AU2008299536B2 - Novel polysaccharide immunogens from clostridium difficile - Google Patents

Novel polysaccharide immunogens from clostridium difficile Download PDF

Info

Publication number
AU2008299536B2
AU2008299536B2 AU2008299536A AU2008299536A AU2008299536B2 AU 2008299536 B2 AU2008299536 B2 AU 2008299536B2 AU 2008299536 A AU2008299536 A AU 2008299536A AU 2008299536 A AU2008299536 A AU 2008299536A AU 2008299536 B2 AU2008299536 B2 AU 2008299536B2
Authority
AU
Australia
Prior art keywords
cell surface
subject
clostridium difficile
polysaccharide
surface polysaccharide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2008299536A
Other languages
English (en)
Other versions
AU2008299536A1 (en
Inventor
Jeyabarathy Ganeshapillai
Mario Artur Monteiro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Guelph
Original Assignee
University of Guelph
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Guelph filed Critical University of Guelph
Publication of AU2008299536A1 publication Critical patent/AU2008299536A1/en
Application granted granted Critical
Publication of AU2008299536B2 publication Critical patent/AU2008299536B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0066—Isolation or extraction of proteoglycans from organs
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AU2008299536A 2007-09-11 2008-09-11 Novel polysaccharide immunogens from clostridium difficile Active AU2008299536B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97141107P 2007-09-11 2007-09-11
US60/971,411 2007-09-11
PCT/CA2008/001593 WO2009033268A1 (en) 2007-09-11 2008-09-11 Novel polysaccharide immunogens from clostridium difficile

Publications (2)

Publication Number Publication Date
AU2008299536A1 AU2008299536A1 (en) 2009-03-19
AU2008299536B2 true AU2008299536B2 (en) 2014-06-12

Family

ID=40451511

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008299536A Active AU2008299536B2 (en) 2007-09-11 2008-09-11 Novel polysaccharide immunogens from clostridium difficile

Country Status (9)

Country Link
US (1) US8597663B2 (enExample)
EP (2) EP2674169B1 (enExample)
JP (1) JP5501969B2 (enExample)
CN (1) CN101896197B (enExample)
AU (1) AU2008299536B2 (enExample)
CA (2) CA2941174C (enExample)
ES (2) ES2528648T3 (enExample)
NZ (1) NZ583750A (enExample)
WO (1) WO2009033268A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008299536B2 (en) * 2007-09-11 2014-06-12 University Of Guelph Novel polysaccharide immunogens from clostridium difficile
EP2655389A2 (en) * 2010-12-24 2013-10-30 Novartis AG Compounds
CA2828374A1 (en) 2011-03-08 2012-09-13 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Oligosaccharides and oligosaccharide-protein conjugates derived from clostridium difficile polysaccharide ps-ii, methods of synthesis and uses thereof, in particular as a vaccine
EP2554549A1 (en) 2011-08-02 2013-02-06 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Oligosaccharides and oligosaccharides-protein conjugates derived from clostridium difficile polysaccharide PS-I, methods of synthesis and uses thereof, in particular as vaccines and diagnostic tools
US9815889B2 (en) 2011-08-02 2017-11-14 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Antibodies for prevention and treatment of diseases caused by clostridium difficile
WO2013071409A1 (en) 2011-11-18 2013-05-23 National Research Council Of Canada (Nrc) Clostridium difficile lipoteichoic acid and uses thereof
EP2872535A1 (en) 2012-07-16 2015-05-20 Pfizer Inc. Saccharides and uses thereof
ES2672045T3 (es) * 2014-07-25 2018-06-12 Biosynth S.R.L. Vacunas de productos glicoconjugados que comprenden unidades básicas de una construcción molecular que expresa múltiples epítopos incorporados para la formulación de una vacuna de amplio espectro contra infecciones debidas a bacterias enteropatógenas
CA3084847A1 (en) * 2017-12-19 2019-06-27 The Governors Of The University Of Alberta Clostridium perfringens surface glycans and uses thereof
US10933126B2 (en) 2018-05-03 2021-03-02 The Board Of Regents Of The University Of Oklahoma Clostridium difficile immunogenic compositions and methods of use
CN113329766A (zh) * 2018-11-16 2021-08-31 马特里瓦克斯公司 艰难梭菌多组分疫苗
US12187756B2 (en) 2018-11-22 2025-01-07 Idorsia Pharmaceuticals Ltd Stable vaccine against Clostridium difficile

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4673574A (en) 1981-08-31 1987-06-16 Anderson Porter W Immunogenic conjugates
CA1331443C (en) 1987-05-29 1994-08-16 Charlotte A. Kensil Saponin adjuvant
US5283185A (en) 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
US5562909A (en) 1993-07-12 1996-10-08 Massachusetts Institute Of Technology Phosphazene polyelectrolytes as immunoadjuvants
GB9326174D0 (en) 1993-12-22 1994-02-23 Biocine Sclavo Mucosal adjuvant
US20030072774A1 (en) 1994-06-10 2003-04-17 Diane M. Gajewczyk Proteinaceous adjuvants
US6019982A (en) 1994-08-26 2000-02-01 The Administrators Of The Tulane Educational Fund Mutant enterotoxin effective as a non-toxic oral adjuvant
FR2726764B1 (fr) 1994-11-14 1997-01-31 Pasteur Merieux Serums Vacc Adjuvant pour composition vaccinale
US6284884B1 (en) 1995-06-07 2001-09-04 North American Vaccine, Inc. Antigenic group B streptococcus type II and type III polysaccharide fragments having a 2,5-anhydro-D-mannose terminal structure and conjugate vaccine thereof
WO1999055715A2 (en) 1998-04-28 1999-11-04 Galenica Pharmaceuticals, Inc. Polysaccharide-antigen conjugates
GB0115176D0 (en) * 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
FI20011403A7 (fi) * 2001-06-29 2002-12-30 Carbion Oy Menetelmä ja koostumukset vatsan sairauksien hoitoon
US7541043B2 (en) * 2002-01-16 2009-06-02 The United States Of America As Represented By The Department Of Health And Human Services Vaccine for protection against Shigella sonnei disease
WO2007038122A2 (en) 2005-09-21 2007-04-05 The United States Of America As Represented By The Secretary Of The Navy Immunogenic capsule composition for use as a vaccine component against campylobacter jejuni
GB0713880D0 (en) * 2007-07-17 2007-08-29 Novartis Ag Conjugate purification
AU2008299536B2 (en) * 2007-09-11 2014-06-12 University Of Guelph Novel polysaccharide immunogens from clostridium difficile

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GANESHAPILLAI J ET AL: "Clostridium difficile cell-surface polysaccharides: Towards a carbohydrate-based vaccine", ABSTRACTS OF THE GENERAL MEETING OF THE AMERICAN SOCIETY FOR MICROBIOLOGY, THE SOCIETY, vol. 107, 2007, p 232 *
MACNAIR J E ET AL: 11 Alignment of absolute and relative molecular size specifications for a polyvalent pneumococcal polysaccharide vaccine (PNEUMOVAXR)23) 11, BIOLOGICALS, vol. 33, no. l, 2005 pp 49-58 *

Also Published As

Publication number Publication date
CN101896197B (zh) 2013-10-23
EP2674169B1 (en) 2015-01-28
US20100330125A1 (en) 2010-12-30
ES2534671T3 (es) 2015-04-27
CA2941174A1 (en) 2009-03-19
CN101896197A (zh) 2010-11-24
EP2674169A1 (en) 2013-12-18
EP2195018B1 (en) 2014-11-12
ES2528648T3 (es) 2015-02-11
EP2195018A1 (en) 2010-06-16
EP2195018A4 (en) 2011-01-12
CA2698157C (en) 2016-10-11
CA2698157A1 (en) 2009-03-19
CA2941174C (en) 2018-05-08
WO2009033268A1 (en) 2009-03-19
AU2008299536A1 (en) 2009-03-19
JP2010539256A (ja) 2010-12-16
US8597663B2 (en) 2013-12-03
JP5501969B2 (ja) 2014-05-28
NZ583750A (en) 2012-05-25

Similar Documents

Publication Publication Date Title
AU2008299536B2 (en) Novel polysaccharide immunogens from clostridium difficile
JP6771499B2 (ja) 新規の多糖及びその使用
CN115803087B (zh) 多价疫苗组合物及其用途
US20140378669A1 (en) Methods for conjugation of oligosaccharides or polysaccharides to protein carriers through oxime linkages via 3-deoxy-d-manno-octulsonic acid
EP4313135A1 (en) Production of e. coli o18 bioconjugates
WO2020010016A1 (en) Self-adjuvanted immunogenic conjugates
US11097000B2 (en) Klebsiella pneumoniae capsule polysaccharide vaccines
US20150322176A1 (en) Novel polysaccharide immunogens from clostridium bolteae isolated from autistic subjects and methods and uses thereof
EP1747262B1 (en) Conserved inner core lipopolysaccharide epitopes as multi-species vaccine candidates
CN101014698A (zh) 作为多种疫苗候选物的保守性内核脂多糖表位
HK1189508A (en) Polysaccharide immunogens from clostridium difficile
WO2009033269A1 (en) Novel polysaccharide immunogens from alloiococcus otitidis and synthesis of a glycoconjugate vaccine thereof
KR20070031936A (ko) 다종 백신 후보로서의 보존된 내부 코어 지질다당류에피토프
Donaldson Antimicrobial Carbohydrate Vaccines: Development of Burkholderia pseudomallei immunogens

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)