AU2003256606A1 - Spliceosome mediated rna trans-splicing for correction of skin disorders - Google Patents

Spliceosome mediated rna trans-splicing for correction of skin disorders Download PDF

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Publication number
AU2003256606A1
AU2003256606A1 AU2003256606A AU2003256606A AU2003256606A1 AU 2003256606 A1 AU2003256606 A1 AU 2003256606A1 AU 2003256606 A AU2003256606 A AU 2003256606A AU 2003256606 A AU2003256606 A AU 2003256606A AU 2003256606 A1 AU2003256606 A1 AU 2003256606A1
Authority
AU
Australia
Prior art keywords
cell
nucleic acid
acid molecule
skin
mrna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003256606A
Other languages
English (en)
Inventor
Johann Bauer
Guenter Dallinger
Alfred Klausegger
Lloyd G. Mitchell
Madaiah Puttaraju
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INTRONN Inc
Original Assignee
INTRONN Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INTRONN Inc filed Critical INTRONN Inc
Publication of AU2003256606A1 publication Critical patent/AU2003256606A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003256606A 2002-07-17 2003-07-17 Spliceosome mediated rna trans-splicing for correction of skin disorders Abandoned AU2003256606A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/198,447 2002-07-17
US10/198,447 US20040018622A1 (en) 2002-07-17 2002-07-17 Spliceosome mediated RNA trans-splicing for correction of skin disorders
PCT/US2003/022469 WO2004006678A1 (en) 2002-07-17 2003-07-17 Spliceosome mediated rna trans-splicing for correction of skin disorders

Publications (1)

Publication Number Publication Date
AU2003256606A1 true AU2003256606A1 (en) 2004-02-02

Family

ID=30115154

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003256606A Abandoned AU2003256606A1 (en) 2002-07-17 2003-07-17 Spliceosome mediated rna trans-splicing for correction of skin disorders

Country Status (6)

Country Link
US (2) US20040018622A1 (enExample)
EP (1) EP1542532A1 (enExample)
JP (1) JP2005532815A (enExample)
AU (1) AU2003256606A1 (enExample)
CA (1) CA2492469A1 (enExample)
WO (1) WO2004006678A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005207053A1 (en) * 2004-01-23 2005-08-04 Virxsys Corporation Expression of ApoA-1 and variants thereof using spliceosome mediated RNA trans-splicing
AU2005210679B2 (en) * 2004-02-03 2009-10-01 Hybrid Biosciences Pty Ltd Method of identifying genes which promote hybrid vigour and hybrid debility and uses thereof
US20110252488A1 (en) * 2004-02-03 2011-10-13 Peter Hamilton Kay Method of Identifying Genes which Promote Hybrid Vigour and Hybrid Debility and Uses Thereof
US20060134658A1 (en) * 2004-08-09 2006-06-22 Garcia-Blanco Mariano A Use of RNA trans-splicing for generation of interfering RNA molecules
KR20080040735A (ko) * 2005-07-29 2008-05-08 하이브리드 바이오사이언시스 피티와이 엘티디 잡종 강세 또는 잡종 약세를 촉진시키는 유전자 및 그산물의 동정 방법 및 이의 용도
KR100907106B1 (ko) 2007-10-25 2009-07-09 국립암센터 라이보자임을 함유한 아데노바이러스를 이용한 질병의분자영상진단법
US8829159B2 (en) 2008-04-14 2014-09-09 The General Hospital Corporation Plectin-1 targeted agents for detection and treatment of pancreatic ductal adenocarcinoma
EP2151248A1 (en) * 2008-07-30 2010-02-10 Johann Bauer Improved pre-mRNA trans-splicing molecule (RTM) molecules and their uses
GB201219762D0 (en) * 2012-11-02 2012-12-19 Bauer Johann A RNA trans-splicing molecule (RTM) for use in the treatment of cancer
US10987433B2 (en) 2015-11-19 2021-04-27 The Trustees Of The University Of Pennsylvania Compositions and methods for correction of heritable ocular disease
EP3781213A4 (en) 2018-04-17 2022-10-19 The Trustees of the University of Pennsylvania TRANS-SPLICE MOLECULES
CA3252043A1 (en) 2022-05-13 2023-11-16 Ascidian Therapeutics, Inc. ABCA4 TRANS-SPLICING MOLECULES

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5914265A (en) * 1992-04-30 1999-06-22 Baylor College Of Medicine Keratin K1 expression vectors and methods of use
US5874560A (en) * 1994-04-22 1999-02-23 The United States Of America As Represented By The Department Of Health And Human Services Melanoma antigens and their use in diagnostic and therapeutic methods
US5872241A (en) * 1995-01-25 1999-02-16 The Trustees Of Columbia University In The City Of New York Multiple component RNA catalysts and uses thereof
US6280978B1 (en) * 1995-12-15 2001-08-28 Intronn Holdings, Llc Methods and compositions for use in spliceosome mediated RNA trans-splicing
US6083702A (en) * 1995-12-15 2000-07-04 Intronn Holdings Llc Methods and compositions for use in spliceosome mediated RNA trans-splicing
AU730305B2 (en) * 1995-12-15 2001-03-01 Intronn Llc Therapeutic molecules generated by trans-splicing

Also Published As

Publication number Publication date
JP2005532815A (ja) 2005-11-04
EP1542532A1 (en) 2005-06-22
CA2492469A1 (en) 2004-01-22
US20040248141A1 (en) 2004-12-09
US20040018622A1 (en) 2004-01-29
WO2004006678A1 (en) 2004-01-22

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Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period