AU2004275815A1 - 1,3-diaclyated,26,27-alkyl/haloalkyl vitamin D3 compounds and methods of use thereof - Google Patents

Info

Publication number

AU2004275815A1

AU2004275815A1 AU2004275815A AU2004275815A AU2004275815A1 AU 2004275815 A1 AU2004275815 A1 AU 2004275815A1 AU 2004275815 A AU2004275815 A AU 2004275815A AU 2004275815 A AU2004275815 A AU 2004275815A AU 2004275815 A1 AU2004275815 A1 AU 2004275815A1

Authority

AU

Australia

Prior art keywords

compound

vitamin

cholecalciferol

dihydroxy

acetyl

Prior art date

2003-09-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 title claims description 153
• -1 haloalkyl vitamin D3 compounds Chemical class 0.000 title claims description 112
• 150000001875 compounds Chemical class 0.000 claims description 232
• QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 222
• 239000011647 vitamin D3 Substances 0.000 claims description 138
• 229940021056 vitamin d3 Drugs 0.000 claims description 138
• 210000004027 cell Anatomy 0.000 claims description 134
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 99
• 101000984186 Homo sapiens Leukocyte immunoglobulin-like receptor subfamily B member 4 Proteins 0.000 claims description 62
• 102100025578 Leukocyte immunoglobulin-like receptor subfamily B member 4 Human genes 0.000 claims description 62
• QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 61
• 208000035475 disorder Diseases 0.000 claims description 58
• 239000000203 mixture Substances 0.000 claims description 58
• 238000011282 treatment Methods 0.000 claims description 50
• 125000000217 alkyl group Chemical group 0.000 claims description 48
• 235000005282 vitamin D3 Nutrition 0.000 claims description 43
• 201000010099 disease Diseases 0.000 claims description 41
• 125000001188 haloalkyl group Chemical group 0.000 claims description 34
• 239000011575 calcium Substances 0.000 claims description 33
• 229910052739 hydrogen Inorganic materials 0.000 claims description 33
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 31
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 29
• 229910052791 calcium Inorganic materials 0.000 claims description 29
• 241000282414 Homo sapiens Species 0.000 claims description 27
• 239000008194 pharmaceutical composition Substances 0.000 claims description 26
• 229910052799 carbon Inorganic materials 0.000 claims description 23
• 238000009472 formulation Methods 0.000 claims description 22
• 210000000612 antigen-presenting cell Anatomy 0.000 claims description 20
• 230000003463 hyperproliferative effect Effects 0.000 claims description 20
• 208000023275 Autoimmune disease Diseases 0.000 claims description 19
• 229910019142 PO4 Inorganic materials 0.000 claims description 19
• 230000002401 inhibitory effect Effects 0.000 claims description 19
• 239000010452 phosphate Substances 0.000 claims description 19
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 19
• 230000001594 aberrant effect Effects 0.000 claims description 18
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 17
• 230000004770 neurodegeneration Effects 0.000 claims description 16
• 206010052779 Transplant rejections Diseases 0.000 claims description 15
• 201000011510 cancer Diseases 0.000 claims description 15
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 15
• 206010069632 Bladder dysfunction Diseases 0.000 claims description 14
• 208000032839 leukemia Diseases 0.000 claims description 14
• 230000037396 body weight Effects 0.000 claims description 13
• 208000026278 immune system disease Diseases 0.000 claims description 13
• 230000004060 metabolic process Effects 0.000 claims description 13
• 210000001185 bone marrow Anatomy 0.000 claims description 12
• 239000003937 drug carrier Substances 0.000 claims description 12
• 239000001257 hydrogen Substances 0.000 claims description 12
• 230000001939 inductive effect Effects 0.000 claims description 12
• 230000001613 neoplastic effect Effects 0.000 claims description 12
• 229940002612 prodrug Drugs 0.000 claims description 12
• 239000000651 prodrug Substances 0.000 claims description 12
• 230000028327 secretion Effects 0.000 claims description 12
• 102000003982 Parathyroid hormone Human genes 0.000 claims description 11
• 108090000445 Parathyroid hormone Proteins 0.000 claims description 11
• 230000001506 immunosuppresive effect Effects 0.000 claims description 11
• 210000000056 organ Anatomy 0.000 claims description 11
• 239000000199 parathyroid hormone Substances 0.000 claims description 11
• 229960001319 parathyroid hormone Drugs 0.000 claims description 11
• 229940088594 vitamin Drugs 0.000 claims description 11
• 229930003231 vitamin Natural products 0.000 claims description 11
• 235000013343 vitamin Nutrition 0.000 claims description 11
• 239000011782 vitamin Substances 0.000 claims description 11
• 201000004681 Psoriasis Diseases 0.000 claims description 10
• 150000002148 esters Chemical class 0.000 claims description 10
• 150000003839 salts Chemical class 0.000 claims description 10
• 210000000329 smooth muscle myocyte Anatomy 0.000 claims description 10
• 206010005003 Bladder cancer Diseases 0.000 claims description 9
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 9
• 210000002449 bone cell Anatomy 0.000 claims description 9
• 201000005112 urinary bladder cancer Diseases 0.000 claims description 9
• 150000003722 vitamin derivatives Chemical class 0.000 claims description 9
• 210000004443 dendritic cell Anatomy 0.000 claims description 8
• 206010012601 diabetes mellitus Diseases 0.000 claims description 8
• 230000001900 immune effect Effects 0.000 claims description 8
• 239000007787 solid Substances 0.000 claims description 8
• 201000004624 Dermatitis Diseases 0.000 claims description 7
• 206010020853 Hypertonic bladder Diseases 0.000 claims description 7
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 7
• 230000003831 deregulation Effects 0.000 claims description 7
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 7
• 210000001616 monocyte Anatomy 0.000 claims description 7
• 125000004950 trifluoroalkyl group Chemical group 0.000 claims description 7
• 241000124008 Mammalia Species 0.000 claims description 6
• 208000001132 Osteoporosis Diseases 0.000 claims description 6
• 208000009722 Overactive Urinary Bladder Diseases 0.000 claims description 6
• 208000018737 Parkinson disease Diseases 0.000 claims description 6
• 230000001363 autoimmune Effects 0.000 claims description 6
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 6
• 206010025135 lupus erythematosus Diseases 0.000 claims description 6
• 210000002540 macrophage Anatomy 0.000 claims description 6
• 208000020629 overactive bladder Diseases 0.000 claims description 6
• 230000000849 parathyroid Effects 0.000 claims description 6
• 210000004927 skin cell Anatomy 0.000 claims description 6
• 208000011580 syndromic disease Diseases 0.000 claims description 6
• 208000024827 Alzheimer disease Diseases 0.000 claims description 5
• 206010020772 Hypertension Diseases 0.000 claims description 5
• 208000001126 Keratosis Diseases 0.000 claims description 5
• 206010046851 Uveitis Diseases 0.000 claims description 5
• 230000001684 chronic effect Effects 0.000 claims description 5
• 210000004072 lung Anatomy 0.000 claims description 5
• 230000001404 mediated effect Effects 0.000 claims description 5
• 238000012545 processing Methods 0.000 claims description 5
• 206010039073 rheumatoid arthritis Diseases 0.000 claims description 5
• 201000000306 sarcoidosis Diseases 0.000 claims description 5
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 4
• 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims description 4
• 208000033222 Biliary cirrhosis primary Diseases 0.000 claims description 4
• 206010008909 Chronic Hepatitis Diseases 0.000 claims description 4
• 208000015943 Coeliac disease Diseases 0.000 claims description 4
• 201000011240 Frontotemporal dementia Diseases 0.000 claims description 4
• 208000030836 Hashimoto thyroiditis Diseases 0.000 claims description 4
• 206010019755 Hepatitis chronic active Diseases 0.000 claims description 4
• 208000023105 Huntington disease Diseases 0.000 claims description 4
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
• 206010020649 Hyperkeratosis Diseases 0.000 claims description 4
• 206010020880 Hypertrophy Diseases 0.000 claims description 4
• 208000000609 Pick Disease of the Brain Diseases 0.000 claims description 4
• 208000012654 Primary biliary cholangitis Diseases 0.000 claims description 4
• 206010060862 Prostate cancer Diseases 0.000 claims description 4
• 201000001263 Psoriatic Arthritis Diseases 0.000 claims description 4
• 208000036824 Psoriatic arthropathy Diseases 0.000 claims description 4
• 108090000783 Renin Proteins 0.000 claims description 4
• 102100028255 Renin Human genes 0.000 claims description 4
• 208000007502 anemia Diseases 0.000 claims description 4
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 4
• 230000001419 dependent effect Effects 0.000 claims description 4
• 239000003085 diluting agent Substances 0.000 claims description 4
• 206010014599 encephalitis Diseases 0.000 claims description 4
• 210000003890 endocrine cell Anatomy 0.000 claims description 4
• 201000001441 melanoma Diseases 0.000 claims description 4
• 206010028417 myasthenia gravis Diseases 0.000 claims description 4
• 208000019553 vascular disease Diseases 0.000 claims description 4
• 208000030507 AIDS Diseases 0.000 claims description 3
• 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims description 3
• 208000026872 Addison Disease Diseases 0.000 claims description 3
• 206010002556 Ankylosing Spondylitis Diseases 0.000 claims description 3
• 208000004300 Atrophic Gastritis Diseases 0.000 claims description 3
• 206010004146 Basal cell carcinoma Diseases 0.000 claims description 3
• 206010009944 Colon cancer Diseases 0.000 claims description 3
• 201000003066 Diffuse Scleroderma Diseases 0.000 claims description 3
• 208000036495 Gastritis atrophic Diseases 0.000 claims description 3
• 206010018364 Glomerulonephritis Diseases 0.000 claims description 3
• 208000003807 Graves Disease Diseases 0.000 claims description 3
• 208000015023 Graves' disease Diseases 0.000 claims description 3
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 3
• 102000004877 Insulin Human genes 0.000 claims description 3
• 108090001061 Insulin Proteins 0.000 claims description 3
• 201000001779 Leukocyte adhesion deficiency Diseases 0.000 claims description 3
• 206010025323 Lymphomas Diseases 0.000 claims description 3
• 201000009906 Meningitis Diseases 0.000 claims description 3
• 206010034277 Pemphigoid Diseases 0.000 claims description 3
• 241000721454 Pemphigus Species 0.000 claims description 3
• 208000031845 Pernicious anaemia Diseases 0.000 claims description 3
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 3
• 208000033464 Reiter syndrome Diseases 0.000 claims description 3
• 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims description 3
• 208000021386 Sjogren Syndrome Diseases 0.000 claims description 3
• 201000009594 Systemic Scleroderma Diseases 0.000 claims description 3
• 206010042953 Systemic sclerosis Diseases 0.000 claims description 3
• 201000007023 Thrombotic Thrombocytopenic Purpura Diseases 0.000 claims description 3
• 206010047115 Vasculitis Diseases 0.000 claims description 3
• 206010047124 Vasculitis necrotising Diseases 0.000 claims description 3
• 210000000481 breast Anatomy 0.000 claims description 3
• 208000016644 chronic atrophic gastritis Diseases 0.000 claims description 3
• 208000025302 chronic primary adrenal insufficiency Diseases 0.000 claims description 3
• 208000029742 colonic neoplasm Diseases 0.000 claims description 3
• 201000001981 dermatomyositis Diseases 0.000 claims description 3
• 208000028996 habitual spontaneous abortion Diseases 0.000 claims description 3
• 230000002949 hemolytic effect Effects 0.000 claims description 3
• 208000027866 inflammatory disease Diseases 0.000 claims description 3
• 229940125396 insulin Drugs 0.000 claims description 3
• 210000004153 islets of langerhan Anatomy 0.000 claims description 3
• 206010027175 memory impairment Diseases 0.000 claims description 3
• 201000008968 osteosarcoma Diseases 0.000 claims description 3
• 208000005987 polymyositis Diseases 0.000 claims description 3
• 210000002307 prostate Anatomy 0.000 claims description 3
• 208000002574 reactive arthritis Diseases 0.000 claims description 3
• 201000003068 rheumatic fever Diseases 0.000 claims description 3
• 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 claims description 3
• 230000002792 vascular Effects 0.000 claims description 3
• 201000001320 Atherosclerosis Diseases 0.000 claims description 2
• 206010063408 Bladder hypertrophy Diseases 0.000 claims description 2
• 208000013725 Chronic Kidney Disease-Mineral and Bone disease Diseases 0.000 claims description 2
• 206010016654 Fibrosis Diseases 0.000 claims description 2
• 206010062624 High turnover osteopathy Diseases 0.000 claims description 2
• 201000002980 Hyperparathyroidism Diseases 0.000 claims description 2
• 208000002624 Osteitis Fibrosa Cystica Diseases 0.000 claims description 2
• 206010031240 Osteodystrophy Diseases 0.000 claims description 2
• 208000037849 arterial hypertension Diseases 0.000 claims description 2
• 230000007882 cirrhosis Effects 0.000 claims description 2
• 208000019425 cirrhosis of liver Diseases 0.000 claims description 2
• 210000001035 gastrointestinal tract Anatomy 0.000 claims description 2
• 201000008972 osteitis fibrosa Diseases 0.000 claims description 2
• 208000005368 osteomalacia Diseases 0.000 claims description 2
• 201000006409 renal osteodystrophy Diseases 0.000 claims description 2
• 208000037803 restenosis Diseases 0.000 claims description 2
• 208000007442 rickets Diseases 0.000 claims description 2
• 230000002459 sustained effect Effects 0.000 claims description 2
• 150000002431 hydrogen Chemical class 0.000 claims 2
• 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
• 208000034189 Sclerosis Diseases 0.000 claims 1
• 206010039984 Senile osteoporosis Diseases 0.000 claims 1
• 208000032594 Vascular Remodeling Diseases 0.000 claims 1
• 101710123661 Venom allergen 5 Proteins 0.000 claims 1
• 239000000018 receptor agonist Substances 0.000 claims 1
• 229940044601 receptor agonist Drugs 0.000 claims 1
• 206010038038 rectal cancer Diseases 0.000 claims 1
• 201000001275 rectum cancer Diseases 0.000 claims 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 79
• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 67
• 230000000694 effects Effects 0.000 description 63
• WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 51
• 241001465754 Metazoa Species 0.000 description 41
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 40
• 239000000243 solution Substances 0.000 description 39
• 210000003932 urinary bladder Anatomy 0.000 description 38
• OAYLNYINCPYISS-UHFFFAOYSA-N ethyl acetate;hexane Chemical compound CCCCCC.CCOC(C)=O OAYLNYINCPYISS-UHFFFAOYSA-N 0.000 description 37
• 206010028980 Neoplasm Diseases 0.000 description 33
• 230000015572 biosynthetic process Effects 0.000 description 29
• 239000000427 antigen Substances 0.000 description 28
• TZIHFWKZFHZASV-UHFFFAOYSA-N methyl formate Chemical compound COC=O TZIHFWKZFHZASV-UHFFFAOYSA-N 0.000 description 28
• 210000001519 tissue Anatomy 0.000 description 28
• 238000001727 in vivo Methods 0.000 description 26
• 102000036639 antigens Human genes 0.000 description 25
• 108091007433 antigens Proteins 0.000 description 25
• 238000003786 synthesis reaction Methods 0.000 description 24
• 239000003795 chemical substances by application Substances 0.000 description 23
• UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 20
• 239000012267 brine Substances 0.000 description 19
• 239000003814 drug Substances 0.000 description 19
• 238000000338 in vitro Methods 0.000 description 19
• HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 19
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 18
• 229930003316 Vitamin D Natural products 0.000 description 18
• 210000000988 bone and bone Anatomy 0.000 description 18
• 210000002569 neuron Anatomy 0.000 description 18
• 235000019166 vitamin D Nutrition 0.000 description 18
• 239000011710 vitamin D Substances 0.000 description 18
• 229940046008 vitamin d Drugs 0.000 description 18
• 210000004369 blood Anatomy 0.000 description 17
• 239000008280 blood Substances 0.000 description 17
• 230000012010 growth Effects 0.000 description 17
• 230000001575 pathological effect Effects 0.000 description 17
• 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 16
• 208000004403 Prostatic Hyperplasia Diseases 0.000 description 16
• PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 16
• 229940079593 drug Drugs 0.000 description 16
• 231100000682 maximum tolerated dose Toxicity 0.000 description 16
• 239000012044 organic layer Substances 0.000 description 16
• 229910052938 sodium sulfate Inorganic materials 0.000 description 16
• 235000011152 sodium sulphate Nutrition 0.000 description 16
• 239000000126 substance Substances 0.000 description 16
• 241000700159 Rattus Species 0.000 description 15
• 239000004480 active ingredient Substances 0.000 description 15
• 125000003118 aryl group Chemical group 0.000 description 15
• 230000028993 immune response Effects 0.000 description 15
• 238000003556 assay Methods 0.000 description 14
• 230000006870 function Effects 0.000 description 14
• 239000000463 material Substances 0.000 description 14
• 150000003710 vitamin D derivatives Chemical class 0.000 description 14
• 201000009030 Carcinoma Diseases 0.000 description 13
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 13
• 230000004044 response Effects 0.000 description 13
• GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 description 12
• 102000009310 vitamin D receptors Human genes 0.000 description 12
• 108050000156 vitamin D receptors Proteins 0.000 description 12
• 210000002865 immune cell Anatomy 0.000 description 11
• 125000001424 substituent group Chemical group 0.000 description 11
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
• 208000009329 Graft vs Host Disease Diseases 0.000 description 10
• 241000699670 Mus sp. Species 0.000 description 10
• 210000003443 bladder cell Anatomy 0.000 description 10
• 230000004069 differentiation Effects 0.000 description 10
• 208000024908 graft versus host disease Diseases 0.000 description 10
• 229940088597 hormone Drugs 0.000 description 10
• 239000005556 hormone Substances 0.000 description 10
• 230000035755 proliferation Effects 0.000 description 10
• 210000002966 serum Anatomy 0.000 description 10
• 150000003431 steroids Chemical class 0.000 description 10
• 208000024891 symptom Diseases 0.000 description 10
• 230000001225 therapeutic effect Effects 0.000 description 10
• 241000282412 Homo Species 0.000 description 9
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
• 230000000118 anti-neoplastic effect Effects 0.000 description 9
• 235000020964 calcitriol Nutrition 0.000 description 9
• 239000011612 calcitriol Substances 0.000 description 9
• 229960005084 calcitriol Drugs 0.000 description 9
• 238000011161 development Methods 0.000 description 9
• 230000018109 developmental process Effects 0.000 description 9
• 230000013632 homeostatic process Effects 0.000 description 9
• 239000007924 injection Substances 0.000 description 9
• 238000002347 injection Methods 0.000 description 9
• VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 9
• 238000012552 review Methods 0.000 description 9
• 235000002639 sodium chloride Nutrition 0.000 description 9
• 241000894007 species Species 0.000 description 9
• CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 8
• UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical class [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 8
• 210000001744 T-lymphocyte Anatomy 0.000 description 8
• 230000001413 cellular effect Effects 0.000 description 8
• 230000001965 increasing effect Effects 0.000 description 8
• 210000004698 lymphocyte Anatomy 0.000 description 8
• 238000004519 manufacturing process Methods 0.000 description 8
• 239000002207 metabolite Substances 0.000 description 8
• 229920001223 polyethylene glycol Polymers 0.000 description 8
• 239000000843 powder Substances 0.000 description 8
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 7
• 241000699666 Mus <mouse, genus> Species 0.000 description 7
• 238000010521 absorption reaction Methods 0.000 description 7
• 239000000443 aerosol Substances 0.000 description 7
• 239000002775 capsule Substances 0.000 description 7
• 230000004663 cell proliferation Effects 0.000 description 7
• 230000008602 contraction Effects 0.000 description 7
• 125000000753 cycloalkyl group Chemical group 0.000 description 7
• 230000007850 degeneration Effects 0.000 description 7
• 239000002552 dosage form Substances 0.000 description 7
• 235000019441 ethanol Nutrition 0.000 description 7
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 7
• 206010020718 hyperplasia Diseases 0.000 description 7
• 210000000987 immune system Anatomy 0.000 description 7
• 230000006698 induction Effects 0.000 description 7
• 210000002510 keratinocyte Anatomy 0.000 description 7
• 239000007788 liquid Substances 0.000 description 7
• 210000004185 liver Anatomy 0.000 description 7
• 210000005170 neoplastic cell Anatomy 0.000 description 7
• 230000011164 ossification Effects 0.000 description 7
• 239000000546 pharmaceutical excipient Substances 0.000 description 7
• 239000000725 suspension Substances 0.000 description 7
• 239000003826 tablet Substances 0.000 description 7
• 238000012360 testing method Methods 0.000 description 7
• 241000283984 Rodentia Species 0.000 description 6
• MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 6
• 229940034982 antineoplastic agent Drugs 0.000 description 6
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 6
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 6
• 125000004432 carbon atom Chemical group C* 0.000 description 6
• 239000000969 carrier Substances 0.000 description 6
• 230000034994 death Effects 0.000 description 6
• 231100000517 death Toxicity 0.000 description 6
• 210000001320 hippocampus Anatomy 0.000 description 6
• 125000004435 hydrogen atom Chemical group [H]* 0.000 description 6
• 230000008105 immune reaction Effects 0.000 description 6
• 230000005764 inhibitory process Effects 0.000 description 6
• 210000003734 kidney Anatomy 0.000 description 6
• 239000002609 medium Substances 0.000 description 6
• 230000009826 neoplastic cell growth Effects 0.000 description 6
• 229910052760 oxygen Inorganic materials 0.000 description 6
• 239000001301 oxygen Substances 0.000 description 6
• 230000008569 process Effects 0.000 description 6
• 238000000926 separation method Methods 0.000 description 6
• 239000011734 sodium Substances 0.000 description 6
• 239000007921 spray Substances 0.000 description 6
• 239000003981 vehicle Substances 0.000 description 6
• NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 5
• 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 5
• 208000031261 Acute myeloid leukaemia Diseases 0.000 description 5
• 239000004322 Butylated hydroxytoluene Substances 0.000 description 5
• NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 5
• 108010010803 Gelatin Proteins 0.000 description 5
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
• 208000037147 Hypercalcaemia Diseases 0.000 description 5
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 5
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 5
• 229930006000 Sucrose Natural products 0.000 description 5
• 125000005907 alkyl ester group Chemical group 0.000 description 5
• 208000026935 allergic disease Diseases 0.000 description 5
• 239000003963 antioxidant agent Substances 0.000 description 5
• 235000006708 antioxidants Nutrition 0.000 description 5
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 5
• 235000010354 butylated hydroxytoluene Nutrition 0.000 description 5
• 229940095259 butylated hydroxytoluene Drugs 0.000 description 5
• 239000006071 cream Substances 0.000 description 5
• 230000006866 deterioration Effects 0.000 description 5
• 230000002124 endocrine Effects 0.000 description 5
• 238000002474 experimental method Methods 0.000 description 5
• 238000011049 filling Methods 0.000 description 5
• 239000006260 foam Substances 0.000 description 5
• 239000008273 gelatin Substances 0.000 description 5
• 229920000159 gelatin Polymers 0.000 description 5
• 239000007903 gelatin capsule Substances 0.000 description 5
• 235000019322 gelatine Nutrition 0.000 description 5
• 235000011852 gelatine desserts Nutrition 0.000 description 5
• 239000008103 glucose Substances 0.000 description 5
• 235000011187 glycerol Nutrition 0.000 description 5
• 229910052736 halogen Inorganic materials 0.000 description 5
• 125000000623 heterocyclic group Chemical group 0.000 description 5
• 150000002430 hydrocarbons Chemical group 0.000 description 5
• 230000000148 hypercalcaemia Effects 0.000 description 5
• 208000030915 hypercalcemia disease Diseases 0.000 description 5
• 230000000121 hypercalcemic effect Effects 0.000 description 5
• 239000004615 ingredient Substances 0.000 description 5
• 238000007912 intraperitoneal administration Methods 0.000 description 5
• 230000003902 lesion Effects 0.000 description 5
• 230000027939 micturition Effects 0.000 description 5
• 201000006417 multiple sclerosis Diseases 0.000 description 5
• 229910052757 nitrogen Inorganic materials 0.000 description 5
• 239000003921 oil Substances 0.000 description 5
• 239000002674 ointment Substances 0.000 description 5
• 210000000963 osteoblast Anatomy 0.000 description 5
• 239000006072 paste Substances 0.000 description 5
• 238000002360 preparation method Methods 0.000 description 5
• 239000003755 preservative agent Substances 0.000 description 5
• 108090000623 proteins and genes Proteins 0.000 description 5
• 102000005962 receptors Human genes 0.000 description 5
• 108020003175 receptors Proteins 0.000 description 5
• 230000009467 reduction Effects 0.000 description 5
• 230000002829 reductive effect Effects 0.000 description 5
• 210000003491 skin Anatomy 0.000 description 5
• 239000002904 solvent Substances 0.000 description 5
• 230000000638 stimulation Effects 0.000 description 5
• 239000005720 sucrose Substances 0.000 description 5
• 239000000829 suppository Substances 0.000 description 5
• 230000000699 topical effect Effects 0.000 description 5
• 238000002054 transplantation Methods 0.000 description 5
• 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 4
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 4
• 241000416162 Astragalus gummifer Species 0.000 description 4
• 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 4
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 4
• 241000282472 Canis lupus familiaris Species 0.000 description 4
• 108090000790 Enzymes Proteins 0.000 description 4
• 102000004190 Enzymes Human genes 0.000 description 4
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
• 206010020751 Hypersensitivity Diseases 0.000 description 4
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
• 238000005481 NMR spectroscopy Methods 0.000 description 4
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
• 239000002202 Polyethylene glycol Substances 0.000 description 4
• 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 4
• 206010037211 Psychomotor hyperactivity Diseases 0.000 description 4
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
• 229920002472 Starch Polymers 0.000 description 4
• 229920001615 Tragacanth Polymers 0.000 description 4
• 230000001154 acute effect Effects 0.000 description 4
• 125000004442 acylamino group Chemical group 0.000 description 4
• 208000009956 adenocarcinoma Diseases 0.000 description 4
• 125000003282 alkyl amino group Chemical group 0.000 description 4
• 125000002877 alkyl aryl group Chemical group 0.000 description 4
• 230000007815 allergy Effects 0.000 description 4
• 238000010171 animal model Methods 0.000 description 4
• 206010003246 arthritis Diseases 0.000 description 4
• 230000008901 benefit Effects 0.000 description 4
• 230000004097 bone metabolism Effects 0.000 description 4
• 229940098773 bovine serum albumin Drugs 0.000 description 4
• 230000010261 cell growth Effects 0.000 description 4
• 238000001516 cell proliferation assay Methods 0.000 description 4
• 210000003169 central nervous system Anatomy 0.000 description 4
• 125000004093 cyano group Chemical group *C#N 0.000 description 4
• 229960004397 cyclophosphamide Drugs 0.000 description 4
• 230000007423 decrease Effects 0.000 description 4
• 239000003995 emulsifying agent Substances 0.000 description 4
• 210000000750 endocrine system Anatomy 0.000 description 4
• 229940088598 enzyme Drugs 0.000 description 4
• 239000000499 gel Substances 0.000 description 4
• 239000008187 granular material Substances 0.000 description 4
• 150000002367 halogens Chemical class 0.000 description 4
• 210000003958 hematopoietic stem cell Anatomy 0.000 description 4
• 125000001072 heteroaryl group Chemical group 0.000 description 4
• 125000005842 heteroatom Chemical group 0.000 description 4
• 230000002390 hyperplastic effect Effects 0.000 description 4
• 230000006058 immune tolerance Effects 0.000 description 4
• 230000001976 improved effect Effects 0.000 description 4
• 208000015181 infectious disease Diseases 0.000 description 4
• 230000004054 inflammatory process Effects 0.000 description 4
• 208000014674 injury Diseases 0.000 description 4
• 210000000936 intestine Anatomy 0.000 description 4
• 239000008101 lactose Substances 0.000 description 4
• 239000003446 ligand Substances 0.000 description 4
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
• 238000012423 maintenance Methods 0.000 description 4
• 230000036210 malignancy Effects 0.000 description 4
• 230000007246 mechanism Effects 0.000 description 4
• 235000019198 oils Nutrition 0.000 description 4
• 210000002997 osteoclast Anatomy 0.000 description 4
• 238000007911 parenteral administration Methods 0.000 description 4
• 239000006187 pill Substances 0.000 description 4
• 229920000642 polymer Polymers 0.000 description 4
• 230000002265 prevention Effects 0.000 description 4
• 230000000750 progressive effect Effects 0.000 description 4
• 239000011541 reaction mixture Substances 0.000 description 4
• 230000001105 regulatory effect Effects 0.000 description 4
• 235000019698 starch Nutrition 0.000 description 4
• 238000003756 stirring Methods 0.000 description 4
• 235000000346 sugar Nutrition 0.000 description 4
• 150000008163 sugars Chemical class 0.000 description 4
• 230000001629 suppression Effects 0.000 description 4
• 239000000454 talc Substances 0.000 description 4
• 235000012222 talc Nutrition 0.000 description 4
• 229910052623 talc Inorganic materials 0.000 description 4
• 238000002560 therapeutic procedure Methods 0.000 description 4
• 231100000331 toxic Toxicity 0.000 description 4
• 230000002588 toxic effect Effects 0.000 description 4
• 235000010487 tragacanth Nutrition 0.000 description 4
• 239000000196 tragacanth Substances 0.000 description 4
• 229940116362 tragacanth Drugs 0.000 description 4
• 230000032258 transport Effects 0.000 description 4
• 230000008733 trauma Effects 0.000 description 4
• 239000001993 wax Substances 0.000 description 4
• 239000000080 wetting agent Substances 0.000 description 4
• JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 3
• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 3
• 206010000830 Acute leukaemia Diseases 0.000 description 3
• 229920001817 Agar Polymers 0.000 description 3
• 208000000044 Amnesia Diseases 0.000 description 3
• 206010059313 Anogenital warts Diseases 0.000 description 3
• UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
• 206010071445 Bladder outlet obstruction Diseases 0.000 description 3
• 208000006386 Bone Resorption Diseases 0.000 description 3
• 208000026310 Breast neoplasm Diseases 0.000 description 3
• 229930105110 Cyclosporin A Natural products 0.000 description 3
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 3
• 108010036949 Cyclosporine Proteins 0.000 description 3
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
• YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 3
• 206010061218 Inflammation Diseases 0.000 description 3
• 208000005615 Interstitial Cystitis Diseases 0.000 description 3
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
• 235000010643 Leucaena leucocephala Nutrition 0.000 description 3
• 240000007472 Leucaena leucocephala Species 0.000 description 3
• 208000026139 Memory disease Diseases 0.000 description 3
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
• GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 3
• 108020005497 Nuclear hormone receptor Proteins 0.000 description 3
• 102000004067 Osteocalcin Human genes 0.000 description 3
• 108090000573 Osteocalcin Proteins 0.000 description 3
• 102000003946 Prolactin Human genes 0.000 description 3
• 108010057464 Prolactin Proteins 0.000 description 3
• 206010039491 Sarcoma Diseases 0.000 description 3
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
• 208000006011 Stroke Diseases 0.000 description 3
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 3
• 230000005867 T cell response Effects 0.000 description 3
• 208000003800 Urinary Bladder Neck Obstruction Diseases 0.000 description 3
• 108700042354 Vitamin D Response Element Proteins 0.000 description 3
• 230000003187 abdominal effect Effects 0.000 description 3
• 230000002159 abnormal effect Effects 0.000 description 3
• 235000010419 agar Nutrition 0.000 description 3
• 235000010443 alginic acid Nutrition 0.000 description 3
• 229920000615 alginic acid Polymers 0.000 description 3
• 125000001931 aliphatic group Chemical group 0.000 description 3
• 125000003545 alkoxy group Chemical group 0.000 description 3
• 125000004453 alkoxycarbonyl group Chemical group 0.000 description 3
• 125000005194 alkoxycarbonyloxy group Chemical group 0.000 description 3
• 125000004947 alkyl aryl amino group Chemical group 0.000 description 3
• 125000003806 alkyl carbonyl amino group Chemical group 0.000 description 3
• 125000004448 alkyl carbonyl group Chemical group 0.000 description 3
• 125000004691 alkyl thio carbonyl group Chemical group 0.000 description 3
• 125000004414 alkyl thio group Chemical group 0.000 description 3
• 125000001769 aryl amino group Chemical group 0.000 description 3
• 125000004658 aryl carbonyl amino group Chemical group 0.000 description 3
• 125000005199 aryl carbonyloxy group Chemical group 0.000 description 3
• 125000005110 aryl thio group Chemical group 0.000 description 3
• 125000005200 aryloxy carbonyloxy group Chemical group 0.000 description 3
• 125000004429 atom Chemical group 0.000 description 3
• 208000010668 atopic eczema Diseases 0.000 description 3
• 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 description 3
• 235000012216 bentonite Nutrition 0.000 description 3
• 230000004071 biological effect Effects 0.000 description 3
• 230000024279 bone resorption Effects 0.000 description 3
• 239000000872 buffer Substances 0.000 description 3
• 235000019282 butylated hydroxyanisole Nutrition 0.000 description 3
• 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 description 3
• 150000007942 carboxylates Chemical class 0.000 description 3
• 238000006243 chemical reaction Methods 0.000 description 3
• 229960001265 ciclosporin Drugs 0.000 description 3
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
• 238000000576 coating method Methods 0.000 description 3
• 239000012230 colorless oil Substances 0.000 description 3
• 238000012258 culturing Methods 0.000 description 3
• 230000007812 deficiency Effects 0.000 description 3
• 125000004663 dialkyl amino group Chemical group 0.000 description 3
• 125000004986 diarylamino group Chemical group 0.000 description 3
• 239000006185 dispersion Substances 0.000 description 3
• 239000000839 emulsion Substances 0.000 description 3
• 238000011156 evaluation Methods 0.000 description 3
• 238000001704 evaporation Methods 0.000 description 3
• 230000008020 evaporation Effects 0.000 description 3
• 230000001605 fetal effect Effects 0.000 description 3
• 239000000945 filler Substances 0.000 description 3
• 210000002216 heart Anatomy 0.000 description 3
• RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
• 239000003018 immunosuppressive agent Substances 0.000 description 3
• 239000003701 inert diluent Substances 0.000 description 3
• 238000001802 infusion Methods 0.000 description 3
• 230000000968 intestinal effect Effects 0.000 description 3
• 239000007928 intraperitoneal injection Substances 0.000 description 3
• 230000036724 intravesical pressure Effects 0.000 description 3
• 230000000622 irritating effect Effects 0.000 description 3
• 235000010445 lecithin Nutrition 0.000 description 3
• 239000000787 lecithin Substances 0.000 description 3
• 229940067606 lecithin Drugs 0.000 description 3
• 239000006210 lotion Substances 0.000 description 3
• 239000000314 lubricant Substances 0.000 description 3
• 229920002521 macromolecule Polymers 0.000 description 3
• 230000003211 malignant effect Effects 0.000 description 3
• 238000005259 measurement Methods 0.000 description 3
• 239000012528 membrane Substances 0.000 description 3
• 230000006984 memory degeneration Effects 0.000 description 3
• 208000023060 memory loss Diseases 0.000 description 3
• 230000004048 modification Effects 0.000 description 3
• 238000012986 modification Methods 0.000 description 3
• 208000025113 myeloid leukemia Diseases 0.000 description 3
• 210000003739 neck Anatomy 0.000 description 3
• 210000005036 nerve Anatomy 0.000 description 3
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 3
• 102000006255 nuclear receptors Human genes 0.000 description 3
• 108020004017 nuclear receptors Proteins 0.000 description 3
• 239000002245 particle Substances 0.000 description 3
• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 3
• 230000002093 peripheral effect Effects 0.000 description 3
• 239000000825 pharmaceutical preparation Substances 0.000 description 3
• 229940097325 prolactin Drugs 0.000 description 3
• 239000003380 propellant Substances 0.000 description 3
• 102000004169 proteins and genes Human genes 0.000 description 3
• 150000003254 radicals Chemical class 0.000 description 3
• 238000011084 recovery Methods 0.000 description 3
• 150000003338 secosteroids Chemical class 0.000 description 3
• 239000000741 silica gel Substances 0.000 description 3
• 229910002027 silica gel Inorganic materials 0.000 description 3
• RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 3
• 235000012239 silicon dioxide Nutrition 0.000 description 3
• 235000010356 sorbitol Nutrition 0.000 description 3
• 239000000600 sorbitol Substances 0.000 description 3
• 238000007920 subcutaneous administration Methods 0.000 description 3
• 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 description 3
• 229910052717 sulfur Inorganic materials 0.000 description 3
• 239000011593 sulfur Substances 0.000 description 3
• 150000003467 sulfuric acid derivatives Chemical group 0.000 description 3
• 239000000375 suspending agent Substances 0.000 description 3
• 239000006188 syrup Substances 0.000 description 3
• 235000020357 syrup Nutrition 0.000 description 3
• 229960003604 testosterone Drugs 0.000 description 3
• CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 description 3
• 230000001988 toxicity Effects 0.000 description 3
• 231100000419 toxicity Toxicity 0.000 description 3
• 210000004881 tumor cell Anatomy 0.000 description 3
• PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
• KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
• WVQFESJNOSYLJI-RGTRFGFKSA-N (1R,3S,5E)-5-[(2E)-2-[(3aS,7aS)-7a-methyl-1-[(2R)-7,7,7-trifluoro-6-hydroxy-6-(trifluoromethyl)hept-4-yn-2-yl]-3a,5,6,7-tetrahydro-3H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol Chemical compound C1(/[C@@H]2CC=C([C@]2(CCC1)C)[C@@H](CC#CC(O)(C(F)(F)F)C(F)(F)F)C)=C\C=C1/C[C@@H](O)C[C@H](O)C1=C WVQFESJNOSYLJI-RGTRFGFKSA-N 0.000 description 2
• GMRQFYUYWCNGIN-UHFFFAOYSA-N 1,25-Dihydroxy-vitamin D3' Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CC(O)C1=C GMRQFYUYWCNGIN-UHFFFAOYSA-N 0.000 description 2
• GMRQFYUYWCNGIN-ZVUFCXRFSA-N 1,25-dihydroxy vitamin D3 Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-ZVUFCXRFSA-N 0.000 description 2
• VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
• WDYVUKGVKRZQNM-UHFFFAOYSA-N 6-phosphonohexylphosphonic acid Chemical compound OP(O)(=O)CCCCCCP(O)(O)=O WDYVUKGVKRZQNM-UHFFFAOYSA-N 0.000 description 2
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
• HGINCPLSRVDWNT-UHFFFAOYSA-N Acrolein Chemical compound C=CC=O HGINCPLSRVDWNT-UHFFFAOYSA-N 0.000 description 2
• 208000016683 Adult T-cell leukemia/lymphoma Diseases 0.000 description 2
• 208000032467 Aplastic anaemia Diseases 0.000 description 2
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
• BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
• 206010006187 Breast cancer Diseases 0.000 description 2
• VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
• 206010056874 Chemical cystitis Diseases 0.000 description 2
• 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 2
• 208000011231 Crohn disease Diseases 0.000 description 2
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 2
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
• FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
• LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 2
• 108090000385 Fibroblast growth factor 7 Proteins 0.000 description 2
• 241000206672 Gelidium Species 0.000 description 2
• 239000004471 Glycine Substances 0.000 description 2
• 208000017604 Hodgkin disease Diseases 0.000 description 2
• 208000010747 Hodgkins lymphoma Diseases 0.000 description 2
• 206010062016 Immunosuppression Diseases 0.000 description 2
• VLSMHEGGTFMBBZ-OOZYFLPDSA-M Kainate Chemical compound CC(=C)[C@H]1C[NH2+][C@H](C([O-])=O)[C@H]1CC([O-])=O VLSMHEGGTFMBBZ-OOZYFLPDSA-M 0.000 description 2
• 229930195725 Mannitol Natural products 0.000 description 2
• 208000007054 Medullary Carcinoma Diseases 0.000 description 2
• 241000699660 Mus musculus Species 0.000 description 2
• 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 2
• 206010033733 Papule Diseases 0.000 description 2
• 241001494479 Pecora Species 0.000 description 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
• 239000004698 Polyethylene Substances 0.000 description 2
• 208000033766 Prolymphocytic Leukemia Diseases 0.000 description 2
• ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
• ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
• KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 description 2
• KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 2
• LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 description 2
• 208000006265 Renal cell carcinoma Diseases 0.000 description 2
• 102000034527 Retinoid X Receptors Human genes 0.000 description 2
• 108010038912 Retinoid X Receptors Proteins 0.000 description 2
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
• 230000006052 T cell proliferation Effects 0.000 description 2
• 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 description 2
• QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 description 2
• FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
• 208000024313 Testicular Neoplasms Diseases 0.000 description 2
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
• YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 2
• 102400000336 Thyrotropin-releasing hormone Human genes 0.000 description 2
• HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 2
• 208000033559 Waldenström macroglobulinemia Diseases 0.000 description 2
• 208000000260 Warts Diseases 0.000 description 2
• XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
• MOQOOKGPCBQMCY-UHFFFAOYSA-N acetic acid;hexane Chemical compound CC(O)=O.CCCCCC MOQOOKGPCBQMCY-UHFFFAOYSA-N 0.000 description 2
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 2
• 239000002671 adjuvant Substances 0.000 description 2
• 201000006966 adult T-cell leukemia Diseases 0.000 description 2
• 208000011341 adult acute respiratory distress syndrome Diseases 0.000 description 2
• 201000000028 adult respiratory distress syndrome Diseases 0.000 description 2
• 230000032683 aging Effects 0.000 description 2
• 239000000783 alginic acid Substances 0.000 description 2
• 229960001126 alginic acid Drugs 0.000 description 2
• 150000004781 alginic acids Chemical class 0.000 description 2
• 125000002723 alicyclic group Chemical group 0.000 description 2
• 150000001336 alkenes Chemical class 0.000 description 2
• 125000003342 alkenyl group Chemical group 0.000 description 2
• 125000005196 alkyl carbonyloxy group Chemical group 0.000 description 2
• 230000000961 alloantigen Effects 0.000 description 2
• 230000000735 allogeneic effect Effects 0.000 description 2
• 230000004075 alteration Effects 0.000 description 2
• WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
• 210000004727 amygdala Anatomy 0.000 description 2
• 229960003473 androstanolone Drugs 0.000 description 2
• 239000002246 antineoplastic agent Substances 0.000 description 2
• 239000007864 aqueous solution Substances 0.000 description 2
• 208000006673 asthma Diseases 0.000 description 2
• 229960002170 azathioprine Drugs 0.000 description 2
• LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 description 2
• 210000003719 b-lymphocyte Anatomy 0.000 description 2
• 239000000440 bentonite Substances 0.000 description 2
• 229910000278 bentonite Inorganic materials 0.000 description 2
• SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
• IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 description 2
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
• 239000011230 binding agent Substances 0.000 description 2
• 229920002988 biodegradable polymer Polymers 0.000 description 2
• 239000004621 biodegradable polymer Substances 0.000 description 2
• 238000001574 biopsy Methods 0.000 description 2
• 208000029162 bladder disease Diseases 0.000 description 2
• 210000004556 brain Anatomy 0.000 description 2
• 230000003913 calcium metabolism Effects 0.000 description 2
• 208000035269 cancer or benign tumor Diseases 0.000 description 2
• 239000011203 carbon fibre reinforced carbon Substances 0.000 description 2
• 239000001768 carboxy methyl cellulose Substances 0.000 description 2
• 150000001732 carboxylic acid derivatives Chemical class 0.000 description 2
• 150000001735 carboxylic acids Chemical class 0.000 description 2
• 239000012876 carrier material Substances 0.000 description 2
• 238000004113 cell culture Methods 0.000 description 2
• 230000024245 cell differentiation Effects 0.000 description 2
• 235000010980 cellulose Nutrition 0.000 description 2
• 229920002678 cellulose Polymers 0.000 description 2
• 239000001913 cellulose Substances 0.000 description 2
• 230000008859 change Effects 0.000 description 2
• OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
• 208000020832 chronic kidney disease Diseases 0.000 description 2
• 208000024207 chronic leukemia Diseases 0.000 description 2
• 239000011248 coating agent Substances 0.000 description 2
• 229940110456 cocoa butter Drugs 0.000 description 2
• 235000019868 cocoa butter Nutrition 0.000 description 2
• 208000010877 cognitive disease Diseases 0.000 description 2
• 239000003086 colorant Substances 0.000 description 2
• 230000001010 compromised effect Effects 0.000 description 2
• 230000001054 cortical effect Effects 0.000 description 2
• 235000012343 cottonseed oil Nutrition 0.000 description 2
• CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 2
• 230000002089 crippling effect Effects 0.000 description 2
• 201000007241 cutaneous T cell lymphoma Diseases 0.000 description 2
• 201000003146 cystitis Diseases 0.000 description 2
• 230000006378 damage Effects 0.000 description 2
• 230000008260 defense mechanism Effects 0.000 description 2
• 230000002950 deficient Effects 0.000 description 2
• 230000006735 deficit Effects 0.000 description 2
• 230000003111 delayed effect Effects 0.000 description 2
• 230000001627 detrimental effect Effects 0.000 description 2
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
• 238000002845 discoloration Methods 0.000 description 2
• 239000002270 dispersing agent Substances 0.000 description 2
• 239000008298 dragée Substances 0.000 description 2
• 239000003792 electrolyte Substances 0.000 description 2
• 230000000925 erythroid effect Effects 0.000 description 2
• MMXKVMNBHPAILY-UHFFFAOYSA-N ethyl laurate Chemical compound CCCCCCCCCCCC(=O)OCC MMXKVMNBHPAILY-UHFFFAOYSA-N 0.000 description 2
• LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 2
• 229940093471 ethyl oleate Drugs 0.000 description 2
• 238000001914 filtration Methods 0.000 description 2
• 230000004907 flux Effects 0.000 description 2
• 210000004907 gland Anatomy 0.000 description 2
• 230000000762 glandular Effects 0.000 description 2
• 239000003102 growth factor Substances 0.000 description 2
• 239000001963 growth medium Substances 0.000 description 2
• 201000009277 hairy cell leukemia Diseases 0.000 description 2
• 125000005843 halogen group Chemical group 0.000 description 2
• 230000036541 health Effects 0.000 description 2
• 210000002443 helper t lymphocyte Anatomy 0.000 description 2
• BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 2
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
• 230000005965 immune activity Effects 0.000 description 2
• 229940124589 immunosuppressive drug Drugs 0.000 description 2
• 238000002513 implantation Methods 0.000 description 2
• 238000010874 in vitro model Methods 0.000 description 2
• 229910052500 inorganic mineral Inorganic materials 0.000 description 2
• 238000010255 intramuscular injection Methods 0.000 description 2
• 238000007913 intrathecal administration Methods 0.000 description 2
• 238000001990 intravenous administration Methods 0.000 description 2
• 206010023332 keratitis Diseases 0.000 description 2
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
• 210000000265 leukocyte Anatomy 0.000 description 2
• 201000011486 lichen planus Diseases 0.000 description 2
• 230000000670 limiting effect Effects 0.000 description 2
• 239000002502 liposome Substances 0.000 description 2
• 239000008297 liquid dosage form Substances 0.000 description 2
• 210000000627 locus coeruleus Anatomy 0.000 description 2
• 230000000527 lymphocytic effect Effects 0.000 description 2
• 210000003563 lymphoid tissue Anatomy 0.000 description 2
• 235000019359 magnesium stearate Nutrition 0.000 description 2
• 239000000594 mannitol Substances 0.000 description 2
• 235000010355 mannitol Nutrition 0.000 description 2
• 208000023356 medullary thyroid gland carcinoma Diseases 0.000 description 2
• 230000002503 metabolic effect Effects 0.000 description 2
• 235000013336 milk Nutrition 0.000 description 2
• 239000008267 milk Substances 0.000 description 2
• 210000004080 milk Anatomy 0.000 description 2
• 235000010755 mineral Nutrition 0.000 description 2
• 239000011707 mineral Substances 0.000 description 2
• 210000002864 mononuclear phagocyte Anatomy 0.000 description 2
• 230000000877 morphologic effect Effects 0.000 description 2
• 238000000465 moulding Methods 0.000 description 2
• 210000003205 muscle Anatomy 0.000 description 2
• 201000005962 mycosis fungoides Diseases 0.000 description 2
• 210000000478 neocortex Anatomy 0.000 description 2
• 230000001537 neural effect Effects 0.000 description 2
• 230000000324 neuroprotective effect Effects 0.000 description 2
• 239000012299 nitrogen atmosphere Substances 0.000 description 2
• 230000008298 non-genomic mechanism Effects 0.000 description 2
• 238000011580 nude mouse model Methods 0.000 description 2
• JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 2
• 239000004006 olive oil Substances 0.000 description 2
• 235000008390 olive oil Nutrition 0.000 description 2
• 230000003287 optical effect Effects 0.000 description 2
• 210000000496 pancreas Anatomy 0.000 description 2
• 239000002304 perfume Substances 0.000 description 2
• 239000002953 phosphate buffered saline Substances 0.000 description 2
• DHRLEVQXOMLTIM-UHFFFAOYSA-N phosphoric acid;trioxomolybdenum Chemical compound O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.OP(O)(O)=O DHRLEVQXOMLTIM-UHFFFAOYSA-N 0.000 description 2
• 125000004437 phosphorous atom Chemical group 0.000 description 2
• 125000003367 polycyclic group Chemical group 0.000 description 2
• 229920000573 polyethylene Polymers 0.000 description 2
• 229920005862 polyol Polymers 0.000 description 2
• 150000003077 polyols Chemical class 0.000 description 2
• 239000002243 precursor Substances 0.000 description 2
• 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 description 2
• 230000002062 proliferating effect Effects 0.000 description 2
• 230000002035 prolonged effect Effects 0.000 description 2
• 238000011321 prophylaxis Methods 0.000 description 2
• 235000018102 proteins Nutrition 0.000 description 2
• 230000001185 psoriatic effect Effects 0.000 description 2
• 230000005855 radiation Effects 0.000 description 2
• ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 2
• 238000011552 rat model Methods 0.000 description 2
• 230000004043 responsiveness Effects 0.000 description 2
• 230000000630 rising effect Effects 0.000 description 2
• 239000012679 serum free medium Substances 0.000 description 2
• 239000008159 sesame oil Substances 0.000 description 2
• 235000011803 sesame oil Nutrition 0.000 description 2
• QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 2
• 229960002930 sirolimus Drugs 0.000 description 2
• 201000010153 skin papilloma Diseases 0.000 description 2
• 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
• DAEPDZWVDSPTHF-UHFFFAOYSA-M sodium pyruvate Chemical compound [Na+].CC(=O)C([O-])=O DAEPDZWVDSPTHF-UHFFFAOYSA-M 0.000 description 2
• GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
• 230000002037 soft tissue calcification Effects 0.000 description 2
• 239000007909 solid dosage form Substances 0.000 description 2
• 239000008247 solid mixture Substances 0.000 description 2
• 239000003381 stabilizer Substances 0.000 description 2
• 239000008107 starch Substances 0.000 description 2
• 229940032147 starch Drugs 0.000 description 2
• 239000007858 starting material Substances 0.000 description 2
• 238000010254 subcutaneous injection Methods 0.000 description 2
• 125000000547 substituted alkyl group Chemical group 0.000 description 2
• 238000006467 substitution reaction Methods 0.000 description 2
• 125000004434 sulfur atom Chemical group 0.000 description 2
• 239000004094 surface-active agent Substances 0.000 description 2
• 238000001356 surgical procedure Methods 0.000 description 2
• 230000004083 survival effect Effects 0.000 description 2
• 239000011975 tartaric acid Substances 0.000 description 2
• 235000002906 tartaric acid Nutrition 0.000 description 2
• 238000011285 therapeutic regimen Methods 0.000 description 2
• 230000004797 therapeutic response Effects 0.000 description 2
• 230000008719 thickening Effects 0.000 description 2
• 125000003396 thiol group Chemical group [H]S* 0.000 description 2
• 229960000984 tocofersolan Drugs 0.000 description 2
• 238000013518 transcription Methods 0.000 description 2
• 230000035897 transcription Effects 0.000 description 2
• ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 2
• 230000001960 triggered effect Effects 0.000 description 2
• 230000002485 urinary effect Effects 0.000 description 2
• 210000001635 urinary tract Anatomy 0.000 description 2
• 210000002700 urine Anatomy 0.000 description 2
• 238000012800 visualization Methods 0.000 description 2
• GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
• NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
• QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 description 1
• QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 1
• ITOFPJRDSCGOSA-KZLRUDJFSA-N (2s)-2-[[(4r)-4-[(3r,5r,8r,9s,10s,13r,14s,17r)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]-3-(1h-indol-3-yl)propanoic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H](CC[C@]13C)[C@@H]2[C@@H]3CC[C@@H]1[C@H](C)CCC(=O)N[C@H](C(O)=O)CC1=CNC2=CC=CC=C12 ITOFPJRDSCGOSA-KZLRUDJFSA-N 0.000 description 1
• WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
• MIOPJNTWMNEORI-GMSGAONNSA-N (S)-camphorsulfonic acid Chemical compound C1C[C@@]2(CS(O)(=O)=O)C(=O)C[C@@H]1C2(C)C MIOPJNTWMNEORI-GMSGAONNSA-N 0.000 description 1
• BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 description 1
• 229940058015 1,3-butylene glycol Drugs 0.000 description 1
• JNODDICFTDYODH-UHFFFAOYSA-N 2-hydroxytetrahydrofuran Chemical compound OC1CCCO1 JNODDICFTDYODH-UHFFFAOYSA-N 0.000 description 1
• 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 description 1
• LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
• JWUBBDSIWDLEOM-UHFFFAOYSA-N 25-Hydroxycholecalciferol Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CCC1=C JWUBBDSIWDLEOM-UHFFFAOYSA-N 0.000 description 1
• JWUBBDSIWDLEOM-DCHLRESJSA-N 25-Hydroxyvitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C/C=C1\C[C@@H](O)CCC1=C JWUBBDSIWDLEOM-DCHLRESJSA-N 0.000 description 1
• JWUBBDSIWDLEOM-NQZHSCJISA-N 25-hydroxy-3 epi cholecalciferol Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@H](O)CCC1=C JWUBBDSIWDLEOM-NQZHSCJISA-N 0.000 description 1
• MGGVALXERJRIRO-UHFFFAOYSA-N 4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-2-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-1H-pyrazol-5-one Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C=1C(=NN(C=1)CC(=O)N1CC2=C(CC1)NN=N2)O MGGVALXERJRIRO-UHFFFAOYSA-N 0.000 description 1
• FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
• QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
• 102000003678 AMPA Receptors Human genes 0.000 description 1
• 108090000078 AMPA Receptors Proteins 0.000 description 1
• 208000004998 Abdominal Pain Diseases 0.000 description 1
• 208000002874 Acne Vulgaris Diseases 0.000 description 1
• 208000036762 Acute promyelocytic leukaemia Diseases 0.000 description 1
• 239000005995 Aluminium silicate Substances 0.000 description 1
• 206010002091 Anaesthesia Diseases 0.000 description 1
• 201000003076 Angiosarcoma Diseases 0.000 description 1
• 108010064733 Angiotensins Proteins 0.000 description 1
• 102000015427 Angiotensins Human genes 0.000 description 1
• 235000003276 Apios tuberosa Nutrition 0.000 description 1
• 244000105624 Arachis hypogaea Species 0.000 description 1
• 235000010777 Arachis hypogaea Nutrition 0.000 description 1
• 235000010744 Arachis villosulicarpa Nutrition 0.000 description 1
• 206010003399 Arthropod bite Diseases 0.000 description 1
• 206010003571 Astrocytoma Diseases 0.000 description 1
• 206010003645 Atopy Diseases 0.000 description 1
• 208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 description 1
• 238000012935 Averaging Methods 0.000 description 1
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 1
• 206010004593 Bile duct cancer Diseases 0.000 description 1
• 206010048994 Bladder spasm Diseases 0.000 description 1
• 241000283690 Bos taurus Species 0.000 description 1
• 208000014644 Brain disease Diseases 0.000 description 1
• NYQDCVLCJXRDSK-UHFFFAOYSA-N Bromofos Chemical compound COP(=S)(OC)OC1=CC(Cl)=C(Br)C=C1Cl NYQDCVLCJXRDSK-UHFFFAOYSA-N 0.000 description 1
• COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 1
• 239000004255 Butylated hydroxyanisole Substances 0.000 description 1
• 238000011740 C57BL/6 mouse Methods 0.000 description 1
• 102000016838 Calbindin 1 Human genes 0.000 description 1
• 108010028310 Calbindin 1 Proteins 0.000 description 1
• 102000055006 Calcitonin Human genes 0.000 description 1
• 108060001064 Calcitonin Proteins 0.000 description 1
• MBLYZRMZFUWLOZ-UHFFFAOYSA-N Calcitroic acid Natural products C1CCC2(C)C(C(CC(O)=O)C)CCC2C1=CC=C1CC(O)CC(O)C1=C MBLYZRMZFUWLOZ-UHFFFAOYSA-N 0.000 description 1
• 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
• 208000005623 Carcinogenesis Diseases 0.000 description 1
• 208000017897 Carcinoma of esophagus Diseases 0.000 description 1
• 201000000274 Carcinosarcoma Diseases 0.000 description 1
• 206010008342 Cervix carcinoma Diseases 0.000 description 1
• 208000005243 Chondrosarcoma Diseases 0.000 description 1
• 201000009047 Chordoma Diseases 0.000 description 1
• 208000006332 Choriocarcinoma Diseases 0.000 description 1
• 108090000746 Chymosin Proteins 0.000 description 1
• 235000001258 Cinchona calisaya Nutrition 0.000 description 1
• 208000028698 Cognitive impairment Diseases 0.000 description 1
• 206010009900 Colitis ulcerative Diseases 0.000 description 1
• 102000029816 Collagenase Human genes 0.000 description 1
• 108060005980 Collagenase Proteins 0.000 description 1
• 208000000907 Condylomata Acuminata Diseases 0.000 description 1
• 206010010741 Conjunctivitis Diseases 0.000 description 1
• 206010010774 Constipation Diseases 0.000 description 1
• 102000002585 Contractile Proteins Human genes 0.000 description 1
• 108010068426 Contractile Proteins Proteins 0.000 description 1
• 229920002261 Corn starch Polymers 0.000 description 1
• 208000009798 Craniopharyngioma Diseases 0.000 description 1
• 241000938605 Crocodylia Species 0.000 description 1
• 229920002785 Croscarmellose sodium Polymers 0.000 description 1
• 238000003591 CyQUANT Cell Proliferation Assay Kit Methods 0.000 description 1
• 102000010907 Cyclooxygenase 2 Human genes 0.000 description 1
• 108010037462 Cyclooxygenase 2 Proteins 0.000 description 1
• 206010011793 Cystitis haemorrhagic Diseases 0.000 description 1
• 206010063057 Cystitis noninfective Diseases 0.000 description 1
• UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 description 1
• 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 description 1
• 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 description 1
• 108090000695 Cytokines Proteins 0.000 description 1
• 102000004127 Cytokines Human genes 0.000 description 1
• 108010037414 Cytoskeletal Proteins Proteins 0.000 description 1
• 102000010831 Cytoskeletal Proteins Human genes 0.000 description 1
• NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
• 208000002506 Darier Disease Diseases 0.000 description 1
• 206010011891 Deafness neurosensory Diseases 0.000 description 1
• 206010011968 Decreased immune responsiveness Diseases 0.000 description 1
• 206010012438 Dermatitis atopic Diseases 0.000 description 1
• 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
• 208000019872 Drug Eruptions Diseases 0.000 description 1
• 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
• 208000003556 Dry Eye Syndromes Diseases 0.000 description 1
• 206010013774 Dry eye Diseases 0.000 description 1
• 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
• 238000002965 ELISA Methods 0.000 description 1
• 201000009051 Embryonal Carcinoma Diseases 0.000 description 1
• 208000032274 Encephalopathy Diseases 0.000 description 1
• 206010014967 Ependymoma Diseases 0.000 description 1
• 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
• 108090000371 Esterases Proteins 0.000 description 1
• 239000001856 Ethyl cellulose Substances 0.000 description 1
• ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
• 208000006168 Ewing Sarcoma Diseases 0.000 description 1
• 229940123511 Excitatory amino acid receptor antagonist Drugs 0.000 description 1
• 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
• 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
• 201000008808 Fibrosarcoma Diseases 0.000 description 1
• 229920001917 Ficoll Polymers 0.000 description 1
• 239000004606 Fillers/Extenders Substances 0.000 description 1
• BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
• 230000005526 G1 to G0 transition Effects 0.000 description 1
• 241000287828 Gallus gallus Species 0.000 description 1
• CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
• 229930182566 Gentamicin Natural products 0.000 description 1
• 208000032612 Glial tumor Diseases 0.000 description 1
• 206010018338 Glioma Diseases 0.000 description 1
• AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 1
• 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 description 1
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
• 206010072579 Granulomatosis with polyangiitis Diseases 0.000 description 1
• 208000003084 Graves Ophthalmopathy Diseases 0.000 description 1
• 206010061187 Haematopoietic neoplasm Diseases 0.000 description 1
• 208000001258 Hemangiosarcoma Diseases 0.000 description 1
• 208000002250 Hematologic Neoplasms Diseases 0.000 description 1
• 239000004705 High-molecular-weight polyethylene Substances 0.000 description 1
• 208000021519 Hodgkin lymphoma Diseases 0.000 description 1
• 101001128393 Homo sapiens Interferon-induced GTP-binding protein Mx1 Proteins 0.000 description 1
• AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical class ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 1
• 208000000038 Hypoparathyroidism Diseases 0.000 description 1
• 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 description 1
• 108060003951 Immunoglobulin Proteins 0.000 description 1
• 208000029523 Interstitial Lung disease Diseases 0.000 description 1
• 206010023129 Jaundice cholestatic Diseases 0.000 description 1
• 208000003456 Juvenile Arthritis Diseases 0.000 description 1
• 206010059176 Juvenile idiopathic arthritis Diseases 0.000 description 1
• 208000002260 Keloid Diseases 0.000 description 1
• 208000009319 Keratoconjunctivitis Sicca Diseases 0.000 description 1
• 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 1
• QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
• 208000006404 Large Granular Lymphocytic Leukemia Diseases 0.000 description 1
• 208000018142 Leiomyosarcoma Diseases 0.000 description 1
• 206010024229 Leprosy Diseases 0.000 description 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
• 206010025476 Malabsorption Diseases 0.000 description 1
• 208000004155 Malabsorption Syndromes Diseases 0.000 description 1
• 240000003183 Manihot esculenta Species 0.000 description 1
• 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
• 208000000172 Medulloblastoma Diseases 0.000 description 1
• 206010027406 Mesothelioma Diseases 0.000 description 1
• 208000029725 Metabolic bone disease Diseases 0.000 description 1
• 206010027476 Metastases Diseases 0.000 description 1
• 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
• 208000016285 Movement disease Diseases 0.000 description 1
• 101100006982 Mus musculus Ppcdc gene Proteins 0.000 description 1
• 208000010428 Muscle Weakness Diseases 0.000 description 1
• 206010028372 Muscular weakness Diseases 0.000 description 1
• HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 description 1
• 208000012902 Nervous system disease Diseases 0.000 description 1
• 206010029260 Neuroblastoma Diseases 0.000 description 1
• 208000025966 Neurological disease Diseases 0.000 description 1
• 208000007256 Nevus Diseases 0.000 description 1
• 108091028043 Nucleic acid sequence Proteins 0.000 description 1
• QMGVPVSNSZLJIA-UHFFFAOYSA-N Nux Vomica Natural products C1C2C3C4N(C=5C6=CC=CC=5)C(=O)CC3OCC=C2CN2C1C46CC2 QMGVPVSNSZLJIA-UHFFFAOYSA-N 0.000 description 1
• 239000004677 Nylon Substances 0.000 description 1
• 201000005267 Obstructive Jaundice Diseases 0.000 description 1
• 240000007817 Olea europaea Species 0.000 description 1
• 239000005642 Oleic acid Substances 0.000 description 1
• ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
• 201000010133 Oligodendroglioma Diseases 0.000 description 1
• 241000906034 Orthops Species 0.000 description 1
• 206010049088 Osteopenia Diseases 0.000 description 1
• 201000000023 Osteosclerosis Diseases 0.000 description 1
• 206010033128 Ovarian cancer Diseases 0.000 description 1
• 206010061535 Ovarian neoplasm Diseases 0.000 description 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
• 235000019483 Peanut oil Nutrition 0.000 description 1
• 208000000450 Pelvic Pain Diseases 0.000 description 1
• 208000027190 Peripheral T-cell lymphomas Diseases 0.000 description 1
• PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 description 1
• OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
• 208000007641 Pinealoma Diseases 0.000 description 1
• 208000007913 Pituitary Neoplasms Diseases 0.000 description 1
• 206010035226 Plasma cell myeloma Diseases 0.000 description 1
• 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
• 239000004952 Polyamide Substances 0.000 description 1
• 229920002732 Polyanhydride Polymers 0.000 description 1
• 206010065159 Polychondritis Diseases 0.000 description 1
• 229920000954 Polyglycolide Polymers 0.000 description 1
• 229920001710 Polyorthoester Polymers 0.000 description 1
• 241000288906 Primates Species 0.000 description 1
• 206010036774 Proctitis Diseases 0.000 description 1
• 239000004792 Prolene Substances 0.000 description 1
• XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical class CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
• 108010072866 Prostate-Specific Antigen Proteins 0.000 description 1
• 102100038358 Prostate-specific antigen Human genes 0.000 description 1
• 206010051482 Prostatomegaly Diseases 0.000 description 1
• 102100021486 Protein S100-G Human genes 0.000 description 1
• WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 description 1
• 206010037660 Pyrexia Diseases 0.000 description 1
• CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
• IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
• 241000700157 Rattus norvegicus Species 0.000 description 1
• 101000935120 Rattus norvegicus Voltage-dependent P/Q-type calcium channel subunit alpha-1A Proteins 0.000 description 1
• 201000000582 Retinoblastoma Diseases 0.000 description 1
• 235000004443 Ricinus communis Nutrition 0.000 description 1
• 108010079423 S100 Calcium Binding Protein G Proteins 0.000 description 1
• 235000019485 Safflower oil Nutrition 0.000 description 1
• 206010039710 Scleroderma Diseases 0.000 description 1
• 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
• 206010039796 Seborrhoeic keratosis Diseases 0.000 description 1
• 208000005770 Secondary Hyperparathyroidism Diseases 0.000 description 1
• 201000010208 Seminoma Diseases 0.000 description 1
• 208000009966 Sensorineural Hearing Loss Diseases 0.000 description 1
• 108010071390 Serum Albumin Proteins 0.000 description 1
• 102000007562 Serum Albumin Human genes 0.000 description 1
• 235000002595 Solanum tuberosum Nutrition 0.000 description 1
• 244000061456 Solanum tuberosum Species 0.000 description 1
• 206010041303 Solar dermatitis Diseases 0.000 description 1
• 206010041969 Steatorrhoea Diseases 0.000 description 1
• 206010042033 Stevens-Johnson syndrome Diseases 0.000 description 1
• 231100000168 Stevens-Johnson syndrome Toxicity 0.000 description 1
• 241000282887 Suidae Species 0.000 description 1
• 208000031672 T-Cell Peripheral Lymphoma Diseases 0.000 description 1
• 201000008717 T-cell large granular lymphocyte leukemia Diseases 0.000 description 1
• 102000003929 Transaminases Human genes 0.000 description 1
• 108090000340 Transaminases Proteins 0.000 description 1
• 206010070517 Type 2 lepra reaction Diseases 0.000 description 1
• 102100021657 Tyrosine-protein phosphatase non-receptor type 6 Human genes 0.000 description 1
• 101710128901 Tyrosine-protein phosphatase non-receptor type 6 Proteins 0.000 description 1
• 201000006704 Ulcerative Colitis Diseases 0.000 description 1
• 208000000921 Urge Urinary Incontinence Diseases 0.000 description 1
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
• 206010046914 Vaginal infection Diseases 0.000 description 1
• 201000008100 Vaginitis Diseases 0.000 description 1
• 241000934136 Verruca Species 0.000 description 1
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
• 208000014070 Vestibular schwannoma Diseases 0.000 description 1
• 102000050760 Vitamin D-binding protein Human genes 0.000 description 1
• 101710179590 Vitamin D-binding protein Proteins 0.000 description 1
• 208000008383 Wilms tumor Diseases 0.000 description 1
• 240000008042 Zea mays Species 0.000 description 1
• 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
• 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
• 230000005856 abnormality Effects 0.000 description 1
• 239000002250 absorbent Substances 0.000 description 1
• 230000002745 absorbent Effects 0.000 description 1
• 239000003655 absorption accelerator Substances 0.000 description 1
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
• BLAKAEFIFWAFGH-UHFFFAOYSA-N acetyl acetate;pyridine Chemical compound C1=CC=NC=C1.CC(=O)OC(C)=O BLAKAEFIFWAFGH-UHFFFAOYSA-N 0.000 description 1
• 239000002253 acid Substances 0.000 description 1
• 206010000496 acne Diseases 0.000 description 1
• 208000004064 acoustic neuroma Diseases 0.000 description 1
• 208000009621 actinic keratosis Diseases 0.000 description 1
• 230000009471 action Effects 0.000 description 1
• 230000004913 activation Effects 0.000 description 1
• 239000013543 active substance Substances 0.000 description 1
• 125000002252 acyl group Chemical group 0.000 description 1
• 230000010933 acylation Effects 0.000 description 1
• 238000005917 acylation reaction Methods 0.000 description 1
• 125000004423 acyloxy group Chemical group 0.000 description 1
• 239000008272 agar Substances 0.000 description 1
• 239000000556 agonist Substances 0.000 description 1
• 150000001298 alcohols Chemical class 0.000 description 1
• 125000004183 alkoxy alkyl group Chemical group 0.000 description 1
• 125000000304 alkynyl group Chemical group 0.000 description 1
• 201000009961 allergic asthma Diseases 0.000 description 1
• 230000000172 allergic effect Effects 0.000 description 1
• 208000004631 alopecia areata Diseases 0.000 description 1
• 229940087168 alpha tocopherol Drugs 0.000 description 1
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
• 229910052782 aluminium Inorganic materials 0.000 description 1
• 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
• 235000012211 aluminium silicate Nutrition 0.000 description 1
• 230000001668 ameliorated effect Effects 0.000 description 1
• 150000001408 amides Chemical class 0.000 description 1
• 229940024606 amino acid Drugs 0.000 description 1
• 235000001014 amino acid Nutrition 0.000 description 1
• 150000001413 amino acids Chemical class 0.000 description 1
• 230000037005 anaesthesia Effects 0.000 description 1
• 210000003484 anatomy Anatomy 0.000 description 1
• 239000003098 androgen Substances 0.000 description 1
• 102000001307 androgen receptors Human genes 0.000 description 1
• 108010080146 androgen receptors Proteins 0.000 description 1
• 229940030486 androgens Drugs 0.000 description 1
• 150000008064 anhydrides Chemical class 0.000 description 1
• 230000008485 antagonism Effects 0.000 description 1
• 239000003242 anti bacterial agent Substances 0.000 description 1
• 230000002280 anti-androgenic effect Effects 0.000 description 1
• 230000000844 anti-bacterial effect Effects 0.000 description 1
• 230000001093 anti-cancer Effects 0.000 description 1
• 230000001773 anti-convulsant effect Effects 0.000 description 1
• 230000001022 anti-muscarinic effect Effects 0.000 description 1
• 230000001028 anti-proliverative effect Effects 0.000 description 1
• 230000000259 anti-tumor effect Effects 0.000 description 1
• 239000000051 antiandrogen Substances 0.000 description 1
• 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 description 1
• 239000001961 anticonvulsive agent Substances 0.000 description 1
• 229960003965 antiepileptics Drugs 0.000 description 1
• 239000003429 antifungal agent Substances 0.000 description 1
• 229940121375 antifungal agent Drugs 0.000 description 1
• 230000000890 antigenic effect Effects 0.000 description 1
• 229940030600 antihypertensive agent Drugs 0.000 description 1
• 239000002220 antihypertensive agent Substances 0.000 description 1
• 229940041181 antineoplastic drug Drugs 0.000 description 1
• 208000002399 aphthous stomatitis Diseases 0.000 description 1
• 230000036528 appetite Effects 0.000 description 1
• 235000019789 appetite Nutrition 0.000 description 1
• 238000013459 approach Methods 0.000 description 1
• 239000007900 aqueous suspension Substances 0.000 description 1
• 150000007860 aryl ester derivatives Chemical class 0.000 description 1
• 235000010323 ascorbic acid Nutrition 0.000 description 1
• 229960005070 ascorbic acid Drugs 0.000 description 1
• 239000011668 ascorbic acid Substances 0.000 description 1
• 235000010385 ascorbyl palmitate Nutrition 0.000 description 1
• 201000008937 atopic dermatitis Diseases 0.000 description 1
• 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 description 1
• 230000005784 autoimmunity Effects 0.000 description 1
• 230000004888 barrier function Effects 0.000 description 1
• 210000000270 basal cell Anatomy 0.000 description 1
• 210000004227 basal ganglia Anatomy 0.000 description 1
• 230000009286 beneficial effect Effects 0.000 description 1
• 230000002146 bilateral effect Effects 0.000 description 1
• 201000007180 bile duct carcinoma Diseases 0.000 description 1
• 238000004166 bioassay Methods 0.000 description 1
• 238000002306 biochemical method Methods 0.000 description 1
• 230000033228 biological regulation Effects 0.000 description 1
• 230000008512 biological response Effects 0.000 description 1
• 210000003969 blast cell Anatomy 0.000 description 1
• 230000000903 blocking effect Effects 0.000 description 1
• 230000036772 blood pressure Effects 0.000 description 1
• 230000036760 body temperature Effects 0.000 description 1
• 210000002798 bone marrow cell Anatomy 0.000 description 1
• 210000002805 bone matrix Anatomy 0.000 description 1
• 210000005013 brain tissue Anatomy 0.000 description 1
• RRKTZKIUPZVBMF-IBTVXLQLSA-N brucine Chemical compound O([C@@H]1[C@H]([C@H]2C3)[C@@H]4N(C(C1)=O)C=1C=C(C(=CC=11)OC)OC)CC=C2CN2[C@@H]3[C@]41CC2 RRKTZKIUPZVBMF-IBTVXLQLSA-N 0.000 description 1
• RRKTZKIUPZVBMF-UHFFFAOYSA-N brucine Natural products C1=2C=C(OC)C(OC)=CC=2N(C(C2)=O)C3C(C4C5)C2OCC=C4CN2C5C31CC2 RRKTZKIUPZVBMF-UHFFFAOYSA-N 0.000 description 1
• 239000006172 buffering agent Substances 0.000 description 1
• 230000003139 buffering effect Effects 0.000 description 1
• 229960002092 busulfan Drugs 0.000 description 1
• 239000001273 butane Substances 0.000 description 1
• 235000019437 butane-1,3-diol Nutrition 0.000 description 1
• 229940043253 butylated hydroxyanisole Drugs 0.000 description 1
• CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
• 230000035563 calcemia Effects 0.000 description 1
• BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 1
• 229960004015 calcitonin Drugs 0.000 description 1
• MBLYZRMZFUWLOZ-FEUSBDLHSA-N calcitroic acid Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CC(O)=O)C)=C\C=C1\C[C@H](O)C[C@@H](O)C1=C MBLYZRMZFUWLOZ-FEUSBDLHSA-N 0.000 description 1
• 229910000019 calcium carbonate Inorganic materials 0.000 description 1
• 235000010216 calcium carbonate Nutrition 0.000 description 1
• 239000001506 calcium phosphate Substances 0.000 description 1
• 235000012241 calcium silicate Nutrition 0.000 description 1
• CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
• 239000008116 calcium stearate Substances 0.000 description 1
• 235000013539 calcium stearate Nutrition 0.000 description 1
• 230000036952 cancer formation Effects 0.000 description 1
• 208000020670 canker sore Diseases 0.000 description 1
• 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
• 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
• 231100000504 carcinogenesis Toxicity 0.000 description 1
• 230000000747 cardiac effect Effects 0.000 description 1
• 230000015556 catabolic process Effects 0.000 description 1
• 230000020411 cell activation Effects 0.000 description 1
• 230000011712 cell development Effects 0.000 description 1
• 230000007969 cellular immunity Effects 0.000 description 1
• 230000019522 cellular metabolic process Effects 0.000 description 1
• 230000036755 cellular response Effects 0.000 description 1
• 229920002301 cellulose acetate Polymers 0.000 description 1
• 210000001638 cerebellum Anatomy 0.000 description 1
• 201000010881 cervical cancer Diseases 0.000 description 1
• 210000003679 cervix uteri Anatomy 0.000 description 1
• 238000012512 characterization method Methods 0.000 description 1
• 239000002738 chelating agent Substances 0.000 description 1
• 210000000038 chest Anatomy 0.000 description 1
• 235000013330 chicken meat Nutrition 0.000 description 1
• 229960004630 chlorambucil Drugs 0.000 description 1
• JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 description 1
• 229960004926 chlorobutanol Drugs 0.000 description 1
• 150000005827 chlorofluoro hydrocarbons Chemical class 0.000 description 1
• 230000001713 cholinergic effect Effects 0.000 description 1
• 210000002932 cholinergic neuron Anatomy 0.000 description 1
• 238000004587 chromatography analysis Methods 0.000 description 1
• 208000019069 chronic childhood arthritis Diseases 0.000 description 1
• 201000003139 chronic cystitis Diseases 0.000 description 1
• 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
• LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 1
• 239000004927 clay Substances 0.000 description 1
• 230000006999 cognitive decline Effects 0.000 description 1
• 230000001149 cognitive effect Effects 0.000 description 1
• 229960002424 collagenase Drugs 0.000 description 1
• 210000001072 colon Anatomy 0.000 description 1
• 238000007398 colorimetric assay Methods 0.000 description 1
• 238000004040 coloring Methods 0.000 description 1
• 238000004440 column chromatography Methods 0.000 description 1
• 229940125810 compound 20 Drugs 0.000 description 1
• 239000007891 compressed tablet Substances 0.000 description 1
• 238000007906 compression Methods 0.000 description 1
• 230000006835 compression Effects 0.000 description 1
• 239000000470 constituent Substances 0.000 description 1
• 238000013270 controlled release Methods 0.000 description 1
• 230000001276 controlling effect Effects 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 235000005822 corn Nutrition 0.000 description 1
• 235000005687 corn oil Nutrition 0.000 description 1
• 239000002285 corn oil Substances 0.000 description 1
• 239000008120 corn starch Substances 0.000 description 1
• 210000004087 cornea Anatomy 0.000 description 1
• 210000003618 cortical neuron Anatomy 0.000 description 1
• 239000002385 cottonseed oil Substances 0.000 description 1
• 229960003624 creatine Drugs 0.000 description 1
• 239000006046 creatine Substances 0.000 description 1
• 238000004132 cross linking Methods 0.000 description 1
• 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
• 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 description 1
• 239000013078 crystal Substances 0.000 description 1
• 208000004921 cutaneous lupus erythematosus Diseases 0.000 description 1
• 125000004122 cyclic group Chemical group 0.000 description 1
• 125000000392 cycloalkenyl group Chemical group 0.000 description 1
• 208000002445 cystadenocarcinoma Diseases 0.000 description 1
• 229960001305 cysteine hydrochloride Drugs 0.000 description 1
• 229960000684 cytarabine Drugs 0.000 description 1
• 230000016396 cytokine production Effects 0.000 description 1
• 210000005220 cytoplasmic tail Anatomy 0.000 description 1
• 230000003436 cytoskeletal effect Effects 0.000 description 1
• 230000001086 cytosolic effect Effects 0.000 description 1
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
• 231100000135 cytotoxicity Toxicity 0.000 description 1
• 230000003013 cytotoxicity Effects 0.000 description 1
• KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
• 238000007405 data analysis Methods 0.000 description 1
• 238000006731 degradation reaction Methods 0.000 description 1
• 230000002939 deleterious effect Effects 0.000 description 1
• 238000005115 demineralization Methods 0.000 description 1
• 230000002328 demineralizing effect Effects 0.000 description 1
• 230000000994 depressogenic effect Effects 0.000 description 1
• 238000009795 derivation Methods 0.000 description 1
• 108700001680 des-(1-3)- insulin-like growth factor 1 Proteins 0.000 description 1
• 238000003745 diagnosis Methods 0.000 description 1
• NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
• 229940038472 dicalcium phosphate Drugs 0.000 description 1
• 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
• 235000005911 diet Nutrition 0.000 description 1
• 230000037213 diet Effects 0.000 description 1
• 235000014113 dietary fatty acids Nutrition 0.000 description 1
• 208000018554 digestive system carcinoma Diseases 0.000 description 1
• UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 description 1
• AASUFOVSZUIILF-UHFFFAOYSA-N diphenylmethanone;sodium Chemical compound [Na].C=1C=CC=CC=1C(=O)C1=CC=CC=C1 AASUFOVSZUIILF-UHFFFAOYSA-N 0.000 description 1
• 239000007884 disintegrant Substances 0.000 description 1
• 238000004090 dissolution Methods 0.000 description 1
• 238000009826 distribution Methods 0.000 description 1
• 231100000673 dose–response relationship Toxicity 0.000 description 1
• 230000003828 downregulation Effects 0.000 description 1
• 230000002183 duodenal effect Effects 0.000 description 1
• 230000004064 dysfunction Effects 0.000 description 1
• 230000008030 elimination Effects 0.000 description 1
• 238000003379 elimination reaction Methods 0.000 description 1
• 230000001804 emulsifying effect Effects 0.000 description 1
• 201000002491 encephalomyelitis Diseases 0.000 description 1
• 239000003623 enhancer Substances 0.000 description 1
• 239000002702 enteric coating Substances 0.000 description 1
• 238000009505 enteric coating Methods 0.000 description 1
• 210000001353 entorhinal cortex Anatomy 0.000 description 1
• 229960002179 ephedrine Drugs 0.000 description 1
• 210000001339 epidermal cell Anatomy 0.000 description 1
• 230000036566 epidermal hyperplasia Effects 0.000 description 1
• 210000002615 epidermis Anatomy 0.000 description 1
• 208000037828 epithelial carcinoma Diseases 0.000 description 1
• 210000002919 epithelial cell Anatomy 0.000 description 1
• 239000003797 essential amino acid Substances 0.000 description 1
• 235000020776 essential amino acid Nutrition 0.000 description 1
• 230000032050 esterification Effects 0.000 description 1
• 238000005886 esterification reaction Methods 0.000 description 1
• 229940011871 estrogen Drugs 0.000 description 1
• 239000000262 estrogen Substances 0.000 description 1
• BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
• 235000019325 ethyl cellulose Nutrition 0.000 description 1
• 229920001249 ethyl cellulose Polymers 0.000 description 1
• 239000000928 excitatory amino acid agonist Substances 0.000 description 1
• 210000002744 extracellular matrix Anatomy 0.000 description 1
• 238000000605 extraction Methods 0.000 description 1
• 239000003885 eye ointment Substances 0.000 description 1
• 239000000194 fatty acid Substances 0.000 description 1
• 229930195729 fatty acid Natural products 0.000 description 1
• 201000010073 fibrogenesis imperfecta ossium Diseases 0.000 description 1
• DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 description 1
• 229960004039 finasteride Drugs 0.000 description 1
• 238000003818 flash chromatography Methods 0.000 description 1
• 239000000796 flavoring agent Substances 0.000 description 1
• NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 1
• 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 description 1
• 238000001640 fractional crystallisation Methods 0.000 description 1
• 238000013467 fragmentation Methods 0.000 description 1
• 238000006062 fragmentation reaction Methods 0.000 description 1
• 210000001222 gaba-ergic neuron Anatomy 0.000 description 1
• 230000002496 gastric effect Effects 0.000 description 1
• 238000003304 gavage Methods 0.000 description 1
• 230000008297 genomic mechanism Effects 0.000 description 1
• 229960002518 gentamicin Drugs 0.000 description 1
• 239000003862 glucocorticoid Substances 0.000 description 1
• 229930195712 glutamate Natural products 0.000 description 1
• YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
• SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
• 150000002334 glycols Chemical class 0.000 description 1
• 244000144993 groups of animals Species 0.000 description 1
• 230000003394 haemopoietic effect Effects 0.000 description 1
• 210000003128 head Anatomy 0.000 description 1
• 238000010438 heat treatment Methods 0.000 description 1
• 201000002222 hemangioblastoma Diseases 0.000 description 1
• 201000005787 hematologic cancer Diseases 0.000 description 1
• 230000002607 hemopoietic effect Effects 0.000 description 1
• 201000002802 hemorrhagic cystitis Diseases 0.000 description 1
• 230000002008 hemorrhagic effect Effects 0.000 description 1
• 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
• 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 150000002390 heteroarenes Chemical class 0.000 description 1
• 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 210000004295 hippocampal neuron Anatomy 0.000 description 1
• 210000003630 histaminocyte Anatomy 0.000 description 1
• 230000003118 histopathologic effect Effects 0.000 description 1
• 230000003054 hormonal effect Effects 0.000 description 1
• 102000048122 human MX1 Human genes 0.000 description 1
• 239000003906 humectant Substances 0.000 description 1
• 230000028996 humoral immune response Effects 0.000 description 1
• 229930195733 hydrocarbon Natural products 0.000 description 1
• 230000007062 hydrolysis Effects 0.000 description 1
• 238000006460 hydrolysis reaction Methods 0.000 description 1
• 230000002209 hydrophobic effect Effects 0.000 description 1
• 230000033444 hydroxylation Effects 0.000 description 1
• 238000005805 hydroxylation reaction Methods 0.000 description 1
• 230000003553 hypophosphatemic effect Effects 0.000 description 1
• 230000006450 immune cell response Effects 0.000 description 1
• 230000008629 immune suppression Effects 0.000 description 1
• 230000036039 immunity Effects 0.000 description 1
• 102000018358 immunoglobulin Human genes 0.000 description 1
• 230000016784 immunoglobulin production Effects 0.000 description 1
• 238000010324 immunological assay Methods 0.000 description 1
• 229960003444 immunosuppressant agent Drugs 0.000 description 1
• 238000011065 in-situ storage Methods 0.000 description 1
• 230000002779 inactivation Effects 0.000 description 1
• 238000010348 incorporation Methods 0.000 description 1
• 125000001041 indolyl group Chemical group 0.000 description 1
• 230000002458 infectious effect Effects 0.000 description 1
• 210000004969 inflammatory cell Anatomy 0.000 description 1
• 239000003112 inhibitor Substances 0.000 description 1
• 108091008042 inhibitory receptors Proteins 0.000 description 1
• 230000000977 initiatory effect Effects 0.000 description 1
• 239000007972 injectable composition Substances 0.000 description 1
• 230000000266 injurious effect Effects 0.000 description 1
• 230000015788 innate immune response Effects 0.000 description 1
• 230000003993 interaction Effects 0.000 description 1
• 230000031891 intestinal absorption Effects 0.000 description 1
• 238000001361 intraarterial administration Methods 0.000 description 1
• 230000003834 intracellular effect Effects 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 239000007927 intramuscular injection Substances 0.000 description 1
• 238000010253 intravenous injection Methods 0.000 description 1
• 238000011835 investigation Methods 0.000 description 1
• 201000004614 iritis Diseases 0.000 description 1
• 230000007794 irritation Effects 0.000 description 1
• 208000028867 ischemia Diseases 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
• 239000000644 isotonic solution Substances 0.000 description 1
• 239000007951 isotonicity adjuster Substances 0.000 description 1
• 210000000281 joint capsule Anatomy 0.000 description 1
• 201000002215 juvenile rheumatoid arthritis Diseases 0.000 description 1
• NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
• 210000001117 keloid Anatomy 0.000 description 1
• 208000011379 keloid formation Diseases 0.000 description 1
• 230000003780 keratinization Effects 0.000 description 1
• 201000010666 keratoconjunctivitis Diseases 0.000 description 1
• 201000004607 keratosis follicularis Diseases 0.000 description 1
• 235000014655 lactic acid Nutrition 0.000 description 1
• 239000004310 lactic acid Substances 0.000 description 1
• 210000001821 langerhans cell Anatomy 0.000 description 1
• 239000010410 layer Substances 0.000 description 1
• 231100001231 less toxic Toxicity 0.000 description 1
• 208000002741 leukoplakia Diseases 0.000 description 1
• 206010024627 liposarcoma Diseases 0.000 description 1
• 238000004811 liquid chromatography Methods 0.000 description 1
• 239000006194 liquid suspension Substances 0.000 description 1
• 239000007937 lozenge Substances 0.000 description 1
• 201000005296 lung carcinoma Diseases 0.000 description 1
• 210000002751 lymph Anatomy 0.000 description 1
• 208000037829 lymphangioendotheliosarcoma Diseases 0.000 description 1
• 208000012804 lymphangiosarcoma Diseases 0.000 description 1
• 210000004324 lymphatic system Anatomy 0.000 description 1
• VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
• 239000000347 magnesium hydroxide Substances 0.000 description 1
• 229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
• 230000014759 maintenance of location Effects 0.000 description 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
• 238000007726 management method Methods 0.000 description 1
• 229960002510 mandelic acid Drugs 0.000 description 1
• 239000011159 matrix material Substances 0.000 description 1
• 230000035800 maturation Effects 0.000 description 1
• 210000003622 mature neutrocyte Anatomy 0.000 description 1
• 230000010534 mechanism of action Effects 0.000 description 1
• 238000011177 media preparation Methods 0.000 description 1
• 229960001924 melphalan Drugs 0.000 description 1
• SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 description 1
• 238000002844 melting Methods 0.000 description 1
• 230000008018 melting Effects 0.000 description 1
• 206010027191 meningioma Diseases 0.000 description 1
• 229940041616 menthol Drugs 0.000 description 1
• GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 1
• 229960001428 mercaptopurine Drugs 0.000 description 1
• 108020004999 messenger RNA Proteins 0.000 description 1
• 230000037345 metabolism of vitamins Effects 0.000 description 1
• 230000001394 metastastic effect Effects 0.000 description 1
• 206010061289 metastatic neoplasm Diseases 0.000 description 1
• MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
• 229960000485 methotrexate Drugs 0.000 description 1
• 239000004530 micro-emulsion Substances 0.000 description 1
• 244000005700 microbiome Species 0.000 description 1
• 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
• 239000008108 microcrystalline cellulose Substances 0.000 description 1
• 229940016286 microcrystalline cellulose Drugs 0.000 description 1
• 238000000520 microinjection Methods 0.000 description 1
• 239000004005 microsphere Substances 0.000 description 1
• 230000005012 migration Effects 0.000 description 1
• 238000013508 migration Methods 0.000 description 1
• 239000007758 minimum essential medium Substances 0.000 description 1
• 230000004898 mitochondrial function Effects 0.000 description 1
• 238000007799 mixed lymphocyte reaction assay Methods 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 230000001483 mobilizing effect Effects 0.000 description 1
• 239000007932 molded tablet Substances 0.000 description 1
• 239000003068 molecular probe Substances 0.000 description 1
• CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
• 239000002324 mouth wash Substances 0.000 description 1
• 239000003149 muscarinic antagonist Substances 0.000 description 1
• 210000000663 muscle cell Anatomy 0.000 description 1
• 201000000050 myeloid neoplasm Diseases 0.000 description 1
• 208000001611 myxosarcoma Diseases 0.000 description 1
• IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
• OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 125000001624 naphthyl group Chemical group 0.000 description 1
• 230000004719 natural immunity Effects 0.000 description 1
• 230000002956 necrotizing effect Effects 0.000 description 1
• 230000035407 negative regulation of cell proliferation Effects 0.000 description 1
• 230000001423 neocortical effect Effects 0.000 description 1
• 208000025189 neoplasm of testis Diseases 0.000 description 1
• 210000001577 neostriatum Anatomy 0.000 description 1
• 201000008383 nephritis Diseases 0.000 description 1
• 210000000653 nervous system Anatomy 0.000 description 1
• 210000004498 neuroglial cell Anatomy 0.000 description 1
• 230000016273 neuron death Effects 0.000 description 1
• 230000003955 neuronal function Effects 0.000 description 1
• 206010029446 nocturia Diseases 0.000 description 1
• 231100000344 non-irritating Toxicity 0.000 description 1
• 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
• 239000012457 nonaqueous media Substances 0.000 description 1
• 239000002736 nonionic surfactant Substances 0.000 description 1
• 231100000252 nontoxic Toxicity 0.000 description 1
• 230000003000 nontoxic effect Effects 0.000 description 1
• 229920001778 nylon Polymers 0.000 description 1
• 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
• 229960002969 oleic acid Drugs 0.000 description 1
• 235000021313 oleic acid Nutrition 0.000 description 1
• 231100000590 oncogenic Toxicity 0.000 description 1
• 230000002246 oncogenic effect Effects 0.000 description 1
• 210000004789 organ system Anatomy 0.000 description 1
• 150000002895 organic esters Chemical class 0.000 description 1
• 201000008482 osteoarthritis Diseases 0.000 description 1
• 208000002865 osteopetrosis Diseases 0.000 description 1
• 210000001672 ovary Anatomy 0.000 description 1
• 230000001590 oxidative effect Effects 0.000 description 1
• 238000006213 oxygenation reaction Methods 0.000 description 1
• 201000002528 pancreatic cancer Diseases 0.000 description 1
• 208000008443 pancreatic carcinoma Diseases 0.000 description 1
• 208000004019 papillary adenocarcinoma Diseases 0.000 description 1
• 201000010198 papillary carcinoma Diseases 0.000 description 1
• 230000002023 papillomaviral effect Effects 0.000 description 1
• 230000003076 paracrine Effects 0.000 description 1
• 239000012188 paraffin wax Substances 0.000 description 1
• 230000001936 parietal effect Effects 0.000 description 1
• 235000010603 pastilles Nutrition 0.000 description 1
• 244000052769 pathogen Species 0.000 description 1
• 230000008506 pathogenesis Effects 0.000 description 1
• 230000001717 pathogenic effect Effects 0.000 description 1
• 230000037361 pathway Effects 0.000 description 1
• 239000000312 peanut oil Substances 0.000 description 1
• 210000001428 peripheral nervous system Anatomy 0.000 description 1
• 229940021222 peritoneal dialysis isotonic solution Drugs 0.000 description 1
• 210000001539 phagocyte Anatomy 0.000 description 1
• 230000003285 pharmacodynamic effect Effects 0.000 description 1
• 238000011458 pharmacological treatment Methods 0.000 description 1
• WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
• 239000008363 phosphate buffer Substances 0.000 description 1
• 235000011007 phosphoric acid Nutrition 0.000 description 1
• 229910052698 phosphorus Inorganic materials 0.000 description 1
• 239000011574 phosphorus Substances 0.000 description 1
• 230000035479 physiological effects, processes and functions Effects 0.000 description 1
• 208000024724 pineal body neoplasm Diseases 0.000 description 1
• 201000004123 pineal gland cancer Diseases 0.000 description 1
• 208000010916 pituitary tumor Diseases 0.000 description 1
• 210000002826 placenta Anatomy 0.000 description 1
• 229920003023 plastic Polymers 0.000 description 1
• 239000004033 plastic Substances 0.000 description 1
• 229920001983 poloxamer Polymers 0.000 description 1
• 229920002647 polyamide Polymers 0.000 description 1
• 229920001296 polysiloxane Polymers 0.000 description 1
• 229920000136 polysorbate Polymers 0.000 description 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
• 230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 description 1
• 229920001592 potato starch Polymers 0.000 description 1
• XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
• 229960004618 prednisone Drugs 0.000 description 1
• 238000002953 preparative HPLC Methods 0.000 description 1
• 230000002335 preservative effect Effects 0.000 description 1
• 125000002924 primary amino group Chemical class [H]N([H])* 0.000 description 1
• 230000001737 promoting effect Effects 0.000 description 1
• 239000001294 propane Substances 0.000 description 1
• 239000000473 propyl gallate Substances 0.000 description 1
• 235000010388 propyl gallate Nutrition 0.000 description 1
• 229940075579 propyl gallate Drugs 0.000 description 1
• 235000013772 propylene glycol Nutrition 0.000 description 1
• 210000004129 prosencephalon Anatomy 0.000 description 1
• 150000003180 prostaglandins Chemical class 0.000 description 1
• 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
• 238000000746 purification Methods 0.000 description 1
• PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 description 1
• 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
• 229960000948 quinine Drugs 0.000 description 1
• 125000005493 quinolyl group Chemical group 0.000 description 1
• 210000001609 raphe nuclei Anatomy 0.000 description 1
• 230000009257 reactivity Effects 0.000 description 1
• 210000000664 rectum Anatomy 0.000 description 1
• 230000029865 regulation of blood pressure Effects 0.000 description 1
• 238000001403 relative X-ray reflectometry Methods 0.000 description 1
• 230000027425 release of sequestered calcium ion into cytosol Effects 0.000 description 1
• 238000007634 remodeling Methods 0.000 description 1
• 238000011160 research Methods 0.000 description 1
• 210000002345 respiratory system Anatomy 0.000 description 1
• 239000003340 retarding agent Substances 0.000 description 1
• 201000009410 rhabdomyosarcoma Diseases 0.000 description 1
• 235000005713 safflower oil Nutrition 0.000 description 1
• 239000003813 safflower oil Substances 0.000 description 1
• YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
• 229960001860 salicylate Drugs 0.000 description 1
• 208000008742 seborrheic dermatitis Diseases 0.000 description 1
• 201000003385 seborrheic keratosis Diseases 0.000 description 1
• 230000003248 secreting effect Effects 0.000 description 1
• 210000002955 secretory cell Anatomy 0.000 description 1
• 231100000879 sensorineural hearing loss Toxicity 0.000 description 1
• 208000023573 sensorineural hearing loss disease Diseases 0.000 description 1
• 230000001568 sexual effect Effects 0.000 description 1
• 238000007493 shaping process Methods 0.000 description 1
• 230000019491 signal transduction Effects 0.000 description 1
• 150000004760 silicates Chemical class 0.000 description 1
• 208000017520 skin disease Diseases 0.000 description 1
• 206010040882 skin lesion Diseases 0.000 description 1
• 231100000444 skin lesion Toxicity 0.000 description 1
• 208000000587 small cell lung carcinoma Diseases 0.000 description 1
• 210000000813 small intestine Anatomy 0.000 description 1
• 210000002460 smooth muscle Anatomy 0.000 description 1
• WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
• 229910000342 sodium bisulfate Inorganic materials 0.000 description 1
• 229940100996 sodium bisulfate Drugs 0.000 description 1
• 229910000029 sodium carbonate Inorganic materials 0.000 description 1
• 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
• 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
• 239000011780 sodium chloride Substances 0.000 description 1
• 239000001509 sodium citrate Substances 0.000 description 1
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
• HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
• 229940001584 sodium metabisulfite Drugs 0.000 description 1
• 235000010262 sodium metabisulphite Nutrition 0.000 description 1
• 229940054269 sodium pyruvate Drugs 0.000 description 1
• 239000008109 sodium starch glycolate Substances 0.000 description 1
• 229940079832 sodium starch glycolate Drugs 0.000 description 1
• 229920003109 sodium starch glycolate Polymers 0.000 description 1
• 229940001482 sodium sulfite Drugs 0.000 description 1
• 235000010265 sodium sulphite Nutrition 0.000 description 1
• 235000010199 sorbic acid Nutrition 0.000 description 1
• 239000004334 sorbic acid Substances 0.000 description 1
• 229940075582 sorbic acid Drugs 0.000 description 1
• 239000003549 soybean oil Substances 0.000 description 1
• 235000012424 soybean oil Nutrition 0.000 description 1
• 238000001228 spectrum Methods 0.000 description 1
• 210000000278 spinal cord Anatomy 0.000 description 1
• 208000020431 spinal cord injury Diseases 0.000 description 1
• 210000000952 spleen Anatomy 0.000 description 1
• 238000005507 spraying Methods 0.000 description 1
• 206010041823 squamous cell carcinoma Diseases 0.000 description 1
• 230000006641 stabilisation Effects 0.000 description 1
• 238000011105 stabilization Methods 0.000 description 1
• 230000003068 static effect Effects 0.000 description 1
• 208000001162 steatorrhea Diseases 0.000 description 1
• 230000000707 stereoselective effect Effects 0.000 description 1
• 239000008174 sterile solution Substances 0.000 description 1
• 239000008223 sterile water Substances 0.000 description 1
• 239000003206 sterilizing agent Substances 0.000 description 1
• 230000004936 stimulating effect Effects 0.000 description 1
• 238000003860 storage Methods 0.000 description 1
• 239000007929 subcutaneous injection Substances 0.000 description 1
• 210000003523 substantia nigra Anatomy 0.000 description 1
• 125000005346 substituted cycloalkyl group Chemical group 0.000 description 1
• 150000005846 sugar alcohols Chemical class 0.000 description 1
• 150000003460 sulfonic acids Chemical class 0.000 description 1
• 201000010965 sweat gland carcinoma Diseases 0.000 description 1
• 239000003765 sweetening agent Substances 0.000 description 1
• 230000000946 synaptic effect Effects 0.000 description 1
• 206010042863 synovial sarcoma Diseases 0.000 description 1
• 238000007910 systemic administration Methods 0.000 description 1
• 230000009885 systemic effect Effects 0.000 description 1
• 230000008685 targeting Effects 0.000 description 1
• 230000002123 temporal effect Effects 0.000 description 1
• 210000003478 temporal lobe Anatomy 0.000 description 1
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• 230000002381 testicular Effects 0.000 description 1
• 201000003120 testicular cancer Diseases 0.000 description 1
• 150000003536 tetrazoles Chemical class 0.000 description 1
• 229940124597 therapeutic agent Drugs 0.000 description 1
• 239000002562 thickening agent Substances 0.000 description 1
• 150000003573 thiols Chemical class 0.000 description 1
• 229930192474 thiophene Natural products 0.000 description 1
• 210000001541 thymus gland Anatomy 0.000 description 1
• 210000001685 thyroid gland Anatomy 0.000 description 1
• 206010043778 thyroiditis Diseases 0.000 description 1
• 239000003104 tissue culture media Substances 0.000 description 1
• 238000004448 titration Methods 0.000 description 1
• 238000011200 topical administration Methods 0.000 description 1
• 231100000027 toxicology Toxicity 0.000 description 1
• 239000003053 toxin Substances 0.000 description 1
• 231100000765 toxin Toxicity 0.000 description 1
• 108700012359 toxins Proteins 0.000 description 1
• 230000002103 transcriptional effect Effects 0.000 description 1
• 238000011269 treatment regimen Methods 0.000 description 1
• 150000003852 triazoles Chemical class 0.000 description 1
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
• 229960001124 trientine Drugs 0.000 description 1
• 125000004385 trihaloalkyl group Chemical group 0.000 description 1
• 206010044697 tropical sprue Diseases 0.000 description 1
• 230000004614 tumor growth Effects 0.000 description 1
• 230000007306 turnover Effects 0.000 description 1
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
• 230000003827 upregulation Effects 0.000 description 1
• 206010046494 urge incontinence Diseases 0.000 description 1
• 230000000450 urinary calcium excretion Effects 0.000 description 1
• 210000002229 urogenital system Anatomy 0.000 description 1
• 210000004509 vascular smooth muscle cell Anatomy 0.000 description 1
• 235000015112 vegetable and seed oil Nutrition 0.000 description 1
• 235000019871 vegetable fat Nutrition 0.000 description 1
• 239000008158 vegetable oil Substances 0.000 description 1
• OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
• 229960004528 vincristine Drugs 0.000 description 1
• OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
• 208000030402 vitamin D-dependent rickets Diseases 0.000 description 1
• 108091023044 voltage-gated calcium channel activity Proteins 0.000 description 1
• 102000038650 voltage-gated calcium channel activity Human genes 0.000 description 1
• 238000005303 weighing Methods 0.000 description 1
• 230000037314 wound repair Effects 0.000 description 1
• 239000011787 zinc oxide Substances 0.000 description 1
• 235000014692 zinc oxide Nutrition 0.000 description 1
• 239000002076 α-tocopherol Substances 0.000 description 1
• 235000004835 α-tocopherol Nutrition 0.000 description 1