AU2005205880B2 - Compounds for the sustained reduction of body weight - Google Patents

Compounds for the sustained reduction of body weight Download PDF

Info

Publication number
AU2005205880B2
AU2005205880B2 AU2005205880A AU2005205880A AU2005205880B2 AU 2005205880 B2 AU2005205880 B2 AU 2005205880B2 AU 2005205880 A AU2005205880 A AU 2005205880A AU 2005205880 A AU2005205880 A AU 2005205880A AU 2005205880 B2 AU2005205880 B2 AU 2005205880B2
Authority
AU
Australia
Prior art keywords
tropane
body weight
compound
use according
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005205880A
Other languages
English (en)
Other versions
AU2005205880A1 (en
Inventor
Ole Graff
Birgit Ohrt Mikkelsen
Stephane Pollentier
Morten Priskorn
Andreas Raschig
Juergen Reess
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch AS filed Critical Neurosearch AS
Publication of AU2005205880A1 publication Critical patent/AU2005205880A1/en
Application granted granted Critical
Publication of AU2005205880B2 publication Critical patent/AU2005205880B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2005205880A 2004-01-22 2005-01-11 Compounds for the sustained reduction of body weight Ceased AU2005205880B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP04001282.5 2004-01-22
EP04001282 2004-01-22
EP04005816 2004-03-11
EP04005816.6 2004-03-11
PCT/EP2005/000165 WO2005070427A1 (en) 2004-01-22 2005-01-11 Compounds for the sustained reduction of body weight

Publications (2)

Publication Number Publication Date
AU2005205880A1 AU2005205880A1 (en) 2005-08-04
AU2005205880B2 true AU2005205880B2 (en) 2010-06-10

Family

ID=34809747

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005205880A Ceased AU2005205880B2 (en) 2004-01-22 2005-01-11 Compounds for the sustained reduction of body weight

Country Status (7)

Country Link
US (1) US20050203124A1 (https=)
EP (1) EP1727547A1 (https=)
JP (1) JP2007519646A (https=)
AU (1) AU2005205880B2 (https=)
CA (1) CA2553649A1 (https=)
NZ (1) NZ547919A (https=)
WO (1) WO2005070427A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007508336A (ja) * 2003-10-16 2007-04-05 ニューロサーチ、アクティーゼルスカブ モノアミン神経伝達物質再取り込みインヒビター及びアセチルコリンエステラーゼインヒビターを含む医薬組成物
AU2005205882A1 (en) * 2004-01-22 2005-08-04 Neurosearch A/S Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an N-methyl-D-aspartate (NMDA) receptors antagonist
EP1779851A1 (en) 2005-10-31 2007-05-02 Boehringer Ingelheim Pharma GmbH & Co.KG Treatment of diabetes
EP2222303A1 (en) * 2007-11-20 2010-09-01 NeuroSearch A/S A method for treating addiction
WO2009065845A1 (en) * 2007-11-20 2009-05-28 Neurosearch A/S A method for treating over-eating disorders
WO2009080693A2 (en) * 2007-12-20 2009-07-02 Neurosearch A/S Pharmaceutical composition comprising tesofensine or its analogue and a beta blocker
CA2709861A1 (en) * 2007-12-20 2009-07-02 Neurosearch A/S Pharmaceutical compositions
HRP20190050T1 (hr) 2012-02-16 2019-03-08 Saniona A/S Farmaceutski pripravci za kombinacijsku terapiju
PE20180187A1 (es) 2015-03-03 2018-01-23 Saniona As Formulacion de combinacion de tesofensina y betabloqueante
US20220218689A1 (en) * 2018-10-24 2022-07-14 Saniona A/S Transdermal tropane compositions and methods for using the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997030997A1 (en) * 1996-02-22 1997-08-28 Neurosearch A/S Tropane-derivatives, their preparation and use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0644775T3 (da) * 1991-11-15 2000-03-06 Nat Inst Health Kokainreceptorbindende ligander
DK154192D0 (da) * 1992-12-23 1992-12-23 Neurosearch As Heterocycliske forbindelser
US5554626A (en) * 1992-12-23 1996-09-10 Neurosearch A/S Substituted heterocyclic compounds as dopamine-reuptake inhibitors
BR9507489A (pt) * 1994-04-19 1997-08-12 Neurosearch As Derivados tropano sua preparacão e uso
US6262081B1 (en) * 1998-07-10 2001-07-17 Dupont Pharmaceuticals Company Composition for and method of treating neurological disorders
EP1397358A1 (en) * 2001-05-23 2004-03-17 Neurosearch A/S Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
DE10148233A1 (de) * 2001-09-28 2003-04-10 Boehringer Ingelheim Pharma Verbindungen zur Reduzierung übermäßiger Nahrungsaufnahme
JP2006517567A (ja) * 2003-02-12 2006-07-27 ニューロサーチ、アクティーゼルスカブ 新規８−アザ−ビシクロ［３．２．１］オクタン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法
JP2007508336A (ja) * 2003-10-16 2007-04-05 ニューロサーチ、アクティーゼルスカブ モノアミン神経伝達物質再取り込みインヒビター及びアセチルコリンエステラーゼインヒビターを含む医薬組成物
AU2005205882A1 (en) * 2004-01-22 2005-08-04 Neurosearch A/S Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an N-methyl-D-aspartate (NMDA) receptors antagonist
JP2008501656A (ja) * 2004-06-04 2008-01-24 ノイロサーチ アクティーゼルスカブ β−アミロイド（Ａβ４０及びＡβ４２）生成阻害のためのモノアミン神経伝達物質再取り込み阻害剤

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997030997A1 (en) * 1996-02-22 1997-08-28 Neurosearch A/S Tropane-derivatives, their preparation and use

Also Published As

Publication number Publication date
NZ547919A (en) 2009-12-24
AU2005205880A1 (en) 2005-08-04
WO2005070427A1 (en) 2005-08-04
EP1727547A1 (en) 2006-12-06
US20050203124A1 (en) 2005-09-15
CA2553649A1 (en) 2005-08-04
JP2007519646A (ja) 2007-07-19
WO2005070427A8 (en) 2005-11-17

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired