AU2003251474A1 - Aminocyclohexene quinolines and their azaisosteric analogues with antibacterial activity - Google Patents
Aminocyclohexene quinolines and their azaisosteric analogues with antibacterial activityInfo
- Publication number
- AU2003251474A1 AU2003251474A1 AU2003251474A AU2003251474A AU2003251474A1 AU 2003251474 A1 AU2003251474 A1 AU 2003251474A1 AU 2003251474 A AU2003251474 A AU 2003251474A AU 2003251474 A AU2003251474 A AU 2003251474A AU 2003251474 A1 AU2003251474 A1 AU 2003251474A1
- Authority
- AU
- Australia
- Prior art keywords
- aminocyclohexene
- quinolines
- antibacterial activity
- azaisosteric
- analogues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- JXCMZSCALSKDNX-UHFFFAOYSA-N cyclohexen-1-amine;quinoline Chemical class NC1=CCCCC1.N1=CC=CC2=CC=CC=C21 JXCMZSCALSKDNX-UHFFFAOYSA-N 0.000 title 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 125000000596 cyclohexenyl group Chemical class C1(=CCCCC1)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0217294.8A GB0217294D0 (en) | 2002-07-25 | 2002-07-25 | Medicaments |
| GB0217294.8 | 2002-07-25 | ||
| PCT/EP2003/008153 WO2004014361A1 (en) | 2002-07-25 | 2003-07-23 | Aminocyclohexene quinolines and their azaisosteric analogues with antibacterial activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003251474A8 AU2003251474A8 (en) | 2004-02-25 |
| AU2003251474A1 true AU2003251474A1 (en) | 2004-02-25 |
Family
ID=9941121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003251474A Abandoned AU2003251474A1 (en) | 2002-07-25 | 2003-07-23 | Aminocyclohexene quinolines and their azaisosteric analogues with antibacterial activity |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20060040925A1 (https=) |
| EP (1) | EP1539133B1 (https=) |
| JP (1) | JP4515260B2 (https=) |
| AT (1) | ATE336995T1 (https=) |
| AU (1) | AU2003251474A1 (https=) |
| DE (1) | DE60307860T2 (https=) |
| ES (1) | ES2270142T3 (https=) |
| GB (1) | GB0217294D0 (https=) |
| WO (1) | WO2004014361A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0118238D0 (en) * | 2001-07-26 | 2001-09-19 | Smithkline Beecham Plc | Medicaments |
| EP1470125A1 (en) | 2002-01-29 | 2004-10-27 | Glaxo Group Limited | Aminopiperidine derivatives |
| WO2003064431A2 (en) | 2002-01-29 | 2003-08-07 | Glaxo Group Limited | Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them |
| TW200406413A (en) | 2002-06-26 | 2004-05-01 | Glaxo Group Ltd | Compounds |
| AR040336A1 (es) * | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto |
| DE60331849D1 (de) | 2002-11-05 | 2010-05-06 | Glaxosmithkline Llc | Antibakterielle wirkstoffe |
| ATE479683T1 (de) | 2002-11-05 | 2010-09-15 | Glaxo Group Ltd | Antibakterielle mittel |
| AU2003294565A1 (en) | 2002-12-04 | 2004-06-23 | Glaxo Group Limited | Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents |
| TW200427688A (en) * | 2002-12-18 | 2004-12-16 | Glaxo Group Ltd | Antibacterial agents |
| US7691850B2 (en) * | 2004-06-15 | 2010-04-06 | Glaxo Group Limited | Antibacterial agents |
| US20080194547A1 (en) * | 2004-07-09 | 2008-08-14 | Glaxo Group Limited | Antibacterial Agents |
| MY150958A (en) | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
| CA2635126A1 (en) | 2006-01-26 | 2007-08-02 | Actelion Pharmaceuticals Ltd | Tetrahydropyrane antibiotics |
| MX2008010671A (es) * | 2006-02-21 | 2008-10-01 | Amgen Inc | Derivados de cinolina como inhibidores de fosfodiesterasa 10. |
| WO2007100880A1 (en) * | 2006-02-28 | 2007-09-07 | Amgen Inc. | Cinnoline and quinazoline derivates as phosphodiesterase 10 inhibitors |
| US20070299067A1 (en) * | 2006-03-08 | 2007-12-27 | Ruiping Liu | Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors |
| WO2007115947A1 (en) | 2006-04-06 | 2007-10-18 | Glaxo Group Limited | Pyrrolo-quinoxalinone derivatives as antibacterials |
| EP2007377A4 (en) | 2006-04-06 | 2011-08-17 | Glaxo Group Ltd | ANTIBACTERIAL ACTIVE SUBSTANCES |
| GB0613208D0 (en) | 2006-07-03 | 2006-08-09 | Glaxo Group Ltd | Compounds |
| EP1992628A1 (en) | 2007-05-18 | 2008-11-19 | Glaxo Group Limited | Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones |
| TW200819457A (en) | 2006-08-30 | 2008-05-01 | Actelion Pharmaceuticals Ltd | Spiro antibiotic derivatives |
| EA015821B1 (ru) * | 2007-04-20 | 2011-12-30 | Глэксо Груп Лимитед | Трициклические азотсодержащие соединения в качестве антибактериальных агентов |
| EP2080761A1 (en) | 2008-01-18 | 2009-07-22 | Glaxo Group Limited | Compounds |
| WO2010043714A1 (en) | 2008-10-17 | 2010-04-22 | Glaxo Group Limited | Tricyclic nitrogen compounds used as antibacterials |
| ES2561631T3 (es) | 2009-01-15 | 2016-02-29 | Glaxo Group Limited | Compuestos de naftiridin-2(1H)-ona útiles como agentes antibacterianos |
| AR089929A1 (es) | 2012-02-10 | 2014-10-01 | Actelion Pharmaceuticals Ltd | Proceso para manufacturar un derivado de naftiridina |
| MX361157B (es) * | 2012-08-30 | 2018-11-28 | Hoffmann La Roche | Compuestos inhibidores de pi3k de dioxino- y oxazin-[2,3-d]pirimid ina y métodos de uso. |
| JP6546654B2 (ja) | 2014-08-22 | 2019-07-17 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | 淋菌感染を治療するための三環式含窒素化合物 |
| CA2994604A1 (en) | 2015-08-07 | 2017-02-16 | Bayer Cropscience Aktiengesellschaft | 2-(het)aryl-substituted condensed heterocyclic derivatives as pest control agents |
| UY36851A (es) | 2015-08-16 | 2017-03-31 | Glaxosmithkline Ip Dev Ltd | Compuestos para uso en aplicaciones antibacterianas |
| EP4045908A1 (en) | 2019-10-18 | 2022-08-24 | The Regents Of The University Of California | Ex vivo tumor angiogenesis model |
| EP4045485A1 (en) | 2019-10-18 | 2022-08-24 | The Regents Of The University Of California | 3-phenylsulphonyl-quinoline derivatives as agents for treating pathogenic blood vessels disorders |
| CN119161260A (zh) * | 2024-06-26 | 2024-12-20 | 安徽大学 | 一种1-（2-氨基-4-氟-5-甲氧基苯基）-1-丙酮的合成方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0790981B1 (en) * | 1994-11-10 | 1999-09-08 | Pfizer Inc. | Aryloxycycloalkenyl and aryloxyiminocycloalkenylhydroxyureas as 5-lipoxygenase inhibitors |
| DE69908555T2 (de) * | 1998-01-26 | 2004-05-06 | Smithkline Beecham P.L.C., Brentford | Chinolinderivate als antibakterielles arzneimittel |
| GB9822450D0 (en) * | 1998-10-14 | 1998-12-09 | Smithkline Beecham Plc | Medicaments |
| EP1144404A1 (en) * | 1999-01-20 | 2001-10-17 | Smithkline Beecham Plc | Piperidinylquinolines as protein tyrosine kinase inhibitors |
| GB9914486D0 (en) * | 1999-06-21 | 1999-08-18 | Smithkline Beecham Plc | Medicaments |
| GB9917406D0 (en) * | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
| GB9917408D0 (en) * | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
| CZ2003243A3 (cs) * | 2000-07-26 | 2003-09-17 | Smithkline Beecham P. L. C. | Aminopiperidinové chinoliny a jejich azaisosterické analogy s antibakteriální aktivitou |
| FR2816618B1 (fr) * | 2000-11-15 | 2002-12-27 | Aventis Pharma Sa | Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent |
| GB0031088D0 (en) * | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
| GB0101577D0 (en) * | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
-
2002
- 2002-07-25 GB GBGB0217294.8A patent/GB0217294D0/en not_active Ceased
-
2003
- 2003-07-23 AT AT03784064T patent/ATE336995T1/de not_active IP Right Cessation
- 2003-07-23 US US10/522,058 patent/US20060040925A1/en not_active Abandoned
- 2003-07-23 WO PCT/EP2003/008153 patent/WO2004014361A1/en not_active Ceased
- 2003-07-23 JP JP2004526773A patent/JP4515260B2/ja not_active Expired - Fee Related
- 2003-07-23 EP EP03784064A patent/EP1539133B1/en not_active Expired - Lifetime
- 2003-07-23 ES ES03784064T patent/ES2270142T3/es not_active Expired - Lifetime
- 2003-07-23 AU AU2003251474A patent/AU2003251474A1/en not_active Abandoned
- 2003-07-23 DE DE60307860T patent/DE60307860T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60307860T2 (de) | 2007-10-11 |
| DE60307860D1 (de) | 2006-10-05 |
| GB0217294D0 (en) | 2002-09-04 |
| AU2003251474A8 (en) | 2004-02-25 |
| EP1539133B1 (en) | 2006-08-23 |
| WO2004014361A9 (en) | 2004-04-08 |
| US20060040925A1 (en) | 2006-02-23 |
| WO2004014361A1 (en) | 2004-02-19 |
| ES2270142T3 (es) | 2007-04-01 |
| ATE336995T1 (de) | 2006-09-15 |
| JP2005538125A (ja) | 2005-12-15 |
| JP4515260B2 (ja) | 2010-07-28 |
| EP1539133A1 (en) | 2005-06-15 |
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