AU2003207944A1 - Apparatus for treating bruxism - Google Patents
Apparatus for treating bruxism Download PDFInfo
- Publication number
- AU2003207944A1 AU2003207944A1 AU2003207944A AU2003207944A AU2003207944A1 AU 2003207944 A1 AU2003207944 A1 AU 2003207944A1 AU 2003207944 A AU2003207944 A AU 2003207944A AU 2003207944 A AU2003207944 A AU 2003207944A AU 2003207944 A1 AU2003207944 A1 AU 2003207944A1
- Authority
- AU
- Australia
- Prior art keywords
- relaxant
- relaxation
- stimulator
- patient
- drug delivery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010006514 bruxism Diseases 0.000 title claims description 16
- 239000002249 anxiolytic agent Substances 0.000 claims description 22
- 210000003205 muscle Anatomy 0.000 claims description 21
- 238000012377 drug delivery Methods 0.000 claims description 16
- 210000005036 nerve Anatomy 0.000 claims description 13
- 230000000694 effects Effects 0.000 claims description 8
- 238000011282 treatment Methods 0.000 claims description 7
- 238000004891 communication Methods 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 230000003387 muscular Effects 0.000 claims description 5
- 230000018405 transmission of nerve impulse Effects 0.000 claims description 3
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 4
- 210000001738 temporomandibular joint Anatomy 0.000 description 4
- 239000013043 chemical agent Substances 0.000 description 3
- 210000001352 masseter muscle Anatomy 0.000 description 3
- 206010028391 Musculoskeletal Pain Diseases 0.000 description 2
- 208000007302 Sleep Bruxism Diseases 0.000 description 2
- 208000028911 Temporomandibular Joint disease Diseases 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 2
- 210000001061 forehead Anatomy 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 210000002698 mandibular nerve Anatomy 0.000 description 2
- 239000003094 microcapsule Substances 0.000 description 2
- 235000013842 nitrous oxide Nutrition 0.000 description 2
- 230000002040 relaxant effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 1
- 241001669679 Eleotris Species 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 241000220010 Rhode Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229940049706 benzodiazepine Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 229960003529 diazepam Drugs 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004228 maxillary nerve Anatomy 0.000 description 1
- 239000001272 nitrous oxide Substances 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 229940125725 tranquilizer Drugs 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 229940072690 valium Drugs 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/389—Electromyography [EMG]
- A61B5/395—Details of stimulation, e.g. nerve stimulation to elicit EMG response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
- A61B5/4538—Evaluating a particular part of the muscoloskeletal system or a particular medical condition
- A61B5/4542—Evaluating the mouth, e.g. the jaw
- A61B5/4557—Evaluating bruxism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/486—Bio-feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/389—Electromyography [EMG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
- A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
Description
WO 03/059160 PCT/L03/00012 1 APPARATUS FOR TREATING BRUXISM FIELD OF THE INVENTION The present invention relates generally to apparatus for treating bruxism. BACKGROUND OF THE INVENTION Bruxism has generally been defined as nonfunctional clenching, grinding, gritting, gnashing, and/or clicking of the teeth. Bruxism may occur while a person is awake or asleep. When the phenomenon occurs during sleep, it is called nocturnal bruxism. Even when it occurs during waking hours, the bruxer is often not conscious of the activity. Biting force exerted during bruxism often significantly exceeds peak biting force exerted during normal chewing. Chronic bruxism may result in musculoskeletal pain, headaches, and damage to the teeth and/or the temporomandibular joint. Bruxism has been connected with temporomandibular disorders (TMD) or temporomandibular joint (TMJ) syndrome. One of the known treatments in the prior art for nocturnal bruxism is the use of intra oral occlusal splints or "mouth guards," which are generally semi-rigid plastic covers for the upper or lower teeth. Occlusal splints are generally fabricated for a specific individual from an impression taken of the individual's teeth. However, the occlusal splints often only protect the teeth themselves, while the user may still suffer musculoskeletal pain and possible damage to the temporomandibular joint. Moreover, occlusal splints present numerous inconveniences to the user. They may require frequent cleaning, may be difficult to clean, may require periodic replacement, may inhibit speech, and may be frequently lost. Other techniques in the art attempt to combat bruxism through biofeedback. For example, an electromyograph has been used to sense the action of the masseter muscle. When muscle activity is detected, an audible tone is generated, which may alert the individual that he or she is bruxing. However, some biofeedback devices involve bulky electronics and may require electrodes to be attached adhesively to the face. Accordingly, such devices are considered impractical for long-term use in treating bruxism, and not well suited for consumer use. Some variations on the biofeedback approach known in the art incorporate sensing means into an occlusal splint in order to sense the onset of bruxing. These approaches may require the presence of electrical devices in the mouth, including, in many cases, batteries, which may contain highly toxic substances. The electrical and chemical health risks of these devices add to the general drawbacks of intra-oral splints described above. Another biofeedback device, called GRINDALERT is commercially available from Brux-Care, Inc., 84 Ship Street, Providence, Rhode Island, USA (www.bruxcare.com).
WO 03/059160 PCT/IL03/00012 2 Instead of sensors in the mouth or bonded to the skin, GRINDALERT has a miniaturized sensing device incorporated into a headband. Bruxing may be sensed by the electrical activity of "obruxism muscles" (e.g., the temporalis and/or masseter muscles used to close the jaw). An electronics module processes the electrical signal from the bruxism muscles. When a threshold of intensity and duration is exceeded, the device emits an audible signal to provide feedback to the user, indicating the onset of a bruxing event. Data (including time, duration, and intensity) may be stored internally in response to a bruxing event. The data may be read out through connection to a personal computer, or via voice synthesis or a display. However, a disadvantage of the audible devices of the art is that users may not wake up upon hearing the sound, especially if the user is a deep sleeper. In addition, users may become accustomed to the audible tone and unconsciously (or even consciously) ignore it. SUMMARY OF THE INVENTION The present invention seeks to provide improved apparatus for treatment of bruxism. The invention may use a variety of biosensors, such as but not limited to, electrodes, muscular activity sensors or nerve electrical impulse sensors, mounted in contact with a user's head, temples, forehead or jaw. In a preferred method of the invention, the biosensor provides biofeedback to a relaxation stimulant to relax the obruxism muscles or nerves, e.g., the temporalis and/or masseter muscles, or the maxillary or mandibular nerves associated with closing the jaw, such as but not limited to, the inferior alveolar nerve. The invention may relax the muscles or nerves by a variety of manners, such as but not limited to, chemical agents (e.g., laughing gas) or electrical stimulants to the muscles or nerves. In contrast to the prior art, the invention may relax the bruxing event without any need for the patient to react to external, audible stimuli. Since the relaxing stimulus of the invention may work directly on the muscle or nerve, the patient may not become accustomed to the relaxing stimulus, thereby providing a significant improvement in reliability of the device. There is thus provided in accordance with a preferred embodiment of the present invention apparatus for the treatment of bruxism, including a biosensor adapted to sense a phenomenon associated with a bruxing event, and a relaxation stimulator in communication with the biosensor and adapted to provide a relaxation stimulus to relax at least one of an obruxism muscle and an obruxism nerve. In accordance with a preferred embodiment of the present invention the relaxation stimulator includes a drug delivery module adapted to administer a relaxant to a patient.
WO 03/059160 PCT/IL03/00012 3 Further in accordance with a preferred embodiment of the present invention the drug delivery module includes an injection module adapted to inject a relaxant to a patient. Still further in accordance with a preferred embodiment of the present invention the drug delivery module is adapted to emit a relaxant to air in a vicinity of a patient. Further in accordance with a preferred embodiment of the present invention the drug delivery module includes a transdermal module adapted to administer a relaxant transdermally into a patient. In accordance with a preferred embodiment of the present invention the drug delivery module includes a relaxant, such as a drug adapted to reduce transmission of nerve impulses to an obruxism muscle tissue. Further in accordance with a preferred embodiment of the present invention the relaxation stimulator includes an electrical stimulator, such as a transcutaneous electrical stimulator. In accordance with a preferred embodiment of the present invention the biosensor includes at least one of an electrode, a muscular activity sensor and a nerve electrical impulse sensor. BRIEF DESCRIPTION OF THE DRAWINGS The present invention will be understood and appreciated more fully from the following detailed description taken in conjunction with the drawings in which: Fig. 1 is a simplified block diagram of apparatus for the treatment of bruxism, constructed and operative in accordance with a preferred embodiment of the present invention; Figs. 2A-2C are simplified illustrations of the apparatus of Fig. 1, in accordance with different preferred embodiments of the present invention, comprising a relaxation stimulator that comprises drug delivery modules; and Fig. 3 is a simplified illustration of the apparatus of Fig. 1, in accordance with another preferred embodiment of the present invention, comprising a relaxation stimulator that comprises an electrical stimulator. DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS Reference is now made to Fig. 1, which illustrates in block diagram format, apparatus 10 for the treatment of bruxism, in accordance with a preferred embodiment of the present invention. Apparatus 10 preferably includes a biosensor 12 adapted to sense a phenomenon associated with a bruxing event. For example, biosensor 12 may comprise a pair of electrodes mounted in contact with a user's skull, for example near the temples. The WO 03/059160 PCT/IL03/00012 4 voltage between the temple electrodes may be amplified and filtered to yield a signal indicative of the tension in the fibers of the temporalis muscle, and thus may indicate a bruxing event. As another example, biosensor 12 may comprise a muscular activity sensor or a nerve electrical impulse sensor, mounted or near the user's head, temples, forehead or jaw. A relaxation stimulator 14 is preferably in communication with biosensor 12. The relaxation stimulator 14 may be in wired or wireless communication (e.g., BLUETOOTH) with biosensor 12. The relaxation stimulator 14 preferably provides a relaxation stimulus to relax an obruxism muscle and/or nerve. A processor 15 may be provided in communication' with biosensor 12 and the relaxation stimulator 14 for processing signals received from biosensor 12 and for controlling operation of the relaxation stimulator 14. A memory module 17 may be provided for storing data, such as but not limited to, data related to bruxing events sensed by biosensor 12, for example. The processor 15 may be programmable to allow flexibility in providing an optimum treatment plan for the patient. Reference is now made to Figs. 2A-2C, which illustrate various embodiments of apparatus 10, wherein the relaxation stimulator 14 comprises a drug delivery module adapted to administer a relaxant to a patient. The relaxant may comprise a drug or chemical agent (the terms being used interchangeably) that reduces transmission of nerve impulses to an obruxism muscle tissue. Such drugs may include, but are not limited to, nitrous oxide (laughing gas) or diazepam (e.g., a benzodiazepine tranquilizer, such as VALIUM). It is noted that in the present invention the term "relaxation" in all its inflections, refers not just to the state of obruxism muscles or other body tissues and parts becoming less tense, but also refers to arresting, reducing or otherwise preventing the bruxing forces applied by such muscles or other body tissues and parts. For example, in accordance with another embodiment of the present invention, the relaxant may comprise a drug or chemical agent that causes the obruxism muscles to "freeze", that is become somewhat motionless or fixed, so that the patient does not bite against his/her teeth, without necessarily reducing the tense state of the muscles. In another embodiment, the relaxant may reduce the biting force applied by the obruxism muscles without necessarily arresting the muscular activity or reducing the tension thereof. All of these influences on the obruxism muscles or nerves are included in the definition of "relaxation" in all its inflections throughout the specification and claims. In Fig. 2A, the drug delivery module may comprise an injection module 16 adapted to inject a relaxant 18 to a patient by means of an injection needle 20. For purposes of WO 03/059160 PCT/IL03/00012 5 example only, the injection module 16 may be worn as a headphone and relaxant 18 may be injected locally near the jaw of the patient or in other places as well. In Fig. 2B, the drug delivery module may emit the relaxant 18 to air in the vicinity of the patient. For example, upon receiving a signal from biosensor 12, a microcapsule 22, containing the relaxant 18, may be ruptured to release the relaxant to the air. The drug delivery module including the microcapsule 22 may be worn as a pendant or earring, if desired. In Fig. 2C, the drug delivery module may comprise a transdermal module 24, such as a skin patch, for example, which administers the relaxant 18 transdermally into the patient. Different techniques may be used to enhance the administration of the relaxant 18, such as but not limited to, iontophoresis. Reference is now made to Fig. 3, which illustrates another embodiment of apparatus 10, wherein the relaxation stimulator 14 comprises an electrical stimulator 26, such as a transcutaneous electrical stimulator. For example, upon receiving a signal from biosensor 12, the electrical stimulator may provide an electrical relaxation stimulus to an obruxism muscle or nerve, so as to cause the patient to relax and stop bruxing. It will be appreciated by person skilled in the art that the present invention is not limited by what has been particularly shown and described herein above. Rather the scope of the present invention is defined only by the claims that follow:
Claims (10)
1. Apparatus for the treatment of bruxism, comprising: a biosensor adapted to sense a phenomenon associated with a bruxing event; and a relaxation stimulator in communication with said biosensor and adapted to provide a relaxation stimulus to relax at least one of an obruxism muscle and an obruxism nerve.
2. Apparatus according to claim 1 wherein said relaxation stimulator comprises a drug delivery module adapted to administer a relaxant to a patient.
3. Apparatus according to claim 2 wherein said drug delivery module comprises an injection module adapted to inject a relaxant to a patient.
4. Apparatus according to claim 2 wherein said drug delivery module is adapted to emit a relaxant to air in a vicinity of a patient.
5. Apparatus according to claim 2 wherein said drug delivery module comprises a transdermal module adapted to administer a relaxant transdermally into a patient.
6. Apparatus according to claim 2 wherein said drug delivery module comprises a relaxant.
7. Apparatus according to claim 6 wherein said relaxant comprises a drug adapted to reduce transmission of nerve impulses to an obruxism muscle tissue.
8. Apparatus according to claim 1 wherein said relaxation stimulator comprises an electrical stimulator.
9. Apparatus according to claim 1 wherein said relaxation stimulator comprises a transcutaneous electrical stimulator.
10. Apparatus according to claim 1 wherein said biosensor comprises at least one of an electrode, a muscular activity sensor and a nerve electrical impulse sensor.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL147468 | 2002-01-03 | ||
IL14746802A IL147468A0 (en) | 2002-01-03 | 2002-01-03 | Apparatus for treating bruxism |
PCT/IL2003/000012 WO2003059160A1 (en) | 2002-01-03 | 2003-01-03 | Apparatus for treating bruxism |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2003207944A1 true AU2003207944A1 (en) | 2003-07-30 |
AU2003207944B2 AU2003207944B2 (en) | 2007-04-05 |
Family
ID=11075923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2003207944A Ceased AU2003207944B2 (en) | 2002-01-03 | 2003-01-03 | Apparatus for treating bruxism |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1469774A1 (en) |
AU (1) | AU2003207944B2 (en) |
IL (1) | IL147468A0 (en) |
WO (1) | WO2003059160A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2403400B1 (en) * | 2009-03-04 | 2016-10-26 | Sunstar Suisse SA | Apparatus for detecting bruxism |
ES2439596B1 (en) | 2012-07-23 | 2014-10-28 | Julio ÁLVAREZ UTRERA | Disposable device to test the existence of bruxism |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4669477A (en) * | 1985-05-20 | 1987-06-02 | Empi, Inc. | Apparatus and method for preventing bruxism |
US4715367A (en) * | 1986-09-15 | 1987-12-29 | Crossley Robert B | Multifunctional behavioral modification device for snoring, bruxism, and apnea |
WO1991015261A1 (en) * | 1990-03-30 | 1991-10-17 | Medtronic, Inc. | Activity controlled electrotransport drug delivery device |
US6093158A (en) * | 1997-05-15 | 2000-07-25 | Morris; Donald E. | Systems for modifying behavioral disorders |
US6089864A (en) * | 1997-11-14 | 2000-07-18 | William L. Hintermister | Bio-feedback, data acquisition teeth guards, methods of their manufacture and use |
US6149577A (en) * | 1999-03-18 | 2000-11-21 | Emf Therapeutics, Inc. | Apparatus and method for creating a substantially contained, finite magnetic field useful for relieving the symptoms pain and discomfort associated with degenerative diseases and disorders in mammals |
-
2002
- 2002-01-03 IL IL14746802A patent/IL147468A0/en not_active IP Right Cessation
-
2003
- 2003-01-03 WO PCT/IL2003/000012 patent/WO2003059160A1/en active IP Right Grant
- 2003-01-03 AU AU2003207944A patent/AU2003207944B2/en not_active Ceased
- 2003-01-03 EP EP03704948A patent/EP1469774A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU2003207944B2 (en) | 2007-04-05 |
EP1469774A1 (en) | 2004-10-27 |
IL147468A0 (en) | 2002-08-14 |
WO2003059160A1 (en) | 2003-07-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FGA | Letters patent sealed or granted (standard patent) | ||
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |