07 | Seres Health, Inc. | Compositions and methods |
| WO2014145958A2 (en) | 2013-03-15 | 2014-09-18 | Seres Health, Inc. | Network-based microbial compositions and methods |
| WO2015076788A1 (en) | 2013-11-19 | 2015-05-28 | The Texas A&M University System | Muricholic acid-based compounds as inhibitors of clostridium difficile spore germination |
| EP3074027B1 (en) | 2013-11-25 | 2024-12-18 | Seres Therapeutics, Inc. | Synergistic bacterial compositions and methods of production and use thereof |
| EP3082431A4 (en) | 2013-12-16 | 2017-11-15 | Seres Therapeutics, Inc. | Bacterial compositions and methods of use thereof for treatment of immune system disorders |
| WO2015179437A1 (en) | 2014-05-19 | 2015-11-26 | Memorial Sloan-Kettering Cancer Center | Methods and compositions for reducing clostridium difficile infection |
| GB201421071D0 (en) * | 2014-11-27 | 2015-01-14 | Univ Aston | Compound for treating clostridium difficile |
| US20180000793A1 (en) | 2015-02-06 | 2018-01-04 | Ernesto Abel-Santos | Inhibiting Germination of Clostridium Perfringens Spores to Reduce Necrotic Enteritis |
| CN115252650A (zh) | 2015-11-03 | 2022-11-01 | 布里格姆及妇女医院股份有限公司 | 用于治疗和/或预防食物变态反应的治疗性微生物群 |
| CN108884434B (zh) * | 2016-04-05 | 2023-06-09 | Nch公司 | 富含营养的萌发剂组合物及孢子培养方法 |
| BR112020002992A2 (pt) | 2017-08-14 | 2020-08-18 | Seres Therapeutics, Inc. | composições e métodos para tratamento de doença colestática |
| KR102323783B1 (ko) * | 2017-09-22 | 2021-11-09 | 주식회사 고바이오랩 | 클로스트리디움 디피실레(Clostridium difficile) 성장 억제효과를 갖는 클로스트리디움 신덴스 균주 |
| CA3080586A1 (en) | 2017-10-30 | 2019-05-09 | Seres Therapeutics, Inc. | Compositions and methods for treating antibiotic resistance |
| AR115921A1 (es) | 2018-08-10 | 2021-03-10 | Phenex Pharmaceuticals Ag | Ácido isolitocólico o ácido isoalolitocólico y derivados deuterados de los mismos para prevenir y tratar enfermedades asociadas a clostridium difficile |
| CA3109900A1 (en) | 2018-08-17 | 2020-02-20 | Universidad Andres Bello | Method and pharmacological composition for the prevention of recurrent infections caused by clostridium difficile |
| WO2020260558A1 (en) | 2019-06-27 | 2020-12-30 | Phenex Pharmaceuticals Ag | 3-modified iso-/isoallo-lithocholic acid derivatives or their homo-analogs for preventing and treating clostridioides difficile-associated diseases |
| US20230146782A1 (en) * | 2019-08-06 | 2023-05-11 | Du Jessica Xinyun | Deoxycholic acid compounds, pharmaceutical compositions and uses thereof |
| US20240325458A1 (en) * | 2020-01-16 | 2024-10-03 | Keio University | Composition for producing bile acids |
| AU2021220800A1 (en) | 2020-02-10 | 2022-07-07 | Native Microbials, Inc. | Microbial compositions and methods of use for canine enteropathy and dysbiosis |
| EP4398890A4 (en) | 2021-09-09 | 2025-07-30 | The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The Univ Of Nevada Las Ve | C. Difficile Spore Germination Inhibitors |
| WO2023079335A1 (en) | 2021-11-03 | 2023-05-11 | Universidad Andrés Bello | Composition based on nystatin and vancomycin nanoparticles for the treatment of clostridioides difficile infection and prevention of recurrence |
| US20250002450A1 (en) | 2021-12-10 | 2025-01-02 | Universidade Do Porto | Cationic steroid compounds, method of obtaining thereof, formulations comprising thereof and their uses |
| CN120905091A (zh) * | 2025-09-30 | 2025-11-07 | 北京常友生物科技有限公司 | 大肠埃希氏菌yc49及其协同拟杆菌在抑制艰难梭菌中的应用 |
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| JPH0749438B2 (ja) * | 1990-10-31 | 1995-05-31 | 東京田辺製薬株式会社 | タウリン抱合型胆汁酸の精製方法 |
| DE19645044A1 (de) * | 1996-10-31 | 1998-05-07 | Falk Pharma Gmbh | Verwendung von Ursodeoxycholsäure zur topischen Behandlung von Entzündungserkrankungen der Schleimhäute |
| IL123998A (en) | 1998-04-08 | 2004-09-27 | Galmed Int Ltd | Conjugates of bile salts and pharmaceutical preparations containing them |
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| AU2007230991A1 (en) * | 2006-03-22 | 2007-10-04 | Syndexa Pharmaceuticals Corporation | Compounds and methods for treatment of disorders associated with ER stress |
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- 2009-11-02 WO PCT/US2009/005929 patent/WO2010062369A2/en not_active Ceased
- 2009-11-02 JP JP2011534525A patent/JP5620392B2/ja not_active Expired - Fee Related
- 2009-11-02 EP EP09829458A patent/EP2367839A4/en not_active Withdrawn
- 2009-11-02 CA CA2779413A patent/CA2779413A1/en not_active Abandoned
- 2009-11-02 US US13/126,687 patent/US9340569B2/en not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2010062369A3 (en) | 2010-10-14 |
| EP2367839A4 (en) | 2012-07-04 |
| WO2010062369A2 (en) | 2010-06-03 |
| US9340569B2 (en) | 2016-05-17 |
| JP5620392B2 (ja) | 2014-11-05 |
| US20170056419A1 (en) | 2017-03-02 |
| CA2779413A1 (en) | 2010-06-03 |
| EP2367839A2 (en) | 2011-09-28 |
| AU2009320350A1 (en) | 2010-06-03 |
| US20110280847A1 (en) | 2011-11-17 |
| JP2012507521A (ja) | 2012-03-29 |
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