AU2007226878A1 - A novel method of protecting islet cells from apoptosis during the donor harvesting process - Google Patents

A novel method of protecting islet cells from apoptosis during the donor harvesting process Download PDF

Info

Publication number
AU2007226878A1
AU2007226878A1 AU2007226878A AU2007226878A AU2007226878A1 AU 2007226878 A1 AU2007226878 A1 AU 2007226878A1 AU 2007226878 A AU2007226878 A AU 2007226878A AU 2007226878 A AU2007226878 A AU 2007226878A AU 2007226878 A1 AU2007226878 A1 AU 2007226878A1
Authority
AU
Australia
Prior art keywords
sirna
eif5a
islet cells
islet
apoptosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2007226878A
Other languages
English (en)
Inventor
Charles A. Dinarello
John E. Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eloxx Pharmaceuticals Inc
Original Assignee
Senesco Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senesco Technologies Inc filed Critical Senesco Technologies Inc
Publication of AU2007226878A1 publication Critical patent/AU2007226878A1/en
Priority to AU2013273798A priority Critical patent/AU2013273798A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2007226878A 2006-03-20 2007-03-20 A novel method of protecting islet cells from apoptosis during the donor harvesting process Abandoned AU2007226878A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013273798A AU2013273798A1 (en) 2006-03-20 2013-12-20 A novel method of protecting islet cells from apoptosis during the donor harvesting process

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78341406P 2006-03-20 2006-03-20
US60/783,414 2006-03-20
PCT/US2007/064424 WO2007109677A2 (fr) 2006-03-20 2007-03-20 Nouvelle méthode pour la protection d'îlots de langerhans de l'apoptose au cours du processus de prélèvement chez un donneur

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2013273798A Division AU2013273798A1 (en) 2006-03-20 2013-12-20 A novel method of protecting islet cells from apoptosis during the donor harvesting process

Publications (1)

Publication Number Publication Date
AU2007226878A1 true AU2007226878A1 (en) 2007-09-27

Family

ID=39680975

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007226878A Abandoned AU2007226878A1 (en) 2006-03-20 2007-03-20 A novel method of protecting islet cells from apoptosis during the donor harvesting process

Country Status (7)

Country Link
EP (1) EP1996707A2 (fr)
JP (1) JP5543774B2 (fr)
AR (1) AR060785A1 (fr)
AU (1) AU2007226878A1 (fr)
CA (1) CA2637137A1 (fr)
IL (1) IL192388A0 (fr)
WO (1) WO2007109677A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2195429A2 (fr) * 2007-08-20 2010-06-16 Senesco Technologies, Inc. Utilisation de l'arnsi eif-5a1 pour protéger des îlots de langerhans de l'apoptose et pour conserver leur fonctionnalité

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7166467B2 (en) * 2001-07-23 2007-01-23 Senesco Technologies, Inc. Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis
NZ542665A (en) * 2003-03-05 2008-05-30 Senesco Technologies Inc Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1
WO2005007853A2 (fr) * 2003-06-06 2005-01-27 Senesco Technologies, Inc. Inhibition d'eif-5a specifique de l'apoptose ('eif-5a1') au moyen d'oligonucleotides antisens et de petits arn interferents utilises comme agents therapeutiques anti-inflammatoires

Also Published As

Publication number Publication date
EP1996707A2 (fr) 2008-12-03
AR060785A1 (es) 2008-07-10
CA2637137A1 (fr) 2007-09-27
JP5543774B2 (ja) 2014-07-09
WO2007109677A3 (fr) 2008-04-24
WO2007109677A2 (fr) 2007-09-27
JP2009530418A (ja) 2009-08-27
IL192388A0 (en) 2008-12-29

Similar Documents

Publication Publication Date Title
Guay et al. Emerging roles of non‐coding RNAs in pancreatic β‐cell function and dysfunction
KR20090098818A (ko) 근육병 및 심혈관병 치료를 위한 조성물 및 방법
Balamurugan et al. Harmful delayed effects of exogenous isolation enzymes on isolated human islets: relevance to clinical transplantation
US10568913B2 (en) Method for generating mature β-like cells
Luo et al. LncRNA-H19 acts as a ceRNA to regulate HE4 expression by sponging miR-140 in human umbilical vein endothelial cells under hyperglycemia with or without α-Mangostin
CN114432452A (zh) RNA Hsa_circ_0063865抑制剂在制备抗食管鳞状细胞癌药物中的应用
CN114191554A (zh) 抑制tert表达的试剂在制备预防或治疗胸主动脉瘤的药物中的应用
CN110157708B (zh) 一种抑制人脑胶质瘤的靶向linc01023基因的抑制剂及其应用
AU2007226878A1 (en) A novel method of protecting islet cells from apoptosis during the donor harvesting process
US20090093434A1 (en) Use of eif-5a1 sirna to protect islets cells from apoptosis and to preserve their functionality
US20080076728A1 (en) Novel method of protecting islet cells from apoptosis during the donor harvesting process
AU2013273798A1 (en) A novel method of protecting islet cells from apoptosis during the donor harvesting process
EP2594634B1 (fr) Procédé de séparation d'îlots pancréatiques, et solution de conservation destinée à conserver les tissus d'îlots pancréatiques
TW200839013A (en) A novel method of protecting islet cells from apoptosis during the donor harvesting process
CN110257377B (zh) 一种抑制人恶性脑胶质瘤的靶向linc00998基因的抑制剂及其应用
CN111920955A (zh) Grb10作为β细胞功能障碍的关键负调节因子中的应用
CN110643707A (zh) 一种与ESCC相关的lncRNA LLNLR-299G3.1及其应用
Walker MicroRNAs and Long Non-Coding RNAs in Pancreatic Beta Cell Function
A-Elgadir et al. Mesenchymal stem cells improve cardiac function in diabetic rats by reducing cardiac injury biomarkers and downregulating JAK/STAT/iNOS and iNOS/Apoptosis signaling pathways
wen Jie et al. Mechanism of denervation muscle atrophy mediated by Ach/p38/MAPK pathway in rats with erectile dysfunction caused by nerve injury
Wang et al. miR-758-3p/ILK signaling modulated angiogenesis by regulating VEGFA in wound healing
Domínguez-Bendala et al. MicroRNAs in Pancreas and Islet Development and Function
CN117503936A (zh) Neu3在制备防治血管内皮炎症损伤药物中的应用
CN118460722A (zh) 一种晚期前列腺癌新型内分泌治疗耐药标志物及其应用
CN116036118A (zh) 体外修饰的血小板对于血管损伤的治疗作用

Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted