AU2003224989B2 - Adjuvant enhanced immunotherapy - Google Patents
Adjuvant enhanced immunotherapy Download PDFInfo
- Publication number
- AU2003224989B2 AU2003224989B2 AU2003224989A AU2003224989A AU2003224989B2 AU 2003224989 B2 AU2003224989 B2 AU 2003224989B2 AU 2003224989 A AU2003224989 A AU 2003224989A AU 2003224989 A AU2003224989 A AU 2003224989A AU 2003224989 B2 AU2003224989 B2 AU 2003224989B2
- Authority
- AU
- Australia
- Prior art keywords
- adjuvant
- hapten
- ligand
- conjugate
- immunogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000002671 adjuvant Substances 0.000 title claims 38
- 238000009169 immunotherapy Methods 0.000 title 1
- 238000000034 method Methods 0.000 claims 19
- 210000004027 cell Anatomy 0.000 claims 10
- 230000001717 pathogenic effect Effects 0.000 claims 9
- 241001465754 Metazoa Species 0.000 claims 7
- 230000002163 immunogen Effects 0.000 claims 7
- 239000003446 ligand Substances 0.000 claims 7
- 241000699670 Mus sp. Species 0.000 claims 6
- 230000028993 immune response Effects 0.000 claims 6
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims 6
- PIGTXFOGKFOFTO-FVFWYJKVSA-N (2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-carboxy-4-formyl-8-hydroxy-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group O([C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)C[C@@H](O)[C@]1(CCC(C[C@H]14)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O PIGTXFOGKFOFTO-FVFWYJKVSA-N 0.000 claims 5
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims 5
- 229930182490 saponin Natural products 0.000 claims 5
- 150000007949 saponins Chemical class 0.000 claims 5
- 230000002708 enhancing effect Effects 0.000 claims 4
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 4
- 210000002865 immune cell Anatomy 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- -1 dinitrophenyl Chemical group 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 239000004599 antimicrobial Substances 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 239000003139 biocide Substances 0.000 claims 2
- 230000022534 cell killing Effects 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 231100000433 cytotoxic Toxicity 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 230000001472 cytotoxic effect Effects 0.000 claims 2
- 230000008030 elimination Effects 0.000 claims 2
- 238000003379 elimination reaction Methods 0.000 claims 2
- 230000036039 immunity Effects 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 239000003961 penetration enhancing agent Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- NKVLDFAVEWLOCX-GUSKIFEASA-N [(2s,3r,4s,5r,6r)-3-[(2s,3r,4s,5r,6s)-5-[(2s,3r,4s,5r)-4-[(2s,3r,4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-3,5-dihydroxyoxan-2-yl]oxy-3,4-dihydroxy-6-methyloxan-2-yl]oxy-4,5-dihydroxy-6-methyloxan-2-yl] (4ar,5r,6as,6br,9s,10s,12ar)-10-[(2r,3r,4s, Chemical group O([C@H]1[C@H](O)CO[C@H]([C@@H]1O)O[C@H]1[C@H](C)O[C@H]([C@@H]([C@@H]1O)O)O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](C)O[C@H]1OC(=O)[C@]12CCC(C)(C)CC1C1=CCC3[C@@]([C@@]1(C[C@H]2O)C)(C)CCC1[C@]3(C)CC[C@@H]([C@@]1(C)C=O)O[C@@H]1O[C@@H]([C@H]([C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)CO2)O)[C@H]1O[C@H]1[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O1)O)O)C(=O)NCCCCCCCCCCCC)[C@@H]1OC[C@](O)(CO)[C@H]1O NKVLDFAVEWLOCX-GUSKIFEASA-N 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
Classifications
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
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- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37381802P | 2002-04-19 | 2002-04-19 | |
| US60/373,818 | 2002-04-19 | ||
| PCT/US2003/011663 WO2003089593A2 (en) | 2002-04-19 | 2003-04-16 | Adjuvant enhanced immunotherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003224989A1 AU2003224989A1 (en) | 2003-11-03 |
| AU2003224989B2 true AU2003224989B2 (en) | 2008-12-04 |
Family
ID=29251090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003224989A Ceased AU2003224989B2 (en) | 2002-04-19 | 2003-04-16 | Adjuvant enhanced immunotherapy |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20030198643A1 (enExample) |
| EP (1) | EP1496934A4 (enExample) |
| JP (2) | JP2005532296A (enExample) |
| CN (1) | CN1662251B (enExample) |
| AR (1) | AR039429A1 (enExample) |
| AU (1) | AU2003224989B2 (enExample) |
| CA (1) | CA2482924A1 (enExample) |
| IL (1) | IL164546A0 (enExample) |
| NZ (1) | NZ536609A (enExample) |
| TW (1) | TW200406220A (enExample) |
| WO (1) | WO2003089593A2 (enExample) |
| ZA (1) | ZA200408427B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA005823B1 (ru) * | 2000-03-31 | 2005-06-30 | Пердью Рисерч Фаундейшн | Способ лечения с использованием конъюгатов лиганд-иммуноген |
| CN1635910A (zh) | 2001-05-02 | 2005-07-06 | 普渡研究基金会 | 巨噬细胞介导的疾病的治疗和诊断 |
| EP1434603B1 (en) * | 2001-09-28 | 2009-12-16 | Purdue Research Foundation | Method of treatment using ligand-immunogen conjugates |
| US8043602B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| US8043603B2 (en) * | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| US7745157B2 (en) * | 2003-02-21 | 2010-06-29 | University Of Maryland, Baltimore | Human lymphocyte medium adjuvant |
| ATE412897T1 (de) | 2003-05-30 | 2008-11-15 | Purdue Research Foundation | Diagnoseverfahren für atherosklerose |
| CN101128152A (zh) * | 2004-12-23 | 2008-02-20 | 普渡研究基金会 | 发射正电子段层成像方法 |
| AU2006230219A1 (en) * | 2005-03-30 | 2006-10-05 | Endocyte, Inc. | Method for cancer prognosis using cellular folate vitamin receptor quantification |
| CN101355928B (zh) | 2005-04-26 | 2013-05-22 | 卫材R&D管理株式会社 | 用于癌症免疫疗法的组合物和方法 |
| WO2007006041A2 (en) | 2005-07-05 | 2007-01-11 | Purdue Research Foundation | Imaging and therapeutic method using monocytes |
| US8715677B2 (en) * | 2005-09-01 | 2014-05-06 | Celgene Corporation | Immunological uses of immunomodulatory compounds for vaccine and anti-infectious disease therapy |
| EP1940473A2 (en) | 2005-09-23 | 2008-07-09 | Purdue Research Foundation | Multiphoton in vivo flow cytometry method and device |
| US20070134259A1 (en) * | 2005-11-21 | 2007-06-14 | David Bundle | Methods and compositions for pharmacologially controlled targeted immunotherapy |
| WO2007092299A2 (en) * | 2006-02-03 | 2007-08-16 | Purdue Research Foundation | Targeted conjugates and radiation |
| CA2663851A1 (en) * | 2006-09-26 | 2008-04-03 | Alexion Pharmaceuticals, Inc. | Compositions and methods for enhancing an adjuvant |
| CA2668197A1 (en) | 2006-11-03 | 2008-05-15 | Philip S. Low | Ex vivo flow cytometry method and device |
| JP5869205B2 (ja) | 2007-02-07 | 2016-02-24 | パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | ポジトロン放射断層画像法 |
| US8961926B2 (en) * | 2007-05-25 | 2015-02-24 | Purdue Research Foundation | Method of imaging localized infections |
| US20090012009A1 (en) * | 2007-06-01 | 2009-01-08 | Low Philip S | Composition and Method for Treating Inflammatory Disease |
| JP5554713B2 (ja) * | 2007-11-15 | 2014-07-23 | エンドサイト，インク． | 接合体を投与する方法 |
| CN103961701B (zh) | 2013-02-05 | 2018-09-14 | 日东电工株式会社 | 疫苗组合物 |
| EP2970349A4 (en) * | 2013-03-15 | 2017-02-15 | Newlink Genetics Corporation | Carbohydrate-modified glycoproteins and uses thereof |
| US10590180B2 (en) | 2015-06-19 | 2020-03-17 | National University Corporation Shizuoka University | Immune function development promoter and growth promoter |
| US20210100896A1 (en) * | 2017-04-05 | 2021-04-08 | University Of Miami | Methods and compositions for stimulating the immune system |
| CN109061172B (zh) * | 2018-09-21 | 2021-07-06 | 中国烟草总公司郑州烟草研究院 | 一种检测仲丁灵的酶联免疫试剂盒及其应用 |
| WO2020200481A1 (en) * | 2019-04-05 | 2020-10-08 | Biontech Rna Pharmaceuticals Gmbh | Treatment involving interleukin-2 (il2) and interferon (ifn) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010031252A1 (en) * | 2000-03-31 | 2001-10-18 | Low Philip Stewart | Method of treatment using ligand-immunogen conjugates |
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|---|---|---|---|---|
| US31252A (en) * | 1861-01-29 | Improvement in iron ties for cotton-bales | ||
| US39583A (en) * | 1863-08-18 | Improved variable exhaust for locomotives | ||
| US2816110A (en) * | 1956-11-23 | 1957-12-10 | Merck & Co Inc | Methods for the production of substituted pteridines |
| US4713249A (en) * | 1981-11-12 | 1987-12-15 | Schroeder Ulf | Crystallized carbohydrate matrix for biologically active substances, a process of preparing said matrix, and the use thereof |
| US4659655A (en) * | 1981-11-25 | 1987-04-21 | Bio-Response, Inc. | Method for isolating product-producing cells |
| US5140104A (en) * | 1982-03-09 | 1992-08-18 | Cytogen Corporation | Amine derivatives of folic acid analogs |
| US5266333A (en) * | 1985-03-06 | 1993-11-30 | American Cyanamid Company | Water dispersible and water soluble carbohydrate polymer compositions for parenteral administration of growth hormone |
| US5062171A (en) * | 1986-09-09 | 1991-11-05 | Kinetic Concepts, Inc. | Patient support air bags and related system with connectors for detachable mounting of the bags |
| WO1990009804A1 (en) * | 1989-02-24 | 1990-09-07 | The Regents Of The University Of California | Genetically engineered immunoglobulins |
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-
2003
- 2003-04-16 CN CN038144425A patent/CN1662251B/zh not_active Expired - Fee Related
- 2003-04-16 JP JP2003586306A patent/JP2005532296A/ja active Pending
- 2003-04-16 CA CA002482924A patent/CA2482924A1/en not_active Abandoned
- 2003-04-16 NZ NZ536609A patent/NZ536609A/en not_active IP Right Cessation
- 2003-04-16 WO PCT/US2003/011663 patent/WO2003089593A2/en not_active Ceased
- 2003-04-16 AU AU2003224989A patent/AU2003224989B2/en not_active Ceased
- 2003-04-16 EP EP03721690A patent/EP1496934A4/en not_active Ceased
- 2003-04-16 AR ARP030101333A patent/AR039429A1/es unknown
- 2003-04-17 US US10/417,903 patent/US20030198643A1/en not_active Abandoned
- 2003-04-18 TW TW092109085A patent/TW200406220A/zh unknown
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2004
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- 2004-10-18 ZA ZA200408427A patent/ZA200408427B/xx unknown
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2010
- 2010-07-09 JP JP2010157088A patent/JP2011012065A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010031252A1 (en) * | 2000-03-31 | 2001-10-18 | Low Philip Stewart | Method of treatment using ligand-immunogen conjugates |
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| Kim S K et al., Vaccine, October 2000, Vol 19, No 4-5, pp530-537 * |
| May Richard D et al. Faseb Journal, March 2002, Vol 16, No 4, pA333 * |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200408427B (en) | 2007-03-28 |
| AU2003224989A1 (en) | 2003-11-03 |
| JP2011012065A (ja) | 2011-01-20 |
| CA2482924A1 (en) | 2003-10-30 |
| WO2003089593A2 (en) | 2003-10-30 |
| TW200406220A (en) | 2004-05-01 |
| CN1662251B (zh) | 2012-10-10 |
| AR039429A1 (es) | 2005-02-16 |
| US20030198643A1 (en) | 2003-10-23 |
| CN1662251A (zh) | 2005-08-31 |
| NZ536609A (en) | 2007-11-30 |
| EP1496934A2 (en) | 2005-01-19 |
| JP2005532296A (ja) | 2005-10-27 |
| EP1496934A4 (en) | 2006-08-02 |
| WO2003089593A3 (en) | 2003-12-24 |
| IL164546A0 (en) | 2005-12-18 |
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