AU2006235698B2 - New tricyclic angiotensin II agonists - Google Patents

New tricyclic angiotensin II agonists Download PDF

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Publication number
AU2006235698B2
AU2006235698B2 AU2006235698A AU2006235698A AU2006235698B2 AU 2006235698 B2 AU2006235698 B2 AU 2006235698B2 AU 2006235698 A AU2006235698 A AU 2006235698A AU 2006235698 A AU2006235698 A AU 2006235698A AU 2006235698 B2 AU2006235698 B2 AU 2006235698B2
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Australia
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compound
formula
alkyl
compounds
mmol
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AU2006235698A1 (en
Inventor
Mathias Alterman
Anders Hallberg
Xiongyu Wu
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Vicore Pharma AB
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Vicore Pharma AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
AU2006235698A 2005-04-12 2006-04-12 New tricyclic angiotensin II agonists Ceased AU2006235698B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67025105P 2005-04-12 2005-04-12
US60/670,251 2005-04-12
PCT/GB2006/001319 WO2006109048A1 (en) 2005-04-12 2006-04-12 New tricyclic angiotensin ii agonists

Publications (2)

Publication Number Publication Date
AU2006235698A1 AU2006235698A1 (en) 2006-10-19
AU2006235698B2 true AU2006235698B2 (en) 2012-03-29

Family

ID=36616540

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006235698A Ceased AU2006235698B2 (en) 2005-04-12 2006-04-12 New tricyclic angiotensin II agonists

Country Status (12)

Country Link
US (1) US8080571B2 (enExample)
EP (1) EP1869023B1 (enExample)
JP (2) JP5202301B2 (enExample)
KR (1) KR101429484B1 (enExample)
CN (1) CN101193886B (enExample)
AT (1) ATE540947T1 (enExample)
AU (1) AU2006235698B2 (enExample)
CA (1) CA2604797C (enExample)
DK (1) DK1869023T3 (enExample)
ES (1) ES2395194T3 (enExample)
MX (1) MX2007012634A (enExample)
WO (1) WO2006109048A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006235698B2 (en) * 2005-04-12 2012-03-29 Vicore Pharma Ab New tricyclic angiotensin II agonists
TW200840566A (en) * 2006-12-22 2008-10-16 Esteve Labor Dr Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments
EP1935886A1 (en) * 2006-12-22 2008-06-25 Laboratorios del Dr. Esteve S.A. Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments
EP2832357A1 (en) 2013-07-29 2015-02-04 Charité - Universitätsmedizin Berlin Selective AT2 receptor agonists for use in treatment of cachexia
EP3820498A1 (en) 2018-06-14 2021-05-19 University College Cork-National University of Ireland Cork Peptide for disease treatment
GB201913603D0 (en) 2019-09-20 2019-11-06 Vicore Pharma Ab New compounds
MX2022011613A (es) * 2020-03-19 2022-10-21 Vicore Pharma Ab Nuevos compuestos útiles para el tratamiento y/o prevención de una enfermedad, trastorno o afección asociada con la angiotensina ii.
GB202007122D0 (en) * 2020-05-14 2020-07-01 Vicore Pharma Ab New process
GB202013721D0 (en) * 2020-09-01 2020-10-14 Vicore Pharma Ab New compounds
WO2023193733A1 (zh) * 2022-04-06 2023-10-12 武汉人福创新药物研发中心有限公司 一种at2r激动剂
CN116355025B (zh) * 2023-04-03 2025-03-28 天津医科大学 一种HO-1i-Pt(IV)配合物和自组装纳米粒的制备方法及其在肿瘤药物中的应用
WO2025044927A1 (zh) * 2023-08-25 2025-03-06 武汉人福创新药物研发中心有限公司 一种作为at2r激动剂的噻吩磺酰基氨基甲酸酯及其用途
CN119504723A (zh) * 2023-08-25 2025-02-25 武汉人福创新药物研发中心有限公司 作为at2r激动剂的噻吩磺酰基氨基甲酸酯
WO2025146172A1 (zh) * 2024-01-03 2025-07-10 武汉人福创新药物研发中心有限公司 一种并环类化合物作为at2r激动剂
WO2025252142A1 (zh) * 2024-06-07 2025-12-11 江苏柯菲平医药股份有限公司 一种血管紧张素ii型2受体激动剂及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004046141A1 (en) * 2002-11-21 2004-06-03 Vicore Pharma Ab New tricyclic angiotensin ii agonists

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE64514B1 (en) 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
GB8911854D0 (en) 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
EP0424317A3 (en) * 1989-10-19 1991-09-25 Ciba-Geigy Ag Pyrimidines
DE4023215A1 (de) 1990-07-21 1992-01-23 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, sie enthaltende mittel und deren verwendung
DE4032522A1 (de) * 1990-10-11 1992-04-16 Schering Ag Neue thienoimidazolderivate, verfahren zu ihrer herstellung und ihre phamazeutische verwendung
IE920175A1 (en) 1991-02-11 1992-08-12 Zeneca Ltd Nitrogen heterocycles
US5177074A (en) * 1991-03-26 1993-01-05 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
US5198438A (en) * 1991-05-07 1993-03-30 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
CZ36394A3 (en) 1991-08-19 1994-07-13 Du Pont Substituted imidazilonone derivatives and pharmaceutical preparations based thereon
CZ36294A3 (en) * 1991-08-19 1994-07-13 Du Pont Substituted imidazilonone derivatives and pharmaceutical preparations based thereon
US5312820A (en) * 1992-07-17 1994-05-17 Merck & Co., Inc. Substituted carbamoyl and oxycarbonyl derivatives of biphenylmethylamines
GB9223371D0 (en) 1992-11-06 1992-12-23 Ici Plc Heterocyclic compounds
US5395844A (en) * 1993-06-10 1995-03-07 The Du Pont Merck Pharmaceutical Company Imidazole 5-position substituted angiotensin II antagonists
US5444067A (en) * 1993-08-30 1995-08-22 Merck & Co., Inc. Pharmaceutical treatment methods using angiotensin II receptor agonists bearing a thiophene moiety
WO1998005624A1 (en) * 1996-08-06 1998-02-12 Taisho Pharmaceutical Co., Ltd. Amino compounds and angiotensin iv receptor agonists
EP0855392A3 (de) * 1997-01-22 2000-01-05 Hoechst Aktiengesellschaft Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
SE9800550D0 (sv) 1998-02-24 1998-02-24 A & Science Invest Ab A pharmaceutical preparation comprising an angiotensin II type 2 receptor agonist, and use thereof
YU78601A (sh) * 1999-05-05 2005-07-19 Aventis Pharma Deutschland Gmbh. 1-(p-tienilbenzil)-imidazoli kao agonisti angiotenzin-(1-7)- receptora, postupak za njihovu proizvodnju, njihova primena i farmaceutski preparati koji ih sadrže
DE10112041A1 (de) * 2001-03-14 2002-09-26 Aventis Pharma Gmbh p-Thienylbenzyl-Amide als Agonisten von Angiotensin-(1-7)-Rezeptoren, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
JP4707321B2 (ja) * 2001-05-31 2011-06-22 ヴィコール・ファルマ・アーベー アンギオテンシンｉｉアゴニストとして有用な三環式化合物
DE60222409T2 (de) * 2001-05-31 2008-09-25 Vicore Pharma Ab Trizyklische verbindungen, nützlich als angiotensin ii agonisten
WO2003064414A1 (en) * 2002-01-29 2003-08-07 Vicore Pharma Ab. Tricyclic compounds useful as angiotensin ii agonists
JP4385113B2 (ja) * 2002-09-18 2009-12-16 株式会社ポーラファルマ 新規ビフェニルイミダゾピリジン誘導体及びそれを有効成分とする医薬
AU2003302027A1 (en) 2002-11-21 2004-06-15 Vicore Pharma Ab New tricyclic angiotensin ii agonists
WO2004046128A1 (en) 2002-11-21 2004-06-03 Vicore Pharma Ab New bicyclic angiotensin ii agonists
JP3874419B2 (ja) * 2003-01-31 2007-01-31 三共株式会社 動脈硬化及び高血圧症の予防及び治療のための医薬
WO2004085420A1 (en) 2003-03-24 2004-10-07 Vicore Pharma Ab Bicyclic compounds useful as angiotensin ii agonists
AU2006235698B2 (en) * 2005-04-12 2012-03-29 Vicore Pharma Ab New tricyclic angiotensin II agonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004046141A1 (en) * 2002-11-21 2004-06-03 Vicore Pharma Ab New tricyclic angiotensin ii agonists

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AU2006235698A1 (en) 2006-10-19
CN101193886A (zh) 2008-06-04
WO2006109048A1 (en) 2006-10-19
JP2013040208A (ja) 2013-02-28
KR101429484B1 (ko) 2014-08-13
JP2008535898A (ja) 2008-09-04
JP5718301B2 (ja) 2015-05-13
US8080571B2 (en) 2011-12-20
JP5202301B2 (ja) 2013-06-05
EP1869023B1 (en) 2012-01-11
CA2604797A1 (en) 2006-10-19
EP1869023A1 (en) 2007-12-26
KR20080009275A (ko) 2008-01-28
ES2395194T3 (es) 2013-02-11
DK1869023T3 (da) 2012-04-10
CA2604797C (en) 2013-05-28
US20090042931A1 (en) 2009-02-12
MX2007012634A (es) 2008-01-11
ATE540947T1 (de) 2012-01-15
CN101193886B (zh) 2014-08-27

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