AU2008240243A1 - Method and apparatus for noninvasive quantitative detection of fibrosis in the heart - Google Patents

Method and apparatus for noninvasive quantitative detection of fibrosis in the heart Download PDF

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Publication number
AU2008240243A1
AU2008240243A1 AU2008240243A AU2008240243A AU2008240243A1 AU 2008240243 A1 AU2008240243 A1 AU 2008240243A1 AU 2008240243 A AU2008240243 A AU 2008240243A AU 2008240243 A AU2008240243 A AU 2008240243A AU 2008240243 A1 AU2008240243 A1 AU 2008240243A1
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AU
Australia
Prior art keywords
sample
fibrosis
extracellular
contrast agent
heart
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2008240243A
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English (en)
Inventor
Sumeet S. Chugh
Michael Jerosch-Herold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oregon Health & Science University
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Oregon Health & Science University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oregon Health & Science University filed Critical Oregon Health & Science University
Publication of AU2008240243A1 publication Critical patent/AU2008240243A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A61B5/0035—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A61B5/004—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0044—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A61B5/0263—Measuring blood flow using NMR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A61B5/0275—Measuring blood flow using tracers, e.g. dye dilution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/503—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/504—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of blood vessels, e.g. by angiography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/281—Means for the use of in vitro contrast agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5602—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution by filtering or weighting based on different relaxation times within the sample, e.g. T1 weighting using an inversion pulse
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10072—Tomographic images
    • G06T2207/10076—4D tomography; Time-sequential 3D tomography
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10072—Tomographic images
    • G06T2207/10088—Magnetic resonance imaging [MRI]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30048—Heart; Cardiac

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Epidemiology (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Quality & Reliability (AREA)
  • Optics & Photonics (AREA)
  • Cardiology (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2008240243A 2007-04-11 2008-04-11 Method and apparatus for noninvasive quantitative detection of fibrosis in the heart Abandoned AU2008240243A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91111007P 2007-04-11 2007-04-11
US60/911,110 2007-04-11
PCT/US2008/060020 WO2008128033A1 (en) 2007-04-11 2008-04-11 Method and apparatus for noninvasive quantitative detection of fibrosis in the heart

Publications (1)

Publication Number Publication Date
AU2008240243A1 true AU2008240243A1 (en) 2008-10-23

Family

ID=39864327

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008240243A Abandoned AU2008240243A1 (en) 2007-04-11 2008-04-11 Method and apparatus for noninvasive quantitative detection of fibrosis in the heart

Country Status (7)

Country Link
US (2) US20100129292A1 (enExample)
EP (1) EP2144554A1 (enExample)
JP (1) JP5242672B2 (enExample)
KR (1) KR20100027101A (enExample)
AU (1) AU2008240243A1 (enExample)
CA (1) CA2720858A1 (enExample)
WO (1) WO2008128033A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008128033A1 (en) 2007-04-11 2008-10-23 Oregon Health & Science University Method and apparatus for noninvasive quantitative detection of fibrosis in the heart
WO2011088513A1 (en) * 2010-01-20 2011-07-28 Equilibrium Imaging Limited A method for measuring interstitial volume in organs and tissues
EP2760337A2 (en) * 2011-09-26 2014-08-06 Acuitas Medical Limited Method for detection of characteristics of organ fibrosis
US10307076B2 (en) 2015-01-30 2019-06-04 Sunnybrook Research Institute System and method for detection of collagen using magnetic resonance imaging
EP3325992B1 (en) * 2015-07-24 2026-01-28 Northeastern University Quantitative magnetic resonance imaging of the vasculature
EP3370617A4 (en) 2015-11-06 2019-08-07 Washington University in St. Louis NON-INVASIVE ILLUSTRATION AND TREATMENT SYSTEM FOR CARDIAC ERRORS
CA3125548A1 (en) 2019-01-03 2020-07-09 Northeastern University Quantitative measurement of disruptions in the blood brain barrier
US12642433B2 (en) 2019-01-25 2026-06-02 Northeastern University Quantitative measurement of the perivascular space for CNS and brain disorders
KR102382199B1 (ko) * 2019-06-27 2022-04-05 고려대학교 산학협력단 인공 기준 지표를 활용한 자기 공명 영상의 처리 장치 및 방법
EP4069076A4 (en) * 2019-12-05 2023-12-27 Gupta, Arbind Kumar QUANTIFICATION AND VISUALIZATION OF CARDIAC MUSCLE FIBROSIS OF THE HUMAN HEART

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3938992A1 (de) * 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
GB9314499D0 (en) * 1993-07-12 1993-08-25 Nycomed Imaging As Method
AU8227398A (en) * 1997-07-01 1999-01-25 Nycomed Imaging As Method
US6205349B1 (en) * 1998-09-29 2001-03-20 Siemens Medical Systems, Inc. Differentiating normal living myocardial tissue, injured living myocardial tissue, and infarcted myocardial tissue in vivo using magnetic resonance imaging
US6526307B2 (en) * 2000-12-29 2003-02-25 Ge Medical Systems Global Technology Co., Llc Method and apparatus to improve myocardial infarction detection with blood pool signal suppression
CA2433657A1 (en) * 2001-01-05 2002-07-11 Duke University Contrast enhancement agent for magnetic resonance imaging
DE60232734D1 (de) * 2001-09-20 2009-08-06 Medi Physics Inc Verwendung von polarisiertem 129Xe zur Herstellung eines Medikaments zur Verwendung in einem in-vivo-NMR-Verfahren
DE10200371B4 (de) * 2002-01-08 2009-10-15 Siemens Ag Verfahren zur Durchführung einer dynamischen Magnetresonanz Messung unter Anwendung von Kontrastmittel
CA2523623A1 (en) * 2002-11-29 2004-07-22 Bracco Imaging, S.P.A. Method and system for scaling control in 3d displays
US7966056B2 (en) * 2002-12-16 2011-06-21 Ge Healthcare As Magnetic resonance imaging method and compounds for use in the method
AR047692A1 (es) * 2003-07-10 2006-02-08 Epix Medical Inc Imagenes de blancos estacionarios
WO2005050563A2 (en) * 2003-11-17 2005-06-02 Aureon Biosciences Corporation Pathological tissue mapping
JP5231736B2 (ja) * 2004-02-06 2013-07-10 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ 非侵襲的イメージングのグローバル組織特性を用いた組織評価および画像のグローバル組織特性を決定するシステム
US7766891B2 (en) * 2004-07-08 2010-08-03 Pneumrx, Inc. Lung device with sealing features
US20070014784A1 (en) * 2005-06-23 2007-01-18 Medtronic Vascular, Inc. Methods and Systems for Treating Injured Cardiac Tissue
WO2008128033A1 (en) 2007-04-11 2008-10-23 Oregon Health & Science University Method and apparatus for noninvasive quantitative detection of fibrosis in the heart

Also Published As

Publication number Publication date
CA2720858A1 (en) 2008-10-23
KR20100027101A (ko) 2010-03-10
US20130267828A1 (en) 2013-10-10
US20100129292A1 (en) 2010-05-27
US10076246B2 (en) 2018-09-18
EP2144554A1 (en) 2010-01-20
JP2010523287A (ja) 2010-07-15
JP5242672B2 (ja) 2013-07-24
WO2008128033A1 (en) 2008-10-23

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