AU2009228354B2 - Human cardiovascular progenitor cells - Google Patents

Human cardiovascular progenitor cells Download PDF

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Publication number
AU2009228354B2
AU2009228354B2 AU2009228354A AU2009228354A AU2009228354B2 AU 2009228354 B2 AU2009228354 B2 AU 2009228354B2 AU 2009228354 A AU2009228354 A AU 2009228354A AU 2009228354 A AU2009228354 A AU 2009228354A AU 2009228354 B2 AU2009228354 B2 AU 2009228354B2
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cells
population
human
progenitor cells
cardiomyocytes
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AU2009228354A
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AU2009228354A1 (en
Inventor
Steven Kattman
Gordon Keller
Lei Yang
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Icahn School of Medicine at Mount Sinai
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Mount Sinai School of Medicine
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/165—Vascular endothelial growth factor [VEGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AU2009228354A 2008-03-27 2009-03-25 Human cardiovascular progenitor cells Active AU2009228354B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4004908P 2008-03-27 2008-03-27
US61/040,049 2008-03-27
PCT/US2009/038220 WO2009120762A2 (en) 2008-03-27 2009-03-25 Human cardiovascular progenitor cells

Publications (2)

Publication Number Publication Date
AU2009228354A1 AU2009228354A1 (en) 2009-10-01
AU2009228354B2 true AU2009228354B2 (en) 2015-01-22

Family

ID=41114664

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009228354A Active AU2009228354B2 (en) 2008-03-27 2009-03-25 Human cardiovascular progenitor cells

Country Status (8)

Country Link
US (2) US10077428B2 (cg-RX-API-DMAC7.html)
EP (1) EP2273996B8 (cg-RX-API-DMAC7.html)
JP (1) JP5801187B2 (cg-RX-API-DMAC7.html)
AU (1) AU2009228354B2 (cg-RX-API-DMAC7.html)
CA (1) CA2717962C (cg-RX-API-DMAC7.html)
DK (1) DK2273996T3 (cg-RX-API-DMAC7.html)
IL (2) IL208334A (cg-RX-API-DMAC7.html)
WO (1) WO2009120762A2 (cg-RX-API-DMAC7.html)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103627671A (zh) * 2007-01-30 2014-03-12 佐治亚大学研究基金会 产生中内胚层细胞及多能游走细胞的方法与细胞群及用途
AU2010315712B2 (en) 2009-10-19 2014-04-17 FUJIFILM Cellular Dynamics, Inc. Cardiomyocyte production
AU2010343137B2 (en) * 2009-12-29 2017-08-03 Cornell University Methods for developing endothelial cells from pluripotent cells and endothelial cells derived
WO2011091945A1 (en) * 2010-01-26 2011-08-04 Université Libre de Bruxelles Tools for isolating and following cardiovascular progenitor cells
AU2010355614B2 (en) 2010-06-13 2015-07-02 Institute Of Biophysics, Chinese Academy Of Sciences Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof
US9181529B2 (en) 2010-10-19 2015-11-10 Cellular Dynamics International, Inc. Titration of differentiation medium components
US20140045265A1 (en) * 2011-02-16 2014-02-13 Salk Institute For Biological Studies Robust and efficient differentiation of human pluripotent stem cells to multipotent vascular progenitors
US9487752B2 (en) 2011-03-30 2016-11-08 Cellular Dynamics International, Inc. Priming of pluripotent stem cells for neural differentiation
GB201109882D0 (en) * 2011-06-13 2011-07-27 Cambridge Entpr Ltd Population of smooth muscle cells of specific embryonic lineages
GB201121101D0 (en) * 2011-12-08 2012-01-18 Nhs Blood & Transplant A method of preparing isolated cells and uses
WO2013137491A1 (ja) * 2012-03-15 2013-09-19 国立大学法人京都大学 人工多能性幹細胞から心筋および血管系混合細胞群を製造する方法
US11339371B2 (en) * 2012-07-23 2022-05-24 Institute Of Biophysics, Chinese Academy Of Sciences Method for inducing pluripotent stem cells to differentiate into ventricular myocytes in vitro
JP5842289B2 (ja) * 2013-05-31 2016-01-13 ｉＨｅａｒｔ Ｊａｐａｎ株式会社 効率的な内皮細胞の誘導方法
US10961531B2 (en) 2013-06-05 2021-03-30 Agex Therapeutics, Inc. Compositions and methods for induced tissue regeneration in mammalian species
JP6981751B2 (ja) * 2013-09-13 2021-12-17 ユニバーシティー ヘルス ネットワーク 心外膜細胞を形成するための方法及び組成物
US11078462B2 (en) 2014-02-18 2021-08-03 ReCyte Therapeutics, Inc. Perivascular stromal cells from primate pluripotent stem cells
US10240127B2 (en) 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
GB201412554D0 (en) * 2014-07-15 2014-08-27 Cambridge Entpr Ltd In vitro mesodermal differentiation
HK1248270A1 (zh) 2015-02-17 2018-10-12 大学健康网路 制备和使用窦房结样起搏器心肌细胞和心室样心肌细胞的方法
AU2016366158B2 (en) 2015-12-07 2023-02-23 Agex Therapeutics, Inc. Methods for the re-derivation of diverse pluripotent stem cell-derived brown fat cells
US10612002B2 (en) 2016-02-19 2020-04-07 University Of Washington Human pluripotent stem cell derived endocardial endothelium
WO2017147381A1 (en) * 2016-02-25 2017-08-31 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Generation of expandable cardiovascular progenitor cells
AU2021269237A1 (en) * 2020-05-08 2022-12-08 University Health Network Methods and compositions for making and using endocardial cells
CN119384700A (zh) 2022-04-15 2025-01-28 艾斯本神经科学公司 细胞分化状态的分类方法和分化细胞的相关组合物

Citations (1)

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Publication number Priority date Publication date Assignee Title
US20050214939A1 (en) * 2004-03-26 2005-09-29 Gold Joseph D Direct differentiation method for making cardiomyocytes from human emberyonic stem cells

Family Cites Families (10)

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US5874301A (en) 1994-11-21 1999-02-23 National Jewish Center For Immunology And Respiratory Medicine Embryonic cell populations and methods to isolate such populations
US5919449A (en) 1995-05-30 1999-07-06 Diacrin, Inc. Porcine cardiomyocytes and their use in treatment of insufficient cardiac function
US20050021439A1 (en) 1999-04-09 2005-01-27 Pinga Louis J. Arcade casino and home investment system
US7425448B2 (en) 2001-07-12 2008-09-16 Geron Corporation Cardiomyocyte precursors from human embryonic stem cells
US20030082153A1 (en) * 2001-10-22 2003-05-01 The Government Of The United States Of America Stem cells that transform to beating cardiomyocytes
US20060003446A1 (en) 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
WO2004094610A2 (en) 2003-04-21 2004-11-04 Baylor College Of Medicine Wnt as a factor for cardiac myogenesis
US20050214938A1 (en) * 2004-03-26 2005-09-29 Gold Joseph D Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function
CN101228264B (zh) 2005-06-22 2017-12-26 阿斯特利亚斯生物治疗股份公司 使灵长类多能干细胞分化成心肌细胞系细胞
WO2007002358A1 (en) 2005-06-23 2007-01-04 Mount Sinai School Of Medicine Of New York University Cardiomyocyte cell populations

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050214939A1 (en) * 2004-03-26 2005-09-29 Gold Joseph D Direct differentiation method for making cardiomyocytes from human emberyonic stem cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Kattman SJ et al. Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages. Dev Cell. 2006 Nov;11(5):723-32. *

Also Published As

Publication number Publication date
IL240870A0 (en) 2015-10-29
EP2273996A2 (en) 2011-01-19
US20180362931A1 (en) 2018-12-20
WO2009120762A3 (en) 2009-12-30
JP5801187B2 (ja) 2015-10-28
EP2273996A4 (en) 2012-02-15
CA2717962C (en) 2019-05-14
IL240870B (en) 2019-08-29
WO2009120762A2 (en) 2009-10-01
AU2009228354A1 (en) 2009-10-01
US10077428B2 (en) 2018-09-18
CA2717962A1 (en) 2009-10-01
JP2011517563A (ja) 2011-06-16
US10947506B2 (en) 2021-03-16
IL208334A0 (en) 2010-12-30
EP2273996B8 (en) 2017-04-26
DK2273996T3 (en) 2017-03-27
EP2273996B1 (en) 2017-02-22
US20090269314A1 (en) 2009-10-29
IL208334A (en) 2015-09-24

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