AU2004285529A1 - Taxoid-fatty acid conjugates and pharmaceutical compositions thereof - Google Patents

Taxoid-fatty acid conjugates and pharmaceutical compositions thereof Download PDF

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Publication number
AU2004285529A1
AU2004285529A1 AU2004285529A AU2004285529A AU2004285529A1 AU 2004285529 A1 AU2004285529 A1 AU 2004285529A1 AU 2004285529 A AU2004285529 A AU 2004285529A AU 2004285529 A AU2004285529 A AU 2004285529A AU 2004285529 A1 AU2004285529 A1 AU 2004285529A1
Authority
AU
Australia
Prior art keywords
taxoid
generation
generation taxoid
cancer
fatty acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2004285529A
Other languages
English (en)
Inventor
Iwao Ojima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation of University of New York
Original Assignee
Research Foundation of University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Foundation of University of New York filed Critical Research Foundation of University of New York
Publication of AU2004285529A1 publication Critical patent/AU2004285529A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2004285529A 2003-10-30 2004-10-28 Taxoid-fatty acid conjugates and pharmaceutical compositions thereof Abandoned AU2004285529A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51578303P 2003-10-30 2003-10-30
US60/515,783 2003-10-30
PCT/US2004/036027 WO2005041881A2 (en) 2003-10-30 2004-10-28 Taxoid-fatty acid conjugates and pharmaceutical compositions thereof

Publications (1)

Publication Number Publication Date
AU2004285529A1 true AU2004285529A1 (en) 2005-05-12

Family

ID=34549443

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004285529A Abandoned AU2004285529A1 (en) 2003-10-30 2004-10-28 Taxoid-fatty acid conjugates and pharmaceutical compositions thereof

Country Status (7)

Country Link
US (1) US7820839B2 (enExample)
EP (1) EP1703904B1 (enExample)
JP (1) JP4884228B2 (enExample)
CN (1) CN1901901B (enExample)
AU (1) AU2004285529A1 (enExample)
CA (1) CA2544128A1 (enExample)
WO (1) WO2005041881A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2544128A1 (en) 2003-10-30 2005-05-12 The Research Foundation Of State University Of New York Taxoid-fatty acid conjugates and pharmaceutical compositions thereof
WO2007021957A2 (en) 2005-08-12 2007-02-22 Research Foundation Of State University Of New York Fluorotaxoids
WO2008021242A2 (en) * 2006-08-10 2008-02-21 The Research Foundation Of State University Of New York Fluorotaxoid-fatty acid conjugates and pharmaceutical compositions thereof
CN101225094A (zh) * 2007-01-18 2008-07-23 天津和美生物技术有限公司 具有抗癌活性的蒽醌四环类化合物
US20090022727A1 (en) 2007-01-26 2009-01-22 Alza Corp. Injectable, nonaqueous suspension with high concentration of therapeutic agent
US9763905B2 (en) 2013-03-15 2017-09-19 The Children's Medical Center Corporation Therapeutic target for the treatment of cancers and related therapies and methods
CN106390122A (zh) * 2015-07-31 2017-02-15 舟山三合生物科技有限公司 化疗类抗癌药口服制剂组合物
CN105343004A (zh) * 2015-09-14 2016-02-24 东北林业大学 一种二十二碳六烯酸靶向多西紫杉醇纳米药物的制备方法
CN109562065A (zh) * 2016-06-07 2019-04-02 塔佳吉尼克斯公司 靶向癌细胞和癌干细胞的紫杉烷类药物的纳米乳剂组合物及其使用方法
US11497713B2 (en) * 2017-12-20 2022-11-15 Targagenix, Inc. Combination taxoid nanoemulsion with immunotherapy in cancer
CN110201182B (zh) * 2019-06-21 2022-09-27 山东大学 一种紫杉醇-dha-右旋糖酐偶联聚合物及其合成方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6100411A (en) * 1994-10-28 2000-08-08 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
US6500858B2 (en) * 1994-10-28 2002-12-31 The Research Foundation Of The State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
US6458976B1 (en) * 1994-10-28 2002-10-01 The Research Foundation Of State University Of New York Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US5919815A (en) * 1996-05-22 1999-07-06 Neuromedica, Inc. Taxane compounds and compositions
CA2255615C (en) * 1996-05-22 2006-08-29 Neuromedica, Inc. Compositions comprising conjugates of cis-docosahexaenoic acid and docetaxel
US6576636B2 (en) * 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
EP1163011A2 (en) * 1999-03-09 2001-12-19 Protarga Inc. Fatty acid-anticancer conjugates and uses thereof
CA2544128A1 (en) 2003-10-30 2005-05-12 The Research Foundation Of State University Of New York Taxoid-fatty acid conjugates and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
WO2005041881A3 (en) 2005-12-08
EP1703904A2 (en) 2006-09-27
JP4884228B2 (ja) 2012-02-29
WO2005041881A2 (en) 2005-05-12
CA2544128A1 (en) 2005-05-12
US7820839B2 (en) 2010-10-26
CN1901901A (zh) 2007-01-24
JP2007510648A (ja) 2007-04-26
EP1703904B1 (en) 2013-02-13
EP1703904A4 (en) 2011-01-19
WO2005041881A8 (en) 2006-06-29
US20070088076A1 (en) 2007-04-19
CN1901901B (zh) 2012-07-04

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Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period