AU2003214981A1 - Molecular hepatotoxicology modeling - Google Patents
Molecular hepatotoxicology modelingInfo
- Publication number
- AU2003214981A1 AU2003214981A1 AU2003214981A AU2003214981A AU2003214981A1 AU 2003214981 A1 AU2003214981 A1 AU 2003214981A1 AU 2003214981 A AU2003214981 A AU 2003214981A AU 2003214981 A AU2003214981 A AU 2003214981A AU 2003214981 A1 AU2003214981 A1 AU 2003214981A1
- Authority
- AU
- Australia
- Prior art keywords
- hepatotoxicology
- modeling
- molecular
- molecular hepatotoxicology
- hepatotoxicology modeling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/142—Toxicological screening, e.g. expression profiles which identify toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/08—Hepato-biliairy disorders other than hepatitis
- G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6008702A | 2002-01-31 | 2002-01-31 | |
| US10/060,087 | 2002-01-31 | ||
| US36405502P | 2002-03-15 | 2002-03-15 | |
| US36404502P | 2002-03-15 | 2002-03-15 | |
| US60/364,045 | 2002-03-15 | ||
| US60/364,055 | 2002-03-15 | ||
| US43664302P | 2002-12-30 | 2002-12-30 | |
| US60/436,643 | 2002-12-30 | ||
| PCT/US2003/003194 WO2003064624A2 (en) | 2002-01-31 | 2003-01-31 | Molecular hepatotoxicology modeling |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2003214981A1 true AU2003214981A1 (en) | 2003-09-02 |
Family
ID=27670970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003214981A Abandoned AU2003214981A1 (en) | 2002-01-31 | 2003-01-31 | Molecular hepatotoxicology modeling |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070027634A1 (https=) |
| EP (1) | EP1476747A4 (https=) |
| JP (1) | JP2005535285A (https=) |
| AU (1) | AU2003214981A1 (https=) |
| CA (1) | CA2471661A1 (https=) |
| WO (1) | WO2003064624A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7447594B2 (en) | 2001-07-10 | 2008-11-04 | Ocimum Biosolutions, Inc. | Molecular cardiotoxicology modeling |
| US20050071088A1 (en) * | 2001-08-13 | 2005-03-31 | Landfield Philip W | Gene expression profile biomarkers and therapeutic targets for brain aging and age-related cognitive impairment |
| EP1361433A3 (en) * | 2002-04-09 | 2005-02-23 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Method for estimating therapeutic efficacy of tumor necrosis factor (TNF) |
| JP2007501617A (ja) * | 2003-08-07 | 2007-02-01 | ジーン ロジック インコーポレイテッド | 初代ラット肝細胞毒性モデリング |
| US7294704B2 (en) | 2003-08-15 | 2007-11-13 | Diadexus, Inc. | Pro108 antibody compositions and methods of use and use of Pro108 to assess cancer risk |
| US8131473B1 (en) * | 2004-05-20 | 2012-03-06 | Metabolon, Inc. | Data analysis methods for locating entities of interest within large, multivariable datasets |
| KR100565698B1 (ko) * | 2004-12-29 | 2006-03-28 | 디지탈 지노믹스(주) | 급성골수성백혈병(aml), b-세포형 급성임파구성백혈병(b-all), t 세포형 급성임파구성백혈병(t-all) 진단용 마커 |
| JP5202296B2 (ja) * | 2005-04-01 | 2013-06-05 | ユニバーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイティド | 肝臓傷害のバイオマーカー |
| US8048638B2 (en) * | 2005-04-01 | 2011-11-01 | University Of Florida Research Foundation, Inc. | Biomarkers of liver injury |
| US10957217B2 (en) | 2006-08-25 | 2021-03-23 | Ronald A. Weitzman | Population-sample regression in the estimation of population proportions |
| US11151895B2 (en) * | 2006-08-25 | 2021-10-19 | Ronald Weitzman | Population-sample regression in the estimation of population proportions |
| ES2665245T3 (es) | 2008-08-11 | 2018-04-25 | Banyan Biomarkers, Inc. | Proceso de detección de biomarcador y ensayo de estado neurológico |
| US12601749B2 (en) | 2008-08-11 | 2026-04-14 | Banyan Biomarkers, Inc. | Biomarker detection process and assay of neurological condition |
| EP2264454A1 (en) * | 2009-06-11 | 2010-12-22 | Universiteit Maastricht | Method for screening compounds for preventing the adverse effects of reactive oxygen species on eukaryotic cells |
| WO2012141674A2 (en) | 2010-01-26 | 2012-10-18 | Banyan Biomarkers, Inc. | Compositions and methods relating to argininosuccinate synthetase |
| JP5804629B2 (ja) * | 2011-07-29 | 2015-11-04 | 株式会社メディクローム | 遺伝子発現変動解析による化学物質の毒性評価方法 |
| EP3077823B1 (en) * | 2013-12-05 | 2019-09-04 | The Broad Institute, Inc. | Compositions and methods for identifying and treating cachexia or pre-cachexia |
| EP3389715A4 (en) | 2015-12-14 | 2019-06-12 | David K. Thomas | COMPOSITIONS AND METHODS FOR TREATING CARDIAL DYSFUNCTION |
| JP2016104032A (ja) * | 2016-02-23 | 2016-06-09 | 株式会社メディクローム | 化学物質の生体毒性の評価方法 |
| WO2018081649A1 (en) | 2016-10-28 | 2018-05-03 | Banyan Biomarkers, Inc. | Antibodies to ubiquitin c-terminal hydrolase l1 (uch-l1) and glial fibrillary acidic protein (gfap) and related methods |
| WO2025192110A1 (ja) * | 2024-03-11 | 2025-09-18 | 国立大学法人東北大学 | ベクターおよびその使用、並びに医薬組成物 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0680517T4 (da) * | 1993-01-21 | 2005-05-02 | Harvard College | Fremgangsmåde og diagnostiske sæt til bestemmelse af en forbindelses toksicitet under anvendelse afstress-promotorer fra pattedyr |
| US5858659A (en) * | 1995-11-29 | 1999-01-12 | Affymetrix, Inc. | Polymorphism detection |
| US6228589B1 (en) * | 1996-10-11 | 2001-05-08 | Lynx Therapeutics, Inc. | Measurement of gene expression profiles in toxicity determination |
| CA2269669A1 (en) * | 1996-11-04 | 1998-05-14 | 3-Dimensional Pharmaceuticals, Inc. | System, method and computer program product for identifying chemical compounds having desired properties |
| US6165709A (en) * | 1997-02-28 | 2000-12-26 | Fred Hutchinson Cancer Research Center | Methods for drug target screening |
| US6153421A (en) * | 1997-07-18 | 2000-11-28 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Cloned genomes of infectious hepatitis C viruses and uses thereof |
| WO1999010536A1 (en) * | 1997-08-22 | 1999-03-04 | Yale University | A process to study changes in gene expression in granulocytic cells |
| CA2310621A1 (en) * | 1997-11-20 | 1999-06-03 | Smithkline Beecham Corporation | Methods for identifying the toxic/pathologic effect of environmental stimuli on gene transcription |
| JP2002505852A (ja) * | 1998-01-26 | 2002-02-26 | シェーリング アクティエンゲゼルシャフト | 化合物をスクリーニングするための遺伝子発現方法 |
| US6403778B1 (en) * | 1998-05-04 | 2002-06-11 | Incyte Genomics, Inc. | Toxicological response markers |
| US6218122B1 (en) * | 1998-06-19 | 2001-04-17 | Rosetta Inpharmatics, Inc. | Methods of monitoring disease states and therapies using gene expression profiles |
| US6132969A (en) * | 1998-06-19 | 2000-10-17 | Rosetta Inpharmatics, Inc. | Methods for testing biological network models |
| US6203987B1 (en) * | 1998-10-27 | 2001-03-20 | Rosetta Inpharmatics, Inc. | Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns |
| EP1137809A1 (en) * | 1998-12-09 | 2001-10-04 | Vistagen, Inc. | Toxicity typing using embryoid bodies |
| EP1147224A1 (en) * | 1999-02-05 | 2001-10-24 | WRAIR (Walter Reed Army Institute of Research) | Method of diagnosing of exposure to toxic agents by measuring distinct pattern in the levels of expression of specific genes |
| US6372431B1 (en) * | 1999-11-19 | 2002-04-16 | Incyte Genomics, Inc. | Mammalian toxicological response markers |
| US20010049139A1 (en) * | 2000-03-23 | 2001-12-06 | Eric Lagasse | Hepatic regeneration from hematopoietic stem cells |
| KR100865664B1 (ko) * | 2000-06-14 | 2008-10-29 | 비스타겐 인코포레이티드 | 간 줄기 세포를 사용하는 독성 타이핑 |
| WO2002006537A2 (en) * | 2000-07-13 | 2002-01-24 | Curagen Corporation | Methods of identifying renal protective factors |
| EP1364049A2 (en) * | 2000-07-31 | 2003-11-26 | Gene Logic, Inc. | Molecular toxicology modeling |
| US20030154032A1 (en) * | 2000-12-15 | 2003-08-14 | Pittman Debra D. | Methods and compositions for diagnosing and treating rheumatoid arthritis |
| US7993907B2 (en) * | 2001-05-08 | 2011-08-09 | Mowycal Lending, Llc | Biochips and method of screening using drug induced gene and protein expression profiling |
| EP1397144A4 (en) * | 2001-05-15 | 2005-02-16 | Psychogenics Inc | SYSTEMS AND METHODS FOR MONITORING BEHAVIOR INFORMATION |
-
2003
- 2003-01-31 EP EP03710830A patent/EP1476747A4/en not_active Withdrawn
- 2003-01-31 CA CA002471661A patent/CA2471661A1/en not_active Abandoned
- 2003-01-31 US US10/501,933 patent/US20070027634A1/en not_active Abandoned
- 2003-01-31 WO PCT/US2003/003194 patent/WO2003064624A2/en not_active Ceased
- 2003-01-31 JP JP2003564220A patent/JP2005535285A/ja active Pending
- 2003-01-31 AU AU2003214981A patent/AU2003214981A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2471661A1 (en) | 2003-08-07 |
| US20070027634A1 (en) | 2007-02-01 |
| JP2005535285A (ja) | 2005-11-24 |
| EP1476747A2 (en) | 2004-11-17 |
| WO2003064624A2 (en) | 2003-08-07 |
| EP1476747A4 (en) | 2008-06-11 |
| WO2003064624A3 (en) | 2003-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |