AU2003260677C1 - Molecular detector arrangement - Google Patents
Molecular detector arrangement Download PDFInfo
- Publication number
- AU2003260677C1 AU2003260677C1 AU2003260677A AU2003260677A AU2003260677C1 AU 2003260677 C1 AU2003260677 C1 AU 2003260677C1 AU 2003260677 A AU2003260677 A AU 2003260677A AU 2003260677 A AU2003260677 A AU 2003260677A AU 2003260677 C1 AU2003260677 C1 AU 2003260677C1
- Authority
- AU
- Australia
- Prior art keywords
- analyte
- conducting surface
- radiation
- detector assembly
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 230000005855 radiation Effects 0.000 claims description 76
- 239000012491 analyte Substances 0.000 claims description 75
- 238000001069 Raman spectroscopy Methods 0.000 claims description 46
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims description 42
- 238000004458 analytical method Methods 0.000 claims description 32
- 229910052751 metal Inorganic materials 0.000 claims description 31
- 239000002184 metal Substances 0.000 claims description 31
- 230000000694 effects Effects 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 15
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 12
- 239000010931 gold Substances 0.000 claims description 12
- 229910052737 gold Inorganic materials 0.000 claims description 12
- 230000008859 change Effects 0.000 claims description 9
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 7
- 239000004332 silver Substances 0.000 claims description 7
- 229910052709 silver Inorganic materials 0.000 claims description 7
- 239000000758 substrate Substances 0.000 claims description 7
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 6
- 239000010949 copper Substances 0.000 claims description 6
- 229910052802 copper Inorganic materials 0.000 claims description 6
- 238000001514 detection method Methods 0.000 claims description 6
- 239000004411 aluminium Substances 0.000 claims description 3
- 229910052782 aluminium Inorganic materials 0.000 claims description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 3
- 230000003287 optical effect Effects 0.000 claims description 2
- 238000005516 engineering process Methods 0.000 claims 1
- 238000004416 surface enhanced Raman spectroscopy Methods 0.000 description 35
- 230000005284 excitation Effects 0.000 description 9
- 230000005672 electromagnetic field Effects 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 239000000203 mixture Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000002032 lab-on-a-chip Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000002923 metal particle Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000001237 Raman spectrum Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000002019 doping agent Substances 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000003574 free electron Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 230000004001 molecular interaction Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000011896 sensitive detection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010408 sweeping Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
- G01N21/554—Attenuated total reflection and using surface plasmons detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N2021/651—Cuvettes therefore
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0215876.4 | 2002-07-10 | ||
| GBGB0215876.4A GB0215876D0 (en) | 2002-07-10 | 2002-07-10 | Spectroscopy methods and devices |
| GB0309492.7 | 2003-04-25 | ||
| GB0309492A GB2403796B (en) | 2002-07-10 | 2003-04-25 | Molecular detector arrangement |
| PCT/GB2003/002962 WO2004008120A1 (en) | 2002-07-10 | 2003-07-09 | Molecular detector arrangement |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2003260677A1 AU2003260677A1 (en) | 2004-02-02 |
| AU2003260677B2 AU2003260677B2 (en) | 2008-11-06 |
| AU2003260677C1 true AU2003260677C1 (en) | 2009-03-26 |
Family
ID=30117106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003260677A Ceased AU2003260677C1 (en) | 2002-07-10 | 2003-07-09 | Molecular detector arrangement |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070030481A1 (https=) |
| EP (1) | EP1552282A1 (https=) |
| JP (1) | JP2005532563A (https=) |
| CN (1) | CN1666099A (https=) |
| AU (1) | AU2003260677C1 (https=) |
| WO (1) | WO2004008120A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7151598B2 (en) * | 2003-04-04 | 2006-12-19 | Vladimir Poponin | Method and apparatus for enhanced nano-spectroscopic scanning |
| US7102747B2 (en) * | 2004-10-13 | 2006-09-05 | Hewlett-Packard Development Company, L.P. | In situ excitation for Surface Enhanced Raman Spectroscopy |
| CA2586197C (en) | 2004-11-04 | 2012-08-14 | Mesophotonics Limited | Metal nano-void photonic crystal for enhanced raman spectroscopy |
| GB0424458D0 (en) * | 2004-11-04 | 2004-12-08 | Mesophotonics Ltd | Metal nano-void photonic crystal for enhanced raman spectroscopy |
| GB2431233A (en) * | 2005-10-14 | 2007-04-18 | E2V Tech | Molecular detector arrangement |
| JP2007171003A (ja) | 2005-12-22 | 2007-07-05 | Fujifilm Corp | 質量分析用基板並びに分析方法および装置 |
| GB0606088D0 (en) * | 2006-03-27 | 2006-05-03 | E2V Biosensors Ltd | Improved serrs substrate |
| US8017408B2 (en) | 2007-04-27 | 2011-09-13 | The Regents Of The University Of California | Device and methods of detection of airborne agents |
| US20090233810A1 (en) * | 2008-03-12 | 2009-09-17 | The Mitre Corporation | Multi-Modal surface plasmon polariton-raman scattering based bio-detection |
| CN102095719A (zh) * | 2010-12-30 | 2011-06-15 | 浙江工业大学 | 基于表面等离子共振和受激拉曼散射的光纤型传感系统 |
| KR101333482B1 (ko) * | 2012-03-08 | 2013-11-26 | 단국대학교 산학협력단 | 표면 플라즈몬 산란 및 공명 검출에 기반한 생체 물질 측정 시스템 |
| EP2834619A1 (en) * | 2012-04-05 | 2015-02-11 | Renishaw Diagnostics Limited | A method for calibrating spectroscopy apparatus and equipment for use in the method |
| CN102680452A (zh) * | 2012-05-14 | 2012-09-19 | 中央民族大学 | 一种集成微流控光学的双探测生化传感检测仪 |
| CN102706835A (zh) * | 2012-05-14 | 2012-10-03 | 中央民族大学 | 一种双探测生化传感检测仪的传感芯片及其制备方法 |
| WO2016118812A1 (en) | 2015-01-23 | 2016-07-28 | Vanderbilt University | A robust interferometer and methods of using same |
| US10627396B2 (en) | 2016-01-29 | 2020-04-21 | Vanderbilt University | Free-solution response function interferometry |
| CN109313137A (zh) | 2016-07-22 | 2019-02-05 | 惠普发展公司，有限责任合伙企业 | 衬底支撑的表面增强发光台和壳体 |
| CN106896095B (zh) * | 2017-01-11 | 2019-08-06 | 四川大学 | 复合表面等离子体共振及表面增强拉曼的显微成像技术 |
| CN109031658B (zh) * | 2017-06-12 | 2020-10-02 | 中国科学院大连化学物理研究所 | 一种薄型激光透射探测窗口 |
| CN108037107A (zh) * | 2017-12-04 | 2018-05-15 | 中国科学院长春光学精密机械与物理研究所 | 一种同步检测装置 |
| CN108152275B (zh) * | 2017-12-27 | 2019-07-19 | 福州大学 | 一种基于电化学发光体系的透明质酸酶检测方法 |
| EP4133253A4 (en) | 2020-04-07 | 2023-08-16 | James I. Scholtz | DEVICE AND METHOD FOR THE SELECTIVE DETECTION OF PATHOGENS AND/OR CHEMICALS |
| CN115561224B (zh) * | 2022-09-27 | 2024-11-26 | 青岛科技大学 | 可循环利用的sers分子检测装置及其使用方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988006726A1 (en) * | 1987-02-25 | 1988-09-07 | Scientific Generics Limited | In vivo blood testing |
| US5266498A (en) * | 1989-10-27 | 1993-11-30 | Abbott Laboratories | Ligand binding assay for an analyte using surface-enhanced scattering (SERS) signal |
| US20010053521A1 (en) * | 1999-09-27 | 2001-12-20 | Kreimer David I. | Amplification of analyte detection by substrates having particle structures with receptors |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4004088A1 (de) * | 1990-02-10 | 1991-08-14 | Basf Ag | Verfahren zur untersuchung physikalischer eigenschaften duenner schichten |
| SE9100392D0 (sv) * | 1991-02-08 | 1991-02-08 | Pharmacia Biosensor Ab | A method of producing a sealing means in a microfluidic structure and a microfluidic structure comprising such sealing means |
| FI96800C (fi) * | 1994-02-16 | 1996-08-26 | Valtion Teknillinen | Laite analyysin suorittamiseksi |
| US6025202A (en) * | 1995-02-09 | 2000-02-15 | The Penn State Research Foundation | Self-assembled metal colloid monolayers and detection methods therewith |
| US6197503B1 (en) * | 1997-11-26 | 2001-03-06 | Ut-Battelle, Llc | Integrated circuit biochip microsystem containing lens |
| EP1236034A4 (en) * | 1999-11-12 | 2006-05-03 | Surromed Inc | PLASMON RESONANCE SURFACE BIODETECTION |
| WO2001063256A1 (de) * | 2000-02-22 | 2001-08-30 | Graffinity Pharmaceutical Design Gmbh | Spr-sensorsystem |
| US20030073139A1 (en) * | 2001-09-21 | 2003-04-17 | Kreimer David I. | Devices and methods for verifying measurement of analytes by raman spectroscopy and surface plasmon resonance |
| US6970239B2 (en) * | 2002-06-12 | 2005-11-29 | Intel Corporation | Metal coated nanocrystalline silicon as an active surface enhanced Raman spectroscopy (SERS) substrate |
| GB2404739B (en) * | 2003-08-05 | 2006-04-12 | E2V Tech Uk Ltd | Sensor |
| GB2431233A (en) * | 2005-10-14 | 2007-04-18 | E2V Tech | Molecular detector arrangement |
-
2003
- 2003-07-09 US US10/520,986 patent/US20070030481A1/en not_active Abandoned
- 2003-07-09 AU AU2003260677A patent/AU2003260677C1/en not_active Ceased
- 2003-07-09 WO PCT/GB2003/002962 patent/WO2004008120A1/en not_active Ceased
- 2003-07-09 JP JP2004520830A patent/JP2005532563A/ja active Pending
- 2003-07-09 CN CN03816280.6A patent/CN1666099A/zh active Pending
- 2003-07-09 EP EP03763975A patent/EP1552282A1/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988006726A1 (en) * | 1987-02-25 | 1988-09-07 | Scientific Generics Limited | In vivo blood testing |
| US5266498A (en) * | 1989-10-27 | 1993-11-30 | Abbott Laboratories | Ligand binding assay for an analyte using surface-enhanced scattering (SERS) signal |
| US20010053521A1 (en) * | 1999-09-27 | 2001-12-20 | Kreimer David I. | Amplification of analyte detection by substrates having particle structures with receptors |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004008120A1 (en) | 2004-01-22 |
| AU2003260677B2 (en) | 2008-11-06 |
| CN1666099A (zh) | 2005-09-07 |
| AU2003260677A1 (en) | 2004-02-02 |
| EP1552282A1 (en) | 2005-07-13 |
| US20070030481A1 (en) | 2007-02-08 |
| JP2005532563A (ja) | 2005-10-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2003260677C1 (en) | Molecular detector arrangement | |
| Chen et al. | Probing the limits of plasmonic enhancement using a two-dimensional atomic crystal probe | |
| Abbas et al. | New trends in instrumental design for surface plasmon resonance-based biosensors | |
| Gryczynski et al. | Effects of sample thickness on the optical properties of surface plasmon-coupled emission | |
| US8877519B2 (en) | Chemical sensor element, sensing apparatus, and sensing method | |
| CN101688809B (zh) | 电场增强结构及使用其的检测装置 | |
| Gryczynski et al. | Ultraviolet surface plasmon-coupled emission using thin aluminum films | |
| CN104849217B (zh) | 分析装置及电子设备 | |
| US8629983B2 (en) | Assembly with absorbing sensor layer | |
| WO2008091666A1 (en) | Surface plasmon enhanced raman spectroscopy | |
| Morales-Vidal et al. | Distributed feedback lasers based on perylenediimide dyes for label-free refractive index sensing | |
| WO2013164642A1 (en) | Active chemical sensing using optical microcavity | |
| JP2010038624A (ja) | 検出方法及び検出装置 | |
| US20120281212A1 (en) | Self-collecting sers substrate | |
| Zhang et al. | Plasmonic external cavity laser refractometric sensor | |
| WO2007046845A2 (en) | Electrical detection of plasmon resonances | |
| Baltog et al. | Surface enhanced Raman scattering on silver grating: optimized antennalike gain of the stokes signal of 104 | |
| Steiner et al. | Surface plasmon resonance within ion implanted silver clusters | |
| US8472018B2 (en) | Grating for multiple discrete wavelengths of Raman scattering | |
| Smith et al. | First observation of surface plasmon-coupled emission due to LED excitation | |
| US8158398B2 (en) | Microelectronic sensor device | |
| GB2403796A (en) | Molecular detector arrangement | |
| GB2400908A (en) | Molecular detector arrangement | |
| Zhang et al. | Ultrasensitive SEIRA sensor based on the graphene acoustic plasmon resonator combined with colloidal crystal of gold nano-cube | |
| Reilly Sr et al. | SPR surface enhanced fluorescence with a gold-coated corrugated sensor chip |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1 | Assignment before grant (sect. 113) |
Owner name: E2V BIOSENSORS LIMITED Free format text: FORMER APPLICANT(S): E2V TECHNOLOGIES (UK) LIMITED |
|
| DA2 | Applications for amendment section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT( S) FILED 12 NOV 2008. |
|
| DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 12 NOV 2008 |
|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |