AU2002305539A1 - Toll/interleukin-1 receptor adaptor protein (tirap) - Google Patents

Toll/interleukin-1 receptor adaptor protein (tirap)

Info

Publication number
AU2002305539A1
AU2002305539A1 AU2002305539A AU2002305539A AU2002305539A1 AU 2002305539 A1 AU2002305539 A1 AU 2002305539A1 AU 2002305539 A AU2002305539 A AU 2002305539A AU 2002305539 A AU2002305539 A AU 2002305539A AU 2002305539 A1 AU2002305539 A1 AU 2002305539A1
Authority
AU
Australia
Prior art keywords
tirap
toll
interleukin
adaptor protein
receptor adaptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002305539A
Other languages
English (en)
Inventor
Gregory Barton
Tiffany Horng
Ruslan Medzhitov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Original Assignee
Yale University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yale University filed Critical Yale University
Publication of AU2002305539A1 publication Critical patent/AU2002305539A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2002305539A 2001-05-09 2002-05-09 Toll/interleukin-1 receptor adaptor protein (tirap) Abandoned AU2002305539A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US28981501P 2001-05-09 2001-05-09
US28973801P 2001-05-09 2001-05-09
US60/289,815 2001-05-09
US60/289,738 2001-05-09
US28986601P 2001-08-29 2001-08-29
US60/289,866 2001-08-29
US10139802A 2002-03-19 2002-03-19
US10/101,398 2002-03-19
PCT/US2002/014915 WO2002090520A2 (en) 2001-05-09 2002-05-09 Toll/interleukin-1 receptor adaptor protein (tirap)

Publications (1)

Publication Number Publication Date
AU2002305539A1 true AU2002305539A1 (en) 2002-11-18

Family

ID=27493201

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002305539A Abandoned AU2002305539A1 (en) 2001-05-09 2002-05-09 Toll/interleukin-1 receptor adaptor protein (tirap)

Country Status (6)

Country Link
US (3) US6960343B2 (enExample)
EP (1) EP1401281A4 (enExample)
JP (1) JP2004536585A (enExample)
AU (1) AU2002305539A1 (enExample)
CA (1) CA2446458A1 (enExample)
WO (1) WO2002090520A2 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303321B1 (en) 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
EP1345617A2 (en) * 2000-12-22 2003-09-24 Synovis Limited Methods of modulating toll-related receptor (trr) signaling
US7304034B2 (en) 2001-05-15 2007-12-04 The Feinstein Institute For Medical Research Use of HMGB fragments as anti-inflammatory agents
US7220723B2 (en) 2001-05-15 2007-05-22 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
JP2004073073A (ja) * 2002-08-16 2004-03-11 Japan Science & Technology Corp エンドトキシン及びリポタンパク・リポペプチド不応答性モデル非ヒト動物
EP1613956A2 (en) * 2003-03-25 2006-01-11 3M Innovative Properties Company Selective activation of cellular activities mediated through a common toll-like receptor
US7696169B2 (en) 2003-06-06 2010-04-13 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
US20050013812A1 (en) * 2003-07-14 2005-01-20 Dow Steven W. Vaccines using pattern recognition receptor-ligand:lipid complexes
AU2004272607B2 (en) 2003-09-11 2008-11-06 Cornerstone Therapeutics Inc. Monoclonal antibodies against HMGB1
US20060002941A1 (en) * 2004-01-23 2006-01-05 Vievax Corp. Compositions comprising immune response altering agents and methods of use
US20050244410A1 (en) * 2004-04-29 2005-11-03 Ashlyn Bassiri Toll-like receptor 9 effector agents and uses thereof
CA2590750A1 (en) 2004-12-20 2006-06-29 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Myd88 homodimerization inhibitors
ZA200707249B (en) * 2005-01-28 2010-08-25 Galen Bio Inc Immunologically active compositions
US20100069297A1 (en) * 2005-04-15 2010-03-18 Mathew J Fenton Selective Inhibition of TLR4 Signaling
DK2178549T3 (en) * 2007-07-26 2017-01-09 Revance Therapeutics Inc Antimicrobial peptide AND COMPOSITIONS THEREOF
US20110151015A1 (en) * 2008-03-04 2011-06-23 Liquikia Technologies, Inc. Immunomodulator particles and methods of treating
WO2012047175A1 (en) 2010-10-05 2012-04-12 Kemijski inštitut Fusion polypeptides comprising tir and dimerization domain for modulation of tlr/innate immunity signaling
KR101566107B1 (ko) 2014-04-18 2015-11-05 영남대학교 산학협력단 Tlr6 tir 도메인의 ３차 구조 및 이를 이용한 약물 스크리닝 방법
US10550173B2 (en) * 2015-02-19 2020-02-04 Compugen, Ltd. PVRIG polypeptides and methods of treatment
IL254039B2 (en) 2015-02-19 2023-12-01 Compugen Ltd Anti-pvrig antibodies and methods of use
EP3095444A1 (en) 2015-05-20 2016-11-23 Dublin City University A method of treating peripheral inflammatory disease
KR102585976B1 (ko) 2016-08-17 2023-10-05 컴퓨젠 엘티디. 항-tigit 항체, 항-pvrig 항체 및 이들의 조합
JP7348072B2 (ja) 2017-06-01 2023-09-20 コンピュジェン リミテッド 三重併用抗体療法
KR20200084569A (ko) * 2019-01-03 2020-07-13 주식회사 젠센 Tlr4 신호전달 경로를 억제하는 펩타이드 및 그 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6271349B1 (en) * 1996-12-23 2001-08-07 Immunex Corporation Receptor activator of NF-κB
US6399584B1 (en) * 1998-03-18 2002-06-04 Institute Curie Pharmaceutical composition containing ezrin mutated on tyrosine 353
US7029861B1 (en) * 1998-09-15 2006-04-18 Board Of Regents, The University Of Texas System LPS-response gene compositions and methods
US7078585B1 (en) 1999-01-14 2006-07-18 Japan Science And Technology Agency Bacterial cell component-unresponsive model mouse
AU4201000A (en) * 1999-04-05 2000-10-23 Incyte Pharmaceuticals, Inc. Molecules of the immune system
US6506769B2 (en) * 1999-10-06 2003-01-14 Boehringer Ingelheim Pharmaceuticals, Inc. Heterocyclic compounds useful as inhibitors of tyrosine kinases
AU2001263236A1 (en) 2000-05-17 2001-11-26 Immunex Corporation Human myd88 adapter-like protein and functional fragments thereof

Also Published As

Publication number Publication date
JP2004536585A (ja) 2004-12-09
WO2002090520A3 (en) 2003-07-10
EP1401281A4 (en) 2004-12-29
US6960343B2 (en) 2005-11-01
US20030023993A1 (en) 2003-01-30
CA2446458A1 (en) 2002-11-14
US7285535B2 (en) 2007-10-23
US20060130164A1 (en) 2006-06-15
EP1401281A2 (en) 2004-03-31
WO2002090520A2 (en) 2002-11-14
US20080096250A1 (en) 2008-04-24

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase