AU2005200176B2 - Methods for identifying and using amyloid-inhibitory compounds - Google Patents

Methods for identifying and using amyloid-inhibitory compounds Download PDF

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Publication number
AU2005200176B2
AU2005200176B2 AU2005200176A AU2005200176A AU2005200176B2 AU 2005200176 B2 AU2005200176 B2 AU 2005200176B2 AU 2005200176 A AU2005200176 A AU 2005200176A AU 2005200176 A AU2005200176 A AU 2005200176A AU 2005200176 B2 AU2005200176 B2 AU 2005200176B2
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AU
Australia
Prior art keywords
animal
level
test compound
estrogen
vivo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005200176A
Other languages
English (en)
Other versions
AU2005200176A1 (en
Inventor
Donald E. Frail
Sam Gandy
Suzana Petanceska
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RESEARCH FOUNDATION FOR MEDICAL HYGIENE
Wyeth LLC
Original Assignee
RES FOUNDATION FOR MEDICAL HYG
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RES FOUNDATION FOR MEDICAL HYG, Wyeth LLC filed Critical RES FOUNDATION FOR MEDICAL HYG
Publication of AU2005200176A1 publication Critical patent/AU2005200176A1/en
Application granted granted Critical
Publication of AU2005200176B2 publication Critical patent/AU2005200176B2/en
Priority to AU2008200349A priority Critical patent/AU2008200349A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pathology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
AU2005200176A 1999-11-05 2000-11-03 Methods for identifying and using amyloid-inhibitory compounds Ceased AU2005200176B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2008200349A AU2008200349A1 (en) 1999-11-05 2008-01-23 Methods for identifying and using amyloid-inhibitory compounds

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16381999P 1999-11-05 1999-11-05
US60/163819 1999-11-05
PCT/US2000/030310 WO2001035106A2 (en) 1999-11-05 2000-11-03 Methods for identifying and using amyloid-inhibitory compounds

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
AU14592/01A Division AU779781B2 (en) 1999-11-05 2000-11-03 Methods for identifying and using amyloid-inhibitory compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2008200349A Division AU2008200349A1 (en) 1999-11-05 2008-01-23 Methods for identifying and using amyloid-inhibitory compounds

Publications (2)

Publication Number Publication Date
AU2005200176A1 AU2005200176A1 (en) 2005-02-10
AU2005200176B2 true AU2005200176B2 (en) 2007-10-25

Family

ID=22591720

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2005200176A Ceased AU2005200176B2 (en) 1999-11-05 2000-11-03 Methods for identifying and using amyloid-inhibitory compounds
AU14592/01A Ceased AU779781B2 (en) 1999-11-05 2000-11-03 Methods for identifying and using amyloid-inhibitory compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU14592/01A Ceased AU779781B2 (en) 1999-11-05 2000-11-03 Methods for identifying and using amyloid-inhibitory compounds

Country Status (10)

Country Link
US (1) US20080085244A1 (https=)
EP (1) EP1272853A2 (https=)
JP (2) JP2003522737A (https=)
AR (1) AR027878A1 (https=)
AU (2) AU2005200176B2 (https=)
CA (1) CA2390161A1 (https=)
MX (1) MXPA02004480A (https=)
NZ (3) NZ518780A (https=)
TW (3) TW200834074A (https=)
WO (1) WO2001035106A2 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6815175B2 (en) 2001-03-16 2004-11-09 Cornell Research Foundation, Inc. Anti-amyloid peptide antibody based diagnosis and treatment of a neurological disease or disorder
US20020173499A1 (en) * 2001-03-16 2002-11-21 Wyeth Estrogen replacement therapy
US6936599B2 (en) 2001-04-25 2005-08-30 The Regents Of The University Of California Estriol therapy for multiple sclerosis and other autoimmune diseases
US20130203722A1 (en) 2006-09-26 2013-08-08 Rhonda R. Voskuhl Estriol therapy for autoimmune and neurodegenerative disease and disorders
US8658627B2 (en) 2001-04-25 2014-02-25 The Regents Of The University Of California Pregnancy hormone combination for treatment of autoimmune diseases
EP1371986A1 (en) * 2002-06-06 2003-12-17 ABETA GmbH Diagnosis of Alzheimer's disease based on the hAbeta42:hAbeta40 ratio
JP2007284351A (ja) * 2004-07-27 2007-11-01 Osaka Bioscience Institute アミロイド蛋白質の凝集を抑制する物質とその作用
EP2698167A3 (en) * 2005-09-26 2014-03-05 The Regents of The University of California Dosage form of an estriol and glatiramer acetate polymer-1 for the treatment of multiple sclerosis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0659418A1 (en) * 1993-12-21 1995-06-28 Eli Lilly And Company 2-Phenyl-3-azoylbenzothiophene for treating Alzheimer's disease
WO1998043647A1 (en) * 1997-03-28 1998-10-08 Massachusetts Institute Of Technology, Inc. Regulation of amyloid precursor protein (app) expression by estrogenic compounds
WO1998048784A2 (en) * 1997-04-28 1998-11-05 The University Of British Columbia Method and composition for modulating amyloidosis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4311870C2 (de) * 1993-04-10 1998-07-30 Altramed Holdings Ltd Verwendung eines Anti-Östrigens zur Therapie und Prophylaxe von Demenz-Erkrankungen
US5554601A (en) * 1993-11-05 1996-09-10 University Of Florida Methods for neuroprotection
JP3552272B2 (ja) * 1994-05-27 2004-08-11 帝国臓器製薬株式会社 免疫化学的簡易アッセイ方法および装置
WO1997046664A1 (en) * 1996-06-06 1997-12-11 University Of Washington Perlecan transgenic animals and methods of identifying compounds for the treatment of amyloidoses
JPH1090261A (ja) * 1996-08-23 1998-04-10 Fuotoreru Patrick 性ステロイドホルモン測定用プレート、これを用いた測定キット及び測定法
US5898094A (en) * 1996-10-21 1999-04-27 University Of South Florida Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes
US6080778A (en) * 1998-03-23 2000-06-27 Children's Medical Center Corporation Methods for decreasing beta amyloid protein

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0659418A1 (en) * 1993-12-21 1995-06-28 Eli Lilly And Company 2-Phenyl-3-azoylbenzothiophene for treating Alzheimer's disease
WO1998043647A1 (en) * 1997-03-28 1998-10-08 Massachusetts Institute Of Technology, Inc. Regulation of amyloid precursor protein (app) expression by estrogenic compounds
WO1998048784A2 (en) * 1997-04-28 1998-11-05 The University Of British Columbia Method and composition for modulating amyloidosis

Also Published As

Publication number Publication date
EP1272853A2 (en) 2003-01-08
AU2005200176A1 (en) 2005-02-10
TWI265026B (en) 2006-11-01
JP2008058329A (ja) 2008-03-13
NZ518780A (en) 2006-02-24
NZ543850A (en) 2009-03-31
TWI302099B (en) 2008-10-21
TW200621221A (en) 2006-07-01
US20080085244A1 (en) 2008-04-10
AU1459201A (en) 2001-06-06
AR027878A1 (es) 2003-04-16
MXPA02004480A (es) 2004-09-10
NZ536461A (en) 2005-02-25
CA2390161A1 (en) 2001-05-17
AU779781B2 (en) 2005-02-10
WO2001035106A2 (en) 2001-05-17
JP2003522737A (ja) 2003-07-29
TW200834074A (en) 2008-08-16
WO2001035106A3 (en) 2002-11-14

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