AU2009282760B2 - Method for chromogenic detection of two or more target molecules in a single sample - Google Patents

Method for chromogenic detection of two or more target molecules in a single sample Download PDF

Info

Publication number
AU2009282760B2
AU2009282760B2 AU2009282760A AU2009282760A AU2009282760B2 AU 2009282760 B2 AU2009282760 B2 AU 2009282760B2 AU 2009282760 A AU2009282760 A AU 2009282760A AU 2009282760 A AU2009282760 A AU 2009282760A AU 2009282760 B2 AU2009282760 B2 AU 2009282760B2
Authority
AU
Australia
Prior art keywords
nucleic acid
target molecule
electron
hapten
labeled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2009282760A
Other languages
English (en)
Other versions
AU2009282760A1 (en
Inventor
Christopher Bieniarz
Michael Farrell
Fabien Gaire
Richard Gniewek
Thomas Grogan
Brian Daniel Kelly
Jerome Kosmeder
Megan Lehrkamp
Hiroaki Nitta
Mary Padilla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ventana Medical Systems Inc
Original Assignee
Ventana Medical Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ventana Medical Systems Inc filed Critical Ventana Medical Systems Inc
Publication of AU2009282760A1 publication Critical patent/AU2009282760A1/en
Application granted granted Critical
Publication of AU2009282760B2 publication Critical patent/AU2009282760B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6841—In situ hybridisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/583—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with non-fluorescent dye label

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2009282760A 2008-08-22 2009-08-21 Method for chromogenic detection of two or more target molecules in a single sample Active AU2009282760B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18975208P 2008-08-22 2008-08-22
US61/189,752 2008-08-22
PCT/US2009/054614 WO2010022332A1 (fr) 2008-08-22 2009-08-21 Procédé pour la détection chromogénique d’au moins deux molécules cibles dans un unique échantillon

Publications (2)

Publication Number Publication Date
AU2009282760A1 AU2009282760A1 (en) 2010-02-25
AU2009282760B2 true AU2009282760B2 (en) 2013-08-15

Family

ID=41315279

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009282760A Active AU2009282760B2 (en) 2008-08-22 2009-08-21 Method for chromogenic detection of two or more target molecules in a single sample

Country Status (8)

Country Link
US (2) US8481270B2 (fr)
EP (1) EP2334827B1 (fr)
JP (1) JP5703219B2 (fr)
AU (1) AU2009282760B2 (fr)
CA (1) CA2734783C (fr)
DK (1) DK2334827T3 (fr)
ES (1) ES2538123T3 (fr)
WO (1) WO2010022332A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011097248A2 (fr) 2010-02-02 2011-08-11 Ventana Medical Systems, Inc. Composition et procédé de stabilisation de particules fluorescentes
US8609354B2 (en) 2010-03-04 2013-12-17 Olli CARPEN Method for selecting patients for treatment with an EGFR inhibitor
KR20140120321A (ko) 2012-02-01 2014-10-13 벤타나 메디컬 시스템즈, 인코포레이티드 조직 샘플들에 있어서의 유전자들을 검출하는 시스템
CN105247348A (zh) 2013-03-12 2016-01-13 文塔纳医疗系统公司 用于多路化组织学的数字增强的显微镜检查
CA2957783C (fr) 2014-10-02 2023-02-28 Ventana Medical Systems, Inc. Polymeres et conjugues comprenant ces polymeres
WO2016120440A1 (fr) 2015-01-29 2016-08-04 Ventana Medical Systems, Inc. Détection de points, classification par couleurs de points et comptage de points classés par couleurs
WO2016120442A1 (fr) 2015-01-30 2016-08-04 Ventana Medical Systems, Inc. Segmentation d'avant-plan et classement des noyaux pour établir un score de classement d'images à double ish
WO2016120441A2 (fr) 2015-01-30 2016-08-04 Ventana Medical Systems, Inc. Mesures de qualité pour l'évaluation automatique d'images ish doubles
US10730892B2 (en) * 2015-08-21 2020-08-04 The Regents Of The University Of California Homoallylamines as formaldehyde-responsive triggers
CA2996798A1 (fr) 2015-08-28 2017-03-09 Ventana Medical Systems, Inc. Dosage de proximite pour la detection de proteines dans un tissu enrobe de paraffine et fixe avec de la formaline au moyen de haptenes en cage
WO2017155996A1 (fr) 2016-03-08 2017-09-14 Ventana Medical Systems, Inc. Immunohistochimie multiplexée utilisant des anticorps recombinants avec des marqueurs d'épitope
JP7021126B2 (ja) 2016-06-28 2022-02-16 ヴェンタナ メディカル システムズ， インク． マルチ色素キノンメチド及びチラミドコンジュゲートによる発色性ｉｈｃ及びｉｓｈ染色のための新規の色
JP7128121B2 (ja) 2016-06-28 2022-08-30 ヴェンタナ メディカル システムズ， インク． Ｉｈｃ及びｉｓｈアッセイにおけるシグナル増幅のためのクリックケミストリーの応用
EP3554556B1 (fr) 2016-12-19 2022-03-09 Ventana Medical Systems, Inc. Conjugués de peptides et d'acides nucléiques
JP2021507695A (ja) 2017-12-18 2021-02-25 ヴェンタナ メディカル システムズ， インク． ペプチド核酸コンジュゲート
EP3853214A1 (fr) 2018-09-20 2021-07-28 Ventana Medical Systems, Inc. Réactifs de réticulation à base de coumarine
CN114829368B (zh) 2019-12-18 2024-06-04 豪夫迈·罗氏有限公司 通过使用连续标记方案的合成进行测序的方法
CN115702349A (zh) * 2020-05-07 2023-02-14 领先细胞医疗诊断有限公司 用于同时检测靶核酸和蛋白质的方法及其试剂盒
US11636870B2 (en) 2020-08-20 2023-04-25 Denso International America, Inc. Smoking cessation systems and methods
US11760169B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Particulate control systems and methods for olfaction sensors
US11932080B2 (en) 2020-08-20 2024-03-19 Denso International America, Inc. Diagnostic and recirculation control systems and methods
US11760170B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Olfaction sensor preservation systems and methods
US12017506B2 (en) 2020-08-20 2024-06-25 Denso International America, Inc. Passenger cabin air control systems and methods
US11828210B2 (en) 2020-08-20 2023-11-28 Denso International America, Inc. Diagnostic systems and methods of vehicles using olfaction
US11813926B2 (en) 2020-08-20 2023-11-14 Denso International America, Inc. Binding agent and olfaction sensor
US11881093B2 (en) 2020-08-20 2024-01-23 Denso International America, Inc. Systems and methods for identifying smoking in vehicles
EP4278181A1 (fr) 2021-01-15 2023-11-22 Ventana Medical Systems, Inc. Haptènes en cage stables au stockage
WO2024002924A2 (fr) 2022-06-28 2024-01-04 F. Hoffmann-La Roche Ag Colorants fluorescents présentant d'importants décalages de stokes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000020641A1 (fr) * 1998-10-07 2000-04-13 Genentech, Inc. Analyse de tissu et necessaires a cet effet
WO2008063378A2 (fr) * 2006-11-01 2008-05-29 Ventana Medical Systems, Inc. Haptènes, conjugués de haptène, compositions de haptène, procédé de fabrication et utilisation

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1564604A (en) 1925-06-12 1925-12-08 Chas S Hodges Water wheel
US5008185A (en) * 1985-11-04 1991-04-16 Cell Analysis Systems, Inc. Methods and apparatus for the quantitation of nuclear proteins
US5595707A (en) 1990-03-02 1997-01-21 Ventana Medical Systems, Inc. Automated biological reaction apparatus
GB9215710D0 (en) 1992-07-23 1992-09-09 Inst Of Cancer The Research Analysis of cells
WO1998002577A1 (fr) 1996-07-15 1998-01-22 The Children's Medical Center Corporation Proceder pour detecter conjointement des genes introduits et leurs produits
US6582962B1 (en) 1998-02-27 2003-06-24 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
WO1999044030A1 (fr) 1998-02-27 1999-09-02 Ventana Medical Systems, Inc. Appareil automatise d'anatomie pathologique moleculaire avec rechauffeurs independants de microplaquettes
US20030211630A1 (en) 1998-02-27 2003-11-13 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
US6649138B2 (en) 2000-10-13 2003-11-18 Quantum Dot Corporation Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
US20020083888A1 (en) 2000-12-28 2002-07-04 Zehnder Donald A. Flow synthesis of quantum dot nanocrystals
US6670113B2 (en) 2001-03-30 2003-12-30 Nanoprobes Enzymatic deposition and alteration of metals
JP4567436B2 (ja) 2001-07-20 2010-10-20 ライフ テクノロジーズ コーポレーション 発光ナノ粒子およびそれらの調製方法
US6949342B2 (en) * 2001-12-21 2005-09-27 Whitehead Institute For Biomedical Research Prostate cancer diagnosis and outcome prediction by expression analysis
AU2003265414A1 (en) * 2002-08-09 2004-02-25 University Of Massachusetts Cancer diagnostics and prognostics
JP4004385B2 (ja) * 2002-11-07 2007-11-07 独立行政法人科学技術振興機構 二重染色法によるガン検出方法
ATE437369T1 (de) 2003-06-24 2009-08-15 Ventana Med Syst Inc Enzymkatalysierte metalldeposition zum verstärkten in-situ-nachweis von immunhistologischen epitopen und nukleinsäuresequenzen
WO2006076371A2 (fr) * 2005-01-10 2006-07-20 Baylor College Of Medicine Methode d'immunohistochimie quantitative et d'hybridation in situ

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000020641A1 (fr) * 1998-10-07 2000-04-13 Genentech, Inc. Analyse de tissu et necessaires a cet effet
WO2008063378A2 (fr) * 2006-11-01 2008-05-29 Ventana Medical Systems, Inc. Haptènes, conjugués de haptène, compositions de haptène, procédé de fabrication et utilisation

Also Published As

Publication number Publication date
JP5703219B2 (ja) 2015-04-15
WO2010022332A1 (fr) 2010-02-25
US8481270B2 (en) 2013-07-09
US20110136130A1 (en) 2011-06-09
JP2012500973A (ja) 2012-01-12
EP2334827B1 (fr) 2015-03-11
EP2334827A1 (fr) 2011-06-22
CA2734783A1 (fr) 2010-02-25
CA2734783C (fr) 2016-04-19
US20130273540A1 (en) 2013-10-17
AU2009282760A1 (en) 2010-02-25
ES2538123T3 (es) 2015-06-17
DK2334827T3 (da) 2015-06-15

Similar Documents

Publication Publication Date Title
AU2009282760B2 (en) Method for chromogenic detection of two or more target molecules in a single sample
US11740233B2 (en) Antibody-nanoparticle conjugates and methods for making and using such conjugates
AU2015207891B2 (en) Enhanced deposition of chromogens utilizing pyrimidine analogs
AU2023201682A1 (en) Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)