AU2007284851B2 - Crystalline antifungal compounds - Google Patents

Crystalline antifungal compounds Download PDF

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Publication number
AU2007284851B2
AU2007284851B2 AU2007284851A AU2007284851A AU2007284851B2 AU 2007284851 B2 AU2007284851 B2 AU 2007284851B2 AU 2007284851 A AU2007284851 A AU 2007284851A AU 2007284851 A AU2007284851 A AU 2007284851A AU 2007284851 B2 AU2007284851 B2 AU 2007284851B2
Authority
AU
Australia
Prior art keywords
chloro
difluorophenyl
hydroxy
methyl
triazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007284851A
Other languages
English (en)
Other versions
AU2007284851A1 (en
Inventor
Elies Molins Grau
Keith Lorimer
Kevin Meyer
Javier Bartroli Orpi
Antonio Canovas Paredes
Anna Roig Serra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Palau Pharma SA
Original Assignee
Palau Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39082545&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2007284851(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP06380225A external-priority patent/EP1887004A1/en
Priority claimed from EP07380186A external-priority patent/EP2009009A1/en
Application filed by Palau Pharma SA filed Critical Palau Pharma SA
Publication of AU2007284851A1 publication Critical patent/AU2007284851A1/en
Assigned to PALAU PHARMA, S.A. reassignment PALAU PHARMA, S.A. Request for Assignment Assignors: PALAU PHARMA, S.A., STIEFEL LABORATORIES, INC.
Application granted granted Critical
Publication of AU2007284851B2 publication Critical patent/AU2007284851B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2007284851A 2006-08-07 2007-08-06 Crystalline antifungal compounds Ceased AU2007284851B2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US83586306P 2006-08-07 2006-08-07
EP06380225A EP1887004A1 (en) 2006-08-07 2006-08-07 Crystalline forms of (1R,2R)-7-Chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one
US60/835,863 2006-08-07
EP06380225.0 2006-08-07
US92940807P 2007-06-26 2007-06-26
US60/929,408 2007-06-26
EP07380186.2 2007-06-26
EP07380186A EP2009009A1 (en) 2007-06-26 2007-06-26 Crystalline antifungal compounds
PCT/US2007/017476 WO2008021049A2 (en) 2006-08-07 2007-08-06 Crystalline antifungal compounds

Publications (2)

Publication Number Publication Date
AU2007284851A1 AU2007284851A1 (en) 2008-02-21
AU2007284851B2 true AU2007284851B2 (en) 2013-05-09

Family

ID=39082545

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007284851A Ceased AU2007284851B2 (en) 2006-08-07 2007-08-06 Crystalline antifungal compounds

Country Status (17)

Country Link
US (2) US7879867B2 (cg-RX-API-DMAC10.html)
EP (2) EP2049504A4 (cg-RX-API-DMAC10.html)
JP (3) JP2010513222A (cg-RX-API-DMAC10.html)
KR (1) KR20090053903A (cg-RX-API-DMAC10.html)
CN (1) CN103232442B (cg-RX-API-DMAC10.html)
AR (1) AR062232A1 (cg-RX-API-DMAC10.html)
AU (1) AU2007284851B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0716026A2 (cg-RX-API-DMAC10.html)
CA (1) CA2658843A1 (cg-RX-API-DMAC10.html)
DK (1) DK2650291T3 (cg-RX-API-DMAC10.html)
ES (1) ES2652670T3 (cg-RX-API-DMAC10.html)
IL (2) IL196722A (cg-RX-API-DMAC10.html)
IN (1) IN2014MN01560A (cg-RX-API-DMAC10.html)
MX (1) MX2009001208A (cg-RX-API-DMAC10.html)
RU (1) RU2500679C2 (cg-RX-API-DMAC10.html)
TW (1) TWI426073B (cg-RX-API-DMAC10.html)
WO (1) WO2008021049A2 (cg-RX-API-DMAC10.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006018853A2 (en) 2004-08-19 2006-02-23 Hetero Drugs Limited Novel polymorphs of efavirenz
TWI363058B (en) * 2006-04-05 2012-05-01 Opko Health Inc Hydrochloride salts of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and preparation process therefor
ITMI20062449A1 (it) * 2006-12-19 2008-06-20 Dipharma Spa Forma cristallina di rabeprazolo sodico
AU2010254064B2 (en) * 2009-05-29 2015-01-22 Palau Pharma, S.L.U Azole antifungal compositions
KR20120079054A (ko) * 2009-07-10 2012-07-11 에볼바 아게 디인 조성물
EP2464230B1 (en) * 2009-08-14 2016-10-05 OPKO Health, Inc. Intravenous formulations of rolapitant
US9435692B2 (en) 2014-02-05 2016-09-06 Lam Research Corporation Calculating power input to an array of thermal control elements to achieve a two-dimensional temperature output
US11039620B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11039621B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US9622483B2 (en) 2014-02-19 2017-04-18 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
GB201410407D0 (en) * 2014-06-11 2014-07-23 Univ Dundee And Syngene Internat Ltd Plc And Consejo Superior De Investigaciones Cientificas And Med Treatment of chagas disease
EA025187B1 (ru) * 2015-04-17 2016-11-30 Тагир Аббасели оглы Сулейманов Производное дитиокарбамата 2-((4-(4-метилпиперазин-1-ил)фенил)амино)-2-оксоетил4-этилпиперазин-1-карбодитиоат, обладающее антифунгальной активностью
CN118695852A (zh) 2021-12-22 2024-09-24 帕劳制药有限公司 多颗粒阿巴康唑组合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997005130A1 (en) * 1995-08-02 1997-02-13 J. Uriach & Cia. S.A. New pyrimidone derivatives with antifungal activity

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0293500A1 (en) 1987-06-01 1988-12-07 American Cyanamid Company 3-heteroalkyl-2,4.quinzaoline-diones
GB8819308D0 (en) 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
TW218017B (cg-RX-API-DMAC10.html) 1992-04-28 1993-12-21 Takeda Pharm Industry Co Ltd
TW297813B (cg-RX-API-DMAC10.html) * 1993-09-24 1997-02-11 Takeda Pharm Industry Co Ltd
CA2134417A1 (en) * 1993-12-22 1995-06-23 Katsumi Itoh Optically active azole derivatives, their production and use
WO1998039305A1 (en) * 1997-03-05 1998-09-11 Takeda Chemical Industries, Ltd. Crystalline form of a bis 1,2,4-triazole compound
ES2159488B1 (es) * 2000-03-07 2002-04-16 Uriach & Cia Sa J Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997005130A1 (en) * 1995-08-02 1997-02-13 J. Uriach & Cia. S.A. New pyrimidone derivatives with antifungal activity
US5807854A (en) * 1995-08-02 1998-09-15 J. Uriah & Cia. S.A. Pyrimidone derivatives with antifungal activity

Also Published As

Publication number Publication date
AU2007284851A1 (en) 2008-02-21
US7879867B2 (en) 2011-02-01
JP2010513222A (ja) 2010-04-30
TWI426073B (zh) 2014-02-11
US20110092702A1 (en) 2011-04-21
EP2650291A1 (en) 2013-10-16
RU2500679C2 (ru) 2013-12-10
IL196722A (en) 2016-10-31
CA2658843A1 (en) 2008-02-21
WO2008021049A2 (en) 2008-02-21
EP2049504A4 (en) 2010-09-22
EP2650291B1 (en) 2017-10-04
AR062232A1 (es) 2008-10-22
JP2014012673A (ja) 2014-01-23
IL248216B (en) 2018-03-29
WO2008021049A9 (en) 2008-10-30
EP2049504A2 (en) 2009-04-22
TW200823197A (en) 2008-06-01
RU2009104959A (ru) 2010-08-20
IN2014MN01560A (cg-RX-API-DMAC10.html) 2015-05-08
WO2008021049A3 (en) 2008-12-31
IL196722A0 (en) 2009-11-18
ES2652670T3 (es) 2018-02-05
US8258296B2 (en) 2012-09-04
DK2650291T3 (en) 2017-10-23
MX2009001208A (es) 2009-04-14
KR20090053903A (ko) 2009-05-28
CN103232442A (zh) 2013-08-07
CN103232442B (zh) 2015-01-21
US20080076787A1 (en) 2008-03-27
BRPI0716026A2 (pt) 2013-08-06
JP2015193642A (ja) 2015-11-05

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Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: PALAU PHARMA, S.A.

Free format text: FORMER APPLICANT(S): STIEFEL LABORATORIES, INC. ; PALAU PHARMA, S.A.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired