AU2005316593A1 - Compositions comprising PDE4 modulators and their use for the treatment or prevention of airway inflammation - Google Patents
Compositions comprising PDE4 modulators and their use for the treatment or prevention of airway inflammation Download PDFInfo
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- AU2005316593A1 AU2005316593A1 AU2005316593A AU2005316593A AU2005316593A1 AU 2005316593 A1 AU2005316593 A1 AU 2005316593A1 AU 2005316593 A AU2005316593 A AU 2005316593A AU 2005316593 A AU2005316593 A AU 2005316593A AU 2005316593 A1 AU2005316593 A1 AU 2005316593A1
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- carbon atoms
- alkyl
- substituted
- phenyl
- hydrogen
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Classifications
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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Landscapes
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- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
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| US60/634,982 | 2004-12-13 | ||
| PCT/US2005/045071 WO2006065814A1 (en) | 2004-12-13 | 2005-12-12 | Compositions comprising pde4 modulators and their use for the treatment or prevention of airway inflammation |
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| AU2005316593A1 true AU2005316593A1 (en) | 2006-06-22 |
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| WO (1) | WO2006065814A1 (enExample) |
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| US20050100529A1 (en) * | 2003-11-06 | 2005-05-12 | Zeldis Jerome B. | Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders |
| ZA200609228B (en) * | 2004-04-23 | 2008-05-28 | Celgene Corp | Methods of using and compositions comprising PDE4 modulators for the treatment and management of pulmonary hypertension |
| AU2006305620A1 (en) * | 2005-10-19 | 2007-04-26 | Ranbaxy Laboratories Limited | Compositions of phosphodiesterase type IV inhibitors |
| US20120149716A1 (en) * | 2009-02-10 | 2012-06-14 | Zeldis Jerome B | Methods of using and compositions comprising pde4 modulators for treatment, prevention and management of tuberculosis |
| AU2010246749B8 (en) | 2009-05-14 | 2014-03-20 | Ganzhou Hemay Pharmaceutical Co., Ltd | Thiophene derivatives |
| US9408831B2 (en) | 2010-04-07 | 2016-08-09 | Celgene Corporation | Methods for treating respiratory viral infection |
| CA2821805A1 (en) | 2010-12-16 | 2012-06-21 | Celgene Corporation | Controlled release oral dosage forms of poorly soluble drugs and uses thereof |
| AU2012205809B2 (en) * | 2011-01-10 | 2015-09-10 | Amgen (Europe) GmbH | Phenethylsulfone isoindoline derivatives as inhibitors of PDE 4 and/or cytokines |
| ES2632979T3 (es) * | 2011-01-10 | 2017-09-18 | Celgene Corporation | Formas de dosificación oral de {2-[(1S)-1-(3-etoxi-4-metoxi-fenil)-2-metanosulfonil-etil]-3-oxo-2,3-dihidro-1H-isoindol-4-il}-amida de ácido ciclopropanocarboxílico |
| EP3320902B1 (en) * | 2011-03-07 | 2021-02-17 | Amgen (Europe) GmbH | Methods for treating diseases using isoindoline compounds |
| US9272035B2 (en) | 2011-04-28 | 2016-03-01 | Celgene Corporation | Methods and compositions using PDE4 inhibitors for the treatment and management of autoimmune and inflammatory diseases |
| CN105050624A (zh) | 2013-03-14 | 2015-11-11 | 细胞基因公司 | 利用阿普斯特来治疗银屑病关节炎的方法 |
| EP3096749B1 (en) * | 2014-01-24 | 2019-05-15 | Celgene Corporation | Methods for the treatment of obesity using apremilast |
| US10092541B2 (en) | 2014-08-15 | 2018-10-09 | Celgene Corporation | Methods for the treatment of diseases ameliorated by PDE4 inhibition using dosage titration of apremilast |
| WO2017030892A1 (en) | 2015-08-14 | 2017-02-23 | Reaction Biology Corp. | Histone deacetylase inhibitors and methods for use thereof |
| JP7029444B2 (ja) * | 2016-08-22 | 2022-04-07 | メッドシャイン ディスカバリー インコーポレイテッド | Ｐｄｅ４阻害剤 |
| CN110291065B (zh) * | 2017-02-28 | 2022-08-19 | 康朴生物医药技术（上海）有限公司 | 一种新的异二氢吲哚衍生物、其药物组合物及应用 |
| EP3595649B1 (en) * | 2017-03-16 | 2025-10-01 | Takeda Pharmaceutical Company Limited | 5-((2r,4ar,10br)-9-ethoxy-2-hydroxy-8-methoxy-1,2,3,4,4a,10b-hexahydro-phenanthridin-6-yl)1-methyl-1h-pyridin-2-one for use in the treatment of idiopathic pulmonary fibrosis |
| GB202306663D0 (en) | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Combination therapy |
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| US6020358A (en) * | 1998-10-30 | 2000-02-01 | Celgene Corporation | Substituted phenethylsulfones and method of reducing TNFα levels |
| US6667316B1 (en) * | 1999-11-12 | 2003-12-23 | Celgene Corporation | Pharmaceutically active isoindoline derivatives |
| US6699899B1 (en) * | 1999-12-21 | 2004-03-02 | Celgene Corporation | Substituted acylhydroxamic acids and method of reducing TNFα levels |
| US6962940B2 (en) * | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
| US7276529B2 (en) * | 2002-03-20 | 2007-10-02 | Celgene Corporation | Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
| US7354948B2 (en) * | 2002-11-06 | 2008-04-08 | Celgene Corporation | Methods for treatment of chronic uveitis using cyclopropyl-n-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide |
| CN1738613A (zh) * | 2002-11-18 | 2006-02-22 | 细胞基因公司 | 包含(+)－3－(3,4－二甲氧基－苯基)－3－(1－氧代－1,3－二氢－异吲哚－2－基)－丙酰胺的组合物及其使用方法 |
| WO2004060313A2 (en) * | 2002-12-30 | 2004-07-22 | Celgene Corporation | Fluoroalkoxy-substituted 1, 3-dihydro-isoindolyl compounds and their pharmaceutical uses |
| ZA200609228B (en) * | 2004-04-23 | 2008-05-28 | Celgene Corp | Methods of using and compositions comprising PDE4 modulators for the treatment and management of pulmonary hypertension |
| CA2565446A1 (en) * | 2004-05-05 | 2005-12-01 | Celgene Corporation | Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases |
| US7244759B2 (en) * | 2004-07-28 | 2007-07-17 | Celgene Corporation | Isoindoline compounds and methods of making and using the same |
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2005
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- 2005-12-12 KR KR1020077015958A patent/KR20070092276A/ko not_active Withdrawn
- 2005-12-12 EP EP05853888A patent/EP1838294A1/en not_active Withdrawn
- 2005-12-12 CN CNA2005800476591A patent/CN101111235A/zh active Pending
- 2005-12-12 MX MX2007006992A patent/MX2007006992A/es unknown
- 2005-12-12 ZA ZA200705540A patent/ZA200705540B/xx unknown
- 2005-12-12 JP JP2007545718A patent/JP2008523102A/ja not_active Abandoned
- 2005-12-12 WO PCT/US2005/045071 patent/WO2006065814A1/en not_active Ceased
- 2005-12-12 AU AU2005316593A patent/AU2005316593A1/en not_active Abandoned
- 2005-12-12 CA CA002590903A patent/CA2590903A1/en not_active Abandoned
- 2005-12-13 AR ARP050105222A patent/AR052047A1/es not_active Application Discontinuation
- 2005-12-13 US US11/299,702 patent/US20060148882A1/en not_active Abandoned
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2007
- 2007-06-12 IL IL183858A patent/IL183858A0/en unknown
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| ZA200705540B (en) | 2009-01-28 |
| WO2006065814A1 (en) | 2006-06-22 |
| IL183858A0 (en) | 2007-10-31 |
| US20060148882A1 (en) | 2006-07-06 |
| CA2590903A1 (en) | 2006-06-22 |
| BRPI0519030A2 (pt) | 2008-12-23 |
| KR20070092276A (ko) | 2007-09-12 |
| CN101111235A (zh) | 2008-01-23 |
| EP1838294A1 (en) | 2007-10-03 |
| MX2007006992A (es) | 2007-08-03 |
| AR052047A1 (es) | 2007-02-28 |
| JP2008523102A (ja) | 2008-07-03 |
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