AU2004247469B2 - 2-hydroxymethyl-3,4,5-trihydroxy-1-benzilpiperidine derivatives as inhibitors of glucosylceramide - Google Patents
2-hydroxymethyl-3,4,5-trihydroxy-1-benzilpiperidine derivatives as inhibitors of glucosylceramide Download PDFInfo
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- AU2004247469B2 AU2004247469B2 AU2004247469A AU2004247469A AU2004247469B2 AU 2004247469 B2 AU2004247469 B2 AU 2004247469B2 AU 2004247469 A AU2004247469 A AU 2004247469A AU 2004247469 A AU2004247469 A AU 2004247469A AU 2004247469 B2 AU2004247469 B2 AU 2004247469B2
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Reproductive Health (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0313678.5 | 2003-06-13 | ||
| GBGB0313678.5A GB0313678D0 (en) | 2003-06-13 | 2003-06-13 | Novel compounds |
| PCT/GB2004/002451 WO2004111002A1 (en) | 2003-06-13 | 2004-06-09 | 2-hydroxymethyl-3,4,5-trihydroxy-1-benzilpiperidine derivatives as inhibitors of glucosylceramide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2004247469A1 AU2004247469A1 (en) | 2004-12-23 |
| AU2004247469B2 true AU2004247469B2 (en) | 2009-11-19 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| AU2004247469A Ceased AU2004247469B2 (en) | 2003-06-13 | 2004-06-09 | 2-hydroxymethyl-3,4,5-trihydroxy-1-benzilpiperidine derivatives as inhibitors of glucosylceramide |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8071780B2 (https=) |
| EP (1) | EP1636186A1 (https=) |
| JP (1) | JP4780785B2 (https=) |
| CN (1) | CN100422149C (https=) |
| AU (1) | AU2004247469B2 (https=) |
| BR (1) | BRPI0411308A8 (https=) |
| CA (1) | CA2528323C (https=) |
| GB (1) | GB0313678D0 (https=) |
| IL (1) | IL172542A (https=) |
| WO (1) | WO2004111002A1 (https=) |
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| GB0100889D0 (en) | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
| AU2003246942B2 (en) * | 2002-07-17 | 2009-06-25 | Idorsia Pharmaceuticals Ltd | Piperidinetriol derivatives as inhibitors of glycosylceramide synthase |
| US7994198B2 (en) * | 2002-07-17 | 2011-08-09 | Actelion Pharmaceuticals Ltd. | Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase |
| GB0313678D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
| GB0313677D0 (en) * | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compound |
| EP1811991B1 (en) * | 2004-11-10 | 2018-11-07 | Genzyme Corporation | Treatment of type 2 diabetes using inhibitors of glycosphingolipid synthesis |
| SI2032134T1 (sl) | 2006-05-09 | 2015-10-30 | Genzyme Corporation | Postopki zdravljenja bolezni zamaščenih jeter, ki obsegajo inhibicijo sintezo glukosfingolipida |
| GB0614947D0 (en) * | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
| EP2594564B1 (en) * | 2007-05-31 | 2016-09-28 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitors |
| GB0712494D0 (en) * | 2007-06-27 | 2007-08-08 | Isis Innovation | Substrate reduction therapy |
| CN101888840A (zh) | 2007-10-05 | 2010-11-17 | 简詹姆公司 | 使用脑酰胺衍生物治疗多囊性肾疾病的方法 |
| CA2731685A1 (en) | 2008-07-28 | 2010-02-04 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
| EP3078373A1 (en) | 2008-10-03 | 2016-10-12 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitor |
| EP3966199B1 (en) | 2019-05-10 | 2026-03-18 | Alectos Therapeutics Inc. | Non-lysosomal glucosylceramidase inhibitors and uses thereof |
| PH12022552955A1 (en) | 2020-05-07 | 2024-02-26 | Alectos Therapeutics Inc | Non-lysosomal glucosylceramidase inhibitors and uses thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002055498A1 (en) * | 2001-01-12 | 2002-07-18 | Oxford Glycosciences (Uk) Ltd | Pharmaceutically active piperidine derivatives |
Family Cites Families (32)
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| NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| DE3007078A1 (de) * | 1980-02-26 | 1981-09-10 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung |
| DE3024901A1 (de) | 1980-07-01 | 1982-01-28 | Bayer Ag, 5090 Leverkusen | Herbizide mittel auf basis von piperidin-derivaten |
| DE3247615A1 (de) * | 1982-12-23 | 1984-07-05 | Hoechst Ag, 6230 Frankfurt | Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3737523A1 (de) * | 1987-11-05 | 1989-05-18 | Bayer Ag | Verwendung von substituierten hydroxypiperidinen als antivirale mittel |
| US5003072A (en) * | 1988-11-03 | 1991-03-26 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-D-glucitol derivatives |
| JPH02306962A (ja) | 1989-05-19 | 1990-12-20 | Meiji Seika Kaisha Ltd | 新規ｎ―置換―１―デオキシノジリマイシン誘導体及びそれを含有する癌細胞転移抑制剤 |
| JPH0324057A (ja) | 1989-06-22 | 1991-02-01 | Tosoh Corp | ポリヒドロキシピペリジン類及びその製造法 |
| KR920703056A (ko) | 1989-09-07 | 1992-12-17 | 아만 히데아키 | 항 바이러스제 |
| CA2086413A1 (en) | 1990-06-29 | 1991-12-30 | Yohji Ezure | Piperidine derivatives |
| US5276120A (en) * | 1991-05-30 | 1994-01-04 | The Scripps Research Institute | Process for forming omega-deuxy-azasugars |
| WO1994025603A1 (de) | 1993-05-05 | 1994-11-10 | Boehringer Mannheim Gmbh | Cholesterinoxidase aus brevibacterium sterolicum |
| US5798366A (en) | 1993-05-13 | 1998-08-25 | Monsanto Company | Method for treatment of CNS-involved lysosomal storage diseases |
| US6291657B1 (en) | 1993-05-13 | 2001-09-18 | Monsanto Company | Deoxygalactonojirimycin derivatives |
| US5451679A (en) * | 1994-03-08 | 1995-09-19 | G. D. Searle & Co. | 2-chloro and 2-bromo derivatives of 1,5-iminosugars |
| ATE322900T1 (de) | 1996-07-15 | 2006-04-15 | Macrozyme Dnm B V | Deoxynojirimycin derivate und ihre verwendung als glukosesylceramidase-inhibitoren |
| WO1998050359A1 (en) * | 1997-05-06 | 1998-11-12 | Novo Nordisk A/S | Novel heterocyclic compounds |
| WO1999001555A1 (en) * | 1997-07-03 | 1999-01-14 | The United States Of America Represented By The Secretary, Department Of Health And Human Services | Genes for niemann-pick type c disease |
| PT1030839E (pt) * | 1997-11-10 | 2004-05-31 | Searle & Co | Utilizacao de iminoacucares para tratar a resistencia a multifarmacos |
| US6610703B1 (en) | 1998-12-10 | 2003-08-26 | G.D. Searle & Co. | Method for treatment of glycolipid storage diseases |
| WO2000056334A1 (en) | 1999-03-19 | 2000-09-28 | The Trustees Of Boston College | Use of imino sugars for anti-tumor therapy |
| GB9909064D0 (en) * | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
| EP1196190B1 (en) * | 1999-07-26 | 2003-03-19 | G.D. SEARLE & CO. | Use of long-chain n-alkyl derivatives of deoxynojirimycin and a glucocerebrosidase enzyme for the manufacture of a medicament for the treatment of glycolipid storage diseases |
| ES2302697T3 (es) | 1999-08-10 | 2008-08-01 | The Chancellor, Masters And Scholars Of The University Of Oxford | Compuestos n-alquilicos de cadena larga y derivados oxa de los mismos y uso como composiciones antivirales. |
| US7256005B2 (en) * | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
| WO2002055489A2 (en) | 2000-12-27 | 2002-07-18 | Univ Columbia | Pim kinase-related methods |
| KR20050025144A (ko) * | 2002-03-13 | 2005-03-11 | 데르 스포엘 아아르노우드 씨 반 | 수컷 피임에 대한 비호르몬적 접근법 |
| US7994198B2 (en) * | 2002-07-17 | 2011-08-09 | Actelion Pharmaceuticals Ltd. | Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase |
| AU2003246942B2 (en) | 2002-07-17 | 2009-06-25 | Idorsia Pharmaceuticals Ltd | Piperidinetriol derivatives as inhibitors of glycosylceramide synthase |
| GB0313677D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compound |
| GB0313678D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
| GB0400812D0 (en) | 2004-01-14 | 2004-02-18 | Celltech R&D Ltd | Novel compounds |
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2003
- 2003-06-13 GB GBGB0313678.5A patent/GB0313678D0/en not_active Ceased
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2004
- 2004-06-09 EP EP04736403A patent/EP1636186A1/en not_active Withdrawn
- 2004-06-09 AU AU2004247469A patent/AU2004247469B2/en not_active Ceased
- 2004-06-09 WO PCT/GB2004/002451 patent/WO2004111002A1/en not_active Ceased
- 2004-06-09 CA CA2528323A patent/CA2528323C/en not_active Expired - Fee Related
- 2004-06-09 US US10/560,385 patent/US8071780B2/en not_active Expired - Fee Related
- 2004-06-09 CN CNB200480016298XA patent/CN100422149C/zh not_active Expired - Fee Related
- 2004-06-09 JP JP2006516391A patent/JP4780785B2/ja not_active Expired - Fee Related
- 2004-06-09 BR BRPI0411308A patent/BRPI0411308A8/pt not_active Application Discontinuation
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2005
- 2005-12-13 IL IL172542A patent/IL172542A/en active IP Right Grant
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002055498A1 (en) * | 2001-01-12 | 2002-07-18 | Oxford Glycosciences (Uk) Ltd | Pharmaceutically active piperidine derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2528323A1 (en) | 2004-12-23 |
| IL172542A (en) | 2011-07-31 |
| CA2528323C (en) | 2012-07-31 |
| GB0313678D0 (en) | 2003-07-16 |
| IL172542A0 (en) | 2006-04-10 |
| BRPI0411308A8 (pt) | 2017-12-26 |
| AU2004247469A1 (en) | 2004-12-23 |
| BRPI0411308A (pt) | 2006-07-11 |
| CN100422149C (zh) | 2008-10-01 |
| CN1805933A (zh) | 2006-07-19 |
| JP4780785B2 (ja) | 2011-09-28 |
| US8071780B2 (en) | 2011-12-06 |
| WO2004111002A1 (en) | 2004-12-23 |
| US20070112028A1 (en) | 2007-05-17 |
| EP1636186A1 (en) | 2006-03-22 |
| JP2006527253A (ja) | 2006-11-30 |
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Legal Events
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| FGA | Letters patent sealed or granted (standard patent) | ||
| PC | Assignment registered |
Owner name: IDORSIA PHARMACEUTICALS LTD Free format text: FORMER OWNER(S): ACTELION PHARMACEUTICALS LTD |
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| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |