AU2008277251A1 - Diagnosis and treatment of varicocele and prostate disorders - Google Patents
Diagnosis and treatment of varicocele and prostate disorders Download PDFInfo
- Publication number
- AU2008277251A1 AU2008277251A1 AU2008277251A AU2008277251A AU2008277251A1 AU 2008277251 A1 AU2008277251 A1 AU 2008277251A1 AU 2008277251 A AU2008277251 A AU 2008277251A AU 2008277251 A AU2008277251 A AU 2008277251A AU 2008277251 A1 AU2008277251 A1 AU 2008277251A1
- Authority
- AU
- Australia
- Prior art keywords
- vein
- catheter
- wire
- prostate
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
- A61M25/007—Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1011—Multiple balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M29/00—Dilators with or without means for introducing media, e.g. remedies
- A61M29/02—Dilators made of swellable material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B18/24—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
- A61M2025/09175—Guide wires having specific characteristics at the distal tip
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
- A61M2025/09175—Guide wires having specific characteristics at the distal tip
- A61M2025/09183—Guide wires having specific characteristics at the distal tip having tools at the distal tip
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1052—Balloon catheters with special features or adapted for special applications for temporarily occluding a vessel for isolating a sector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1095—Balloon catheters with special features or adapted for special applications with perfusion means for enabling blood circulation while the balloon is in an inflated state or in a deflated state, e.g. permanent by-pass within catheter shaft
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/826,283 US20090018486A1 (en) | 2007-07-13 | 2007-07-13 | Diagnosis and treatment of vericocele and prostate disorders |
US11/826,283 | 2007-07-13 | ||
US6451108P | 2008-03-10 | 2008-03-10 | |
US61/064,511 | 2008-03-10 | ||
PCT/IL2008/000971 WO2009010962A2 (fr) | 2007-07-13 | 2008-07-13 | Diagnostic et traitement de la varicocèle et des troubles de la prostate |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2008277251A1 true AU2008277251A1 (en) | 2009-01-22 |
Family
ID=40260179
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2008277252A Abandoned AU2008277252A1 (en) | 2007-07-13 | 2008-07-13 | Methods and apparatuses for vascular and prostate treatment |
AU2008277251A Abandoned AU2008277251A1 (en) | 2007-07-13 | 2008-07-13 | Diagnosis and treatment of varicocele and prostate disorders |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2008277252A Abandoned AU2008277252A1 (en) | 2007-07-13 | 2008-07-13 | Methods and apparatuses for vascular and prostate treatment |
Country Status (6)
Country | Link |
---|---|
EP (2) | EP2170180A4 (fr) |
JP (1) | JP2010533052A (fr) |
CN (1) | CN101801289A (fr) |
AU (2) | AU2008277252A1 (fr) |
CA (3) | CA2693225A1 (fr) |
WO (3) | WO2009010963A2 (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1841368B1 (fr) * | 2005-01-25 | 2015-06-10 | Covidien LP | Structures pour l'occlusion permanente d'une structure anatomique creuse |
JP5982081B2 (ja) | 2010-03-06 | 2016-08-31 | エヌヒュージョン ヴァスキュラー システムズ、エルエルシー | 回収カテーテル・アセンブリ |
US9108029B2 (en) | 2012-05-21 | 2015-08-18 | Nfusion Vascular Systems, Llc | Recovery catheter assembly and method |
EP2858711B1 (fr) | 2012-06-06 | 2018-03-07 | Magenta Medical Ltd. | Valve rénale prothétique |
US10583231B2 (en) | 2013-03-13 | 2020-03-10 | Magenta Medical Ltd. | Blood pump |
US10039874B2 (en) | 2013-03-13 | 2018-08-07 | Magenta Medical Ltd. | Renal pump |
RU2525219C1 (ru) * | 2013-04-02 | 2014-08-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Тверская государственная медицинская академия" Министерства здравоохранения Российской Федерации | Способ ретроградной склеротерапии варикоцеле при брыжеечно-яичковых анастамозах |
US9764113B2 (en) | 2013-12-11 | 2017-09-19 | Magenta Medical Ltd | Curved catheter |
JP2017500144A (ja) * | 2013-12-27 | 2017-01-05 | レナルプロ・メディカル・インコーポレーテッドRenalpro Medical,Inc. | 急性腎障害の治療用デバイスと治療方法 |
RU2572553C1 (ru) * | 2014-08-01 | 2016-01-20 | Леонид Зиновьевич Вельшер | Способ лечения рака предстательной железы |
US11291824B2 (en) | 2015-05-18 | 2022-04-05 | Magenta Medical Ltd. | Blood pump |
JP6981967B2 (ja) | 2015-08-31 | 2021-12-17 | ジェンテュイティ・リミテッド・ライアビリティ・カンパニーGentuity, LLC | 撮像プローブおよびデリバリデバイスを含む撮像システム |
WO2018061002A1 (fr) | 2016-09-29 | 2018-04-05 | Magenta Medical Ltd. | Tube pour vaisseau sanguin |
CN115040776A (zh) | 2016-10-25 | 2022-09-13 | 马真塔医药有限公司 | 心室辅助装置 |
CA3039302A1 (fr) | 2016-11-23 | 2018-05-31 | Magenta Medical Ltd. | Pompes a sang |
JP7160935B2 (ja) | 2017-11-28 | 2022-10-25 | ジェンテュイティ・リミテッド・ライアビリティ・カンパニー | 撮像システム |
WO2019138350A2 (fr) | 2018-01-10 | 2019-07-18 | Magenta Medical Ltd | Dispositif d'assistance ventriculaire |
US10905808B2 (en) | 2018-01-10 | 2021-02-02 | Magenta Medical Ltd. | Drive cable for use with a blood pump |
CN108158654B (zh) * | 2018-01-12 | 2020-06-12 | 郑州大学第一附属医院 | 一种便携式磁感应定位导向装置及其方法 |
US10893927B2 (en) | 2018-03-29 | 2021-01-19 | Magenta Medical Ltd. | Inferior vena cava blood-flow implant |
CN113543836A (zh) | 2019-01-24 | 2021-10-22 | 马真塔医药有限公司 | 心室辅助装置 |
RU2729431C1 (ru) * | 2019-12-27 | 2020-08-06 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Тихоокеанский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ лапароскопического лечения варикоцеле |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4714460A (en) * | 1983-07-29 | 1987-12-22 | Reynaldo Calderon | Methods and systems for retrograde perfusion in the body for curing it of the disease or immume deficiency |
CH668192A5 (de) * | 1985-11-29 | 1988-12-15 | Schneider Medintag Ag | Katheter zur behandlung von verengten stellen, beispielsweise in einem blutgefaess. |
US4762128A (en) * | 1986-12-09 | 1988-08-09 | Advanced Surgical Intervention, Inc. | Method and apparatus for treating hypertrophy of the prostate gland |
DE68922497T2 (de) * | 1988-08-24 | 1995-09-14 | Marvin J Slepian | Endoluminale dichtung mit bisdegradierbaren polymeren. |
FR2639237B1 (fr) * | 1988-11-23 | 1997-10-31 | Boussignac Georges | Catheter destine a etre introduit dans un canal corporel |
CN2086610U (zh) * | 1991-03-05 | 1991-10-16 | 陆秉仁 | 双囊式前列腺尿道扩张装置 |
US5529574A (en) * | 1992-08-21 | 1996-06-25 | Frackelton; James P. | Method and apparatus for treatment of the prostate |
EP0793457B2 (fr) * | 1994-04-06 | 2006-04-12 | WILLIAM COOK EUROPE ApS | Dispositif medical destine a etre implante dans le systeme vasculaire d'un patient |
US5779673A (en) * | 1995-06-26 | 1998-07-14 | Focal, Inc. | Devices and methods for application of intraluminal photopolymerized gels |
US5780435A (en) * | 1995-12-15 | 1998-07-14 | Praecis Pharmaceuticals Incorporated | Methods for treating prostate cancer with LHRH-R antagonists |
US5989230A (en) * | 1996-01-11 | 1999-11-23 | Essex Technology, Inc. | Rotate to advance catheterization system |
US6200312B1 (en) * | 1997-09-11 | 2001-03-13 | Vnus Medical Technologies, Inc. | Expandable vein ligator catheter having multiple electrode leads |
US5947985A (en) * | 1997-11-12 | 1999-09-07 | Imran; Mir A. | Apparatus and method for cleaning diseased vein grafts |
US6319251B1 (en) * | 1998-09-24 | 2001-11-20 | Hosheng Tu | Medical device and methods for treating intravascular restenosis |
US6036689A (en) * | 1998-09-24 | 2000-03-14 | Tu; Lily Chen | Ablation device for treating atherosclerotic tissues |
US6673352B1 (en) * | 1999-09-14 | 2004-01-06 | The General Hospital Corporation | Use of Mullerian inhibiting substance for treating excess androgen states |
US6575932B1 (en) * | 1999-12-02 | 2003-06-10 | Ottawa Heart Institute | Adjustable multi-balloon local delivery device |
WO2001045572A1 (fr) * | 1999-12-22 | 2001-06-28 | Boston Scientific Limited | Catheter pour occlusion et irrigation endoluminale, et mode d'utilisation |
AUPQ641400A0 (en) * | 2000-03-23 | 2000-04-15 | Kleiner, Daniel E. | A device incorporating a hollow member for being positioned along a body cavity of a patient and method of positioning same |
US20050107738A1 (en) * | 2000-07-21 | 2005-05-19 | Slater Charles R. | Occludable intravascular catheter for drug delivery and method of using the same |
GB2369996B (en) * | 2000-12-18 | 2004-06-23 | S T D Pharmaceutical Products | Method and apparatus for producing an injectable foam |
US6710037B2 (en) * | 2001-05-01 | 2004-03-23 | Schering Corporation | Method of treating androgen-dependent disorders |
US7169161B2 (en) * | 2001-11-06 | 2007-01-30 | Possis Medical, Inc. | Guidewire having occlusive device and repeatably crimpable proximal end |
DE50309201D1 (de) * | 2002-03-09 | 2008-04-03 | Jens P Brodersen | Sklerosierungskatheter zur sklerosierung von blutgefässen insbesondere venen |
US20040180855A1 (en) * | 2003-02-19 | 2004-09-16 | Schumacher William A. | Methods of treating thrombosis with reduced risk of increased bleeding times |
US7077801B2 (en) * | 2003-02-19 | 2006-07-18 | Corlife Gbr | Methods and devices for improving cardiac output |
EP1527743B1 (fr) * | 2003-10-29 | 2009-07-29 | Celon AG Medical Instruments | Dispositif médical pour électrotomie |
US20050182342A1 (en) * | 2004-02-13 | 2005-08-18 | Medtronic, Inc. | Monitoring fluid flow in the gastrointestinal tract |
US7824408B2 (en) * | 2004-08-05 | 2010-11-02 | Tyco Healthcare Group, Lp | Methods and apparatus for coagulating and/or constricting hollow anatomical structures |
US20060079923A1 (en) * | 2004-08-09 | 2006-04-13 | Manik Chhabra | Aneurysm treatment using semi-compliant balloon |
WO2006023203A1 (fr) * | 2004-08-19 | 2006-03-02 | Vein Rx, Inc. | Catheter intravasculaire pouvant etre occlus et servant a administrer des medicaments et son procede d'utilisation |
WO2006026412A2 (fr) * | 2004-08-31 | 2006-03-09 | Vnus Medical Technologies, Inc. | Dispositif et composition pour occlusion permanente d'une structure anatomique creuse |
WO2006069098A1 (fr) * | 2004-12-22 | 2006-06-29 | Elan Pharma International Ltd. | Formulations de la bicalutamide nanoparticulaire |
EP1841368B1 (fr) * | 2005-01-25 | 2015-06-10 | Covidien LP | Structures pour l'occlusion permanente d'une structure anatomique creuse |
JP2008173137A (ja) * | 2005-03-03 | 2008-07-31 | Goodman Co Ltd | ダブルバルーンカテーテル |
US20060204588A1 (en) * | 2005-03-10 | 2006-09-14 | Elan Pharma International Limited | Formulations of a nanoparticulate finasteride, dutasteride or tamsulosin hydrochloride, and mixtures thereof |
-
2008
- 2008-07-13 WO PCT/IL2008/000972 patent/WO2009010963A2/fr active Application Filing
- 2008-07-13 AU AU2008277252A patent/AU2008277252A1/en not_active Abandoned
- 2008-07-13 AU AU2008277251A patent/AU2008277251A1/en not_active Abandoned
- 2008-07-13 EP EP08776607A patent/EP2170180A4/fr not_active Withdrawn
- 2008-07-13 EP EP08776606A patent/EP2178594A4/fr not_active Withdrawn
- 2008-07-13 CA CA2693225A patent/CA2693225A1/fr not_active Abandoned
- 2008-07-13 CA CA2693735A patent/CA2693735A1/fr not_active Abandoned
- 2008-07-13 CN CN200880106666A patent/CN101801289A/zh active Pending
- 2008-07-13 WO PCT/IL2008/000973 patent/WO2009010964A2/fr active Application Filing
- 2008-07-13 JP JP2010516646A patent/JP2010533052A/ja active Pending
- 2008-07-13 CA CA2693227A patent/CA2693227A1/fr not_active Abandoned
- 2008-07-13 WO PCT/IL2008/000971 patent/WO2009010962A2/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2009010963A2 (fr) | 2009-01-22 |
CN101801289A (zh) | 2010-08-11 |
EP2178594A4 (fr) | 2011-02-23 |
WO2009010964A3 (fr) | 2010-02-25 |
WO2009010963A3 (fr) | 2010-01-14 |
CA2693735A1 (fr) | 2009-01-22 |
AU2008277252A1 (en) | 2009-01-22 |
WO2009010964A2 (fr) | 2009-01-22 |
WO2009010962A3 (fr) | 2010-09-16 |
CA2693227A1 (fr) | 2009-01-22 |
EP2170180A4 (fr) | 2011-02-23 |
CA2693225A1 (fr) | 2009-01-22 |
WO2009010962A2 (fr) | 2009-01-22 |
JP2010533052A (ja) | 2010-10-21 |
EP2178594A2 (fr) | 2010-04-28 |
EP2170180A2 (fr) | 2010-04-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20090018486A1 (en) | Diagnosis and treatment of vericocele and prostate disorders | |
AU2008277251A1 (en) | Diagnosis and treatment of varicocele and prostate disorders | |
US20100286106A1 (en) | Methods and apparatus for treating the prostate | |
US7766961B2 (en) | Systems and methods for performing bi-lateral interventions or diagnosis in branched body lumens | |
DeWitt et al. | Interventional endoscopic ultrasound: current status and future directions | |
JP2006508776A (ja) | 腎臓内カテーテルを介する選択的物質送達のための方法および装置 | |
WO2009039017A1 (fr) | Procédé et appareil pour réaliser des interventions relatives à une maladie vasculaire périphérique utilisant un nouveau cathéter à ballonnet d'ancrage | |
Ascher et al. | Duplex-guided balloon angioplasty and stenting for femoropopliteal arterial occlusive disease: an alternative in patients with renal insufficiency | |
WO2004107965A2 (fr) | Systemes et procedes destines a realiser des interventions bilaterales ou un diagnostic dans des lumieres du corps ramifiees | |
Khashab et al. | Endoscopic ultrasonography as a therapeutic modality | |
Racadio et al. | Pediatric biliary interventions | |
Marshalleck | Pediatric arterial interventions | |
US20100204639A1 (en) | Diagnosis and treatment of varicocele and prostate disorders | |
Mitsuyama et al. | Internal biliary drainage using double‐balloon endoscopy in a patient with complete obstruction of the hepaticojejunostomy site. | |
IL203271A (en) | Prostate Treatment System | |
Ehrlich et al. | Division of prostatic anterior fibromuscular stroma reduces urethral resistance in an ex vivo human prostate model | |
Navuluri et al. | Imaging and radiologic intervention in the biliary tract | |
Shoji et al. | Percutaneous Closure Based on Physiological Assessment of an Arteriovenous Fistula in a Patient With Chronic Limb Threatening Ischaemia | |
Alexander et al. | Management of pancreaticobiliary disease: endoscopic retrograde cholangiopancreatography (ERCP) | |
Matsubara et al. | Interventional EUS for pancreatic cancer and cholangiocarcinoma | |
EP4106853A2 (fr) | Cathéter à ballonnet d'ancrage pouvant être dévié pour procédures vasculaires | |
Ahuja et al. | Transazygous hemodialysis access in nutcracker syndrome | |
US20150223880A1 (en) | Method for the treatment of benign prostatic hyperplasia | |
Alexander et al. | Management of Pancreatico | |
Cosgrove et al. | Endoscopic Drainage of Pancreatic Fluid Collections |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |