AU2005284565A1 - Combination of polychitosamine and HMG-CoA reductase inhibitor for hyperlipidemia - Google Patents
Combination of polychitosamine and HMG-CoA reductase inhibitor for hyperlipidemia Download PDFInfo
- Publication number
- AU2005284565A1 AU2005284565A1 AU2005284565A AU2005284565A AU2005284565A1 AU 2005284565 A1 AU2005284565 A1 AU 2005284565A1 AU 2005284565 A AU2005284565 A AU 2005284565A AU 2005284565 A AU2005284565 A AU 2005284565A AU 2005284565 A1 AU2005284565 A1 AU 2005284565A1
- Authority
- AU
- Australia
- Prior art keywords
- hmg
- reductase inhibitor
- polychitosamine
- coa reductase
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title claims description 52
- 208000031226 Hyperlipidaemia Diseases 0.000 title claims description 21
- 238000000034 method Methods 0.000 claims description 43
- 239000008194 pharmaceutical composition Substances 0.000 claims description 29
- 238000011282 treatment Methods 0.000 claims description 23
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- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims description 13
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- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims description 8
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- BOZILQFLQYBIIY-UHFFFAOYSA-N mevastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CCC=C21 BOZILQFLQYBIIY-UHFFFAOYSA-N 0.000 claims description 4
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- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims description 4
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- BWFCZHDTTAYGNN-CNZCJKERSA-N calcium;(3r,5r)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid Chemical compound [Ca].C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 BWFCZHDTTAYGNN-CNZCJKERSA-N 0.000 claims 4
- CABVTRNMFUVUDM-VRHQGPGLSA-N (3S)-3-hydroxy-3-methylglutaryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C[C@@](O)(CC(O)=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CABVTRNMFUVUDM-VRHQGPGLSA-N 0.000 claims 3
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 53
- 229920001661 Chitosan Polymers 0.000 description 30
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- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Stereo-Broadcasting Methods (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60983004P | 2004-09-15 | 2004-09-15 | |
| US60/609,830 | 2004-09-15 | ||
| PCT/CA2005/001406 WO2006029524A1 (en) | 2004-09-15 | 2005-09-14 | Combination of polychitosamine and hmg-coa reductase inhibitor for hyperlipidemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2005284565A1 true AU2005284565A1 (en) | 2006-03-23 |
Family
ID=36059676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2005284565A Abandoned AU2005284565A1 (en) | 2004-09-15 | 2005-09-14 | Combination of polychitosamine and HMG-CoA reductase inhibitor for hyperlipidemia |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US20060058261A1 (enExample) |
| EP (1) | EP1812019A4 (enExample) |
| JP (1) | JP2008513379A (enExample) |
| CN (1) | CN101052405A (enExample) |
| AU (1) | AU2005284565A1 (enExample) |
| BR (1) | BRPI0515443A (enExample) |
| CA (1) | CA2580460A1 (enExample) |
| WO (1) | WO2006029524A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US20080182819A1 (en) * | 2007-01-29 | 2008-07-31 | Act Iii Licensing, Llc | Chitosan compositions and methods for using chitosan compositions in the treatment of health disorders |
| CN105859639A (zh) | 2009-03-18 | 2016-08-17 | 雷斯韦洛吉克斯公司 | 新的抗炎剂 |
| CA2758172C (en) | 2009-04-08 | 2019-01-15 | Nanyang Polytechnic | A plant extract comprising statins and preparation techniques and uses thereof |
| CA2869821C (en) | 2011-06-13 | 2018-06-19 | Rival, Societe En Commandite | N,n,n-trialkylaminopolymers, methods of their preparation and uses thereof |
| EP4371866A3 (en) * | 2018-09-26 | 2024-07-17 | TQ-Systems GmbH | Method and device for dynamically controlling a range of an electrically-assisted bicycle, electrically-assisted bicycle |
| IT201900021291A1 (it) * | 2019-11-15 | 2021-05-15 | Biomedica Pharma Gmbh | Chitosano e prodotto medicale per l’uso in un metodo di prevenzione o trattamento di una malattia cardiovascolare |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3903140A (en) * | 1970-09-08 | 1975-09-02 | Alza Corp | Diazadodecane prostaglandin compounds |
| US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| US4444784A (en) * | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| DK149080C (da) * | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
| US4739073A (en) * | 1983-11-04 | 1988-04-19 | Sandoz Pharmaceuticals Corp. | Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof |
| DE69319921T2 (de) * | 1992-12-01 | 1999-04-15 | Minnesota Mining And Mfg. Co., Saint Paul, Minn. | Dauerhafte antimikrobische mittel |
| FI107432B (fi) * | 1997-02-06 | 2001-08-15 | Novasso Oy | Mikrokiteisen kitosaanin käyttö |
| FI982291L (fi) * | 1998-10-23 | 2000-04-24 | Novasso Oy | Aine kolesterolin sekä lipidien pitoisuuden alentamiseksi |
| US20020016307A1 (en) * | 1999-10-27 | 2002-02-07 | Mullins John Jason Gentry | Pharmaceutical composition with both a lipase inhibitor and a lipophilic polysaccharide and an improved method for treating adiposity |
| US6933291B2 (en) * | 2000-12-01 | 2005-08-23 | N.V. Nutricia | Cholesterol lowering supplement |
| KR20040026705A (ko) * | 2001-08-16 | 2004-03-31 | 테바 파마슈티컬 인더스트리즈 리미티드 | 스타틴의 칼슘 염 형태의 제조 방법 |
| GB0302738D0 (en) * | 2003-02-06 | 2003-03-12 | Advanced Biopolymers As | Composition |
-
2005
- 2005-09-01 US US11/218,348 patent/US20060058261A1/en not_active Abandoned
- 2005-09-14 US US11/662,891 patent/US20090197830A1/en not_active Abandoned
- 2005-09-14 JP JP2007531552A patent/JP2008513379A/ja active Pending
- 2005-09-14 CN CNA2005800365828A patent/CN101052405A/zh active Pending
- 2005-09-14 EP EP05785026A patent/EP1812019A4/en not_active Withdrawn
- 2005-09-14 CA CA002580460A patent/CA2580460A1/en not_active Abandoned
- 2005-09-14 WO PCT/CA2005/001406 patent/WO2006029524A1/en not_active Ceased
- 2005-09-14 AU AU2005284565A patent/AU2005284565A1/en not_active Abandoned
- 2005-09-14 BR BRPI0515443-0A patent/BRPI0515443A/pt not_active IP Right Cessation
-
2010
- 2010-03-30 US US12/750,627 patent/US20110028429A1/en not_active Abandoned
-
2012
- 2012-02-10 US US13/370,812 patent/US20120258932A1/en not_active Abandoned
-
2013
- 2013-05-03 US US13/886,536 patent/US20130244973A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20120258932A1 (en) | 2012-10-11 |
| BRPI0515443A (pt) | 2008-07-29 |
| CN101052405A (zh) | 2007-10-10 |
| US20130244973A1 (en) | 2013-09-19 |
| US20060058261A1 (en) | 2006-03-16 |
| EP1812019A1 (en) | 2007-08-01 |
| WO2006029524A1 (en) | 2006-03-23 |
| US20110028429A1 (en) | 2011-02-03 |
| JP2008513379A (ja) | 2008-05-01 |
| US20090197830A1 (en) | 2009-08-06 |
| CA2580460A1 (en) | 2006-03-23 |
| EP1812019A4 (en) | 2007-12-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1 | Assignment before grant (sect. 113) |
Owner name: DNP CANADA INC. Free format text: FORMER APPLICANT(S): MAGISTRAL BIOTECH INC., HAS NO VALUE - ENTRY INCOMPLETE |
|
| DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS: ADD THE CO-INVENTOR NAME TO READ HUC, JEAN-FRANCOIS |
|
| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |