AU2003213204B2 - Artificial receptors, building blocks, and methods - Google Patents

Artificial receptors, building blocks, and methods Download PDF

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Publication number
AU2003213204B2
AU2003213204B2 AU2003213204A AU2003213204A AU2003213204B2 AU 2003213204 B2 AU2003213204 B2 AU 2003213204B2 AU 2003213204 A AU2003213204 A AU 2003213204A AU 2003213204 A AU2003213204 A AU 2003213204A AU 2003213204 B2 AU2003213204 B2 AU 2003213204B2
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AU
Australia
Prior art keywords
building blocks
building block
alkyl
recognition element
framework
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AU2003213204A
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AU2003213204A1 (en
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Robert E. Carlson
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Receptors LLC
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Receptors LLC
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Anticipated expiration legal-status Critical
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00387Applications using probes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/00527Sheets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572Chemical means
    • B01J2219/00576Chemical means fluorophore
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061The surface being organic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623Immobilisation or binding
    • B01J2219/00626Covalent
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632Introduction of reactive groups to the surface
    • B01J2219/00637Introduction of reactive groups to the surface by coating it with another layer
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00659Two-dimensional arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00659Two-dimensional arrays
    • B01J2219/00662Two-dimensional arrays within two-dimensional arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2600/00Assays involving molecular imprinted polymers/polymers created around a molecular template
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575Volumetric liquid transfer
AU2003213204A 2002-03-01 2003-02-19 Artificial receptors, building blocks, and methods Ceased AU2003213204B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2009200852A AU2009200852A1 (en) 2002-03-01 2009-03-04 Artificial receptors, building blocks, and methods

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US36098002P 2002-03-01 2002-03-01
US60/360,980 2002-03-01
US36260002P 2002-03-08 2002-03-08
US60/362,600 2002-03-08
US37565502P 2002-04-26 2002-04-26
US60/375,655 2002-04-26
US40060502P 2002-08-02 2002-08-02
US60/400,605 2002-08-02
US10/244,727 2002-09-16
US10/244,727 US7504364B2 (en) 2002-03-01 2002-09-16 Methods of making arrays and artificial receptors
PCT/US2003/005328 WO2003074990A2 (en) 2002-03-01 2003-02-19 Artificial receptors, building blocks, and methods

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AU2009200852A Division AU2009200852A1 (en) 2002-03-01 2009-03-04 Artificial receptors, building blocks, and methods

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AU2003213204A1 AU2003213204A1 (en) 2003-09-16
AU2003213204B2 true AU2003213204B2 (en) 2009-01-29

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AU2009200852A Abandoned AU2009200852A1 (en) 2002-03-01 2009-03-04 Artificial receptors, building blocks, and methods

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US (5) US7504364B2 (US07964535-20110621-C00027.png)
EP (1) EP1483578B1 (US07964535-20110621-C00027.png)
JP (1) JP4988147B2 (US07964535-20110621-C00027.png)
CN (1) CN100533145C (US07964535-20110621-C00027.png)
AT (1) ATE538379T1 (US07964535-20110621-C00027.png)
AU (2) AU2003213204B2 (US07964535-20110621-C00027.png)
CA (1) CA2477749A1 (US07964535-20110621-C00027.png)
IL (3) IL163686A0 (US07964535-20110621-C00027.png)
MX (1) MXPA04008467A (US07964535-20110621-C00027.png)
NZ (1) NZ535080A (US07964535-20110621-C00027.png)
WO (1) WO2003074990A2 (US07964535-20110621-C00027.png)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7504364B2 (en) 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
US7469076B2 (en) 2003-09-03 2008-12-23 Receptors Llc Sensors employing combinatorial artificial receptors
US7736909B2 (en) * 2003-01-09 2010-06-15 Board Of Regents, The University Of Texas System Methods and compositions comprising capture agents
US20060292569A1 (en) * 2003-03-25 2006-12-28 Klaus Gottschall Method for selectively binding a substrate to sorbents by way of at least bivalent bonds
EP1613737A4 (en) 2003-03-28 2008-12-03 Receptors Llc ARTIFICIAL RECEPTORS COMPRISING REVERSIBLE IMMOBILIZED CONSTRUCTION BLOCKS AND METHODS
EP1664779A2 (en) * 2003-09-03 2006-06-07 Receptors LLC Methods employing combinatorial artificial receptors
EP1664792A2 (en) * 2003-09-03 2006-06-07 Receptors LLC Building blocks for artificial receptors
JP4711326B2 (ja) * 2003-12-22 2011-06-29 キヤノン株式会社 検定試料および検量線の作製方法
US7884052B2 (en) 2004-09-03 2011-02-08 Receptors Llc Combinatorial artificial receptors including tether building blocks on scaffolds
EP1789792A2 (en) 2004-09-11 2007-05-30 Receptors LLC Combinatorial artificial receptors including peptide building blocks
US7879764B2 (en) * 2004-12-28 2011-02-01 Intel Corporation Electrically active combinatorial chemical (EACC) chip for biochemical analyte detection
CA2707395A1 (en) * 2007-11-29 2009-06-11 Receptors Llc Sensors employing combinatorial artificial receptors
US20100137143A1 (en) * 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
BRPI1014995A2 (pt) * 2009-05-29 2016-04-26 Opko Health Inc ligantes peptídeos para o isolamento e tratamento de células t autoimunes
KR20120122869A (ko) * 2009-06-02 2012-11-07 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 신경변성 질환을 갖는 대상에서 항체에 의해 인식되는 소분자의 확인법
TW201124726A (en) * 2009-10-16 2011-07-16 Univ Texas Compositions and methods for producing coded peptoid libraries
CN103221810B (zh) 2010-08-18 2016-08-03 生命科技股份有限公司 用于电化学检测装置的微孔的化学涂层
US20120241391A1 (en) * 2011-03-25 2012-09-27 Receptors Llc Filtration article with microbial removal, micro-biocidal, or static growth capability
US8900352B2 (en) 2011-07-06 2014-12-02 Northwestern University System and method for generating and/or screening potential metal-organic frameworks
WO2013058844A1 (en) * 2011-07-06 2013-04-25 Northwestern University System and method for generating and/or screening potential metal-organic frameworks
US9194840B2 (en) 2012-01-19 2015-11-24 Life Technologies Corporation Sensor arrays and methods for making same
WO2014144133A1 (en) * 2013-03-15 2014-09-18 The Trustees Of The Princeton University Analyte detection enhancement by targeted immobilization, surface amplification, and pixelated reading and analysis
CN111718321A (zh) * 2020-06-18 2020-09-29 中国农业科学院农业质量标准与检测技术研究所 一种二噁英抗体及其制备方法与应用
WO2022122035A1 (zh) * 2020-12-11 2022-06-16 上海领泰生物医药科技有限公司 凝血因子XIa抑制剂及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6489093B1 (en) * 1996-09-20 2002-12-03 President And Fellows Of Harvard College Combinatorial approach for generating novel coordination complexes

Family Cites Families (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4344438A (en) 1978-08-02 1982-08-17 The United States Of America As Represented By The Department Of Health, Education And Welfare Optical sensor of plasma constituents
US5340474A (en) * 1988-03-24 1994-08-23 Terrapin Technologies, Inc. Panels of analyte-binding ligands
US5225374A (en) * 1988-05-13 1993-07-06 The United States Of America As Represented By The Secretary Of The Navy Method of fabricating a receptor-based sensor
US6346413B1 (en) * 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
AU6753390A (en) * 1989-10-02 1991-04-28 University Of Michigan, The Bioanalytical detection system
JP3283041B2 (ja) * 1990-07-13 2002-05-20 学校法人藤田学園 人工抗体
DE4034565A1 (de) 1990-10-26 1992-04-30 Inst Halbleiterphysik Gmbh Stereospezifischer sensor fuer die bestimmung von zuckern
AU8951191A (en) * 1990-10-29 1992-05-26 Dekalb Plant Genetics Isolation of biological materials using magnetic particles
US5178673A (en) * 1991-04-12 1993-01-12 Union Carbide Chemicals & Plastics Technology Corporation Investment casting compositions and processes for the manufacture and use thereof
US5159656A (en) * 1991-04-29 1992-10-27 Advanced Technology Consortium, Inc. Optical fiber scanning/imaging/printing system
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5324633A (en) * 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
US5667988A (en) * 1992-01-27 1997-09-16 The Scripps Research Institute Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
WO1993025910A1 (en) * 1992-06-05 1993-12-23 Pharmacia Biosensor Ab Assay for multiple analytes with co-immobilized ligands
US5512435A (en) * 1993-02-05 1996-04-30 Renschler; Markus F. Receptor-binding antiproliferative peptides
US5677196A (en) 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5811076A (en) * 1993-05-20 1998-09-22 The Regents Of The University Of California Macromolecular contrast media for MR imaging
WO1995002566A1 (en) 1993-07-16 1995-01-26 Ontogen Corporation Synthesis of combinatorial arrays of organic compounds through the use of multiple component combinatorial array syntheses
DE4335729A1 (de) * 1993-10-20 1995-04-27 Boehringer Mannheim Gmbh Verwendung von mit enzymatisch abspaltbaren Schutzgruppen versehenen Nukleosiden und Nukleosid-Derivaten in der Synthese von Oligonukleotiden
US5942393A (en) * 1993-12-29 1999-08-24 The Regents Of The University Of California Method for the detection of the presence or absence of methylthioadenosine phosphorylase (MTASE) in a cell sample by detection of the presence or absence of MTASE encoding nucleic acid in the cell sample
EP0739486A4 (en) * 1994-01-13 1998-09-09 Univ Columbia SYNTHETIC RECEPTORS, LIBRARIES AND THEIR USE
US5453533A (en) * 1994-04-14 1995-09-26 The University Of Alabama At Birmingham Inhibitors of influenza virus neuraminidase and methods of making and using the same
US6419881B1 (en) * 1994-10-18 2002-07-16 Symyx Technologies, Inc. Combinatorial arrays of organometallic compounds and catalysts
US6030917A (en) 1996-07-23 2000-02-29 Symyx Technologies, Inc. Combinatorial synthesis and analysis of organometallic compounds and catalysts
US5998594A (en) * 1994-12-30 1999-12-07 University Of Pittsburgh Of The Commonwealth System Of Higher Education Self-assembling, chromogenic receptors for the recognition of medically important substrates and their method of use
US5990163A (en) * 1995-01-13 1999-11-23 The Salk Institute For Biological Studies Selective modulation of processes mediated by retinoid X receptors, and compounds useful therefor
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
HUP9801679A3 (en) * 1995-03-10 2001-01-29 Meso Scale Technologies Llc Co Process and agent for multi-array, multi-specific electrochemiluminescence testing
US6673533B1 (en) * 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
US5690894A (en) * 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5925529A (en) * 1995-06-07 1999-07-20 The Regents Of The University Of California Method for discovery of peptide agonists
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
DE19527155C2 (de) 1995-07-25 1998-12-10 Deutsches Krebsforsch Verfahren zur Sequenzierung durch Oligomerhybridisierung
US6168912B1 (en) * 1996-01-23 2001-01-02 Martek Biosciences Corporation Method and kit for making a multidimensional combinatorial chemical library
US5880972A (en) * 1996-02-26 1999-03-09 Pharmacopeia, Inc. Method and apparatus for generating and representing combinatorial chemistry libraries
IT1284025B1 (it) * 1996-06-18 1998-05-08 Italtel Spa Convertitore di frequenza per applicazioni alle onde radio millimetriche
US6361944B1 (en) * 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US5770380A (en) * 1996-09-13 1998-06-23 University Of Pittsburgh Synthetic antibody mimics--multiple peptide loops attached to a molecular scaffold
US6875620B1 (en) 1996-10-31 2005-04-05 Agilent Technologies, Inc. Tiling process for constructing a chemical array
AU5588798A (en) * 1996-11-22 1998-06-10 Regents Of The University Of California, The Chemical microsensors for detection of explosives and chemical warfare agents
US6699719B2 (en) * 1996-11-29 2004-03-02 Proteomic Systems, Inc. Biosensor arrays and methods
AU741076B2 (en) * 1996-12-12 2001-11-22 Prolume, Ltd. Apparatus and method for detecting and identifying infectious agents
WO1998027430A1 (en) * 1996-12-17 1998-06-25 Affymetrix Inc. Lithographic mask design and synthesis of diverse probes on a substrate
JP4663824B2 (ja) * 1996-12-31 2011-04-06 ハイ スループット ジェノミクス インコーポレイテッド 多重化分子分析装置および方法
US6310191B1 (en) * 1998-02-02 2001-10-30 Cosmix Molecular Biologicals Gmbh Generation of diversity in combinatorial libraries
US5837860A (en) * 1997-03-05 1998-11-17 Molecular Tool, Inc. Covalent attachment of nucleic acid molecules onto solid-phases via disulfide bonds
US6344272B1 (en) * 1997-03-12 2002-02-05 Wm. Marsh Rice University Metal nanoshells
US7144627B2 (en) * 1997-03-12 2006-12-05 William Marsh Rice University Multi-layer nanoshells comprising a metallic or conducting shell
US6083758A (en) * 1997-04-09 2000-07-04 California Institute Of Technology Method for screening peptides for metal coordinating properties and fluorescent chemosensors derived therefrom
US6660714B1 (en) * 1997-04-16 2003-12-09 Sloan Kettering Institute For Cancer Research α-O-linked glycoconjugates, methods of preparation and uses thereof
US6096511A (en) * 1997-06-10 2000-08-01 Merck & Co., Inc. Protein elongation factor 2 as a target for antifungal and antiparasitic agents
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US5993653C1 (en) 1997-08-11 2001-11-06 Phenomenex Composition and column used in hplc
US6410585B1 (en) * 1997-08-28 2002-06-25 Scott D. Larsen Inhibitors of protein tyrosine phosphatase
WO1999025384A2 (en) 1997-11-17 1999-05-27 University Of Miami Multimeric tethered ligands and their use in receptor-ligand interactions
US6238869B1 (en) 1997-12-19 2001-05-29 High Throughput Genomics, Inc. High throughput assay system
FR2774092B1 (fr) * 1998-01-26 2000-02-18 Air Liquide Procede de preparation de polyazacycloalcanes greffes sur gel de silice et utilisation des composes greffes
US6210910B1 (en) * 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
US6428811B1 (en) * 1998-03-11 2002-08-06 Wm. Marsh Rice University Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery
US7101575B2 (en) * 1998-03-19 2006-09-05 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly
AU758097B2 (en) * 1998-03-25 2003-03-13 Sloan-Kettering Institute For Cancer Research Trimeric antigenic O-linked glycopeptide conjugates, methods of preparation and uses thereof
US6316616B1 (en) * 1998-04-02 2001-11-13 President And Fellows Of Harvard College Parallel combinatorial approach to the discovery and optimization of catalysts and uses thereof
US6111123A (en) * 1998-04-20 2000-08-29 The Regents Of The University Of Michigan Salicylaldimine-crown ether ditopic receptor molecules
US6287765B1 (en) * 1998-05-20 2001-09-11 Molecular Machines, Inc. Methods for detecting and identifying single molecules
AU4829099A (en) * 1998-06-22 2000-01-10 Regents Of The University Of California, The Triggered optical biosensor
ATE377449T1 (de) * 1998-07-15 2007-11-15 Max Planck Gesellschaft Polyelektrolythüllen auf biologischen templaten
US6346189B1 (en) * 1998-08-14 2002-02-12 The Board Of Trustees Of The Leland Stanford Junior University Carbon nanotube structures made using catalyst islands
EP2273270A1 (de) 1998-08-28 2011-01-12 febit holding GmbH Verfahren und Vorrichtung zur Herstellung und/oder Analyse von biochemischen Reaktionsträgern
DE19839538A1 (de) 1998-08-31 2000-03-02 Gluesenkamp Karl Heinz Herstellung von maßgeschneiderten Chromatografiematerialien über intelligenten Oberflächen
WO2000016733A2 (en) 1998-09-22 2000-03-30 The Procter & Gamble Company Personal care compositions containing active proteins tethered to a water insoluble substrate
CA2340905A1 (en) 1999-05-05 2000-11-09 The Regents Of The University Of California Method for detecting biological agents
GB9915074D0 (en) * 1999-06-28 1999-08-25 Cortecs Plc Ligand-binding composition
JP4684507B2 (ja) 1999-07-05 2011-05-18 ノバルティス アーゲー センサープラットホームを使用する方法
US6346423B1 (en) * 1999-07-16 2002-02-12 Agilent Technologies, Inc. Methods and compositions for producing biopolymeric arrays
EA200200220A1 (ru) * 1999-07-29 2002-08-29 Эпикс Медикал, Инк. Нацеливающие мультимерные визуализирующие агенты с механизмом мультилокусного связывания
US7824687B2 (en) * 1999-08-20 2010-11-02 Sloan-Kettering Institute For Cancer Research Clustered multi-antigenic carbohydrate constructs, methods for their preparation, and uses thereof
US7854934B2 (en) 1999-08-20 2010-12-21 Sloan-Kettering Institute For Cancer Research Glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof
US6543639B1 (en) * 1999-08-26 2003-04-08 A & A Global Industries, Inc. Animated candy dispenser and methods
DE19943743C2 (de) 1999-09-03 2002-02-07 Jerini Biotools Gmbh Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays
US6656432B1 (en) 1999-10-22 2003-12-02 Ngk Insulators, Ltd. Micropipette and dividedly injectable apparatus
US6627396B1 (en) * 1999-10-28 2003-09-30 The Regents Of The University Of California Influenza sensor
US6372907B1 (en) * 1999-11-03 2002-04-16 Apptera Corporation Water-soluble rhodamine dye peptide conjugates
US7195780B2 (en) * 2002-10-21 2007-03-27 University Of Florida Nanoparticle delivery system
US6699677B1 (en) 1999-12-20 2004-03-02 Chemocentryx, Inc. Tethered ligands and methods of use
DE10001172A1 (de) * 2000-01-13 2001-07-26 Max Planck Gesellschaft Templatieren von Feststoffpartikeln mit Polymermultischichten
AU2001236757A1 (en) * 2000-02-07 2001-08-14 President And Fellows Of Harvard College Method for analysis of reaction products
EP1385869A2 (en) * 2000-02-08 2004-02-04 The Regents Of The University Of Michigan Protein mapping
JP2003530365A (ja) 2000-04-10 2003-10-14 ザ スクリプス リサーチ インスティチュート プロテオミック分析
US7351376B1 (en) * 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
CN1137999C (zh) * 2000-07-04 2004-02-11 清华大学 集成式微阵列装置
US6584411B1 (en) * 2000-07-26 2003-06-24 Smithkline Beecham Corporation Methods to facilitate the calculation of yields of reaction products
DK1305109T3 (da) * 2000-08-02 2004-12-20 Max Planck Gesellschaft Fremstilling af polyelektrolytkapsler ved overfladepræcipitation
US6977155B2 (en) * 2000-08-10 2005-12-20 Corning Incorporated Arrays of biological membranes and methods and use thereof
US20040013721A1 (en) * 2000-08-28 2004-01-22 Alexei Antipov Controlled and sustained release properties of polyelectrolyte multilayer capsules
EP1197755A1 (en) * 2000-10-11 2002-04-17 Pepscan Systems B.V. Identification of protein binding sites
US6905816B2 (en) 2000-11-27 2005-06-14 Intelligent Medical Devices, Inc. Clinically intelligent diagnostic devices and methods
WO2002042775A2 (en) 2000-11-27 2002-05-30 Genevention L.L.C. Clinically intelligent diagnostic devices and methods
WO2002053290A2 (en) * 2001-01-08 2002-07-11 President And Fellows Of Harvard College Valves and pumps for microfluidic systems and method for making microfluidic systems
US6543936B2 (en) * 2001-04-24 2003-04-08 Daniel Uzbelger Feldman Apparatus for diagnosis and/or treatment in the field of dentistry using fluoroscopic and conventional radiography
JP2004534088A (ja) * 2001-07-06 2004-11-11 スローン−ケッタリング・インスティテュート・フォア・キャンサー・リサーチ 癌のための多価コンジュゲートワクチン
US6698201B1 (en) * 2001-08-16 2004-03-02 Zyvex Corporation Cascaded bimorph rotary actuator
EP1300684A1 (en) 2001-10-08 2003-04-09 Barts and The London National Health Service Trust Homogenous ligand binding assay
AR036833A1 (es) 2001-10-18 2004-10-06 Bayer Corp Anticuerpos humanos que se unen a mn y tienen actividad neutralizante de la adhesion celular.
US20030156991A1 (en) * 2001-10-23 2003-08-21 William Marsh Rice University Optomechanically-responsive materials for use as light-activated actuators and valves
JP2003149242A (ja) 2001-11-09 2003-05-21 Gifu Univ 抗体検出方法及び抗原マイクロアレイ
GB0127989D0 (en) 2001-11-22 2002-01-16 Glaxo Group Ltd Medicament dispensing system
US7141368B2 (en) * 2002-01-30 2006-11-28 Agilent Technologies, Inc. Multi-directional deposition in array fabrication
US7504364B2 (en) 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
ITRM20020133U1 (it) * 2002-07-15 2004-01-16 Plast Wood S R L Complesso di elementi per l'assiemaggio di strutture.
US20060051802A1 (en) * 2002-09-16 2006-03-09 Receptors Llc Artificial receptors, building blocks, and methods
AU2003284227A1 (en) * 2002-10-15 2004-05-04 The Regents Of The University Of Michigan Multidimensional protein separation system
US7256052B2 (en) * 2002-10-18 2007-08-14 Exxonmobil Chemical Patents Inc. Chemical reaction and analysis system
US20040185473A1 (en) 2002-12-17 2004-09-23 Affymetrix, Inc. Releasable polymer arrays
WO2006017180A2 (en) 2004-07-09 2006-02-16 Progenics Pharmaceuticals, Inc. Glycopeptide dimers and uses thereof
GB0426823D0 (en) 2004-12-07 2005-01-12 Precisense As Sensor for detection of glucose

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6489093B1 (en) * 1996-09-20 2002-12-03 President And Fellows Of Harvard College Combinatorial approach for generating novel coordination complexes

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