IL208334A - Methods for Creating Human Cardiovascular Origin Cells of Cardiomyocytes, Endothelial Cells, and Vascular Muscle Cells - Google Patents

Methods for Creating Human Cardiovascular Origin Cells of Cardiomyocytes, Endothelial Cells, and Vascular Muscle Cells

Info

Publication number
IL208334A
IL208334A IL208334A IL20833410A IL208334A IL 208334 A IL208334 A IL 208334A IL 208334 A IL208334 A IL 208334A IL 20833410 A IL20833410 A IL 20833410A IL 208334 A IL208334 A IL 208334A
Authority
IL
Israel
Prior art keywords
cells
cardiomyocytes
methods
smooth muscle
vascular smooth
Prior art date
Application number
IL208334A
Other languages
English (en)
Hebrew (he)
Other versions
IL208334A0 (en
Inventor
Gordon Keller
Lei Yang
Steven Kattman
Original Assignee
Icahn School Med Mount Sinai
Gordon Keller
Lei Yang
Steven Kattman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icahn School Med Mount Sinai, Gordon Keller, Lei Yang, Steven Kattman filed Critical Icahn School Med Mount Sinai
Publication of IL208334A0 publication Critical patent/IL208334A0/en
Publication of IL208334A publication Critical patent/IL208334A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/165—Vascular endothelial growth factor [VEGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IL208334A 2008-03-27 2010-09-21 Methods for Creating Human Cardiovascular Origin Cells of Cardiomyocytes, Endothelial Cells, and Vascular Muscle Cells IL208334A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4004908P 2008-03-27 2008-03-27
PCT/US2009/038220 WO2009120762A2 (en) 2008-03-27 2009-03-25 Human cardiovascular progenitor cells

Publications (2)

Publication Number Publication Date
IL208334A0 IL208334A0 (en) 2010-12-30
IL208334A true IL208334A (en) 2015-09-24

Family

ID=41114664

Family Applications (2)

Application Number Title Priority Date Filing Date
IL208334A IL208334A (en) 2008-03-27 2010-09-21 Methods for Creating Human Cardiovascular Origin Cells of Cardiomyocytes, Endothelial Cells, and Vascular Muscle Cells
IL240870A IL240870B (en) 2008-03-27 2015-08-27 Human cardiovascular progenitor cells

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL240870A IL240870B (en) 2008-03-27 2015-08-27 Human cardiovascular progenitor cells

Country Status (8)

Country Link
US (2) US10077428B2 (cg-RX-API-DMAC7.html)
EP (1) EP2273996B8 (cg-RX-API-DMAC7.html)
JP (1) JP5801187B2 (cg-RX-API-DMAC7.html)
AU (1) AU2009228354B2 (cg-RX-API-DMAC7.html)
CA (1) CA2717962C (cg-RX-API-DMAC7.html)
DK (1) DK2273996T3 (cg-RX-API-DMAC7.html)
IL (2) IL208334A (cg-RX-API-DMAC7.html)
WO (1) WO2009120762A2 (cg-RX-API-DMAC7.html)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101641436A (zh) * 2007-01-30 2010-02-03 佐治亚大学研究基金会 用于产生内胚层和中胚层细胞系及多能游走细胞（mmc）的早期中胚层细胞即稳定的中内胚层细胞群
EP4364797A3 (en) 2009-10-19 2024-07-10 FUJIFILM Cellular Dynamics, Inc. Cardiomyocyte production
US20120301443A1 (en) * 2009-12-29 2012-11-29 Cornell University Methods for developing endothelial cells from pluripotent cells and endothelial cells derived
WO2011091944A1 (en) * 2010-01-26 2011-08-04 Université Libre de Bruxelles Tools for isolating and following cardiovascular progenitor cells
JP2013531497A (ja) 2010-06-13 2013-08-08 インスティチュート・オブ・バイオフィジックス，チャイニーズ・アカデミー・オブ・サイエンシズ 幹細胞から心筋細胞を調製するための方法および組成物ならびにその使用
US9181529B2 (en) 2010-10-19 2015-11-10 Cellular Dynamics International, Inc. Titration of differentiation medium components
WO2012112776A2 (en) * 2011-02-16 2012-08-23 Salk Institute For Biological Studies Robust and efficient differentiation of human pluripotent stem cells to multipotent vascular progenitors
JP6185907B2 (ja) 2011-03-30 2017-08-23 セルラー ダイナミクス インターナショナル， インコーポレイテッド 神経分化のための多能性幹細胞の予備刺激
GB201109882D0 (en) * 2011-06-13 2011-07-27 Cambridge Entpr Ltd Population of smooth muscle cells of specific embryonic lineages
GB201121101D0 (en) * 2011-12-08 2012-01-18 Nhs Blood & Transplant A method of preparing isolated cells and uses
EP2826855B1 (en) * 2012-03-15 2018-08-29 iHeart Japan Corporation Myocardial sheet
CN104508121B (zh) * 2012-07-23 2018-01-19 中国科学院生物物理研究所 体外诱导多能干细胞分化为心室肌细胞的方法
JP5842289B2 (ja) * 2013-05-31 2016-01-13 ｉＨｅａｒｔ Ｊａｐａｎ株式会社 効率的な内皮細胞の誘導方法
CA2914615C (en) 2013-06-05 2023-10-17 Biotime, Inc. Compositions and methods for induced tissue regeneration in mammalian species
KR20160052726A (ko) 2013-09-13 2016-05-12 유니버시티 헬스 네트워크 심장외막 세포 생성을 위한 방법 및 조성물
US11078462B2 (en) 2014-02-18 2021-08-03 ReCyte Therapeutics, Inc. Perivascular stromal cells from primate pluripotent stem cells
US10240127B2 (en) 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
GB201412554D0 (en) * 2014-07-15 2014-08-27 Cambridge Entpr Ltd In vitro mesodermal differentiation
CA2976283C (en) 2015-02-17 2022-04-26 University Health Network Methods for making and using sinoatrial node-like pacemaker cardiomyocytes and ventricular-like cardiomyocytes
WO2017100313A1 (en) 2015-12-07 2017-06-15 Biotime, Inc. Methods for the re-derivation of diverse pluripotent stem cell-derive brown fat cells
US10612002B2 (en) 2016-02-19 2020-04-07 University Of Washington Human pluripotent stem cell derived endocardial endothelium
US20190017029A1 (en) * 2016-02-25 2019-01-17 The J. David Gladstone Institutes, a testament trust established under the Will of J. David Generation of Expandable Cardiovascular Progenitor Cells
AU2021269237A1 (en) * 2020-05-08 2022-12-08 University Health Network Methods and compositions for making and using endocardial cells
CN119384700A (zh) 2022-04-15 2025-01-28 艾斯本神经科学公司 细胞分化状态的分类方法和分化细胞的相关组合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874301A (en) 1994-11-21 1999-02-23 National Jewish Center For Immunology And Respiratory Medicine Embryonic cell populations and methods to isolate such populations
US5919449A (en) * 1995-05-30 1999-07-06 Diacrin, Inc. Porcine cardiomyocytes and their use in treatment of insufficient cardiac function
US20050021439A1 (en) * 1999-04-09 2005-01-27 Pinga Louis J. Arcade casino and home investment system
KR101073411B1 (ko) * 2001-07-12 2011-10-17 제론 코포레이션 인간 다분화능 줄기 세포로부터 제조된 심근 세포 계통의 세포
US20030082153A1 (en) 2001-10-22 2003-05-01 The Government Of The United States Of America Stem cells that transform to beating cardiomyocytes
US20060003446A1 (en) * 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
WO2004094610A2 (en) * 2003-04-21 2004-11-04 Baylor College Of Medicine Wnt as a factor for cardiac myogenesis
US7452718B2 (en) * 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
US20050214938A1 (en) * 2004-03-26 2005-09-29 Gold Joseph D Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function
KR20130099253A (ko) 2005-06-22 2013-09-05 제론 코포레이션 영장류 다능성 줄기 세포의 심근세포 계통 세포로의 분화
CA2620567A1 (en) * 2005-06-23 2007-01-04 Mount Sinai School Of Medicine Of New York University Cardiomyocyte cell populations

Also Published As

Publication number Publication date
AU2009228354B2 (en) 2015-01-22
CA2717962A1 (en) 2009-10-01
JP2011517563A (ja) 2011-06-16
WO2009120762A3 (en) 2009-12-30
EP2273996B8 (en) 2017-04-26
US10947506B2 (en) 2021-03-16
US20090269314A1 (en) 2009-10-29
US10077428B2 (en) 2018-09-18
IL240870B (en) 2019-08-29
DK2273996T3 (en) 2017-03-27
EP2273996A4 (en) 2012-02-15
WO2009120762A2 (en) 2009-10-01
IL240870A0 (en) 2015-10-29
EP2273996A2 (en) 2011-01-19
EP2273996B1 (en) 2017-02-22
AU2009228354A1 (en) 2009-10-01
CA2717962C (en) 2019-05-14
JP5801187B2 (ja) 2015-10-28
US20180362931A1 (en) 2018-12-20
IL208334A0 (en) 2010-12-30

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